Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works

Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis

Grulich, A. E., van Leeuwen, M. T., Falster, M. O., & Vajdic, C. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61050-2 · Cited by 2,321 · see citing works

Inflammatory bowel disease: cause and immunobiology

Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147 · see citing works

International programme on chemical safety

Haines, J. A. (1996) · The Lancet · doi:10.1016/s0140-6736(05)65029-5 · Cited by 1,869 · see citing works

Skin cancers after organ transplantation

Euvrard, S., Kanitakis, J., & Claudy, A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022137 · Cited by 1,575 · see citing works

Mycophenolate mofetil and its mechanisms of action

ALLISON, A. C., & Eugui, E. M. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)00188-0 · Cited by 1,433 · see citing works

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Weinshilboum, R. M., & Sladek, S. L. (1980) · PubMed · Cited by 1,198 · see citing works

Ultraviolet radiation-mediated damage to cellular DNA

Cadet, J., Sage, E., & Douki, T. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.012 · Cited by 932 · see citing works

Oxidative stress‐induced cataract: mechanism of action

Spector, A. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.12.7672510 · Cited by 896 · see citing works

Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus

Relling, M. V., Hancock, M. L., Rivera, G. K., Sandlund, J. T., Ribeiro, R. C., Krynetski, E. Y., Pui, C., & Evans, W. E. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.23.2001 · Cited by 731 · see citing works

Oxidative damage to DNA: formation, measurement and biochemical features

Cadet, J., Douki, T., Gasparutto, D., & Ravanat, J. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.09.001 · Cited by 698 · see citing works

Incidence of non-hodgkin lymphoma in kidney and heart transplant recipients

Opelz, G., & Henderson, R. (1993) · The Lancet · doi:10.1016/s0140-6736(05)80084-4 · Cited by 656 · see citing works

Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage

O'Donovan, P., Perrett, C. M., Zhang, X., Montaner, B., Xu, Y., Harwood, C. A., McGregor, J., Walker, S. L., Hanaoka, F., & Karran, P. (2005) · Science · doi:10.1126/science.1114233 · Cited by 631 · see citing works

Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism

Lennard, L., Loon, J. A. V., & Weinshilboum, R. M. (1989) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1989.119 · Cited by 601 · see citing works

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

Koi, M., Umar, A., Chauhan, D. P., Cherian, S. P., Carethers, J. M., Kunkel, T. A., & Boland, C. R. (1994) · PubMed · Cited by 515 · see citing works

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.

Connell, W. R., Kamm, M. A., Ritchie, J. K., & Lennard‐Jones, J. E. (1993) · Gut · doi:10.1136/gut.34.8.1081 · Cited by 495 · see citing works

TRANSMISSION OF HUMAN EPIDERMIS AND STRATUM CORNEUM AS A FUNCTION OF THICKNESS IN THE ULTRAVIOLET AND VISIBLE WAVELENGTHS

Bruls, W. A. G., Slaper, H., Van Der Leun, J. C., & Berrens, L. (1984) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1984.tb04622.x · Cited by 469 · see citing works

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models

Seril, D. N. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.353 · Cited by 467 · see citing works

Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy

Taylor, A. L., Watson, C. J. E., & Bradley, J. A. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.03.012 · Cited by 446 · see citing works

Nonenzymatic methylation of DNA by the intracellular methyl group donor S‐adenosyl‐L‐methionine is a potentially mutagenic reaction.

Rydberg, B., & Lindahl, T. L. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01149.x · Cited by 410 · see citing works

Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of Thioguanine

SWANN, P. F., Waters, T. R., Moulton, D. C., Xu, Y., Zheng, Q., Edwards, M., & Mace, R. (1996) · Science · doi:10.1126/science.273.5278.1109 · Cited by 409 · see citing works

Clinical Evaluation of a New Antimetabolite, 6-Mercaptopurine, in the Treatment of Leukemia and Allied Diseases

Burchenal, J. H., Murphy, M. L., Ellison, R. R., Sykes, M. P., TAN, T. C., Leone, L. A., Karnofsky, D. A., Craver, L. F., Dargeon, H. W., & Rhoads, C. P. (1953) · Blood · doi:10.1182/blood.v8.11.965.965 · Cited by 394 · see citing works

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

Branch, P., Aquilina, G., Bignami, M., & Karran, P. (1993) · Nature · doi:10.1038/362652a0 · Cited by 361 · see citing works

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

Hawn, M. T., Umar, A., Carethers, J. M., Marra, G., Kunkel, T. A., Boland, C. R., & Koi, M. (1995) · PubMed · Cited by 360 · see citing works

DNA damage tolerance, mismatch repair and genome instability

Karran, P., & Bignami, M. (1994) · BioEssays · doi:10.1002/bies.950161110 · Cited by 310 · see citing works

ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts

Yoshioka, K.-I., Yoshioka, Y., & Hsieh, P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.023 · Cited by 288 · see citing works

Comparative epidemiologic study of premalignant and malignant epithelial cutaneous lesions developing after kidney and heart transplantation

Euvrard, S., Kanitakis, J., Pouteil‐Noble, C., Dureau, G., TOURAINE, J. L., Faure, M., Claudy, A., & Thivolet, J. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)90239-2 · Cited by 250 · see citing works

Mismatch repair-dependent G₂ checkpoint induced by low doses of S_N1 type methylating agents requires the ATR kinase

Stojic, L., Mojas, N., Cejka, P., di Pietro, M., Ferrari, S., Marra, G., & Jiricny, J. (2004) · Genes & Development · doi:10.1101/gad.294404 · Cited by 246 · see citing works

Skin cancers in renal-transplant recipients occur more frequently than previously recognized in a temperate climate

Bordea, C., WOJNAROWSKA, F. T., Millard, P. R., Doll, H., Welsh, K. I., & Morris, P. J. (2004) · Transplantation · doi:10.1097/01.tp.0000108491.62935.df · Cited by 245 · see citing works

Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions

Wang, L., & Weinshilboum, R. (2006) · Oncogene · doi:10.1038/sj.onc.1209372 · Cited by 226 · see citing works

