The DOI matches its Crossref record, with a small difference in title or year; 138 of the 138 references it cites were found in a registry or an index.
G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets
Open accessAbstract
Background: Guanine-rich DNA can fold into highly stable four-stranded DNA structures called G-quadruplexes (G4). In recent years, the G-quadruplex field has blossomed as new evidence strongly suggests that such alternately folded DNA structures are likely to exist in vivo. G4 DNA presents obstacles for the replication machinery, and both eukaryotic DNA helicases and polymerases have evolved to resolve and copy G4 DNA in vivo. In addition, G4-forming sequences are prevalent in gene promoters, suggesting that G4-resolving helicases act to modulate transcription. Methods: We have searched the PubMed database to compile an up-to-date and comprehensive assessment of the field’s current knowledge to provide an overview of the molecular interactions of Gquadruplexes with DNA helicases and polymerases implicated in their resolution. Results: Novel computational tools and alternative strategies have emerged to detect G4-forming sequences and assess their biological consequences. Specialized DNA helicases and polymerases catalytically act upon G4-forming sequences to maintain normal replication and genomic stability as well as appropriate gene regulation and cellular homeostasis. G4 helicases also resolve telomeric repeats to maintain chromosomal DNA ends. Bypass of many G4-forming sequences is achieved by the action of translesion DNS polymerases or the PrimPol DNA polymerase. While the collective work has supported a role of G4 in nuclear DNA metabolism, an emerging field centers on G4 abundance in the mitochondrial genome. Conclusion: Discovery of small molecules that specifically bind and modulate DNA helicases and polymerases or interact with the G4 DNA structure itself may be useful for the development of anticancer regimes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Error-prone polymerases might be engaged at slowed or stalled replication forks to ensure complete G4 replication, as specialized polymerases like eta, kappa, and Rev1 are essential for G4 stability, further increasing the density of localized genomic damages.
“Error-prone polymerases might be engaged at slowed or stalled replication forks to ensure complete G4 replication, as specialized polymerases like eta, kappa, and Rev1 are essential for G4 stability – further increasing the density of localized genomic damages (26,78–80).”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [80]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
Siddiqui-Jain, A., Grand, C. L., Bearss, D. J., & Hurley, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182256799 · Cited by 2,274
Quantitative visualization of DNA G-quadruplex structures in human cells
Biffi, G., Tannahill, D., McCafferty, J., & Balasubramanian, S. (2013) · Nature Chemistry · doi:10.1038/nchem.1548 · Cited by 2,173
Sen, D., & Gilbert, W. (1988) · Nature · doi:10.1038/334364a0 · Cited by 1,866
Prevalence of quadruplexes in the human genome
Huppert, J. L., & Balasubramanian, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki609 · Cited by 1,795
DNA secondary structures: stability and function of G-quadruplex structures
Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,485
Helix formation by guanylic acid.
Gellert, M., Lipsett, M., & Davies, D. R. (1962) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.48.12.2013 · Cited by 1,430
High-throughput sequencing of DNA G-quadruplex structures in the human genome
Chambers, V. S., Marsico, G., Boutell, J. M., Antonio, M. D., Smith, G. P., & Balasubramanian, S. (2015) · Nature Biotechnology · doi:10.1038/nbt.3295 · Cited by 1,261
Inhibition of telomerase by G-quartet DMA structures
Zahler, A. M., Williamson, J. R., Cech, T. R., & Prescott, D. M. (1991) · Nature · doi:10.1038/350718a0 · Cited by 1,164
Highly prevalent putative quadruplex sequence motifs in human DNA
Todd, A. K. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki553 · Cited by 1,002
QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences
Kikin, O., D'Antonio, L., & Bagga, P. (2006) · Nucleic Acids Res. · doi:10.1093/nar/gkl253 · Cited by 974
G-quadruplex structures mark human regulatory chromatin
