FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange

Avidin

Green, N. M. (1975) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60411-8 · Cited by 1,472 · see citing works

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

The Breast Cancer Susceptibility Collaboration (UK), Seal, S., Thompson, D., Renwick, A., Elliott, A., Kelly, P., Barfoot, R., Chagtai, T., Jayatilake, H., Ahmed, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1902 · Cited by 746 · see citing works

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674 · see citing works

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

Wang, W. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2159 · Cited by 663 · see citing works

DNA helicase Srs2 disrupts the Rad51 presynaptic filament

Krejčí, L., Komen, S. V., Li, Y., Villemain, J. L., Reddy, M. S., Klein, H. L., Ellenberger, T. E., & Sung, P. (2003) · Nature · doi:10.1038/nature01577 · Cited by 624 · see citing works

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments

Veaute, X., Jeusset, J., Soustelle, C., Kowalczykowski, S. C., Cam, É. L., & Fabre, F. (2003) · Nature · doi:10.1038/nature01585 · Cited by 612 · see citing works

Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation.

Hendrickson, W. A., Pähler, A., Smith, J. L., Satow, Y., Merritt, E. A., & Phizackerley, R. P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2190 · Cited by 585 · see citing works

The Fanconi Anemia/BRCA pathway: new faces in the crowdPreprint

Kennedy, R. D., & D’Andrea, A. D. (2005) · Genes & Development · doi:10.1101/gad.1370505 · Cited by 464 · see citing works

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

Meetei, A. R., Medhurst, A. L., Ling, C., Xue, Y., Singh, T. R., Bier, P., Steltenpool, J., Stone, S., Dokal, I. S., Mathew, C. G., et al. (2005) · Nature Genetics · doi:10.1038/ng1626 · Cited by 454 · see citing works

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, B. C., Vries, Y. D., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., et al. (2005) · Nature Genetics · doi:10.1038/ng1625 · Cited by 432 · see citing works

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

Wu, Y., Shin-ya, K., & Brosh, R. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02210-07 · Cited by 428 · see citing works

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396 · see citing works

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

Levran, O., Attwooll, C., Henry, R. T., Milton, K. L., Neveling, K., Rio, P., Batish, S. D., Kalb, R., Velleuer, E., Barral, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1624 · Cited by 370 · see citing works

Chromatin remodeling by ATP‐dependent molecular machines

Lusser, A., & Kadonaga, J. T. (2003) · BioEssays · doi:10.1002/bies.10359 · Cited by 351 · see citing works

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filamentsPreprint

Hu, Y., Raynard, S. J., Sehorn, M. G., Lu, X., Bussen, W., Zheng, L., Stark, J. M., Barnes, E. L., Chi, P., Janščák, P., et al. (2007) · Genes & Development · doi:10.1101/gad.1609107 · Cited by 322 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes & Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works

Inhibitory Effects of Expanded GAA·TTC Triplet Repeats from Intron I of the Friedreich Ataxia Gene on Transcription and Replicationin Vivo

Ohshima, K., Montermini, L., Wells, R. D., & Pandolfo, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14588 · Cited by 302 · see citing works

Novel pro- and anti-recombination activities of the Bloom’s syndrome helicasePreprint

Bugreev, D. V., Yu, X., Egelman, E. H., & Mazin, A. V. (2007) · Genes & Development · doi:10.1101/gad.1609007 · Cited by 297 · see citing works

Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA

Cheung, I. K., Schertzer, M. J., Rose, A. M., & Lansdorp, P. M. (2002) · Nature Genetics · doi:10.1038/ng928 · Cited by 270 · see citing works

UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli

Veaute, X., Delmas, S., Selva, M., Jeusset, J., Cam, É. L., Matić, I., Fabre, F., & Petit, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600485 · Cited by 263 · see citing works

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

Sharma, S., Doherty, K. M., & Brosh, R. M. (2006) · Biochemical Journal · doi:10.1042/bj20060450 · Cited by 245 · see citing works