Mechanisms of tolerance to DNA damaging therapeutic drugs

Karran, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.12.1931 · Cited by 226 · see citing works

Mismatch correction at O6-methylguanine residues in E. coli DNA

Karran, P., & Marinus, M. (1982) · Nature · doi:10.1038/296868a0 · Cited by 218 · see citing works

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

Kaina, B., Ziouta, A., Ochs, K., & Coquerelle, T. M. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00187-5 · Cited by 197 · see citing works

Methylation‐induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

Ćejka, P., Stojic, L., Mojaš, N., Russell, A., Heinimann, K., Cannavò, E., di Pietro, M., Marra, G., & Jiricny, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg216 · Cited by 186 · see citing works

Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia

Relling, M. V., Yanishevski, Y., Nemec, J. F., We, E., Boyett, J., Behm, F., & Pui, C. (1998) · Leukemia · doi:10.1038/sj.leu.2400928 · Cited by 185 · see citing works

Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells

Thomsen, J. B., Schr�der, H., Kristinsson, J., Madsen, B., Szumlanski, C. L., Weinshilboum, R. M., Andersen, J. B., & Schmiegelow, K. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990915)86:6 · Cited by 170 · see citing works

Mycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial

Remuzzi, G., Lesti, M., Gotti, E., Ganeva, M. G., Dimitrov, B. D., Ene‐Iordache, B., Gherardi, G., Donati, D., Salvadori, M., Sandrini, S., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16808-6 · Cited by 170 · see citing works

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

Brimmell, M., Mendiola, R., Mangion, J., & Packham, G. (1998) · Oncogene · doi:10.1038/sj.onc.1201704 · Cited by 168 · see citing works

A Cost-Effectiveness Analysis of Alternative Disease Management Strategies in Patients with Crohn's Disease Treated with Azathioprine or 6-Mercaptopurine

Dubinsky, M. C., Reyes, E., Ofman, J. J., Chiou, C., Wade, S. W., & Sandborn, W. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41900.x · Cited by 167 · see citing works

Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin

Harwood, C. A., Surentheran, T., Sasieni, P. D., Proby, C. M., Bordea, C., Leigh, I. M., WOJNAROWSKA, F. T., Breuer, J., & McGregor, J. M. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05847.x · Cited by 161 · see citing works

Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation

Offman, J., Opelz, G., Doehler, B., Cummins, D., Halil, O., Banner, N. R., Burke, M. M., Sullivan, D., Macpherson, P., & Karran, P. (2004) · Blood · doi:10.1182/blood-2003-11-3938 · Cited by 158 · see citing works

Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases

SWANN, P. F. (1990) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(90)90153-u · Cited by 144 · see citing works

Replication of damaged DNA by translesion synthesis in human cells

Lehmann, A. R. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.029 · Cited by 142 · see citing works

Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells

Roberts, J. J., Pascoe, J. M., Plant, J. E., Sturrock, J. E., & Crathorn, A. R. (1971) · Chemico-Biological Interactions · doi:10.1016/0009-2797(71)90024-x · Cited by 141 · see citing works

6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals.

Clarke, D. A., Philips, F. S., Sternberg, S. S., STOCK, C. C., Elion, G. B., & Hitchings, G. H. (1953) · PubMed · Cited by 140 · see citing works

Drug methylation in cancer therapy: lessons from the TPMT polymorphism

Krynetski, E. Y., & Evans, W. E. (2003) · Oncogene · doi:10.1038/sj.onc.1206944 · Cited by 136 · see citing works

Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

Dervieux, T., Blanco, J. G., Krynetski, E. Y., Vanin, E. F., Roussel, M. F., & Relling, M. V. (2001) · PubMed · Cited by 136 · see citing works

Guidelines for prescribing azathioprine in dermatology

ANSTEY, A. V., Wakelin, S. H., & Reynolds, N. J. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06323.x · Cited by 132 · see citing works

Thiopurine biology and pharmacology

Aarbakke, J., Janka-Schaub, G. E., & Elion, G. B. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(96)01007-3 · Cited by 131 · see citing works

THE REACTION OF SINGLET OXYGEN WITH PROTEINS, WITH SPECIAL REFERENCE TO CRYSTALLINS

Balasubramanian, D., Du, X., & Zigler, J. S. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb08679.x · Cited by 123 · see citing works

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.

Krynetski, E. Y., Krynetskaia, N. F., Yanishevski, Y., & Evans, W. E. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08754-1 · Cited by 117 · see citing works

Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light

Zhang, X., Jeffs, G., Ren, X., O’Donovan, P., Montaner, B., Perrett, C. M., Karran, P., & Xu, Y.-Z. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.11.003 · Cited by 110 · see citing works

A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.

Krynetski, E. Y., Krynetskaia, N. F., Bianchi, M. E., & Evans, W. E. (2003) · PubMed · Cited by 108 · see citing works

The genetics of HNPCC: Application to diagnosis and screening

Abdel‐Rahman, W. M., Mecklin, J., & Peltomäki, P. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.11.001 · Cited by 107 · see citing works

DNA mismatch repair (MMR) mediates 6-thioguanine genotoxicity by introducing single-strand breaks to signal a G2-M arrest in MMR-proficient RKO cells.