Hänsel-Hertsch, R., Beraldi, D., Lensing, S. V., Marsico, G., Zyner, K., Parry, A., Di Antonio, M., Pike, J., Kimura, H., Narita, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3662 · Cited by 964
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Hänsel‐Hertsch, R., Antonio, M. D., & Balasubramanian, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.3 · Cited by 882
Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
Sundquist, W., & Klug, A. (1989) · Nature · doi:10.1038/342825a0 · Cited by 868
Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound
Sun, D., Thompson, B., Cathers, B. E., Salazar, M., Kerwin, S. M., Trent, J. O., Jenkins, T. C., Neidle, S., & Hurley, L. H. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970199z · Cited by 794
Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.780 · Cited by 741
Re-evaluation of G-quadruplex propensity with G4Hunter
Bedrat, A., Lacroix, L., & Mergny, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw006 · Cited by 693
Hübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691
Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ
Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996) · Science · doi:10.1126/science.272.5268.1646 · Cited by 660
Molecular structure of nucleic acids
Watson, J. D., & Crick, F. H. C. (2004) · Resonance · doi:10.1007/bf02834980 · Cited by 660
Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity
Crabbé, L., Verdún, R. E., Haggblom, C., & Karlseder, J. (2004) · Science · doi:10.1126/science.1103619 · Cited by 630
Schaffitzel, C., Berger, I., Postberg, J., Hanes, J., Lipps, H., & Plückthun, A. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.141229498 · Cited by 610
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Xu, H., Antonio, M. D., McKinney, S. E., Mathew, V., Ho, B., O’Neil, N. J., Santos, N. D., Silvester, J., Wei, V., Garcia, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14432 · Cited by 574
Paeschke, K., Capra, J. A., & Zakian, V. A. (2011) · Cell · doi:10.1016/j.cell.2011.04.015 · Cited by 566
Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication
Pursell, Z. F., Isoz, I., Lundström, E.-B., Johansson, E., & Kunkel, T. A. (2007) · Science · doi:10.1126/science.1144067 · Cited by 565
RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity
Vannier, J., Pavicic-Kaltenbrunner, V., Petalcorin, M. I. R., Ding, H., & Boulton, S. J. (2012) · Cell · doi:10.1016/j.cell.2012.03.030 · Cited by 491
Besnard, E., Babled, A., Lapasset, L., Milhavet, O., Parrinello, H., Dantec, C., Marin, J., & Lemaı̂tre, J.-M. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2339 · Cited by 468
RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms
Fay, M. M., Lyons, S. M., & Ivanov, P. V. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.05.017 · Cited by 455
Mendoza, Ó., Bourdoncle, A., Boulé, J.-B., Brosh, R. M., & Mergny, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw079 · Cited by 452
Self-citationDetection of G-quadruplex DNA in mammalian cells
Henderson, A., Wu, Y.-L., Huang, Y.-C., Chavez, E., Platt, J., Johnson, F., Brosh, R., Sen, D., & Lansdorp, P. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt957 · Cited by 443
Self-citationWu, Y., Shin-ya, K., & Brosh, R. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02210-07 · Cited by 428
Self-citationNon-B DNA structure-induced genetic instability and evolution
Zhao, J., Bacolla, A., Wang, G., & Vásquez, K. M. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0131-2 · Cited by 421
PrimPol, an Archaic Primase/Polymerase Operating in Human Cells
García-Gómez, S., Reyes, A., Martínez-Jiménez, M. I., Chocrón, E. S., Mouron, S. A., Terrados, G., Powell, C. A., SALIDO, E. C., Méndez, J., Holt, I. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.025 · Cited by 407
Conformational changes of non-B DNA
Choi, J., & Majima, T. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15153c · Cited by 383
Ribeyre, C., Lopes, J., Boulé, J., Piazza, A., Guédin, A., Zakian, V., Mergny, J., & Nicolas, A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000475 · Cited by 367
DNA helicases involved in DNA repair and their roles in cancer
Brosh, R. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3560 · Cited by 361
Self-citationMouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis
Guo, C., Fischhaber, P. L., Luk‐Paszyc, M. J., Masuda, Y., Zhou, J., Kamiya, K., Kisker, C., & Friedberg, E. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg626 · Cited by 353
Repriming of DNA synthesis at stalled replication forks by human PrimPol
Mouron, S. A., Rodríguez‐Acebes, S., Martínez-Jiménez, M. I., García-Gómez, S., Chocrón, S., Blanco, L., & Méndez, J. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2719 · Cited by 345
G‐quadruplex‐induced instability during leading‐strand replication
Lopes, J., Piazza, A., Bermejo, R., Kriegsman, B. A., Colosio, A., Teulade‐Fichou, M., Foiani, M., & Nicolas, A. G. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.316 · Cited by 330
Maizels, N. (2015) · EMBO Reports · doi:10.15252/embr.201540607 · Cited by 312
Epigenetic Instability due to Defective Replication of Structured DNA
Sarkies, P., Reams, C., Simpson, L. J., & Sale, J. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.009 · Cited by 302
PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication
Bianchi, J., Rudd, S. G., Jóźwiakowski, S. K., Bailey, L. J., Soura, V., Taylor, E. M., Stevanović, I., Green, A., Stracker, T. H., Lindsay, H. D., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.035 · Cited by 294
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA
Cheung, I. K., Schertzer, M. J., Rose, A. M., & Lansdorp, P. M. (2002) · Nature Genetics · doi:10.1038/ng928 · Cited by 270
G‐quadruplex nucleic acids and human disease
Wu, Y., & Brosh, R. M. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07760.x · Cited by 265
Self-citationInteraction of hREV1 with three human Y‐family DNA polymerases
Ohashi, E., Murakumo, Y., Kanjo, N., Akagi, J., Masutani, C., Hanaoka, F., & Ohmori, H. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00747.x · Cited by 261
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
Zimmer, J., Tacconi, E. M. C., Folio, C., Badie, S., Porru, M., Klare, K., Tumiati, M., Markkanen, E., Halder, S., Ryan, A., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.004 · Cited by 261
DNA secondary structures and epigenetic determinants of cancer genome evolution
De, S., & Michor, F. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2089 · Cited by 253
FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
London, T. B. C., Barber, L. J., Mosedale, G., Kelly, G. P., Balasubramanian, S., Hickson, I. D., Boulton, S. J., & Hiom, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808152200 · Cited by 252
Rev1 Employs a Novel Mechanism of DNA Synthesis Using a Protein Template
Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S., & Aggarwal, A. K. (2005) · Science · doi:10.1126/science.1116336 · Cited by 249
Koole, W., van Schendel, R., Karambelas, A., van Heteren, J. V., Okihara, K. L., & Tijsterman, M. (2014) · Nature Communications · doi:10.1038/ncomms4216 · Cited by 230
Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7
Murakumo, Y., Ogura, Y., Ishii, H., Numata, S., Ichihara, M., Croce, C. M., Fishel, R. A., & Takahashi, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102051200 · Cited by 230
Human DNA Polymerase κ Encircles DNA: Implications for Mismatch Extension and Lesion Bypass
Lone, S., Townson, S. A., Uljon, S., Johnson, R. E., Brahma, A., Nair, D. T., Prakash, S., Prakash, L., & Aggarwal, A. K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.018 · Cited by 228
Kamath-Loeb, A., Loeb, L., Johansson, E., Burgers, P., & Fry, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100253200 · Cited by 227
RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication
Vannier, J., Sandhu, S., Petalcorin, M. I. R., Wu, X., Nabi, Z., Ding, H., & Boulton, S. J. (2013) · Science · doi:10.1126/science.1241779 · Cited by 220
RNA G-quadruplexes: emerging mechanisms in disease
Cammas, A., & Millevoi, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1280 · Cited by 219
G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
Graybuck, L. T., Vallur, A. C., Eddy, J., & Maizels, N. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1475 · Cited by 217
POLQ (Pol ), a DNA polymerase and DNA-dependent ATPase in human cells
Seki, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg814 · Cited by 213
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
Sarkies, P., Murat, P., Phillips, L. G., Patel, K. J., Balasubramanian, S., & Sale, J. E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr868 · Cited by 211
