Oxidative damage to RPA limits the nucleotide excision repair capacity of human cells
Open accessAbstract
Nucleotide excision repair (NER) protects against sunlight-induced skin cancer. Defective NER is associated with photosensitivity and a high skin cancer incidence. Some clinical treatments that cause photosensitivity can also increase skin cancer risk. Among these, the immunosuppressant azathioprine and the fluoroquinolone antibiotics ciprofloxacin and ofloxacin interact with UVA radiation to generate reactive oxygen species that diminish NER capacity by causing protein damage. The replication protein A (RPA) DNA-binding protein has a pivotal role in DNA metabolism and is an essential component of NER. The relationship between protein oxidation and NER inhibition was investigated in cultured human cells expressing different levels of RPA. We show here that RPA is limiting for NER and that oxidative damage to RPA compromises NER capability. Our findings reveal that cellular RPA is surprisingly vulnerable to oxidation, and we identify oxidized forms of RPA that are associated with impaired NER. The vulnerability of NER to inhibition by oxidation provides a connection between cutaneous photosensitivity, protein damage, and increased skin cancer risk. Our findings emphasize that damage to DNA repair proteins, as well as to DNA itself, is likely to be an important contributor to skin cancer risk.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oxidative stress generated by UVA promotes oxidation of RPA, which debilitates the ability of NER to remove photoproducts from human keratinocytes.
“the oxidative stress generated by UVA promotes oxidation of RPA, which debilitates the ability of the NER to remove photoproducts from human keratinocytes [263].”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [263]
UVA radiation can promote the oxidation of proteins involved in DNA repair, which would impair the removal of DNA damage.
“UVA radiation can promote the oxidation of the proteins that are involved in DNA repair, which would impair the removal of the DNA damage.”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [263]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works
Skin cancers after organ transplantation
Euvrard, S., Kanitakis, J., & Claudy, A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022137 · Cited by 1,575 · see citing works
Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,445 · see citing works
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
Toledo, L. I., Altmeyer, M., Rask, M.-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J., & Lukas, J. (2013) · Cell · doi:10.1016/j.cell.2013.10.043 · Cited by 911 · see citing works
Hwang, B. J., Ford, J. M., Hanawalt, P. C., & Chu, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.424 · Cited by 581 · see citing works
Peyrin‐Biroulet, L., Khosrotehrani, K., Carrat, F., Bouvier, A., Chevaux, J., Simon, T., Carbonnel, F., Colombel, J., Dupas, J., Godeberge, P., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.050 · Cited by 489 · see citing works
NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis
South, A. P., Purdie, K. J., Watt, S. A., Haldenby, S. T., den Breems, N. Y., Dimon, M. T., Arron, S. T., Kluk, M., Aster, J. C., McHugh, A. T., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.154 · Cited by 359 · see citing works
Replication Protein A phosphorylation and the cellular response to DNA damage
Binz, S. K., Sheehan, A. M., & Wold, M. S. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.028 · Cited by 299 · see citing works
Groitl, B., & Jakob, U. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.03.007 · Cited by 237 · see citing works
Requirement for the replication protein SSB in human DMA excision repair
Coverley, D., Kenny, M. K., Munn, M. M., Rupp, W. D., Lane, D. P., & Wood, R. D. (1991) · Nature · doi:10.1038/349538a0 · Cited by 223 · see citing works
Mutational Landscape of Basal Cell Carcinomas by Whole-Exome Sequencing
Jayaraman, S. S., Rayhan, D. J., Hazany, S., & Kolodney, M. S. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.276 · Cited by 221 · see citing works
Genetic Analysis of Yeast RPA1 Reveals Its Multiple Functions in DNA Metabolism