Yan, T., Berry, S. E., Desai, A. B., & Kinsella, T. J. (2003) · PubMed · Cited by 104 · see citing works

De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo

Dervieux, T., Brenner, T. L., Hon, Y. Y., Zhou, Y., Hancock, M. L., Sandlund, J. T., Rivera, G. K., Ribeiro, R. C., Boyett, J. M., Pui, C., et al. (2002) · Blood · doi:10.1182/blood-2002-02-0495 · Cited by 100 · see citing works

Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts

York, S. J., & Modrich, P. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603667200 · Cited by 98 · see citing works

Squamous cell carcinoma of the skin and lip in renal homograft recipients

Mullen, D. L., Silverberg, S. G., Penn, I., & Hammond, W. S. (1976) · Cancer · doi:10.1002/1097-0142(197602)37:2 · Cited by 98 · see citing works

Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides

Tay, B. S. J., Lilley, R. M., Murray, A., & Atkinson, M. R. (1969) · Biochemical Pharmacology · doi:10.1016/0006-2952(69)90069-0 · Cited by 93 · see citing works

Reactive oxygen‐mediated damage to a human DNA replication and repair protein

Montaner, B., O'Donovan, P., Reelfs, O., Perrett, C. M., Zhang, X., Xu, Y., Ren, X., Macpherson, P., Frith, D., & Karran, P. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401084 · Cited by 88 · see citing works

Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen

Taverna, P., Liu, L., Hanson, A. J., Monks, A. P., & Gerson, S. L. (2000) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800000186 · Cited by 87 · see citing works

Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine

Naughton, M. (1999) · British journal of rheumatology · doi:10.1093/rheumatology/38.7.640 · Cited by 85 · see citing works

Therapeutic drug monitoring of antimetabolic cytotoxic drugs

Lennard (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00884.x · Cited by 83 · see citing works

Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

TIDD, D. M., & Paterson, A. R. P. (1974) · PubMed · Cited by 79 · see citing works

Meta-Analysis of Risk of Malignancy with Immunosuppressive Drugs in Inflammatory Bowel Disease

増永, ゆ., Ohno, K., Ogawa, R., Hashiguchi, M., Echizen, H., & Ogata, H. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1h219 · Cited by 78 · see citing works

Photosensitized Growth Inhibition of Cultured Human Skin Cells: Mechanism and Suppression of Oxidative Stress from Solar Irradiation of Glycated Proteins

Wondrak, G. T., Roberts, M. J., Jacobson, M. K., & Jacobson, E. L. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01788.x · Cited by 77 · see citing works

Photodynamic crosslinking of proteins II. Photocrosslinking of a model protein-ribonuclease A

Shen, H.-R., Spikes, J. D., Kopečková, P., & Kopec̆ek, J. (1996) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(96)07300-9 · Cited by 75 · see citing works

Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapy.

Warren, D. J., Andersen, A., & Slørdal, L. (1995) · PubMed · Cited by 75 · see citing works

Ultraviolet Immunosuppression: Mechanisms and Consequences

Hanneman, K. K., Cooper, K. D., & Baron, E. D. (2006) · Dermatologic Clinics · doi:10.1016/j.det.2005.08.003 · Cited by 74 · see citing works

Cancer in the immunosuppressed organ recipient.

Penn, I. (1991) · PubMed · Cited by 72 · see citing works

Methylation of Inorganic and Organic Selenium by the Bacterial Thiopurine Methyltransferase

Ranjard, L., Prigent‐Combaret, C., Nazaret, S., & Cournoyer, B. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.11.3146-3149.2002 · Cited by 71 · see citing works

Effects of Singlet Oxygen on the Extracellular Matrix Protein Collagen: Oxidation of the Collagen Crosslink Histidinohydroxylysinonorleucine and Histidine

Au, V., & Madison, S. A. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2070 · Cited by 68 · see citing works

Preventing Toxicity With a Gene Test

Marshall, E. (2003) · Science · doi:10.1126/science.302.5645.588 · Cited by 65 · see citing works

Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines

Fotoohi, A. K., Appell, M. L., Peterson, C. O., & Albertioni, F. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.134 · Cited by 62 · see citing works

Treatment of Ulcerative Colitis with Antimetabolites

Bean, R. H. D. (1966) · BMJ · doi:10.1136/bmj.1.5495.1081 · Cited by 62 · see citing works

ATM Is Activated in Response toN-Methyl-N′-nitro- N-nitrosoguanidine-induced DNA Alkylation

Adamson, A. W., Kim, W.-J., Shangary, S. K., Baskaran, R., & Brown, K. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204409200 · Cited by 60 · see citing works

A Novel Protein Complex Distinct from Mismatch Repair Binds Thioguanylated DNA

Krynetski, E. Y., Krynetskaia, N. F., Gallo, A. E., Murti, K. G., & Evans, W. E. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.2.367 · Cited by 60 · see citing works

Thiopurine Methyltransferase Enzyme Activity Determination before Treatment of Inflammatory Bowel Disease with Azathioprine: Effect on Cost and Adverse Events

Sayani, F. A., Prosser, C., Bailey, R. J., Jacobs, P., & Fedorak, R. N. (2005) · Canadian Journal of Gastroenterology · doi:10.1155/2005/470863 · Cited by 59 · see citing works

Synthesis by post-synthetic substitution of oligomers containing guanine modified at the 6-position with S-, N-, O-derivatives

Xu, Y., Zheng, Q., & SWANN, P. F. (1992) · Tetrahedron · doi:10.1016/s0040-4020(01)88731-7 · Cited by 55 · see citing works

Assessment of mismatch repair function in leukaemic cell lines and blasts from children with acute lymphoblastic leukaemia

Matheson, E. C. (2003) · Carcinogenesis · doi:10.1093/carcin/24.1.31 · Cited by 53 · see citing works

PHOTOCHEMICAL SENSITIZATION BY AZATHIOPRINE AND ITS METABOLITES—I. 6‐MERCAPTOPURINE

Hemmens, V. J., & Moore, D. E. (1986) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1986.tb05601.x · Cited by 53 · see citing works

High Doses of SN1 Type Methylating Agents Activate DNA Damage Signaling Cascades that are Largely Independent of Mismatch Repair

Stojic, L., Ćejka, P., & Jiricny, J. (2005) · Cell Cycle · doi:10.4161/cc.4.3.1528 · Cited by 49 · see citing works

AIDS-related malignancies

Smith, C. A., Lilly, S. G., Mann, K. P., Livingston, E. G., Myers, S. A., Lyerly, H. K., & Miralles, G. D. (1998) · Annals of Medicine · doi:10.3109/07853899809029932 · Cited by 49 · see citing works