The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair
Ogi, T., & Lehmann, A. R. (2006) · Nature Cell Biology · doi:10.1038/ncb1417 · Cited by 211
Idling by DNA polymerase δ maintains a ligatable nick during lagging-strand DNA replication
Garg, P., Stith, C. M., Sabouri, N., Johansson, E., & Burgers, P. M. (2004) · Genes & Development · doi:10.1101/gad.1252304 · Cited by 211
Aggarwal, M., Sommers, J. A., Shoemaker, R. H., & Brosh, R. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006423108 · Cited by 207
Self-citationPiazza, A., Boulé, J.-B., Lopes, J., Mingo, K., Largy, E., Teulade‐Fichou, M., & Nicolas, A. G. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq136 · Cited by 198
Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro
Wanrooij, S., Fusté, J. M., Farge, G., Shi, Y., Gustafsson, C. M., & Falkenberg, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805399105 · Cited by 185
Masumoto, H., Sugino, A., & Araki, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2809-2817.2000 · Cited by 184
A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells
Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P. A., et al. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.10.016 · Cited by 169
Mammalian DNA2 helicase/nuclease cleaves G‐quadruplex DNA and is required for telomere integrity
Lin, W., Sampathi, S., Dai, H., Liu, C., Zhou, M., Hu, J., Huang, Q. M., Campbell, J. L., Shin‐ya, K., Zheng, L., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.88 · Cited by 166
BLM helicase facilitates telomere replication during leading strand synthesis of telomeres
Drosopoulos, W. C., Kosiyatrakul, S. T., & Schildkraut, C. L. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201410061 · Cited by 164
PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells
Schiavone, D., Jozwiakowski, S. K., Romanello, M., Guilbaud, G., Guilliam, T. A., Bailey, L. J., Sale, J., & Doherty, A. (2016) · Molecules and Cells · doi:10.1016/j.molcel.2015.10.038 · Cited by 164
Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability
Wang, G., & Vásquez, K. M. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.017 · Cited by 162
FANCJ promotes DNA synthesis through G‐quadruplex structures
Bosch, P. C., Segura‐Bayona, S., Koole, W., van Heteren, J., Dewar, J. M., Tijsterman, M., & Knipscheer, P. (2014) · The EMBO Journal · doi:10.15252/embj.201488663 · Cited by 160
Yadav, V. K., Abraham, J. K., Mani, P., Kulshrestha, R., & Chowdhury, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm781 · Cited by 156
Johnson, J. E., Cao, K.-J., Ryvkin, P., Wang, L.-S., & Johnson, F. B. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1103 · Cited by 154
Bharti, S. K., Sommers, J. A., Zhou, J., Kaplan, D. L., Spelbrink, J. N., Mergny, J., & Brosh, R. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567073 · Cited by 140
Self-citationDirect evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents
Huang, W., Tseng, T., Chen, Y., Chang, C., Wang, Z., Wang, C., Hsu, T.-N., Li, P., Chen, C., Lin, J., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1061 · Cited by 139
Bharti, S. K., Sommers, J. A., George, F., Kuper, J., Hamon, F., Shin‐ya, K., Teulade‐Fichou, M., Kisker, C., & Brosh, R. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.496463 · Cited by 138
Self-citationBetous, R., Rey, L., Wang, G., Pillaire, M., Puget, N., Sèlves, J., Biard, D. S. F., Shin‐ya, K., Vásquez, K. M., Cazaux, C., et al. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20509 · Cited by 135
Lemmens, B., van Schendel, R., & Tijsterman, M. (2015) · Nature Communications · doi:10.1038/ncomms9909 · Cited by 133
Nguyen, G. H., Tang, W., Robles, A. I., Beyer, R. P., Graybuck, L. T., Welsh, J. A., Schetter, A. J., Kumamoto, K., Wang, X. W., Hickson, I. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404807111 · Cited by 132
Kobayashi, K., Guilliam, T. A., Tsuda, M., Yamamoto, J., Bailey, L. J., Iwai, S., Takeda, S., Doherty, A. J., & Hirota, K. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1191711 · Cited by 128
Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints
Dong, D. W., Pereira, F., Barrett, S. P., Kolesar, J. E., Cao, K., Damas, J., Yatsunyk, L. A., Johnson, F. B., & Kaufman, B. A. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-677 · Cited by 123