Umezu, K., Sugawara, N., Chen, C., Haber, J. E., & Kolodner, R. D. (1998) · Genetics · doi:10.1093/genetics/148.3.989 · Cited by 206 · see citing works
ATR/Mec1: coordinating fork stability and repair
Friedel, A. M., Pike, B. L., & Gasser, S. M. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.017 · Cited by 157 · see citing works
Chen, C. C., Umezu, K., & Kolodner, R. D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80109-4 · Cited by 157 · see citing works
Wang, Y., Putnam, C. D., Kane, M., Zhang, W., Edelmann, L. J., Russell, R. G., Carrion, D. V., Chin, L., Kucherlapati, R., Kolodner, R. D., et al. (2005) · Nature Genetics · doi:10.1038/ng1587 · Cited by 154 · see citing works
Lin, Y., Shivji, M. K. K., Chen, C., Kolodner, R. D., Wood, R. D., & Dutta, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1453 · Cited by 145 · see citing works
Risk factors for actinic keratosis in eight European centres: a case-control study
Traianou, A., Ulrich, M., Apalla, Z., de Vries, E., Bakirtzi, K., Kalabalikis, D., Ferrándiz, L., Ruiz-de-Casas, A., Moreno-Ramírez, D., Sotiriadis, D., et al. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.11085.x · Cited by 111 · see citing works
Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light
Zhang, X., Jeffs, G., Ren, X., O’Donovan, P., Montaner, B., Perrett, C. M., Karran, P., & Xu, Y.-Z. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.11.003 · Cited by 110 · see citing works
Self-citationDodson, G. E., Shi, Y., & Tibbetts, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400242200 · Cited by 96 · see citing works
Photosensitized DNA Damage: The Case of Fluoroquinolones†
Lhiaubet‐Vallet, V., Boscá, F., & Miranda, M. A. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00548.x · Cited by 70 · see citing works
Rapić-Otrin, V., McLenigan, M. P., Takao, M., Levine, A. S., & Protić, M. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.10.1159 · Cited by 67 · see citing works
Park, J.-S., Wang, M., Park, S.-J., & Lee, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29075 · Cited by 65 · see citing works
Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins
Qian, J. X., Klomsiri, C., Wright, M. W., King, S. B., Tsang, A. W., Poole, L. B., & Furdui, C. M. (2011) · Chemical Communications · doi:10.1039/c1cc12127h · Cited by 58 · see citing works
Protein Oxidation and DNA Repair Inhibition by 6-Thioguanine and UVA Radiation
Guéranger, Q., Li, F., Peacock, M., Larnicol, A., Brem, R., Macpherson, P., Egly, J., & Karran, P. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.509 · Cited by 54 · see citing works
Self-citationTsaalbi-Shtylik, A., Moser, J., Mullenders, L. H. F., Jansen, J. G., & de Wind, N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1412 · Cited by 28 · see citing works
DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib
Peacock, M., Brem, R., Macpherson, P., & Karran, P. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1213 · Cited by 24 · see citing works
Self-citationRedox‐dependent formation of disulfide bonds in human replication protein A
Men, L., Roginskaya, M., Zou, Y., & Wang, Y. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3144 · Cited by 18 · see citing works
Itoh, T., Miyauchi‐Hashimoto, H., Sugihara, A., Tanaka, K., & Horio, T. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23862.x · Cited by 16 · see citing works
Thiopurines and Risk of Nonmelanoma Skin Cancer in Inflammatory Bowel Disease
Ramiscal, J. A. B., & Brewer, J. D. (2013) · JAMA Dermatology · doi:10.1001/2013.jamadermatol.616 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Peacock M UVA photosensitizers, protein oxidation and DNA repair 2014 University College London PhD Thesis
Cited by
Sorted by citations
Sunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works
Formation of UV-induced DNA damage contributing to skin cancer development
Cadet, J., & Douki, T. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00395a · Cited by 435 · see citing works
Tafani, M., Sansone, L., Limana, F., Arcangeli, T., Santis, E. D., Polese, M., Fini, M., & Russo, M. A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3907147 · Cited by 371 · see citing works
Solar UV damage to cellular DNA: from mechanisms to biological effects