The Effect of O6-Methylguanine DNA Adducts on the Adenosine Nucleotide Switch Functions of hMSH2-hMSH6 and hMSH2-hMSH3

Berardini, M. D., Mazurek, A., & Fishel, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003589200 · Cited by 48 · see citing works

Peripheral Blood Mononuclear Cell DNA 6-Thioguanine Metabolite Levels Correlate with Decreased Interferon-γ Production in Patients with Crohn's Disease on AZA Therapy

Cuffari, C., Li, D. Y., Mahoney, J. A., Barnes, Y., & Bayless, T. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000011614.88494.ee · Cited by 41 · see citing works

Clinical investigators as critical determinants in pharmaceutical innovation

Flowers, C. R., & Melmon, K. L. (1997) · Nature Medicine · doi:10.1038/nm0297-136 · Cited by 41 · see citing works

Mutation Accumulation in the Intestine and Colon of Mice Deficient in Two Intracellular Glutathione Peroxidases

Lee, D.-H., Esworthy, R. S., Chu, C., Pfeifer, G. P., & Chu, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0732 · Cited by 41 · see citing works

Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells.

Aquilina, G., Giammarioli, A. M., Zijno, A., Muccio, A. D., Dogliotti, E., & Bignami, M. (1990) · PubMed · Cited by 40 · see citing works

Differential Effects of Targeted Disruption of Thiopurine Methyltransferase on Mercaptopurine and Thioguanine Pharmacodynamics

Hartford, C. M., Vasquez, E., Schwab, M. G., Edick, M. J., Rehg, J. E., Grosveld, G. C., Pui, C., Evans, W. E., & Relling, M. V. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3508 · Cited by 40 · see citing works

Utilization of 2'-deoxy-6-thioguanosine 5'-triphosphate in DNA synthesis in vitro by DNA polymerase alpha from calf thymus.

Yoshida, S., Yamada, M., Masaki, S., & Saneyoshi, M. (1979) · PubMed · Cited by 40 · see citing works

Azathioprine Pharmacogenetics: The Relationship between 6-Thioguanine Nucleotides and Thiopurine Methyltransferase in Patients after Heart and Kidney Transplantation

Schütz, E., Gummert, J. F., Armstrong, V. W., Mohr, F. W., & Oellerich, M. (1996) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1996.34.3.199 · Cited by 40 · see citing works

Replication of the base pair 6-thioguanine/5-methyl-2-pyrimidinone with the large Klenow fragment of Escherichia coli DNA polymerase I

Rappaport, H. P. (1993) · Biochemistry · doi:10.1021/bi00063a016 · Cited by 38 · see citing works

DNA replication arrest and tolerance to DNA methylation damage

Zhukovskaya, N. L., Branch, P., Aquilina, G., & Karran, P. (1994) · Carcinogenesis · doi:10.1093/carcin/15.10.2189 · Cited by 34 · see citing works

Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents

Pepponi, R., D’Atri, S., & Vernole, P. (2003) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0660-6 · Cited by 31 · see citing works

2′-Deoxy-6-Thioguanosine 5′-Triphosphate as a Substrate for Purified Human DNA Polymerases and Calf Thymus Terminal Deoxynucleotidyltransferase In Vitro

Ling, Y.-H., Nelson, J. A., Cheng, Y., Anderson, R. S., & Beattie, K. L. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15361-3 · Cited by 31 · see citing works

Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients

Rozen, P., Lubin, F., Papo, N., Knaani, J., Farbstein, H., Farbstein, M., & Zajicek, G. (2001) · Cancer · doi:10.1002/1097-0142(20010215)91:4 · Cited by 27 · see citing works

Is mycophenolate mofetil really necessary in renal transplantation? A review of the MYSS follow-up study

Brennan, D. C., & Koch, M. J. (2007) · Nature Reviews Nephrology · doi:10.1038/ncpneph0597 · Cited by 11 · see citing works

Effects of solar simulated radiation on the human immune system: influence of phototypes and wavebands

Young, A. R., & Walker, S. L. (2002) · Experimental Dermatology · doi:10.1034/j.1600-0625.11.s.1.5.x · Cited by 9 · see citing works

Investigation of 6-thiodeoxyguanosine alkylation products and their role in the potentiation of BCNU cytotoxicity.

Wj, B. (1986) · PubMed · Cited by 5 · see citing works

Impaired Transport as a Mechanism of Resistance to Thiopurines in Human T-Lymphoblastic Leukemia Cells

Fotoohi, A. K., Lindqvist, M., Peterson, C., & Albertioni, F. (2006) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770600890848 · Cited by 4 · see citing works

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813 · see citing works

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Zhou, Y., Hou, Y., Shen, J., Huang, Y., Martin, W., & Cheng, F. (2020) · Cell Discovery · doi:10.1038/s41421-020-0153-3 · Cited by 1,588 · see citing works

Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins

Mascio, P. D., Martinez, G. R., Miyamoto, S., Ronsein, G. E., de Medeiros, M. H. G., & Cadet, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00554 · Cited by 665 · see citing works

Stimuli-Responsive Therapeutic Metallodrugs

Wang, X., Wang, X., Jin, S., Nafees, M., & Guo, Z. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00209 · Cited by 651 · see citing works

DNA mismatch repair in cancer

Baretti, M., & Le, D. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.04.004 · Cited by 559 · see citing works

Type I Photosensitizers Revitalizing Photodynamic Oncotherapy

Chen, D., Xu, Q., Wang, W., Shao, J., Huang, W., & Dong, X. (2021) · Small · doi:10.1002/smll.202006742 · Cited by 483 · see citing works

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

Moriyama, T., Nishii, R., Pérez-Andreu, V., Yang, W., Antillón‐Klussmann, F., Zhao, X., Lin, T.-N., Hoshitsuki, K., Nersting, J., Kihira, K., et al. (2016) · Nature Genetics · doi:10.1038/ng.3508 · Cited by 478 · see citing works

An emerging molecular design approach to heavy-atom-free photosensitizers for enhanced photodynamic therapy under hypoxia