Ca 2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity

Bugreev, D. V., & Mazin, A. V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402105101 · Cited by 245 · see citing works

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S., & Livingston, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308717101 · Cited by 240 · see citing works

The yeast Pif1p helicase removes telomerase from telomeric DNA

Boulé, J.-B., Vega, L. R., & Zakian, V. A. (2005) · Nature · doi:10.1038/nature04091 · Cited by 229 · see citing works

Replication Stalling at Friedreich's Ataxia (GAA)n Repeats In Vivo

Krasilnikova, M. M., & Mirkin, S. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2286-2295.2004 · Cited by 207 · see citing works

Human premature aging, DNA repair and RecQ helicases

Brosh, R. M., & Bohr, V. A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1008 · Cited by 203 · see citing works

Naturally occurring H-DNA-forming sequences are mutagenic in mammalian cells.

Wang, G., & Vasquez, K. M. (2004) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0405116101 · Cited by 191 · see citing works

The FANCJ/MutLα interaction is required for correction of the cross‐link response in FA‐J cells

Peng, M., Litman, R., Xie, J., Sharma, S., Brosh, R. M., & Cantor, S. B. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601754 · Cited by 181 · see citing works

Rad54p Is a Chromatin Remodeling Enzyme Required for Heteroduplex DNA Joint Formation with Chromatin

Jaskelioff, M., Komen, S. V., Krebs, J. E., Sung, P., & Peterson, C. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211545200 · Cited by 180 · see citing works

GAA Instability in Friedreich's Ataxia Shares a Common, DNA-Directed and Intraallelic Mechanism with Other Trinucleotide Diseases

Gacy, A. M., Goellner, G. M., Spiro, C., Chen, X., Gupta, G., Bradbury, E. M., Dyer, R. B., Mikesell, M. J., Yao, J. Z., Johnson, A. J., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80058-1 · Cited by 170 · see citing works

Visualization of Rad54, a Chromatin Remodeling Protein, Translocating on Single DNA Molecules

Amitani, I., Baskin, R. J., & Kowalczykowski, S. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.009 · Cited by 159 · see citing works

Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1*[boxs]

Sharma, S., Sommers, J. A., Choudhary, S., Faulkner, J. K., Cui, S., Andreoli, L., Muzzolini, L., Vindigni, A., & Brosh, R. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500264200 · Cited by 156 · see citing works

A fork‐clearing role for UvrD

Flores, M. J., Sanchez, N., & Michel, B. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04753.x · Cited by 152 · see citing works

Analysis of the DNA Substrate Specificity of the Human BACH1 HelicaseAssociated with BreastCancer

Gupta, R., Sharma, S., Sommers, J. A., Jin, Z., Cantor, S. B., & Brosh, R. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501995200 · Cited by 131 · see citing works

The 3′-tail of a forked-duplex sterically determines whether one or two DNA strands pass through the central channel of a replication-fork helicase

Kaplan, D. L. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3965 · Cited by 129 · see citing works

Biochemical Characterization of the DNA Substrate Specificity of Werner Syndrome Helicase

Brosh, R. M., Waheed, J., & Sommers, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111446200 · Cited by 128 · see citing works

WRN Helicase and FEN-1 Form a Complex upon Replication Arrest and Together Process Branchmigrating DNA Structures Associated with the Replication Fork

Sharma, S., Otterlei, M., Sommers, J. A., Driscoll, H. C., Dianov, G. L., Kao, H.-I., Bambara, R. A., & Brosh, R. M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-08-0567 · Cited by 128 · see citing works

Protein displacement by an assembly of helicase molecules aligned along single-stranded DNA

Byrd, A. K., & Raney, K. D. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb774 · Cited by 126 · see citing works

Properties of the T4 bacteriophage DNA replication apparatus: The T4 dda DNA helicase is required to pass a bound RNA polymerase molecule

Bedinger, P. A., Hochstrasser, M., Jongeneel, C. V., & Alberts, B. (1983) · Cell · doi:10.1016/0092-8674(83)90141-1 · Cited by 122 · see citing works