Mullenders, L. H. F. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c8pp00182k · Cited by 215 · see citing works
Protein oxidation, UVA and human DNA repair
Karran, P., & Brem, R. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.024 · Cited by 163 · see citing works
Self-citationRoles of UVA radiation and DNA damage responses in melanoma pathogenesis
Khan, A. Q., Travers, J. B., & Kemp, M. G. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22176 · Cited by 152 · see citing works
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
Dueva, R., & Iliakis, G. E. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa022 · Cited by 130 · see citing works
Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA
Brem, R., Guven, M., & Karran, P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.488 · Cited by 136 · see citing works
Self-citationAutophagy in UV Damage Response
Sample, A., & He, Y. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12691 · Cited by 90 · see citing works
McAdam, E., Brem, R., & Karran, P. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0053 · Cited by 86 · see citing works
Self-citationThe Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
Tuieng, R. J., Cartmell, S. H., Kirwan, C., & Sherratt, M. J. (2021) · Cells · doi:10.3390/cells10113041 · Cited by 85 · see citing works
Skin Cancer Following Solid Organ Transplantation: A Review of Risk Factors and Models of Care
Howard, M. D., Su, J. C., & Chong, A. H. (2018) · American Journal of Clinical Dermatology · doi:10.1007/s40257-018-0355-8 · Cited by 78 · see citing works
Kumar, N., Moreno, N. C., Feltes, B. C., Menck, C. F. M., & Houten, B. V. (2020) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2019-0104 · Cited by 74 · see citing works
Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin
Kemp, M. G., Spandau, D. F., & Travers, J. B. (2017) · Molecules · doi:10.3390/molecules22030356 · Cited by 62 · see citing works
The role of radiation induced oxidative stress as a regulator of radio-adaptive responses
Sisakht, M., Darabian, M., Mahmoodzadeh, A., Bazı, A., Shafiee, S. M., Mokarram, P., & Khoshdel, Z. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1721597 · Cited by 60 · see citing works
Insight in DNA Repair of UV ‐induced Pyrimidine Dimers by Chromatographic Methods
Douki, T., von Koschembahr, A., & Cadet, J. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12685 · Cited by 58 · see citing works
A new perspective on oxidation of DNA repair proteins and cancer
Alnajjar, K. S., & Sweasy, J. B. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.02.006 · Cited by 49 · see citing works
Brem, R., Macpherson, P., Guven, M., & Karran, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-04614-8 · Cited by 44 · see citing works
Self-citationCurrent Insights into the Role of UV Radiation-Induced Oxidative Stress in Melanoma Pathogenesis
Gieniusz, E., Skrzydlewska, E., & Łuczaj, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111651 · Cited by 42 · see citing works
Insights and controversies on sunscreen safety
de Paiva, J. P., Diniz, R. R., Leitão, Á. C., Cabral, L. M., Fortunato, R. S., Santos, B. A. M. C., & de Padula, M. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1826899 · Cited by 38 · see citing works
Ji, Y., Karbaschi, M., & Cooke, M. S. (2019) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2019.05.010 · Cited by 32 · see citing works
The key role of UVA-light induced oxidative stress in human Xeroderma Pigmentosum Variant cells
Moreno, N. C., Garcia, C. C. M., Munford, V., Rocha, C. R. R., Pelegrini, A. L., Corradi, C., Sarasin, A. R., & Menck, C. F. M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.012 · Cited by 32 · see citing works
Douki, T. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13278 · Cited by 32 · see citing works
Redox controls RecA protein activity via reversible oxidation of its methionine residues
Henry, C., Loiseau, L., Vergnes, A., Vertommen, D., Mérida-Floriano, Á., Chitteni‐Pattu, S., Wood, E. A., Casadesús, J., Cox, M. M., Barras, F., et al. (2021) · eLife · doi:10.7554/elife.63747 · Cited by 31 · see citing works
The role of calcium hydroxylapatite (Radiesse) in nonsurgical aesthetic rejuvenation.
