HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer
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Abstract
Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The locus encoding the transcription factor HNF1A harbors susceptibility variants for pancreatic ductal adenocarcinoma (PDAC), while KDM6A , encoding Lysine‐specific demethylase 6A, carries somatic mutations in PDAC. Here, we show that pancreas‐specific Hnf1a null mutant transcriptomes phenocopy those of Kdm6a mutations, and both defects synergize with Kras G12D to cause PDAC with sarcomatoid features. We combine genetic, epigenomic, and biochemical studies to show that HNF1A recruits KDM6A to genomic binding sites in pancreatic acinar cells. This remodels the acinar enhancer landscape, activates differentiated acinar cell programs, and indirectly suppresses oncogenic and epithelial–mesenchymal transition genes. We also identify a subset of non‐classical PDAC samples that exhibit the HNF1A/KDM6A ‐deficient molecular phenotype. These findings provide direct genetic evidence that HNF1A deficiency promotes PDAC. They also connect the tumor‐suppressive role of KDM6A deficiency with a cell‐specific molecular mechanism that underlies PDAC subtype definition.
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Deletion of KDM6A in GEMMs results in accelerated tumorigenesis and acquisition of an aggressive transcriptional subtype.
“deletion of KDM6A results in accelerated tumorigenesis and acquisition of an aggressive transcriptional subtype95–97.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [95]
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437 · see citing works
WGCNA: an R package for weighted correlation network analysis
Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
ggplot2: Elegant Graphics for Data Analysis
Wickham, H. (2009) · doi:10.1007/978-0-387-98141-3 · Cited by 14,447 · see citing works
The Molecular Signatures Database Hallmark Gene Set Collection
Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J. P., & Tamayo, P. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.004 · Cited by 13,807 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
Salmon provides fast and bias-aware quantification of transcript expression
Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700 · see citing works
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799 · see citing works
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works
deepTools2: a next generation web server for deep-sequencing data analysis
Ramírez, F., Ryan, D. P., Grüning, B., Bhardwaj, V., Kilpert, F., Richter, A. S., Heyne, S., Dündar, F., & Manke, T. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw257 · Cited by 8,096 · see citing works
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
Wilkerson, M. D., & Hayes, D. N. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq170 · Cited by 5,719 · see citing works
Genetic effects on gene expression across human tissues
GTEx Consortium (2017) · Nature · doi:10.1038/nature24277 · Cited by 4,036 · see citing works
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works
Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621 · cited 13× · see citing works
“Samples from the ICGC-PACA-AU study were classified into molecular subtypes based on signature genes from Collisson et al (2011), Moffitt et al (2015), or Bailey et al (2016).”
BackgroundMethodInfluentialWhole genomes redefine the mutational landscape of pancreatic cancer
Initiative, A. P. C. G., Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., et al. (2015) · Nature · doi:10.1038/nature14169 · Cited by 2,642 · cited 3× · see citing works
“Up to 18% of PDAC tumors carry mutations in KDM6A (Waddell et al, 2015), which encodes Lysine-specific demethylase 6A (KDM6A), a component of the MLL/COMPASS transcriptional co-regulatory complex (Cho et al, 2007).”
BackgroundPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348 · see citing works
Moffitt, R. A., Marayati, R., Flate, E. L., Volmar, K. E., Loeza, S. G. H., Hoadley, K. A., Rashid, N. U., Williams, L. A., Eaton, S. C., Chung, A. H., et al. (2015) · Nature Genetics · doi:10.1038/ng.3398 · Cited by 2,194 · see citing works
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
Ross-Innes, C. S., Stark, R., Teschendorff, A. E., Holmes, K. A., Ali, H. R., Dunning, M., Brown, G. D., Gojiš, O., Ellis, I. O., Green, A. R., et al. (2012) · Nature · doi:10.1038/nature10730 · Cited by 2,182 · see citing works
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058 · see citing works
Reich, M. M., Liefeld, T., Gould, J., Lerner, J., Tamayo, P., & Mesirov, J. P. (2006) · Nature Genetics · doi:10.1038/ng0506-500 · Cited by 2,035 · see citing works
Integrated genomic characterization of pancreatic ductal adenocarcinoma
Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019 · see citing works
Remmele, W., & Stegner, H.-E. (1987) · PubMed · Cited by 1,976 · see citing works
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
Collisson, E. A., Sadanandam, A., Olson, P., Gibb, W. J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G. E., Jakkula, L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2344 · Cited by 1,967 · see citing works
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint
Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,877 · see citing works
JASPAR: an open-access database for eukaryotic transcription factor binding profiles
Sandelin, A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh012 · Cited by 1,763 · see citing works
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
Yamagata, K., Oda, N., Kaisaki, P. J., Menzel, S., Furuta, H., Vaxillaire, M., Southam, L., Cox, R., Lathrop, M. G., Boriraj, V. V., et al. (1996) · Nature · doi:10.1038/384455a0 · Cited by 1,610 · see citing works
Differential Oestrogen Receptor Binding is Associated with Clinical Outcome in Breast Cancer
Stark, R. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-29627-7_30 · Cited by 1,403 · see citing works
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
Agger, K., Cloos, P. A., Christensen, J. F., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E., & Helin, K. (2007) · Nature · doi:10.1038/nature06145 · Cited by 1,392 · see citing works
A Single-Cell Transcriptome Atlas of the Human Pancreas
Muraro, M. J., Dharmadhikari, G., Grün, D., Gröen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.002 · Cited by 1,288 · see citing works
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
Rodríguez, C. I., Buchholz, F., Galloway, J. L., Sequerra, R., Kasper, J. S., Ayala, R., Stewart, A. F., & Dymecki, S. M. (2000) · Nature Genetics · doi:10.1038/75973 · Cited by 1,162 · see citing works
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007 · cited 3× · see citing works
“Four or three pancreases from, respectively, 4-day-old or adult female mice of each genotype were analyzed: Kdm6aLoxP/LoxP and Pdx1Cre; Kdm6aLoxP/LoxP or Ptf1aCre and Ptf1aCre;Hnf1aLoxP/LoxP.”