Unwinding of a DNA Triple Helix by the Werner and Bloom Syndrome Helicases

Brosh, R. M., Majumdar, A., Desai, S., Hickson, I. D., Bohr, V. A., & Seidman, M. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006784200 · Cited by 120 · see citing works

A Hexameric Helicase Encircles One DNA Strand and Excludes the Other during DNA Unwinding

Hacker, K. J., & Johnson, K. A. (1997) · Biochemistry · doi:10.1021/bi971644v · Cited by 116 · see citing works

FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein

Gupta, R., Sharma, S., Sommers, J. A., Kenny, M. K., Cantor, S. B., & Brosh, R. M. (2007) · Blood · doi:10.1182/blood-2006-11-057273 · Cited by 113 · see citing works

Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase

Kumaraswamy, E., & Shiekhattar, R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00961-07 · Cited by 110 · see citing works

DNA unwinding and protein displacement by superfamily 1 and superfamily 2 helicases

Mackintosh, S. G., & Raney, K. D. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl501 · Cited by 67 · see citing works

Triplex DNA and human disease

Bissler, J. J. (2007) · Frontiers in bioscience · doi:10.2741/2408 · Cited by 58 · see citing works

Displacement of a DNA binding protein by Dda helicase

Byrd, A. K. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl369 · Cited by 55 · see citing works

Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand

Gupta, R., Sharma, S., Doherty, K. M., Sommers, J. A., Cantor, S. B., & Brosh, R. M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl964 · Cited by 41 · see citing works

Helicase-catalysed translocation and strand separation

Eoff, R. L., & Raney, K. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051474 · Cited by 25 · see citing works

Repair Pathway Choices and Consequences at the Double-Strand Break

Ceccaldi, R., Rondinelli, B., & D’Andrea, A. D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.009 · Cited by 1,499 · see citing works

Regulation of Homologous Recombination in Eukaryotes

Heyer, W.-D., Ehmsen, K. T., & Liu, J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-051710-150955 · Cited by 1,066 · see citing works

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 923 · see citing works

Homologous recombination and its regulation

Krejčí, L., Altmannová, V., Spirek, M., & Zhao, X. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks270 · Cited by 642 · see citing works

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayPreprint

Kim, H., & D’Andrea, A. D. (2012) · Genes & Development · doi:10.1101/gad.195248.112 · Cited by 510 · see citing works

An Overview of the Molecular Mechanisms of Recombinational DNA RepairPreprint

Kowalczykowski, S. C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016410 · Cited by 475 · see citing works

Expanded roles of the Fanconi anemia pathway in preserving genomic stabilityPreprint

Kee, Y., & D’Andrea, A. D. (2010) · Genes & Development · doi:10.1101/gad.1955310 · Cited by 309 · see citing works

Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

Liu, J., Renault, L. L. R., Veaute, X., Fabre, F., Stahlberg, H., & Heyer, W. (2011) · Nature · doi:10.1038/nature10522 · Cited by 203 · see citing works

Regulation of DNA Pairing in Homologous RecombinationPreprint

Daley, J. M., Gaines, W. A., Kwon, Y., & Sung, P. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017954 · Cited by 173 · see citing works

DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster

Wu, Y., & Brosh, R. M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks039 · Cited by 142 · see citing works

RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination

Uringa, E.-J., Youds, J. L., Lisaingo, K., Lansdorp, P. M., & Boulton, S. J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1045 · Cited by 124 · see citing works

Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1

Cantor, S. B., & Guillemette, S. (2011) · Future Oncology · doi:10.2217/fon.10.191 · Cited by 106 · see citing works

Biochemical Characterization of Warsaw Breakage Syndrome Helicase*

Wu, Y.-L., Sommers, J. A., Khan, I., de Winter, J., & Brosh, R. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276022 · Cited by 110 · see citing works

Human DHX9 Helicase Unwinds Triple-Helical DNA Structures

Jain, A., Bacolla, A., Chakraborty, P., Große, F., & Vásquez, K. M. (2010) · Biochemistry · doi:10.1021/bi100795m · Cited by 103 · see citing works