Nguyen, V.-N., Qi, S., Kim, S., Kwon, N., Kim, G., Yim, Y., Park, S., & Yoon, J. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09220 · Cited by 457 · see citing works

European Evidence-based Consensus: Inflammatory Bowel Disease and Malignancies

Annese, V., Beaugerie, L., Egan, L. J., Biancone, L., Bolling, C., Brandts, C., Dierickx, D., Dummer, R., Fiorino, G., Gornet, J. M., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv141 · Cited by 428 · see citing works

Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions^†

Cadet, J., Mouret, S., Ravanat, J., & Douki, T. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01200.x · Cited by 300 · see citing works

Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy

Alam, J., Jantan, I., & Bukhari, S. N. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.055 · Cited by 286 · see citing works

Mercaptopurine/Methotrexate Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia

Schmiegelow, K., Nielsen, S. N., Frandsen, T. L., & Nersting, J. (2014) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000206 · Cited by 240 · see citing works

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

Osorio, F. G., Huber, A. R., Oka, R., Verheul, M., Patel, S. H., Hasaart, K., de la Fonteijne, L., Varela, I., Camargo, F. D., & van Boxtel, R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.014 · Cited by 237 · see citing works

Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood

Tabori, U. Y., Hansford, J. R., Achatz, M. I., Kratz, C. P., Plon, S. E., Frébourg, T., & Brugières, L. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0574 · Cited by 226 · see citing works

Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death

Maharjan, P. S., & Bhattarai, H. K. (2022) · Journal of Oncology · doi:10.1155/2022/7211485 · Cited by 222 · see citing works

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Baptista, M. S., Cadet, J., Greer, A., & Thomas, A. H. (2021) · Photochemistry and Photobiology · doi:10.1111/php.13470 · Cited by 205 · see citing works

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

Yang, J. J. J., Bhojwani, D., Yang, W., Cai, X., Stocco, G., Crews, K. R., Wang, J., Morrison, D. J., Devidas, M., Hunger, S. P., et al. (2008) · Blood · doi:10.1182/blood-2008-06-165027 · Cited by 194 · see citing works

Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy

Wu, H., Gong, Y., Ji, P., Xie, Y., Jiang, Y.-Z., & Liu, G. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01263-x · Cited by 192 · see citing works

Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

Cheng, K.-W., Cheng, S., Chen, W., Lin, M.-H., Chuang, S.-J., Cheng, I.-H., Sun, C.-Y., & Chou, C. (2014) · Antiviral Research · doi:10.1016/j.antiviral.2014.12.011 · Cited by 186 · see citing works

Nucleoside Analogues as Antibacterial Agents

Thomson, J. M., & Lamont, I. L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00952 · Cited by 177 · see citing works

Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL

Li, B., Li, H., Bai, Y., Kirschner‐Schwabe, R., Yang, J. J. J., Chen, Y., Lü, G., Tzoneva, G., Ma, X., Wu, T., et al. (2015) · Nature Medicine · doi:10.1038/nm.3840 · Cited by 175 · see citing works

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

Shuvalov, O., Petukhov, A., Daks, A., Fedorova, O., Vasileva, E., & Barlev, N. A. (2017) · Oncotarget · doi:10.18632/oncotarget.15053 · Cited by 168 · see citing works

2,4-Dithiothymine as a Potent UVA Chemotherapeutic Agent

Pollum, M., Jockusch, S., & Crespo‐Hernández, C. E. (2014) · Journal of the American Chemical Society · doi:10.1021/ja510611j · Cited by 164 · see citing works

Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine

Mender, I., Gryaznov, S. M., Dikmen, Z. G., Wright, W. E., & Shay, J. W. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0609 · Cited by 161 · see citing works

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

Schmiegelow, K., Al-Modhwahi, I., Andersen, M. K., Behrendtz, M., Forestier, E., Hasle, H., Heyman, M. M., Kristinsson, J., Nersting, J., Nygaard, R., et al. (2009) · Blood · doi:10.1182/blood-2008-11-187880 · Cited by 152 · see citing works

Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia

Bhatia, R., Landier, W., Hageman, L., Chen, Y., Kim, H., Sun, C., Kornegay, N., Evans, W. E., Angiolillo, A. L., Bostrom, B., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.0245 · Cited by 150 · see citing works

Photochemical and Photodynamical Properties of Sulfur‐Substituted Nucleic Acid Bases,

Ashwood, B., Pollum, M., & Crespo‐Hernández, C. E. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12975 · Cited by 149 · see citing works

Second Malignant Neoplasms After Treatment of Childhood Acute Lymphoblastic Leukemia

Schmiegelow, K., Levinsen, M., Attarbaschi, A., Baruchel, A., Devidas, M., Escherich, G., Gibson, B. E. S., Heydrich, C., Horibe, K., Ishida, Y., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.47.0500 · Cited by 139 · see citing works

Competing ultrafast intersystem crossing and internal conversion: a time resolved picture for the deactivation of 6-thioguanine

Martínez‐Fernández, L., Corral, I., Granucci, G., & Persico, M. (2013) · Chemical Science · doi:10.1039/c3sc52856a · Cited by 138 · see citing works

Intersystem Crossing Pathways in the Noncanonical Nucleobase 2-Thiouracil: A Time-Dependent Picture

Mai, S., Marquetand, P., & González, L. (2016) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.6b00616 · Cited by 137 · see citing works

Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations

Toksvang, L. N., Lee, S. H. R., Yang, J. J. J., & Schmiegelow, K. (2022) · Leukemia · doi:10.1038/s41375-022-01591-4 · Cited by 137 · see citing works

Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

Dinkova-Kostova, A. (2008) · Planta Medica · doi:10.1055/s-2008-1081296 · Cited by 136 · see citing works

Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA

Brem, R., Guven, M., & Karran, P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.488 · Cited by 136 · see citing works

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

Tsesmetzis, N., Paulin, C. B. J., Rudd, S. G., & Herold, N. (2018) · Cancers · doi:10.3390/cancers10070240 · Cited by 136 · see citing works