Kulakovskiy, I. V., Vorontsov, I. E., Yevshin, I., Sharipov, R., Fedorova, A. D., Rumynskiy, E. I., Medvedeva, Y. A., Magana-Mora, A., Bajić, V. B., Papatsenko, D., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1106 · Cited by 921 · see citing works
BoxPlotR: a web tool for generation of box plots
Spitzer, M., Wildenhain, J., Rappsilber, J., & Tyers, M. (2014) · Nature Methods · doi:10.1038/nmeth.2811 · Cited by 809 · see citing works
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
van Haaften, G., Dalgliesh, G. L., Davies, H., Chen, L., Bignell, G., Greenman, C., Edkins, S., Hardy, C., O'Meara, S., Teague, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.349 · Cited by 784 · see citing works
A histone H3 lysine 27 demethylase regulates animal posterior development
Lan, F., Bayliss, P. E., Rinn, J. L., Whetstine, J. R., Wang, J. K., Chen, S., Iwase, S., Alpatov, R., Issaeva, I., Canaani, E., et al. (2007) · Nature · doi:10.1038/nature06192 · Cited by 782 · see citing works
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
Lee, M. G., Villa, R., Trojer, P., Norman, J. A., Yan, K.-P., Reinberg, D., Croce, L. D., & Shiekhattar, R. (2007) · Science · doi:10.1126/science.1149042 · Cited by 772 · see citing works
Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697 · see citing works
[20] Isolation of RNA using guanidinium salts
MacDonald, R. J., Swift, G. H., Przybyla, A., & Chirgwin, J. M. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)52023-7 · Cited by 599 · see citing works
Pontoglio, M., Barra, J., Hadchouel, M., Doyen, A., Kress, C., Poggi-Bach, J., Babinet, C., & Yaniv, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81033-8 · Cited by 580 · see citing works
Pancreatic cancer: from state-of-the-art treatments to promising novel therapies
Garrido‐Laguna, I., & Hidalgo, M. M. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.53 · Cited by 565 · see citing works
Stratification of pancreatic ductal adenocarcinomas based on tumor and microenvironment features
Puleo, F., Nicolle, R., Blum, Y., Cros, J., Marisa, L., Demetter, P., Quertinmont, E., Svrcek, M., Elarouci, N., Iovanna, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.033 · Cited by 563 · see citing works
PlotsOfData—A web app for visualizing data together with their summaries
Postma, M., & Goedhart, J. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000202 · Cited by 554 · see citing works
PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex
Cho, Y., Hong, T., Hong, S., Guo, H. W., Yu, H., Kim, D., Guszczynski, T., Dressler, G. R., Copeland, T. D., Kalkum, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701574200 · Cited by 528 · see citing works
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
Notta, F., Chan-Seng-Yue, M., Lemire, M., Li, Y., Wilson, G. W., Connor, A. A., Denroche, R. E., Liang, S.-B., Brown, A. M. K., Kim, J. C., et al. (2016) · Nature · doi:10.1038/nature19823 · Cited by 528 · see citing works
Self-citationSolar, M., Cardalda, C., Houbracken, I., Martín, M., Maestro, M., Demedts, N., Xu, X.-B., Grau, V., Heimberg, H., Bouwens, L., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.003 · Cited by 516 · see citing works
Self-citationChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors
Schmidl, C., Rendeiro, A. F., Sheffield, N. C., & Bock, C. (2015) · Nature Methods · doi:10.1038/nmeth.3542 · Cited by 509 · see citing works
Inferring direct DNA binding from ChIP-seq
Bailey, T. L., & Machanick, P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks433 · Cited by 472 · see citing works
Agouti C57BL/6N embryonic stem cells for mouse genetic resources
Pettitt, S. J., Liang, Q., Rairdan, X. Y., Moran, J. L., Prosser, H. M., Beier, D. R., Lloyd, K. C. K., Bradley, A., & Skarnes, W. C. (2009) · Nature Methods · doi:10.1038/nmeth.1342 · Cited by 384 · see citing works
Miller, S. A., Mohn, S. E., & Weinmann, A. S. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.028 · Cited by 365 · see citing works
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer
Roberts, N. J., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0402 · Cited by 361 · see citing works