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

Suhasini, A. N., Rawtani, N., Wu, Y., Sommers, J. A., Sharma, S., Mosedale, G., North, P. S., Cantor, S. B., Hickson, I. D., & Brosh, R. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.362 · Cited by 102 · see citing works

Iron–sulfur cluster biosynthesis and trafficking – impact on human disease conditions

Wachnowsky, C., Fidai, I., & Cowan, J. A. (2017) · Metallomics · doi:10.1039/c7mt00180k · Cited by 96 · see citing works

Regulation of Recombination and Genomic MaintenancePreprint

Heyer, W. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016501 · Cited by 94 · see citing works

DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells

Jain, A., Bacolla, A., del Mundo, I. M., Zhao, J., Wang, G., & Vasquez, K. M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt804 · Cited by 77 · see citing works

Triplex technology in studies of DNA damage, DNA repair, and mutagenesis

Mukherjee, A., & Vásquez, K. M. (2011) · Biochimie · doi:10.1016/j.biochi.2011.04.001 · Cited by 81 · see citing works

Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia

Brosh, R. M., & Cantor, S. B. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00372 · Cited by 77 · see citing works

Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes

Wu, Y., Sommers, J. A., Suhasini, A. N., Leonard, T., Deakyne, J. S., Mazin, A. V., Shin-ya, K., Kitao, H., & Brosh, R. M. (2010) · Blood · doi:10.1182/blood-2009-11-256016 · Cited by 72 · see citing works

DNA replication stress: from molecular mechanisms to human disease

Muñoz, S., & Méndez, J. (2016) · Chromosoma · doi:10.1007/s00412-016-0573-x · Cited by 65 · see citing works

The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway

Rudolf, J., Rouillon, C., Schwarz‐Linek, U., & White, M. F. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1058 · Cited by 64 · see citing works

BRCA Gene Structure and Function in Tumor Suppression

Murphy, C. G., & Moynahan, M. E. (2010) · The Cancer Journal · doi:10.1097/ppo.0b013e3181cf0204 · Cited by 62 · see citing works

Disease-causing missense mutations in human DNA helicase disorders

Suhasini, A. N., & Brosh, R. M. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.12.004 · Cited by 62 · see citing works

Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome

Bharti, S. K., Khan, I., Banerjee, T., Sommers, J. A., Wu, Y., & Brosh, R. M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1569-4 · Cited by 61 · see citing works

Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer

Moyer, C. L., Ivanovich, J. L., Gillespie, J. L., Doberstein, R., Radke, M. R., Richardson, M. E., Kaufmann, S. H., Swisher, E. M., & Goodfellow, P. J. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1991 · Cited by 61 · see citing works

Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass

Xie, J., Litman, R., Wang, S., Peng, M., Guillemette, S., Rooney, T., & Cantor, S. B. (2010) · Oncogene · doi:10.1038/onc.2010.18 · Cited by 60 · see citing works

Presynaptic filament dynamics in homologous recombination and DNA repair

Liu, J., Ehmsen, K. T., Heyer, W., & Morrical, S. W. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.576007 · Cited by 59 · see citing works

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathwayPreprint

MATSUZAKI, K., Borel, V., Adelman, C. A., Schindler, D., & Boulton, S. J. (2015) · Genes & Development · doi:10.1101/gad.272740.115 · Cited by 58 · see citing works

A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase

Guo, M., Hundseth, K., Ding, H., Vidhyasagar, V., Inoue, A., Nguyen, C.-H., Zain, R., Lee, J. S., & Wu, Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.634923 · Cited by 53 · see citing works

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

Li, Q., Saito, T. T., Deshong, A. J., Martínez García, M., Nadarajan, S., Lawrence, K. S., Checchi, P. M., Colaiácovo, M. P., & Engebrecht, J. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007701 · Cited by 48 · see citing works