Targeting DNA repair, DNA metabolism and replication stress as anti‐cancer strategies
Puigvert, J. C., Sanjiv, K., & Helleday, T. (2015) · FEBS Journal · doi:10.1111/febs.13574 · Cited by 117
Impediments to replication fork movement: stabilisation, reactivation and genome instability
Lambert, S., & Carr, A. M. (2013) · Chromosoma · doi:10.1007/s00412-013-0398-9 · Cited by 117
Weitzmann, M. N., Woodford, K. J., & Usdin, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20958 · Cited by 116
Predicting and understanding the stability of G-quadruplexes
Stegle, O., Payet, L., Mergny, J., Mackay, D., & Huppert, J. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp210 · Cited by 116
Hoshina, S., Yura, K., Teranishi, H., Kiyasu, N., Tominaga, A., Kadoma, H., Nakatsuka, A., Kunichika, T., Obuse, C., & Shou, W.-G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.492504 · Cited by 115
The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription
Tang, W., Robles, A. I., Beyer, R. P., Gray, L. T., Nguyen, G. H., Oshima, J., Maizels, N., Harris, C. C., & Monnat, R. J. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw079 · Cited by 109
Molecular basis for PrimPol recruitment to replication forks by RPA
Guilliam, T. A., Brissett, N. C., Ehlinger, A. C., Keen, B. A., Kolesár, P., Taylor, E. M., Bailey, L. J., Lindsay, H. D., Chazin, W., & Doherty, A. J. (2017) · Nature Communications · doi:10.1038/ncomms15222 · Cited by 107
FANCJ couples replication past natural fork barriers with maintenance of chromatin structure
Schwab, R. A., Nieminuszczy, J., Shin‐ya, K., & Niedźwiedź, W. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201208009 · Cited by 102
G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins
Mishra, S., Tawani, A., Mishra, A., & Kumar, A. (2016) · Scientific Reports · doi:10.1038/srep38144 · Cited by 102
Newman, J. A., Cooper, C. D. O., Aitkenhead, H., & Gileadi, O. (2015) · Structure · doi:10.1016/j.str.2015.10.014 · Cited by 101
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures
Northam, M. R., Moore, E. A., Mertz, T. M., Binz, S. K., Stith, C. M. W., Stepchenkova, E. I., Wendt, K. L., Burgers, P., & Shcherbakova, P. V. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt830 · Cited by 99
Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p
Lawrence, C. W., & Maher, V. M. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0001 · Cited by 95
Aggarwal, M., Banerjee, T., Sommers, J. A., Iannascoli, C., Pichierri, P., Shoemaker, R. H., & Brosh, R. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2975 · Cited by 91
Self-citationDNA polymerases in the mitochondria A critical review of the evidence
Copeland, W. C. (2016) · Frontiers in bioscience · doi:10.2741/4510 · Cited by 91
A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy
Liu, W., Zhou, M., Li, Z., Li, H., Polaczek, P., Dai, H., Wu, Q., Liu, C., Karanja, K. K., Popuri, V., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.043 · Cited by 89
The Quaternary Structure of DNA Polymerase ε from Saccharomyces cerevisiae
Chilkova, O., Jonsson, B., & Johansson, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211818200 · Cited by 85
Exome sequencing reveals CCDC111 mutation associated with high myopia
Zhao, F., Wu, J., Xue, A., Su, Y., Wang, X., Xian-min, L., Zhou, Z., Qu, J., & Zhou, X. (2013) · Human Genetics · doi:10.1007/s00439-013-1303-6 · Cited by 84
A Toolbox for Predicting G‐Quadruplex Formation and Stability
Wong, H. M., Stegle, O., Rodgers, S., & Huppert, J. L. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/564946 · Cited by 84
Human Rev1 polymerase disrupts G-quadruplex DNA
Eddy, S., Ketkar, A. D., Zafar, M. K., Maddukuri, L., Choi, J., & Eoff, R. L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1314 · Cited by 80
Structure of DNA Polymerase δ from Saccharomyces cerevisiae
Johansson, E., Majka, J., & Burgers, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108842200 · Cited by 76
Structure of the Human Rev1–DNA–dNTP Ternary Complex
Swan, M. K., Johnson, R. E., Prakash, L., Prakash, S., & Aggarwal, A. K. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.05.026 · Cited by 76
Karthikeyan, R., Vonarx, E. J., Straffon, A. F. L., Simon, M., Faye, G., & Kunz, B. A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3744 · Cited by 76
Isolation and characterization of a DNA primase from human mitochondria.