Andricovich, J., Perkail, S., Kai, Y., Casasanta, N., Peng, W., & Tzatsos, A. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.02.003 · Cited by 320 · see citing works
UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development
Shpargel, K. B., Sengoku, T., Yokoyama, S., & Magnuson, T. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002964 · Cited by 310 · see citing works
Self-citationRyan, D. P., Hong, T. S., & Bardeesy, N. M. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1412266 · Cited by 291 · see citing works
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
Klein, A. P., Wolpin, B. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Mocci, E., Zhang, M., Canzian, F., Childs, E. J., Hoskins, J. W., Jermusyk, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02942-5 · Cited by 268 · see citing works
Self-citationChilds, E. J., Mocci, E., Campa, D., Bracci, P. M., Gallinger, S., Goggins, M., Li, D., Neale, R. Ε., Olson, S. H., Scélo, G., et al. (2015) · Nature Genetics · doi:10.1038/ng.3341 · Cited by 265 · see citing works
Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in theHnf-1α Knockout Mouse
Lee, Y., Sauer, B., & Gonzalez, F. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.3059 · Cited by 262 · see citing works
A transcription factor regulatory circuit in differentiated pancreatic cells
Boj, S. F., Párrizas, M., Maestro, M. A., & Ferrer, J. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241349398 · Cited by 253 · see citing works
Self-citationWang, S., Tang, Z., Chen, C.-W. D., Shimada, M., Koche, R. P., Wang, L.-H., Nakadai, T., Chramiec, A. G., Krivtsov, A. V., Armstrong, S. A., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.028 · Cited by 242 · see citing works
TP63-mediated enhancer reprogramming drives the squamous subtype of pancreatic ductal adenocarcinoma
Somerville, T. D. D., Xu, Y., Miyabayashi, K., Tiriac, H., Cleary, C. R., Maia-Silva, D., Milazzo, J. P., Tuveson, D. A., & Vakoc, C. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.051 · Cited by 225 · see citing works
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
Mann, K. M., Ward, J. M., Yew, C. C. K., Kovochich, A., Dawson, D. W., Black, M. A., Brett, B. T., Scheetz, T. E., Dupuy, A. J., Initiative, A. P. C. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202490109 · Cited by 210 · see citing works
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2916 · Cited by 190 · see citing works
Self-citationThe acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma
Krah, N. M., De La O, J.-P., Swift, G. H., Hoang, C. Q., Willet, S. G., Chen Pan, F., Cash, G. M., Bronner, M. P., Wright, C. V., MacDonald, R. J., et al. (2015) · eLife · doi:10.7554/elife.07125 · Cited by 166 · see citing works
Ruscoe, J. E., Rosario, L. A., Wang, T., Gaté, L., Arifoglu, P., Wolf, C. R., Henderson, C. J., Ronai, Z. A., & Tew, K. D. (2001) · PubMed · Cited by 165 · see citing works
Wang, L., & Shilatifard, A. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.01.001 · Cited by 165 · see citing works
Gozdecka, M., Meduri, E., Mazan, M. M., Tzelepis, K., Dudek, M., Knights, A. J., Pardo, M., Yu, L., Choudhary, J. S., Metzakopian, E., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0114-z · Cited by 157 · see citing works
Control of Cell Identity in Pancreas Development and Regeneration
Stanger, B. Z., & Hebrok, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.074 · Cited by 154 · see citing works
Tie, F., Banerjee, R., Conrad, P. A., Scacheri, P. C., & Harte, P. J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06392-11 · Cited by 146 · see citing works
Diaferia, G. R., Balestrieri, C., Prosperini, E., Nicoli, P., Spaggiari, P., Zerbi, A., & Natoli, G. (2016) · The EMBO Journal · doi:10.15252/embj.201592404 · Cited by 143 · see citing works
Servitja, J., Pignatelli, M., Maestro, M. Á., Cardalda, C. A., Boj, S. F., Lozano, J. J., Blanco, E., Lafuente, A., McCarthy, M. I., Sumoy, L., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01389-08 · Cited by 140 · see citing works
Self-citationTranscriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