Homologous Recombination Subpathways: A Tangle to Resolve

Elbakry, A., & Löbrich, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.723847 · Cited by 52 · see citing works

Visualizing RAD51-mediated joint molecules: implications for recombination mechanism and the effect of sequence heterology

Ristić, D., Kanaar, R., & Wyman, C. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq766 · Cited by 48 · see citing works

FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response

Xie, J., Peng, M., Guillemette, S., Quan, S., Maniatis, S., Wu, Y., Venkatesh, A., Shaffer, S. A., Brosh, R. M., & Cantor, S. B. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002786 · Cited by 43 · see citing works

Fanconi anemia: at the Crossroads of DNA repair

Deakyne, J. S., & Mazin, A. V. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911010068 · Cited by 40 · see citing works

Distinct roles of RECQ1 in the maintenance of genomic stability

Wu, Y., & Brosh, R. M. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.010 · Cited by 41 · see citing works

DNA helicases and their roles in cancer

Dhar, S., Datta, A., & Brosh, R. M. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102994 · Cited by 40 · see citing works

Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases

Sharma, S. (2011) · Journal of Nucleic Acids · doi:10.4061/2011/724215 · Cited by 41 · see citing works

FANCJ: Solving problems in DNA replication

Hiom, K. J. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.005 · Cited by 40 · see citing works

The Q Motif of Fanconi Anemia Group J Protein (FANCJ) DNA Helicase Regulates Its Dimerization, DNA Binding, and DNA Repair Function

Wu, Y., Sommers, J. A., Loiland, J., Kitao, H., Kuper, J., Kisker, C., & Brosh, R. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.351338 · Cited by 38 · see citing works

Unwinding of synthetic replication and recombination substrates by Srs2

Marini, V., & Krejčí, L. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.05.007 · Cited by 37 · see citing works

Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase

Masuda-Ozawa, T., Hoang, T. T., Seo, Y., Chen, L., & Spies, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt056 · Cited by 37 · see citing works

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1

Dohrn, L., Salles, D. C., Siehler, S. Y., Kaufmann, J., & Wiesmüller, L. (2011) · Biochemical Journal · doi:10.1042/bj20110314 · Cited by 37 · see citing works

FANCJ is essential to maintain microsatellite structure genome-wide during replication stress

Barthelemy, J., Hanenberg, H., & Leffak, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw433 · Cited by 37 · see citing works

Creation and resolution of non-B-DNA structural impediments during replication

Mellor, C., Perez, C., & Sale, J. E. (2022) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2022.2121803 · Cited by 37 · see citing works

The Regulation of Homologous Recombination by Helicases

Huselid, E., & Bunting, S. F. (2020) · Genes · doi:10.3390/genes11050498 · Cited by 35 · see citing works

Novel Function of the Fanconi Anemia Group J or RECQ1 Helicase to Disrupt Protein-DNA Complexes in a Replication Protein A-stimulated Manner

Sommers, J. A., Banerjee, T., Hinds, T., Wan, B., Wold, M. S., Lei, M., & Brosh, R. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.542456 · Cited by 34 · see citing works

FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination

Ito, M., Furukohri, A., Matsuzaki, K., Fujita, Y., Toyoda, A., & Shinohara, A. (2023) · Nature Communications · doi:10.1038/s41467-023-42576-w · Cited by 31 · see citing works

Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11

Pisani, F. M., Napolitano, E., Napolitano, L. M. R., & Onesti, S. (2018) · Genes · doi:10.3390/genes9110564 · Cited by 32 · see citing works

Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

Zinovyev, A. Y., Kuperstein, I., Barillot, E., & Heyer, W. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003016 · Cited by 32 · see citing works

Helicase-inactivating mutations as a basis for dominant negative phenotypes

Wu, Y., & Brosh, R. M. (2010) · Cell Cycle · doi:10.4161/cc.9.20.13667 · Cited by 32 · see citing works

Two steps forward, one step back: Determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers

Spies, M. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.01.013 · Cited by 30 · see citing works

An Arabidopsis FANCJ helicase homologue is required for DNA crosslink repair and rDNA repeat stability