British Association of Dermatologists’ guidelines for the safe and effective prescribing of azathioprine 2011

Meggitt, S. J., Anstey, A. V., Mustapa, M. F. M., Reynolds, N. J., Wakelin, S. H., Tidman, M. J., Fuller, L. C., McLelland, J., Lear, J. T., Hughes, J. R., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10575.x · Cited by 130 · see citing works

Predisposition to cancer in children and adolescents

Kratz, C. P., Jongmans, M. C., Cavé, H., Wimmer, K., Behjati, S., Guerrini-Rousseau, L., Milde, T., Pajtler, K. W., Golmard, L., Gauthier-Villars, M., et al. (2021) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(20)30275-3 · Cited by 129 · see citing works

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

Diouf, B., Cheng, Q., Krynetskaia, N. F., Yang, W., Cheok, M., Pei, D., Fan, Y., Cheng, C., Krynetskiy, E. Y., Geng, H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2430 · Cited by 129 · see citing works

Cancer risk in immune-mediated inflammatory diseases (IMID)

Beyaert, R., Beaugerie, L., Assche, G. V., Brochez, L., Renauld, J., Viguier, M. A., Cocquyt, V., Jérusalem, G., Machiels, J., Prenen, H., et al. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-98 · Cited by 127 · see citing works

Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy

Tang, J., Wang, L., Loredo, A., Cole, C. C., & Xiao, H. (2020) · Chemical Science · doi:10.1039/d0sc02286a · Cited by 124 · see citing works

Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

Schmiegelow, K., Forestier, E., Kristinsson, J., Söderhäll, S., Vettenranta, K. K., Weinshilboum, R. M., Wesenberg, F., & On behalf of the Nordic Society of Paediatric Haematology and Oncology (NOPHO) (2008) · Leukemia · doi:10.1038/leu.2008.316 · Cited by 122 · see citing works

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

Valerie, N. C. K., Hagenkort, A., Page, B. D. G., Masuyer, G., Rehling, D., Carter, M., Bevc, L., Herr, P., Homan, E. J., Gustafsson, N., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0584 · Cited by 122 · see citing works

Sulfur-Based Intramolecular Hydrogen-Bond: Excited-State Hydrogen-Bond On/Off Switch with Dual Room-Temperature Phosphorescence

Liu, Z., Hu, J., Huang, C., Huang, T.-H., Chen, D., Ho, S., Chen, K., Li, E. Y., & Chou, P. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b02765 · Cited by 122 · see citing works

Massively parallel variant characterization identifies <i>NUDT15</i> alleles associated with thiopurine toxicity

Suiter, C. C., Moriyama, T., Matreyek, K. A., Yang, W., Scaletti, E. R., Nishii, R., Yang, W., Hoshitsuki, K., Singh, M., Trehan, A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915680117 · Cited by 121 · see citing works

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T.-J., Clarke, R. G., et al. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0362 · Cited by 121 · see citing works

Photochemistry of Nucleic Acid Bases and Their Thio- and Aza-Analogues in Solution

Pollum, M., Martínez‐Fernández, L., & Crespo‐Hernández, C. E. (2014) · Topics in current chemistry · doi:10.1007/128_2014_554 · Cited by 116 · see citing works

Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance

Cagiada, M., Johansson, K. E., Valančiūtė, A., Nielsen, S. V., Hartmann‐Petersen, R., Yang, J. J. J., Fowler, D. M., Stein, A., & Lindorff‐Larsen, K. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab095 · Cited by 113 · see citing works

Immunosuppressive disorders and risk of anal squamous cell carcinoma: A nationwide cohort study in Denmark, 1978–2005

Gotschalck, K. A., Nørgaard, M., Thorlacius‐Ussing, O., & Laurberg, S. (2009) · International Journal of Cancer · doi:10.1002/ijc.25080 · Cited by 113 · see citing works

Cumulative exposure to tacrolimus and incidence of cancer after liver transplantation

Rodríguez‐Perálvarez, M., Colmenero, J., González, A., Gastaca, M., Curell, A. B., Marcos, A., Sánchez-Martínez, A., Maira, T. D., Herrero, J. I., Almohalla, C., et al. (2022) · American Journal of Transplantation · doi:10.1111/ajt.17021 · Cited by 110 · see citing works

Excited-State Dynamics in 6-Thioguanosine from the Femtosecond to Microsecond Time Scale

Reichardt, C., Guo, C., & Crespo-Hernández, C. E. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp112018u · Cited by 109 · see citing works

DNA-thioguanine nucleotide concentration and relapse-free survival during maintenance therapy of childhood acute lymphoblastic leukaemia (NOPHO ALL2008): a prospective substudy of a phase 3 trial

Nielsen, S. N., Grell, K., Nersting, J., Abrahamsson, J., Lund, B., Kanerva, J. A., Jónsson, Ó. G., Vaitkevičienė, G. E., Pruunsild, K., Hjalgrim, L. L., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30154-7 · Cited by 108 · see citing works

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry

Moriyama, T., Yang, Y., Nishii, R., Ariffin, H., Liu, C., Lin, T.-N., Yang, W., Lin, D., Yu, C., Kham, S. K. Y., et al. (2017) · Blood · doi:10.1182/blood-2017-05-782383 · Cited by 108 · see citing works

Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance

Durno, C. A., Ercan, A. B., Bianchi, V., Edwards, M., Aronson, M. D., Galati, M. A., Atenafu, E. G., Campino, G. A., Al-Battashi, A., Alharbi, M., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02636 · Cited by 108 · see citing works

Coordination of DNA Mismatch Repair and Base Excision Repair Processing of Chemotherapy and Radiation Damage for Targeting Resistant Cancers

Kinsella, T. J. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1307 · Cited by 105 · see citing works

Liver transplantation

Rodríguez‐Perálvarez, M., de la Mata, M., & Burroughs, A. K. (2014) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000069 · Cited by 104 · see citing works