Cobo, I., Martinelli, P., Flández, M., Bakiri, L., Zhang, M.-F., Pau, E. C. D. S., Jia, J.-P., Lobo, V. J. S.-A., Megías, D., Felipe, I., et al. (2018) · Nature · doi:10.1038/nature25751 · Cited by 130 · see citing works
Self-citationUTX-guided neural crest function underlies craniofacial features of Kabuki syndrome
Shpargel, K. B., Starmer, J., Wang, C., Ge, K., & Magnuson, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705011114 · Cited by 96 · see citing works
Self-citationThe acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice
Martinelli, P., Madriles, F., Cañamero, M., Pau, E., Pozo, N. D., Guerra, C., & Real, F. (2015) · Gut · doi:10.1136/gutjnl-2014-308042 · Cited by 95 · see citing works
Self-citationVandamme, J., Lettier, G., Sidoli, S., Schiavi, E. D., Jensen, O. N., & Salcini, A. E. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002647 · Cited by 94 · see citing works
Using GenePattern for Gene Expression Analysis
Kuehn, H., Liberzon, A., Reich, M. M., & Mesirov, J. P. (2008) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi0712s22 · Cited by 87 · see citing works
Zha, L., Li, F., Wu, R., Artinian, L. R., Rehder, V., Yu, L., Liang, H., Xue, B., & Shi, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662650 · Cited by 81 · see citing works
Sacco, F., Tinti, M., Palma, A., Ferrari, E., Nardozza, A. P., van Huijsduijnen, R. H., Takahashi, T., Castagnoli, L., & Cesareni, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.002758 · Cited by 70 · see citing works
Xue, B., Wu, Y., Yin, Z., Zhang, H., Sun, S., Yi, T., & Luo, L. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.06.034 · Cited by 62 · see citing works
Pierce, B. L., & Ahsan, H. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0124 · Cited by 60 · see citing works
Jägle, S., Busch, H. S., Freihen, V., Beyes, S., Schrempp, M., Boerries, M., & Hecht, A. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007109 · Cited by 60 · see citing works
Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A
Hoskins, J. W., Jia, J., Flández, M., Parikh, H. M., Xiao, W., Collins, I. J., Emmanuel, M. A., Ibrahim, A. M., Powell, J. I., Zhang, L., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu193 · Cited by 54 · see citing works
Self-citationHepatocyte Nuclear Factor 1A (HNF1A) as a Possible Tumor Suppressor in Pancreatic Cancer
Luo, Z., Li, Y., Wang, H., Fleming, J. B., Li, M., Kang, Y., Zhang, R., & Li, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121082 · Cited by 49 · see citing works
Molero, X., Vaquero, E., Flández, M., González, A., Ortiz, M. A., Cibrián-Uhalte, E., Servitja, J., Merlos, A. M., Juanpere, N., Massumi, M., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-300360 · Cited by 49 · see citing works
Self-citationChen, X., Xiong, X., Cui, D., Yang, F., Wei, D., Li, H., Shu, J., Bi, Y., Dai, X.-Q., Gong, L., et al. (2019) · Oncogene · doi:10.1038/s41388-019-1085-y · Cited by 44 · see citing works
Expression profile of MODY3/HNF-1α protein in the developing mouse pancreas
Nammo, T., Yamagata, K., Hamaoka, R., Zhu, Q., Akiyama, T. E., Gonzalez, F. J., Miyagawa, J., & Matsuzawa, Y. (2002) · Diabetologia · doi:10.1007/s00125-002-0892-8 · Cited by 43 · see citing works
Abstract 4352: Systemic levels of neuropeptide Y are elevated in Ewing's sarcoma patients
Tilan, J. U., Mtaweh, H., Everhart, L. M., Long, J., Barkauskas, D. A., Krailo, M., Jeha, D., Toretsky, J. A., & Kitlinska, J. B. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-4352 · Cited by 8 · see citing works
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Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works
A gene–environment-induced epigenetic program initiates tumorigenesis
Alonso‐Curbelo, D., Ho, Y.-J., Burdziak, C., Mååg, J. L. V., Morris, J. P., Chandwani, R., Chen, H.-A., Tsanov, K. M., Barriga, F. M., Luan, W., et al. (2021) · Nature · doi:10.1038/s41586-020-03147-x · Cited by 306 · see citing works
Lysine Demethylase KDM6A in Differentiation, Development, and Cancer
Tran, N., Broun, A., & Ge, K. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00341-20 · Cited by 166 · see citing works