Dorn, A., Feller, L., Castri, D., Röhrig, S., Enderle, J., Herrmann, N. J., Block-Schmidt, A. S., Trapp, O., Köhler, L., & Puchta, H. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008174 · Cited by 30 · see citing works

Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair

Cantor, S. B., & Xie, J. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20568 · Cited by 29 · see citing works

RecQ and Fe–S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions

Estep, K. N., & Brosh, R. M. (2017) · Biochemical Society Transactions · doi:10.1042/bst20170044 · Cited by 29 · see citing works

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Bharti, S. K., Sommers, J. A., Awate, S., Bellani, M. A., Khan, I., Bradley, L. M., King, G. A., Seol, Y., Vidhyasagar, V., Wu, Y., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky403 · Cited by 27 · see citing works

FANCJ is essential to maintain microsatellite structure genome-wide during replication stress

Barthelemy, J., Hanenberg, H., & Leffak, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1091 · Cited by 27 · see citing works

Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability

Andriuskevicius, T., Kotenko, O., & Makovets, S. (2018) · Cell Stress · doi:10.15698/cst2018.05.134 · Cited by 23 · see citing works

The Fanconi Anemia Proteins FANCD2 and FANCJ Interact and Regulate Each Other's Chromatin Localization

Chen, X., Wilson, J. B., McChesney, P. A., Williams, S. A., Kwon, Y., Longerich, S., Marriott, A. S., Sung, P., Jones, N. J., & Kupfer, G. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.552570 · Cited by 23 · see citing works

PROBING GENOME MAINTENANCE FUNCTIONS OF HUMAN RECQ1

Sami, F., & Sharma, S. (2013) · Computational and Structural Biotechnology Journal · doi:10.5936/csbj.201303014 · Cited by 22 · see citing works

The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer

Mahtab, M., Boavida, A., Santos, D., & Pisani, F. M. (2021) · Genes · doi:10.3390/genes12030395 · Cited by 20 · see citing works

Histone Deacetylase Inhibitors Selectively Target Homology Dependent DNA Repair Defective Cells and Elevate Non-Homologous Endjoining Activity

Smith, S. N., Fox, J. T., Mejia, M., Ruangpradit, W., Saberi, A., Kim, S., Choi, Y., Oh, S., Wang, Y., Choi, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087203 · Cited by 20 · see citing works

FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

Kitao, H., Nanda, I., Sugino, R. P., Kinomura, A., Yamazoe, M., Arakawa, H., Schmid, M., Innan, H., Hiom, K. J., & Takata, M. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01523.x · Cited by 20 · see citing works

Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability

Sommers, J. A., Suhasini, A. N., & Brosh, R. M. (2015) · Biomolecules · doi:10.3390/biom5020590 · Cited by 18 · see citing works

FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation

Clark, D. W., Tripathi, K. K., Dorsman, J. C., & Palle, K. (2015) · Oncotarget · doi:10.18632/oncotarget.5006 · Cited by 17 · see citing works

FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids

Nath, S., Somyajit, K., Mishra, A., Scully, R., & Nagaraju, G. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx586 · Cited by 17 · see citing works

The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice

Horan, T. S. A., Ascenção, C. F. R., Mellor, C., Wang, M., Smolka, M. B., & Cohen, P. E. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011175 · Cited by 16 · see citing works

The N-Terminal Domain of Human DNA Helicase Rtel1 Contains a Redox Active Iron-Sulfur Cluster

Landry, A. P., & Ding, H. (2014) · BioMed Research International · doi:10.1155/2014/285791 · Cited by 15 · see citing works

Spotlight on Warsaw Breakage Syndrome

Pisani, F. M. (2019) · The Application of Clinical Genetics · doi:10.2147/tacg.s186476 · Cited by 16 · see citing works

A Novel Role for BRIP1/FANCJ in Neuronal Cells Health and in Resolving Oxidative Stress-Induced DNA Lesions