Lizzul, P. F., & Narurkar, V. A. (2010) · PubMed · Cited by 30 · see citing works
Kemp, M. G., Spandau, D. F., Simman, R., & Travers, J. B. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.765883 · Cited by 29 · see citing works
Kim, S. H., Kim, G. H., Kemp, M. G., & Choi, J. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac214 · Cited by 27 · see citing works
Stress Marks on the Genome: Use or Lose?
Bokhari, B. T., & Sharma, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020364 · Cited by 26 · see citing works
DNA repair and anti-cancer mechanisms in the long-lived bowhead whalePreprint
Firsanov, D., Zacher, M., Tian, X., Sformo, T. L., Zhao, Y., Tombline, G., Lu, J. Y., Zheng, Z., Perelli, L., Gurreri, E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.07.539748 · Cited by 26 · see citing works
Damage removal and gap filling in nucleotide excision repair
Kemp, M. G. (2019) · The Enzymes · doi:10.1016/bs.enz.2019.06.001 · Cited by 22 · see citing works
Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I. M., Proby, C. M., Fahey, J. W., Cole, P. A., & Dinkova‐Kostova, A. T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213095 · Cited by 19 · see citing works
Moser, B., Basílio, J., Gotzmann, J., Brachner, A., & Foisner, R. (2020) · Cells · doi:10.3390/cells9020463 · Cited by 20 · see citing works
Guven, M., Barnouin, K., Snijders, A. P., & Karran, P. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00717 · Cited by 16 · see citing works
Self-citationToxicity and DNA repair in normal human keratinocytes co-exposed to benzo[a]pyrene and sunlight
von Koschembahr, A., Youssef, A., Beal, D. M., Gudimard, L., Giot, J., & Douki, T. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104744 · Cited by 15 · see citing works
Ibuki, Y., Komaki, Y., Yang, G., & Toyooka, T. (2021) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-021-00050-w · Cited by 14 · see citing works
Blue light impairs the repair of UVB‐induced pyrimidine dimers in a human skin model
Douki, T., Bacqueville, D., Jacques, C., Géniès, C., Roullet, N., Bessou‐Touya, S., & Duplan, H. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13921 · Cited by 13 · see citing works
Feltes, B. C., & Menck, C. F. M. (2022) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2022.108436 · Cited by 13 · see citing works
Yang, G., & Ibuki, Y. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.7b00304 · Cited by 13 · see citing works
Krasikova, Y. S., Rechkunova, N. I., & Lavrik, O. I. (2016) · Molecular Biology · doi:10.1134/s0026893316030080 · Cited by 13 · see citing works
Efeitos da luz UVA em células de pacientes com Xeroderma Pigmentosum Variante
Moreno, N. C. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2018.tde-22012018-162542 · Cited by 13 · see citing works
Nutraceutical strategies for alleviation of UVB phototoxicity
McCarty, M. F., Benzvi, C., Vojdani, A., & Lerner, A. (2023) · Experimental Dermatology · doi:10.1111/exd.14777 · Cited by 12 · see citing works
Redox-Redux and NADPH Oxidase (NOX): Even More Complicated than We Thought it Might Be
Meyskens, F. L., & Liu, F. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.01.019 · Cited by 11 · see citing works
Negishi, T., Xing, F., Koike, R., Iwasaki, M., Wakasugi, M., & Matsunaga, T. (2023) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2023.503616 · Cited by 10 · see citing works
Krasikova, Y. S., Rechkunova, N. I., & Lavrik, O. I. (2016) · Molecular Biology · doi:10.7868/s0026898416030083 · Cited by 10 · see citing works
Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects
Sua-Cespedes, C. D., Lacerda, J. T., Zanetti, G., David, D. D., Moraes, M. N., de Assis, L. V. M., & Castrucci, A. M. D. L. (2023) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2023.112702 · Cited by 9 · see citing works