Incidence and susceptibility to therapy-related myeloid neoplasms

Leone, G. G. M., Fianchi, L., Pagano, L., & Voso, M. T. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.12.013 · Cited by 104 · see citing works

Increased Risk of Acute Myeloid Leukemias and Myelodysplastic Syndromes in Patients Who Received Thiopurine Treatment for Inflammatory Bowel Disease

Lopez, A., Mounier, M., Bouvier, A., Carrat, F., Maynadié, M., Beaugerie, L., & Peyrin‐Biroulet, L. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.026 · Cited by 104 · see citing works

6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance

Issaeva, N., Thomas, H. D., Djurenovic, T., Jaspers, J. E., Stoimenov, I., Kyle, S., Pedley, N., Gottipati, P., Zur, R., Sleeth, K. M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3416 · Cited by 104 · see citing works

Non-infectious chemotherapy-associated acute toxicities during childhood acute lymphoblastic leukemia therapy

Schmiegelow, K., Müller, K., Mogensen, S. S., Mogensen, P. R., Wolthers, B. O., Stoltze, U. K., Tuckuviene, R., & Frandsen, T. L. (2017) · F1000Research · doi:10.12688/f1000research.10768.1 · Cited by 102 · see citing works

Inflammation, Aging, and Cancer: Tumoricidal Versus Tumorigenesis of Immunity

Khatami, M. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9059-2 · Cited by 100 · see citing works

Hydroxycarbamide: a user’s guide for chronic myeloproliferative disorders

Spivak, J. L., & Hasselbalch, H. C. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.11.10 · Cited by 98 · see citing works

Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease

Smith, M. A., Irving, P. M., Marinaki, A. M., & Sanderson, J. D. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04330.x · Cited by 95 · see citing works

UVA photosensitization of thiopurines and skin cancer in organ transplant recipients

Attard, N. R., & Karran, P. (2012) · Photochemical &amp; Photobiological Sciences · doi:10.1039/c1pp05194f · Cited by 94 · see citing works

Excited-State Dynamics of 6-Aza-2-thiothymine and 2-Thiothymine: Highly Efficient Intersystem Crossing and Singlet Oxygen Photosensitization

Kuramochi, H., Kobayashi, T., Suzuki, T., & Ichimura, T. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp102067t · Cited by 80 · see citing works

Thiopurine Analogue Inhibitors of Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease, a Deubiquitinating and deISGylating Enzyme

Chen, X., Chou, C., & Chang, G. (2009) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020901900402 · Cited by 79 · see citing works

Etiology of increased cancer incidence after solid organ transplantation

Acuña, S. A. (2018) · Transplantation Reviews · doi:10.1016/j.trre.2018.07.001 · Cited by 78 · see citing works

An ab initio mechanism for efficient population of triplet states in cytotoxic sulfur substituted DNA bases: the case of 6-thioguanine

Martínez‐Fernández, L., González, L., & Corral, I. (2012) · Chemical Communications · doi:10.1039/c2cc15775f · Cited by 77 · see citing works

Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine

Brem, R., & Karran, P. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.01043.x · Cited by 76 · see citing works

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia

Moriyama, T., Nishii, R., Lin, T.-N., Kihira, K., Toyoda, H., Nersting, J., Kato, M., Koh, K., Inaba, H., Manabe, A., et al. (2017) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000282 · Cited by 74 · see citing works

Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

Chin, D., Goncheva, M. I., Flannagan, R. S., Deecker, S. R., Guariglia-Oropeza, V., Ensminger, A. W., & Heinrichs, D. E. (2021) · Nature Communications · doi:10.1038/s41467-021-22175-3 · Cited by 72 · see citing works

A Static Picture of the Relaxation and Intersystem Crossing Mechanisms of Photoexcited 2-Thiouracil

Mai, S., Marquetand, P., & González, L. (2015) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.5b06639 · Cited by 72 · see citing works

2-Thiouracil intersystem crossing photodynamics studied by wavelength-dependent photoelectron and transient absorption spectroscopies

Sánchez-Rodríguez, J. A., Mohamadzade, A., Mai, S., Ashwood, B., Pollum, M., Marquetand, P., González, L., Crespo‐Hernández, C. E., & Ullrich, S. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp02258a · Cited by 72 · see citing works

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Jeanbart, L., Kourtis, I. C., van der Vlies, A. J., Swartz, M. A., & Hubbell, J. A. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1702-8 · Cited by 68 · see citing works

Thiopurines: Factors influencing toxicity and response

Fotoohi, A. K., Coulthard, S. A., & Albertioni, F. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.01.006 · Cited by 68 · see citing works

Long term efficacy and safety of allopurinol and azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease

Leung, Y., Sparrow, M., Schwartz, M., & Hanauer, S. B. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.02.003 · Cited by 67 · see citing works

In perspective: An update on telomere targeting in cancer

Sugarman, E. T., Zhang, G., & Shay, J. W. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23035 · Cited by 66 · see citing works

A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen

Kodama, M., & Nakayama, K. I. (2020) · BioEssays · doi:10.1002/bies.202000169 · Cited by 65 · see citing works

Photoinduced Processes in Nucleic Acids

Barbatti, M., Borin, A. C., & Ullrich, S. (2014) · Topics in current chemistry · doi:10.1007/128_2014_569 · Cited by 65 · see citing works

Liquid chromatography–tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard

Jacobsen, J. H., Schmiegelow, K., & Nersting, J. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.11.032 · Cited by 62 · see citing works

Management of Juvenile Myasthenia Gravis

Ionita, C., & Acsádi, G. (2013) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2012.07.008 · Cited by 60 · see citing works

Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light‐Activated Pyrimidine Anticancer Drugs

Martínez‐Fernández, L., Granucci, G., Pollum, M., Crespo‐Hernández, C. E., Persico, M., & Corral, I. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201604543 · Cited by 59 · see citing works

Simple and selective determination of 6-thioguanine by using polyethylenimine (PEI) functionalized carbon dots

Zeng, H., Li, L., Ding, Y., & Zhuang, Q. (2017) · Talanta · doi:10.1016/j.talanta.2017.09.087 · Cited by 59 · see citing works

6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2

Chuang, S.-J., Cheng, S., Tang, H.-C., Sun, C.-Y., & Chou, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-21476-w · Cited by 59 · see citing works

Risk of myeloid neoplasms after solid organ transplantation

Morton, L. M., Gibson, T. M., Clarke, C. A., Lynch, C. F., Anderson, L. A., Pfeiffer, R. M., Landgren, O., Weisenburger, D. D., & Engels, E. A. (2014) · Leukemia · doi:10.1038/leu.2014.132 · Cited by 58 · see citing works

Excited-State Dynamics of the Thiopurine Prodrug 6-Thioguanine: Can N9-Glycosylation Affect Its Phototoxic Activity?