Mani, C., Acharya, G., Kshirsagar, S., Vijayan, M., Khan, H. M. R., Reddy, P. H., & Palle, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215305 · Cited by 16 · see citing works

HP1 regulates the localization of FANCJ at sites of DNA double‐strand breaks

Wu, W., Togashi, Y., Johmura, Y., Miyoshi, Y., Nobuoka, S., Nakanishi, M., & Ohta, T. (2016) · Cancer Science · doi:10.1111/cas.13008 · Cited by 16 · see citing works

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart

Zhang, Q., Fan, J., Xu, W., Cao, H., Qiu, C., Xiong, Y., Zhao, H., Wang, Y., Huang, J., & Yu, C. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad596 · Cited by 13 · see citing works

Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations

Guo, M., Vidhyasagar, V., Ding, H., & Wu, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.538892 · Cited by 15 · see citing works

The role of the Fanconi anemia network in the response to DNA replication stress

Gari, K., & Constantinou, A. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903154150 · Cited by 14 · see citing works

FANCJ at the FORK

Cantor, S. B., & Nayak, S. U. (2016) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2016.02.003 · Cited by 13 · see citing works

Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways

Olson, H., Davis, L., Kiianitsa, K., Khoo, K. J., Liu, Y., Knijnenburg, T., & Maizels, N. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky727 · Cited by 13 · see citing works

Close encounters for the first time: Helicase interactions with DNA damage

Khan, I., Sommers, J. A., & Brosh, R. M. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.06.003 · Cited by 12 · see citing works

Concise Review: Getting to the Core of Inherited Bone Marrow Failures

Adam, S. S., Melguizo‐Sanchis, D., El‐Kamah, G. Y., Samarasinghe, S., Alharthi, S., Armstrong, L., & Lako, M. (2016) · Stem Cells · doi:10.1002/stem.2543 · Cited by 12 · see citing works

BLM’s balancing act and the involvement of FANCJ in DNA repair

Dhar, S., & Brosh, R. M. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1520567 · Cited by 12 · see citing works

DNA substrate recognition and processing by the full-length human UPF1 helicase

Dehghani-Tafti, S., & Sanders, C. M. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx478 · Cited by 12 · see citing works

Homologous recombination defects and how they affect replication fork maintenance

Son, M. Y., & Hasty, P. (2018) · Global Medical Genetics · doi:10.3934/genet.2018.4.192 · Cited by 12 · see citing works

Delineating the mechanism of fragility at BCL6 breakpoint region associated with translocations in diffuse large B cell lymphoma

Gopalakrishnan, V., Roy, U., Srivastava, S., Kariya, K. M., Sharma, S., Javedakar, S. M., Choudhary, B., & Raghavan, S. C. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05042-w · Cited by 11 · see citing works

Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology

Santos, D., Mahtab, M., Boavida, A., & Pisani, F. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052308 · Cited by 11 · see citing works

Guardians of the Genome: Iron–Sulfur Proteins in the Nucleus

Novoa‐Aponte, L., León-Torres, A., & Philpott, C. C. (2024) · Inorganics · doi:10.3390/inorganics12120316 · Cited by 9 · see citing works

Three- and four-stranded nucleic acid structures and their ligands

Hashimoto, Y., Shil, S., Tsuruta, M., Kawauchi, K., & Miyoshi, D. (2025) · RSC Chemical Biology · doi:10.1039/d4cb00287c · Cited by 9 · see citing works

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments

Kuthethur, R., Safa Nasrin, V. Z., Sengodan, S. K., Fonseca, C., Braunshier, S., Nagar, N., Acharya, A., Wang, X., Theil, A. F., Ibini, O., et al. (2025) · Science · doi:10.1126/science.adt1210 · Cited by 9 · see citing works

FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

Awate, S., Sommers, J. A., Datta, A., Nayak, S. U., Bellani, M. A., Yang, O., Dunn, C., Nicolae, C. M., Moldovan, G., Seidman, M. M., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa660 · Cited by 9 · see citing works