Wong, T. W., & Clayton, D. A. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39063-4 · Cited by 75
Kaguni, L. S., & Clayton, D. A. (1982) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.79.4.983 · Cited by 73
QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs
Frees, S., Menendez, C., Crum, M., & Bagga, P. S. (2014) · Human Genomics · doi:10.1186/1479-7364-8-8 · Cited by 70
Guilliam, T. A., & Doherty, A. J. (2017) · Genes · doi:10.3390/genes8010020 · Cited by 70
Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome
Singh, B., Li, X., Owens, K. M., Vanniarajan, A., Liang, P., & Singh, K. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140409 · Cited by 62
Beagan, K., Armstrong, R. L., Witsell, A. L., Roy, U., Renedo, N., Baker, A. E., Schärer, O. D., & McVey, M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006813 · Cited by 57
Metabolism of DNA secondary structures at the eukaryotic replication fork
León-Ortiz, A. M., Svendsen, J. M., & Boulton, S. J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.016 · Cited by 56
Rocca, R., Moraca, F., Costa, G., Nadai, M., Scalabrin, M., Talarico, C., Distinto, S., Maccioni, E., Ortuso, F., Artese, A., et al. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.12.023 · Cited by 55
Menendez, C., Frees, S., & Bagga, P. S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks422 · Cited by 48
Saccharomyces cerevisiae Polymerase ζ Functions in Mitochondria
Zhang, H., Chatterjee, A., & Singh, K. K. (2006) · Genetics · doi:10.1534/genetics.105.051029 · Cited by 47
Getting it done at the ends: Pif1 family DNA helicases and telomeres
Geronimo, C. L. A., & Zakian, V. A. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.021 · Cited by 47
Human PrimPol activity is enhanced by RPA
Martínez-Jiménez, M. I., Lahera, A., & Blanco, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-00958-3 · Cited by 47
Contributions of the specialised DNA polymerases to replication of structured DNA
Wickramasinghe, C. M., Arzouk, H., Frey, A., Maiter, A., & Sale, J. E. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.01.004 · Cited by 46
Mitochondrial DNA replication: a PrimPol perspective
Bailey, L. J., & Doherty, A. J. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160162 · Cited by 45
Kamath‐Loeb, A. S., Loeb, L. A., & Fry, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030189 · Cited by 45
Musumeci, D., Amato, J., Zizza, P., Platella, C., Cosconati, S., Cingolani, C., Biroccio, A., Novellino, E., Randazzo, A., Giancola, C., et al. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.01.024 · Cited by 45
Salvati, E., Botta, L., Amato, J., Leva, F. S. D., Zizza, P., Gioiello, A., Pagano, B., Graziani, G., Tarsounas, M., Randazzo, A., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01563 · Cited by 45
Lormand, J. D., Buncher, N. A., Murphy, C. T., Kaur, P., Lee, M. Y., Burgers, P., Wang, H., Kunkel, T. A., & Opresko, P. L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt813 · Cited by 44
Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae
Piazza, A., Cui, X., Adrian, M., Samazan, F., Heddi, B., Phan, A. T., & Nicolas, A. G. (2017) · eLife · doi:10.7554/elife.26884 · Cited by 44
Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA
Eddy, S., Maddukuri, L., Ketkar, A., Zafar, M. K., Henninger, E. E., Pursell, Z., & Eoff, R. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00060 · Cited by 43
Eddy, S., Tillman, M., Maddukuri, L., Ketkar, A. D., Zafar, M. K., & Eoff, R. L. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00374 · Cited by 43
Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription
Smestad, J. A., & Maher, L. J. (2015) · BMC Medical Genetics · doi:10.1186/s12881-015-0236-4 · Cited by 39