Tu, M., Klein, L., Espinet, E., Georgomanolis, T., Wegwitz, F., Li, X., Urbach, L., Danieli‐Mackay, A., Küffer, S., Bojarczuk, K., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00258-w · Cited by 112 · see citing works
Kloesch, B., Ionasz, V. S., Paliwal, S., Hruschka, N., de Villarreal, J. M., Öllinger, R., Mueller, S., Dienes, H. P., Schindl, M., Gruber, E. S., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-321397 · Cited by 90 · see citing works
Self-citationKDM6A epigenetically regulates subtype plasticity in small cell lung cancer
Duplaquet, L., Li, Y., Booker, M. A., Xie, Y., Olsen, S. N., Patel, R. A., Hong, D., Hatton, C., Denize, T., Walton, E., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01210-z · Cited by 76 · see citing works
Mechanisms of PDAC subtype heterogeneity and therapy response
Espinet, E., Klein, L., Puré, E., & Singh, S. K. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.08.005 · Cited by 70 · see citing works
Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC
Zhou, X., An, J., Kurilov, R., Brors, B., Hu, K., Peccerella, T., Roessler, S. K., Pfütze, K., Schulz, A., Wolf, S., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00628-6 · Cited by 66 · see citing works
HNF1A Mutations and Beta Cell Dysfunction in Diabetes
Miyachi, Y., Miyazawa, T., & Ogawa, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063222 · Cited by 63 · see citing works
Tricarico, R., Nicolas, É., Hall, M. J., & Golemis, E. A. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1741 · Cited by 60 · see citing works
HDAC2 Facilitates Pancreatic Cancer Metastasis
Krauß, L., Urban, B. C., Hastreiter, S., Schneider, C., Wenzel, P., Hassan, Z., Wirth, M., Lankes, K., Terrasi, A., Klement, C., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3209 · Cited by 49 · see citing works
Camolotto, S. A., Belova, V. K., Torre-Healy, L. A., Vahrenkamp, J. M., Berrett, K. C., Conway, H., Shea, J., Stubben, C., Moffitt, R. A., Gertz, J., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-321316 · Cited by 46 · see citing works
Chen, X., Xiong, X., Cui, D., Yang, F., Wei, D., Li, H., Shu, J., Bi, Y., Dai, X.-Q., Gong, L., et al. (2019) · Oncogene · doi:10.1038/s41388-019-1085-y · Cited by 44 · see citing works
Yang, R., Zhang, G., Dong, Z., Wang, S., Li, Y., Lian, F., Liu, X., Li, H., Wei, X., & Cui, H. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac231 · Cited by 40 · see citing works
The SUMO pathway in pancreatic cancer: insights and inhibition
Schneeweis, C., Hassan, Z., Schick, M., Keller, U. B., & Schneider, G. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01119-6 · Cited by 36 · see citing works
Cell Lineage Infidelity in PDAC Progression and Therapy Resistance
Malinova, A., Veghini, L., Real, F. X., & Corbo, V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.795251 · Cited by 35 · see citing works
Self-citationROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma
Benitz, S., Steep, A., Nasser, M. M., Preall, J. B., Mahajan, U. M., McQuithey, H., Loveless, I. M., Davis, E. T., Wen, H.-J., Long, D. W., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0137 · Cited by 27 · see citing works
Milan, M., Diaferia, G. R., & Natoli, G. (2021) · The EMBO Journal · doi:10.15252/embj.2020107206 · Cited by 27 · see citing works
Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster
Miguel-Escalada, I., Maestro, M. Á., Balboa, D., Elek, A., Bernal, A., Bernardo, E., Grau, V., García-Hurtado, J., Sebé-Pedrós, A., & Ferrer, J. P. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.07.014 · Cited by 22 · see citing works
Self-citationEVI1 activates tumor-promoting transcriptional enhancers in pancreatic cancer
Kim, H.-R., Yim, J., Yoo, H.-B., Lee, S. E., Oh, S., Jung, S., Hwang, C., Shin, D., Kim, T. S., Yoo, K. H., et al. (2021) · NAR Cancer · doi:10.1093/narcan/zcab023 · Cited by 21 · see citing works
Chen, L., Xu, X.-Y., Zhong, X.-D., Liu, Y., Zhu, M.-H., Tao, F., Li, C.-Y., She, Q. S., Yang, G.-J., & Chen, J. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106409 · Cited by 21 · see citing works