Ashwood, B., Jockusch, S., & Crespo‐Hernández, C. E. (2017) · Molecules · doi:10.3390/molecules22030379 · Cited by 58 · see citing works

The management of immunosuppression in patients with inflammatory bowel disease and cancer

Bernheim, O. E., Colombel, J., Ullman, T. A., Laharie, D., Beaugerie, L., & Itzkowitz, S. H. (2013) · Gut · doi:10.1136/gutjnl-2013-305300 · Cited by 57 · see citing works

NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble

Turtola, M., & Belogurov, G. A. (2016) · eLife · doi:10.7554/elife.18096 · Cited by 57 · see citing works

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

Nishii, R., Moriyama, T., Janke, L. J., Yang, W., Suiter, C. C., Lin, T.-N., Li, L., Kihira, K., Toyoda, H., Hofmann, U., et al. (2018) · Blood · doi:10.1182/blood-2017-11-815506 · Cited by 57 · see citing works

PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients

Harwood, C. A., Attard, N. R., O’Donovan, P., Chambers, P. A., Perrett, C. M., Proby, C. M., McGregor, J. M., & Karran, P. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604665 · Cited by 56 · see citing works

MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia

Evensen, N. A., Madhusoodhan, P. P., Meyer, J., Saliba, J., Chowdhury, A., Araten, D. J., Nersting, J., Bhatla, T., Vincent, T. L., Teachey, D. T., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.176362 · Cited by 55 · see citing works

Maintenance therapy of childhood acute lymphoblastic leukemia revisited—Should drug doses be adjusted by white blood cell, neutrophil, or lymphocyte counts?

Schmiegelow, K., Nersting, J., Nielsen, S. N., Heyman, M. M., Wesenberg, F., Kristinsson, J., Vettenranta, K. K., Schrøeder, H., Weinshilboum, R. M., Jensen, K. L., et al. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26139 · Cited by 55 · see citing works

Protein Oxidation and DNA Repair Inhibition by 6-Thioguanine and UVA Radiation

Guéranger, Q., Li, F., Peacock, M., Larnicol, A., Brem, R., Macpherson, P., Egly, J., & Karran, P. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.509 · Cited by 54 · see citing works

Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia

de Beaumais, T. A., & Jacqz-Aigrain, É. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1251-4 · Cited by 53 · see citing works

Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings

Chang, W., Tanoshima, R., Ross, C. J., & Carleton, B. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-030920-025745 · Cited by 53 · see citing works

The effect of immunosuppressive molecules on T-cell metabolic reprogramming

Fernández-Ramos, A. A., Poindessous, V., Marchetti, C., Pallet, N., & Loriot, M. (2016) · Biochimie · doi:10.1016/j.biochi.2016.04.016 · Cited by 52 · see citing works

Mutagenicity and Potential Carcinogenicity of Thiopurine Treatment in Patients with Inflammatory Bowel Disease

Nguyen, T. T., Vacek, P. M., O'Neill, P., Colletti, R. B., & Finette, B. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0451 · Cited by 51 · see citing works

6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1

Yuan, B., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S. E., Pradhan, S., & Wang, Y. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3430 · Cited by 51 · see citing works

Targeting cancer-specific metabolic pathways for developing novel cancer therapeutics

Pal, S., Sharma, A. K., Mathew, S. P., & Jaganathan, B. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955476 · Cited by 49 · see citing works

Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation

Brem, R., Daehn, I., & Karran, P. (2011) · DNA Repair · doi:10.1016/j.dnarep.2011.05.010 · Cited by 48 · see citing works

Combination of azathioprine and UVA irradiation is a major source of cellular 8-oxo-7,8-dihydro-2′-deoxyguanosine

Cooke, M. S., Duarte, T. L., Cooper, D., Chen, J., Nandagopal, S., & Evans, M. D. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.08.007 · Cited by 48 · see citing works

Facile Syntheses of S,N-Codoped Carbon Quantum Dots and Their Applications to a Novel Off–On Nanoprobe for Detection of 6-Thioguanine and Its Bioimaging

Yu, C., Jiang, X., Qin, D., Mo, G., Zheng, X., & Deng, B. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b02886 · Cited by 47 · see citing works

Mutagenicity and Potential Carcinogenicity of Thiopurine Treatment in Patients with Inflammatory Bowel Disease

Nguyen, T. T., Vacek, P. M., O'Neill, P., Colletti, R. B., & Finette, B. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0451 · Cited by 51 · see citing works

Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease

Smith, M. A., Irving, P. M., Marinaki, A. M., & Sanderson, J. D. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04330.x · Cited by 95 · see citing works

Thiopurines, DNA damage, DNA repair and therapy-related cancer

Karran, P. (2006) · British Medical Bulletin · doi:10.1093/bmb/ldl020 · Cited by 182 · see citing works

Thiopurines and myeloid disorders: is more caution needed when treating inflammatory bowel disease patients?

Lopez, A., Beaugerie, L., & Peyrin‐Biroulet, L. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.977261 · Cited by 3 · see citing works

In Vivo Genotoxicity and Selection Associated with Thiopurine Treatment in Subjects with Inflammatory Bowel Disease

Nguyen, T. (2008) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)