Li, X. L., Lu, X., Parvathaneni, S., Bilke, S., Zhang, H., Thangavel, S., Vindigni, A., Hara, T., Zhu, Y. J., Meltzer, P. S., et al. (2014) · Cell Cycle · doi:10.4161/cc.29419 · Cited by 37
Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites
Andersen, P. L., Xu, F., Ziola, B. R., McGregor, W. G., & Xiao, W. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-12-0938 · Cited by 35
Hiraga, S., Hayashi-Hagihara, A., Ohya, T., & Sugino, A. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00843.x · Cited by 35
Feng, W., Rodriguez-Menocal, L., Tolun, G., & D’Urso, G. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-02-0088 · Cited by 33
PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage
Bailey, L. J., Bianchi, J., Hégarat, N., Hochegger, H., & Doherty, A. J. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1128597 · Cited by 30
Efficiency, Fidelity and Enzymatic Switching DurinG Translesion DNA Synthesis
McCulloch, S. D., Kokoska, R. J., & Kunkel, T. A. (2004) · Cell Cycle · doi:10.4161/cc.3.5.893 · Cited by 27
Song, Q., Sherrer, S. M., Suo, Z., & Taylor, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333591 · Cited by 25
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles
Bharti, S., Awate, S., Banerjee, T., & Brosh, R. M. (2016) · Genes · doi:10.3390/genes7070031 · Cited by 22
Self-citationQuantitative analysis and prediction of G-quadruplex forming sequences in double-stranded DNA
Kim, M., Kreig, A., Lee, C.-Y., Rube, H., Calvert, J., Song, J. S., & Myong, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw272 · Cited by 21
Yeom, M., Kim, I.-H., Kim, J.-K., Kang, K., Eoff, R. L., Guengerich, F. P., & Choi, J. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00513 · Cited by 15
Assessment of G-quadruplex Prediction Tools
Tradigo, G., Mannella, L., & Veltri, P. (2014) · Proceedings - IEEE Symposium on Computer-Based Medical Systems · doi:10.1109/cbms.2014.146 · Cited by 3
Lyonnais, S., Tarrés-Solé, A., Rubio‐Cosials, A., Cuppari, A., Brito, R., Jaumot, J., Gargallo, R., Vilaseca, M., Silva, C., Granzhan, A., et al. (2017) · Scientific Reports · doi:10.1038/srep45948 · Cited by 3
G-quadruplex Structure Prediction and integration in the GenData2020 data model
Tradigo, G., Cristiano, F., Alcaro, S., Greco, S., Pollastri, G., Veltri, P., & Prosperi, M. (2016) · ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics (ACM-BCB) · doi:10.1145/2975167.2985692 · Cited by 1
Flagged first, then by citations
Research works printed but not linked: 1
- Bang I.; Untersuchungen über die Guanylsäure. Biochemistry 1910,26,293-231
Cited by
Sorted by citations
Guiblet, W. M., Cremona, M. A., Harris, R. S., Chen, D., Eckert, K. A., Chiaromonte, F., Huang, Y.-F., & Makova, K. D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa1269 · Cited by 115
“Alternatively, the skewed spectrum may reflect the error specificity of specialized polymerases that are engaged at G4 motifs (122).”
BackgroundInfluentialG-Quadruplexes: More Than Just a Kink in Microbial Genomes
Saranathan, N., & Vivekanandan, P. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.08.011 · Cited by 110
“Persistence of G4 structures can dysregulate the cellular activities they control and also compromise genomic integrity [15,16].”
G-Quadruplex-Binding Proteins: Promising Targets for Drug Design
Shu, H., Zhang, R., Xiao, K., Yang, J., & Sun, X. S. (2022) · Biomolecules · doi:10.3390/biom12050648 · Cited by 89
“For instance, the elevated expression of G4-resolving helicases such as WRN and BLM has been demonstrated in cancer cells in order for highly proliferating cells to deal with increasing replicative lesions [53,123].”
BackgroundInfluentialBrosh, R. M., & Matson, S. W. (2020) · Genes · doi:10.3390/genes11030255 · Cited by 91
“G4-resolving helicases are discussed in recent reviews [78,79].”