Distinct Histone H3 Lysine 27 Modifications Dictate Different Outcomes of Gene Transcription
Konuma, T., & Zhou, M. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168376 · Cited by 23 · see citing works
Epigenetic control of pancreatic cancer metastasis
Krauß, L., Schneider, C., Heßmann, E., Saur, D., & Schneider, G. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10132-z · Cited by 20 · see citing works
The emerging roles of histone demethylases in cancers
Tong, D., Tang, Y., & Zhong, P. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10160-9 · Cited by 20 · see citing works
Tamagawa, H., Fujii, M., Togasaki, K., Seino, T., Kawasaki, S., Takano, A., Toshimitsu, K., Takahashi, S., Ohta, Y., Matano, M., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01498-5 · Cited by 20 · see citing works
Zhang, X., Du, Y., Behrens, A., & Lan, L. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.07.002 · Cited by 19 · see citing works
Gao, H., Cao, M., Deng, K., Yang, Y., Song, J., Ni, M., Xie, C., Fan, W., Ou, C., Huang, D., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.805451 · Cited by 19 · see citing works
Wang, Y., Liu, S., Wang, Y., Li, B., Liang, J., Chen, Y., Tang, B., Yu, S., & Wang, H. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02020-4 · Cited by 18 · see citing works
Bernardo, E., Vas, M. G. D., Balboa, D., Cuenca-Ardura, M., Bonàs‐Guarch, S., Planas-Fèlix, M., Mollandin, F., Torrens-Dinarès, M., Maestro, M. A., García-Hurtado, J., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.007 · Cited by 17 · see citing works
Self-citationRefining the Treatment of Pancreatic Cancer From Big Data to Improved Individual Survival
Bailey, P. J., Zhou, X., An, J., Peccerella, T., Hu, K., Springfeld, C., Büchler, M. W., & Neoptolemos, J. P. (2023) · Function · doi:10.1093/function/zqad011 · Cited by 17 · see citing works
Xu, Y. X., & Zhu, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054820 · Cited by 16 · see citing works
Hilmi, M., Delecourt, F., Raffenne, J., Bourega, T. A., Dusetti, N., Iovanna, J., Blum, Y., Richard, M., Neuzillet, C., Couvelard, A., et al. (2025) · The Journal of Pathology · doi:10.1002/path.6398 · Cited by 15 · see citing works
Guo, Q., Zhang, X., Shen, T., & Wang, X. (2021) · Life · doi:10.3390/life11080835 · Cited by 15 · see citing works
Loss of FGFR4 promotes the malignant phenotype of PDAC
D’Agosto, S. L., Pezzini, F., Veghini, L., Delfino, P., Fiorini, C., Tane, G. D. T., Curatolo, A. D., Vicentini, C., Ferrari, G., Pasini, D., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02432-5 · Cited by 15 · see citing works
Alarcón, T., Josep Sardanyés, A., Guillamon, A., & Menéndez, J. A. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008408 · Cited by 15 · see citing works
Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer
Ding, L.-Y., Hou, Y., Kuo, I., Hsu, T.-Y., Tsai, T.-C., Chang, H.-W., Hsu, W.-Y., Tsao, C.-C., Tian, C.-C., Wang, P., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00878-6 · Cited by 15 · see citing works
HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
Xia, R., Hu, C., Ye, Y., Zhang, X., Li, T., He, R., Zheng, S., Wen, X., & Chen, R. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5493 · Cited by 14 · see citing works
Current advances and future directions in targeting histone demethylases for cancer therapy
Shin, J.-H., Yoo, H.-B., & Roe, J. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100192 · Cited by 11 · see citing works
Wei, J., Alfajaro, M. M., Cai, W. L., Graziano, V. R., Strine, M. S., Filler, R. B., Biering, S. B., Sarnik, S. A., Patel, S., Menasché, B. L., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011351 · Cited by 11 · see citing works
Zhang, C., Liang, S., Zhang, H., Wang, R., & Qiao, H. (2023) · Oncology Reports · doi:10.3892/or.2023.8687 · Cited by 11 · see citing works
Chen, S., Zhong, M., Wang, X., Su, Y., Zhao, Y., Wang, S., Liu, S., Zhao, Y., Zhang, Y., Fan, X., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2509255122 · Cited by 10 · see citing works
Two rare cancers of the exocrine pancreas: to treat or not to treat like ductal adenocarcinoma?