Moreno, N. C., Garcia, C. C. M., Rocha, C. R. R., Munford, V., & Menck, C. F. M. (2018) · Photochemistry and Photobiology · doi:10.1111/php.13041 · Cited by 9 · see citing works
Generation of cellular reactive oxygen and nitrogen species by exposure to ultraviolet radiation
Menoni, M., Alcoba, P., Zuluaga, M. J., & Peluffo, R. D. (2025) · Biophysical Reviews · doi:10.1007/s12551-025-01298-7 · Cited by 8 · see citing works
Sunlight-Induced DNA Damage: Molecular Mechanisms and Photoprotection Strategies
Douki, T. (2016) · Springer eBooks · doi:10.1007/978-3-319-43157-4_3 · Cited by 8 · see citing works
Medications Associated with Increased Risk of Keratinocyte Carcinoma
Crow, L. D., Kaizer-Salk, K. A., Juszczak, H. M., & Arron, S. T. (2019) · Dermatologic Clinics · doi:10.1016/j.det.2019.02.005 · Cited by 7 · see citing works
Chhabra, A., Jain, N. F., Varshney, R. K., & Sharma, M. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110664 · Cited by 5 · see citing works
Ghazi, M., Khanna, S., Subramaniam, Y. J., Rengaraju, J., Sultan, F., Gupta, I., Sharma, K., Chandna, S., Gokhale, R. S., & Natarajan, V. T. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad704 · Cited by 5 · see citing works
Skin Cancers and Lung Transplant
Wilken, R., Carucci, J. A., & Stevenson, M. L. (2021) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1728798 · Cited by 5 · see citing works
UVA-light-induced mutagenesis in the exome of human nucleotide excision repair-deficient cells
Ruiz, N. Q., Corradi, C., Moreno, N. C., de Souza, T. A., & Menck, C. F. M. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00697-9 · Cited by 5 · see citing works
Fatima, N., Yaqoob, S., Rana, S., Hameed, A., Mirza, M. R., & Jabeen, A. (2024) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2024.112841 · Cited by 3 · see citing works
Douki, T. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112169 · Cited by 3 · see citing works
Low extracellular pH inhibits nucleotide excision repair
Fukuda, T., Komaki, Y., Mori, Y., & Ibuki, Y. (2021) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2021.503374 · Cited by 3 · see citing works
Interface of DNA Repair and Metabolism
Marconi, D., Ranfley, H., Menck, C. F. M., Ferreira, C. P., & Câmara, N. O. S. (2020) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-020-00018-5 · Cited by 1 · see citing works
Ultraviolet Light, Chromophores, Reactive Oxygen Species, and Human Health
Ahmad, S. (2016) · CRC Press eBooks · doi:10.1201/b20228-5 · Cited by 2 · see citing works
Fluoroquinolones as enhancers of photocarcinogenesis: Proposed pathomechanisms
Gonçalo, M., & Lopes, R. T. (2022) · Portuguese Journal of Dermatology and Venereology · doi:10.24875/pjd.m22000006 · Cited by 1 · see citing works
McKay, R. L., & Wu, S. (2025) · Journal of Dermato-Oncology · doi:10.1080/29944376.2025.2595383 · Cited by 1 · see citing works
- Authors
- Guven, M., Brem, R., Macpherson, P., Peacock, M., & Karran, P.
- Affiliations
- The Francis Crick Institute (GB)
- Corresponding author
- Karran, Peter
- ORCID
- Brem, Reto
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 135
- Issue
- 11
- Pages
- 2834-2841
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC4669849
- OpenAlex
- W1520446265
- Cited by
- 61
- References
- 31
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- nucleotide excision repair, replication protein A, protein oxidation, oxidative damage, skin cancer risk, photosensitivity, reactive oxygen species, azathioprine, fluoroquinolones, UVA, DNA repair proteins
- MeSH terms
- Cells, Cultured, DNA Damage, DNA Repair, DNA-Binding Proteins, Enzyme-Linked Immunosorbent Assay, Humans, Oxidation-Reduction, Photosensitivity Disorders, Skin Neoplasms, Thioguanine, Ultraviolet Rays, Immunoblotting, Photosensitizing Agents, Oxidative Stress, Replication Protein A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