How DNA secondary structures drive replication fork instability

Sethi, A., Fernández-Casañas, M., Delpino, B., & Coster, G. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103913 · Cited by 7 · see citing works

Inhibitors of the Fanconi anaemia pathway as potential antitumour agents for ovarian cancer

Taylor, S. J., Arends, M. J., & Langdon, S. P. (2020) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2020.00003 · Cited by 8 · see citing works

Molecular analyses of DNA helicases involved in the replicational stress response

Wu, Y., Sommers, J. A., Suhasini, A. N., Aggarwal, M., & Brosh, R. M. (2010) · Methods · doi:10.1016/j.ymeth.2010.02.021 · Cited by 7 · see citing works

RTEL1 is required for silencing and epigenome stability

Olivier, M., Hesketh, A., Pouch-Pélissier, M.-N., Pélissier, T., Huang, Y., Latrasse, D., Benhamed, M., & Mathieu, O. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad610 · Cited by 6 · see citing works

The Inability to Disassemble Rad51 Nucleoprotein Filaments Leads to Aberrant Mitosis and Cell Death

Andriuskevicius, T., Dubenko, A., & Makovets, S. (2023) · Biomedicines · doi:10.3390/biomedicines11051450 · Cited by 3 · see citing works

Tissue-Specific Effects of the DNA Helicase FANCJ/BRIP1/BACH1 on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders

Jimenez, D. A., Walker, A. K., Usdin, K., & Zhao, X.-N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062655 · Cited by 2 · see citing works

Reconstituting the Key Steps of the DNA Double-Strand Break Repair In Vitro

Rossi, M. J., Bugreev, D. V., Mazina, O. M., & Mazin, A. V. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-129-1_23 · Cited by 2 · see citing works

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filamentsPreprint

Kuthethur, R., Acharya, A., Sengodan, S. K., Fonseca, C., Nagar, N., Safa Nasrin, V. Z., Ibini, O., Manolika, E. M., de Koning, K., Braunshier, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.03.621741 · Cited by 2 · see citing works

Regulation of BACH1/FANCJ Function in DNA Damage Repair: A Dissertation

Xie, J. (2009) · eScholarship@UMassChan · doi:10.13028/95cm-wn54 · Cited by 1 · see citing works

Eukaryote DNA Replication and Recombination: an Intimate Association

Ramsay, J., Al-Zeer, K., & Jacob, Z. (2011) · InTech eBooks · doi:10.5772/19995 · Cited by 1 · see citing works

Purification and biochemical characterization of the G4 resolvase and DNA helicase FANCJ

Kulikowicz, T., Sommers, J. A., Fuchs, K. F., Wu, Y., & Brosh, R. M. (2024) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2023.12.006 · Cited by 1 · see citing works

Mammalian Resilience Revealed by a Comparison of Human Diseases and Mouse Models Associated With DNA Helicase Deficiencies

Kohzaki, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.934042 · Cited by 1 · see citing works

The role of helicases and helicase-like proteins in homologous recombination

Deakyne, J. S., & Mazin, A. V. (2013) · doi:10.17918/00000647

FANCJ Helicase Operates in the Fanconi Anemia DNA Repair Pathway and the Response to Replicational Stress

Wu, Y., & Brosh, R. M. (2009) · Current Molecular Medicine · doi:10.2174/156652409788167159 · Cited by 35 · see citing works

Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia

Brosh, R. M., & Cantor, S. B. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00372 · Cited by 77 · see citing works

FANCJ Helicase Uniquely Senses Oxidative Base Damage in Either Strand of Duplex DNA and Is Stimulated by Replication Protein A to Unwind the Damaged DNA Substrate in a Strand-specific Manner

Suhasini, A. N., Sommers, J. A., Mason, A. C., Voloshin, O. N., Camerini‐Otero, R. D., Wold, M. S., & Brosh, R. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.012229 · Cited by 53 · see citing works

Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations

Guo, M., Vidhyasagar, V., Ding, H., & Wu, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.538892 · Cited by 15 · see citing works