Skorupan, N., Ghabra, S., Maldonado, J. A., Zhang, Y., & Alewine, C. (2023) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2022.106 · Cited by 10 · see citing works
Pancreas development and the Polycomb group protein complexes
Dumasia, N. P., & Pethe, P. S. (2020) · Mechanisms of Development · doi:10.1016/j.mod.2020.103647 · Cited by 10 · see citing works
Association of epigenetic landscapes with heterogeneity and plasticity in pancreatic cancer
Manoukian, P., Kuhnen, L. C., van Laarhoven, H. W. M., & Bijlsma, M. F. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104573 · Cited by 9 · see citing works
Circular RNAs in pancreatic cancer progression
Bao, H., Li, J., Dong, Q., Liang, Z., Yang, C., & Xu, Y. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117633 · Cited by 7 · see citing works
KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
Figuerola-Bou, E., Ríos-Astorch, C., Blanco, E., Sánchez-Jiménez, M., Táboas, P., Fernández, G., Gómez‐González, S., Muñoz, O., Castellano‐Escuder, P., Pérez‐Jaume, S., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3452 · Cited by 6 · see citing works
Jamali, M., Barar, E., & Shi, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105069 · Cited by 6 · see citing works
Bärthel, S., Schneider, G., & Saur, D. (2020) · The EMBO Journal · doi:10.15252/embj.2020104759 · Cited by 6 · see citing works
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions
Sun, S., Sun, Y., Lan, L., Luan, S., Zhou, J. R., Deng, J., Yuan, Y., & Wu, Z. (2025) · MedComm · doi:10.1002/mco2.70541 · Cited by 6 · see citing works
Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma
Crawford, K. J., Humphrey, K. S., Gomez, E. C., Wang, J., Kumarasamy, V. M., Wan, Y., Long, M. D., Feigin, M. E., Witkiewicz, A. K., Mann, K. M., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02408-5 · Cited by 4 · see citing works
Drivers of Pancreatic Cancer: Beyond the Big 4
Porcza, L. M., Ballesteros-Cillero, R., Lam, L. T., Maiello, C., & Leslie, N. R. (2025) · Cancers · doi:10.3390/cancers17142354 · Cited by 4 · see citing works
Transcription factor switching drives subtype-specific pancreatic cancer
Rao, S. V., Young, L., Cheeseman, D., Flynn, S. M., Krebs, N., Couturier, D., Mack, S., Brais, R. J., Temple, J., Smith, A. R., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02389-7 · Cited by 3 · see citing works
Epigenetic dysregulation and microenvironment remodeling in pancreatic cancer
Niu, N., Chen, M., & Xue, J. (2026) · Trends in cancer · doi:10.1016/j.trecan.2026.01.011 · Cited by 3 · see citing works
Parassiadis, C., & Johnsen, S. A. (2026) · Gastroenterology report · doi:10.1093/gastro/goag028 · Cited by 3 · see citing works
A narrative review on pathogenetic mechanisms of hyperinsulinemic hypoglycemia in Kabuki syndrome
Maines, E., Maiorana, A., Leonardi, L., Piccoli, G., Soffiati, M., & Franceschi, R. (2023) · Endocrine Regulations · doi:10.2478/enr-2023-0016 · Cited by 3 · see citing works
Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis
Goto, S., Deshpande, V., Yilmaz, Ö. H., & Goto, N. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.05.013 · Cited by 3 · see citing works
Feng, M., Chai, C., Hao, X., Lai, X., Luo, Y., Zhang, H., Tang, W., Gao, N., Pan, G., Liu, X., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03029-w · Cited by 2 · see citing works
Lysine-specific Demethylase 6A Upregulates Cadherin-1 and Accelerates Gastric Cancer Growth
Li, D., Zhang, S., Yan, Q., & Li, Y. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666230320100504 · Cited by 1 · see citing works
Yan, B., Fritsche, A., Haußner, E., Inamdar, T. V., Laumen, H., Boettcher, M., Gericke, M. T., Michl, P., & Rosendahl, J. (2025) · Cancers · doi:10.3390/cancers17101676 · Cited by 1 · see citing works
Zheng, G., Chen, H.-J., Guo, Z., Ma, L.-X., Zheng, A., Huang, T., Chen, W.-R., Tu, S., Li, Y.-X., & Shao, Z.-Y. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.11.026 · Cited by 1 · see citing works
Chen, L., Kang, Z., Härdfeldt, J., Li, Z., Pedrelli, M., Li, Q., Lyu, R., Allo, P. V., Sych, T., Zheng, X., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70846-w · Cited by 1 · see citing works
Regulatory elements in the Sox9 locus license the initiation of pancreatic ductal adenocarcinoma
Ballester, M., Kurilla, A., Dai, Y., Bergara-Muguruza, L., Radke, K., Maurer, H. C., Espinet, E., Høj, K., Marisch-Delgado, A., Seymour, P. A., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117176 · Cited by 2 · see citing works
A shifting adversary: control of pancreatic cancer transcriptomic subtypes
David, C. J. (2022) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2022.71 · Cited by 1 · see citing works
