Brosh, Robert M.

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

Wu, Y., Shin-ya, K., & Brosh, R. M. (2008) · Molecular and Cellular Biology

DNA and Nucleic Acid ChemistryDNA Repair Mechanisms

Cited by 428

The FANCJ/MutLα interaction is required for correction of the cross‐link response in FA‐J cells

Peng, M., Litman, R., Xie, J., Sharma, S., Brosh, R. M., & Cantor, S. B. (2007) · The EMBO Journal

DNA Repair MechanismsGenetic factors in colorectal cancer

Cited by 181

Analysis of the DNA Substrate Specificity of the Human BACH1 HelicaseAssociated with BreastCancer

Gupta, R., Sharma, S., Sommers, J. A., Jin, Z., Cantor, S. B., & Brosh, R. M. (2005) · Journal of Biological Chemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 131

FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange

Sommers, J. A., Rawtani, N., Gupta, R., Bugreev, D. V., Mazin, A. V., Cantor, S. B., & Brosh, R. M. (2009) · Journal of Biological Chemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 112

Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes

Wu, Y., Sommers, J. A., Suhasini, A. N., Leonard, T., Deakyne, J. S., Mazin, A. V., Shin-ya, K., Kitao, H., & Brosh, R. M. (2010) · Blood

DNA Repair MechanismsBlood disorders and treatments

Cited by 72

G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets

Estep, K. N., Butler, T. J., Ding, J., & Brosh, R. M. (2019) · Current Medicinal Chemistry

DNA and Nucleic Acid ChemistryDNA Repair Mechanisms

Cited by 58

Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand

Gupta, R., Sharma, S., Doherty, K. M., Sommers, J. A., Cantor, S. B., & Brosh, R. M. (2006) · Nucleic Acids Research

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 41