Ortega, Sagrario

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

Marión, R. M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Serrano, M., & Blasco, M. A. (2009) · Nature

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 1,028

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 968

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

Malumbres, M., Sotillo, R., Santamarı́a, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., & Barbacid, M. (2004) · Cell

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 793

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

Abad, M., Mosteiro, L., Pantoja, C., Cañamero, M., Rayon, T., Ors, I., Graña, O., Megías, D., Domínguez, O., Martínez, D., et al. (2013) · Nature

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 547

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Maus, M., López-Polo, V., Mateo, L., Lafarga, M., Aguilera, M., De Lama, E., Meyer, K., Sola, A., Lopez-Martinez, C., López-Alonso, I., et al. (2023) · Nature Metabolism

Telomeres, Telomerase, and SenescenceIron Metabolism and Disorders

Cited by 215

Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number

Martín, J., Hunt, S. L., Dubus, P., Sotillo, R., Néhmé-Pélluard, F., Magnuson, M. A., Parlow, A. F., Malumbres, M., Ortega, S., & Barbacid, M. (2003) · Oncogene

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 122

Complete regression of advanced pancreatic ductal adenocarcinomas upon combined inhibition of EGFR and C-RAF

Blasco, M. T., Navas, C., Martín-Serrano, G., Graña-Castro, O., Lechuga, C. G., Martín-Díaz, L., Djurec, M., Li, J., Morales-Cacho, L., Esteban-Burgos, L., et al. (2019) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 115

HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer

Kalisz, M., Bernardo, E., Beucher, A., Maestro, M. A., del Pozo, N., Millán, I., Haeberle, L., Schlensog, M., Safi, S. A., Knoefel, W. T., et al. (2020) · The EMBO Journal

Pancreatic and Hepatic Oncology ResearchEpigenetics and DNA Methylation

Cited by 77

Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas

Salmón, M., Álvarez-Díaz, R., Fustero-Torre, C., Brehey, O., Lechuga, C. G., Sanclemente, M., Fernández-García, F., López-García, A., Martín-Guijarro, M. C., Rodríguez-Perales, S., et al. (2023) · Journal of Clinical Investigation

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 52