Taub, M. L. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.108992 · Cited by 1 · see citing works
HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway
Yang, G., Su, F., Han, B., Su, H.-X., Guo, C.-H., Yu, S., Guan, Q., & Hou, X. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116133 · Cited by 1 · see citing works
Data from HDAC2 Facilitates Pancreatic Cancer Metastasis
Krauß, L., Urban, B. C., Hastreiter, S., Schneider, C., Wenzel, P., Hassan, Z., Wirth, M., Lankes, K., Terrasi, A., Klement, C., et al. (2023) · doi:10.1158/0008-5472.c.6513666
Ballester, M., Kurilla, A., Dai, Y., Maurer, H. C., Espinet, E., Høj, K., Delgado, A. M., Seymour, P. A., Omar, S., Rift, C. V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.06.658264
Inner and Outer Determinants of Pancreatic Cancer Stem Cells
López-Gil, J. C., Navarro, D., & Sáinz, B. (2025) · Cancer Heterogeneity and Plasticity · doi:10.47248/2502020010
Inner and Outer Determinants of Pancreatic Cancer Stem Cells
López-Gil, J. C., Navarro, D., & Sáinz, B. (2025) · Cancer Heterogeneity and Plasticity · doi:10.47248/chp2502020010
Yuan, W., Sun, D., Wang, J., Yue, Y., & Li, X. (2025) · OncoTargets and Therapy · doi:10.2147/ott.s523599
Humphrey, K. S., Crawford, K. J., Muppavarapu, B., Mayberry, M. M., Morris, W., Torres, E., Long, M. D., Wang, J., Knudsen, E. S., Witkiewicz, A. K., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-10685-z
Chatterjee, S., Jaiswal, R., Roy, A., Chowdhury, S., Mukherjee, S., & Chowdhury, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.04.686665
Acosta-Montalvo, A. (2022) · theses.fr (ABES) · doi:10.70675/3712a689zf56fz4ce7z814bz28dc25f0cc70
Hoskins, J. W., Christensen, T. A., Eiser, D., Char, E., Mobaraki, M., O’Brien, A., Collins, I. J., Zhong, J., Patel, M. B., Prasad, G., et al. (2026) · medRxiv · doi:10.64898/2026.04.13.26350790
Twist1 overexpression models an aggressive subtype of pancreatic ductal adenocarcinoma in vivo
Khan, M. A., Chang, J., Song, Y., Shetty, A. C., Nguyen, T., Waters, D. N., Chowdhury, D. D., Simms, E. R., Chan, A., Tseng, H. W., et al. (2026) · Lab Animal · doi:10.1038/s41684-026-01729-2
Madriles, F., de Andrés, M. P., Chesnokov, M., de Villarreal, J. M., Alonso‐Curbelo, D., del Pozo, N., Iglesias, M., Pau, E. C. D. S., Iovanna, J., Soriano, F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.22.724502
Self-citation
- Authors
- Kalisz, M., Bernardo, E., Beucher, A., Maestro, M. A., del Pozo, N., Millán, I., Haeberle, L., Schlensog, M., Safi, S. A., Knoefel, W. T., Grau, V., de Vas, M., Shpargel, K. B., Vaquero, E., Magnuson, T., Ortega, S., Esposito, I., Real, F. X., & Ferrer, J.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Imperial College London (GB)
- Düsseldorf University Hospital (DE)
- University of North Carolina at Chapel Hill (US)
- Hospital Clínic de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- Corresponding author
- Ferrer, Jorge
- ORCID
- Venue
- The EMBO Journal
- Published
- 2020-03-10
- Volume
- 39
- Issue
- 9
- Pages
- e102808-e102808
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC7196917
- OpenAlex
- W3010741834
- Cited by
- 77
- References
- 94
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 8 · 2023: 16 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 1
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The EMBO Journal (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (WT101033)
- UK Research and Innovation|Medical Research Council (MR/L02036X/1)
- European Research Council Advanced Grant (789055)
- Ministerio de Economía y Competitividad (BFU2014-54284-R, RTI2018-095666-B-I00, SAF2011-29530, SAF2015-70553-R)
- MEC|Instituto de Salud Carlos III (RD12/0036/0034, RD12/0036/0050)
- Juvenile Diabetes Research Foundation United States of America (3-PDF-2014-192-A-N)
- Fundación Bancaja (LCF/BQ/ES18/11670009)
- CERCA Programme
- Generalitat de Catalunya
- Ministerio de Ciencia, Innovación y Universidades Ministry of Science, Innovation and Universities (SEV-2012-0208, SEV-2016-0510)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- HNF1A, KDM6A, pancreatic ductal adenocarcinoma, pancreatic acinar cells, KRAS G12D, enhancer landscape, epigenetic regulation, epithelial-mesenchymal transition, sarcomatoid differentiation, tumor suppressor, transcriptional regulation
- MeSH terms
- Animals, Humans, Mutation, Organ Specificity, Pancreas, Pancreatic Neoplasms, Gene Expression Regulation, Neoplastic, Carcinoma, Pancreatic Ductal, Epigenesis, Genetic, Mice, Hepatocyte Nuclear Factor 1-alpha, Gene Regulatory Networks, Histone Demethylases, Acinar Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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