BackgroundSelf-citationG-Quadruplex Structures in Bacteria: Biological Relevance and Potential as an Antimicrobial Target
Yadav, P., Kim, N., Kumari, M., Verma, S., Sharma, T. K., Yadav, V., & Kumar, A. (2021) · Journal of Bacteriology · doi:10.1128/jb.00577-20 · Cited by 83
Takahashi, S., & Sugimoto, N. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00594k · Cited by 80
Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair
Pavlova, A. V., Kubareva, E. A., Monakhova, M. V., Zvereva, M. I., & Dolinnaya, N. G. (2021) · Biomolecules · doi:10.3390/biom11091284 · Cited by 69
“Failure to bypass the G4 barrier has been demonstrated for various human polymerases involved in both DNA replication and repair [69].”
BackgroundThe Relevance of G-Quadruplexes for DNA Repair
Linke, R., Limmer, M., Juranek, S., Heine, A., & Paeschke, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212599 · Cited by 70
“Human Pol κ has a decreased fidelity and an enhanced activity two nucleotides before the G4 motif, which may suggest that Pol κ prepares for synthesis before the G4 motif [203].”
BackgroundG-quadruplex resolution: From molecular mechanisms to physiological relevance
Sato, K., & Knipscheer, P. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103552 · Cited by 67
Deiana, M., Castán, J. M. A., Josse, P., Kahsay, A. G., Sánchez, D. P., Morice, K., Gillet, N., Ravindranath, R., Patel, A. K., Sengupta, P., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad365 · Cited by 67
“…ymerases and thereby induce DNA damage in the form of SSBs or DSBs, the increased le v els of G4 structures in the genome may also be interpreted as a trigger for DSBs, if the le v els of G4s are too high for specialized G4 helicases to resolve these structures in a timely manner ( 53 , 90–96 ).”
Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair
Magis, A. D., Götz, S., Hajikazemi, M., Fekete-Szücs, E., Caterino, M., Juranek, S., & Paeschke, K. (2020) · Nature Communications · doi:10.1038/s41467-020-17701-8 · Cited by 55
Ligands stimulating antitumour immunity as the next G-quadruplex challenge
Miglietta, G., Marinello, J., Russo, M., & Capranico, G. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01649-y · Cited by 44
Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma
Akter, J., Katai, Y., Parvin, S., Takenobu, H., Haruta, M., Sugino, R. P., Mukae, K., Satoh, S., Wada, T., Ohira, M., et al. (2021) · Oncogenesis · doi:10.1038/s41389-021-00363-6 · Cited by 27
“To avoid RS, G4 helicases prevent G4-induced genome instability by resolving G4 structures [25, 26].”
BackgroundZareie, A. R., Dabral, P., & Verma, S. C. (2024) · Pathogens · doi:10.3390/pathogens13010060 · Cited by 26
“G4s in promoter regions of these genes can regulate transcription by inhibiting the binding of transcription factors or blocking the access of RNA polymerase to the promoter region [156].”
BackgroundVariation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity
Stein, M., Hile, S. E., Weissensteiner, M. H., Lee, M., Zhang, S., Kejnovský, E., Kejnovská, I., Makova, K. D., & Eckert, K. A. (2022) · DNA Repair · doi:10.1016/j.dnarep.2022.103402 · Cited by 23
G-quadruplex-mediated genomic instability drives SNVs in cancer
Richl, T., Kuper, J., & Kisker, C. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae098 · Cited by 20
“Error-prone polymerases might be engaged at slowed or stalled replication forks to ensure complete G4 replication, as specialized polymerases like eta, kappa, and Rev1 are essential for G4 stability – further increasing the density of localized genomic damages ( 26 ,78–80 ).”
BackgroundStein, M., & Eckert, K. A. (2021) · Genes · doi:10.3390/genes12111779 · Cited by 20
“For reviews concerning these structure-specific DNA helicases and the evidence that these act to prevent replication fork stalling at G4 motifs, see [57,60,61].”
BackgroundParsa, F. G., Nobili, S., Karimpour, M., Aghdaei, H. A., Mojarad, E. N., & Mini, E. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030396 · Cited by 21
“Therefore, DNA helicases might be potential targets in cancer therapy by exploiting the synthetic lethality approaches [63,64].”
BackgroundG-quadruplex as an essential structural element in cytomegalovirus replication origin
Park, D., Chung, W., Gong, S., Ravichandran, S., Lee, G. M., Han, M., Kim, K. K., & Ahn, J. (2024) · Nature Communications · doi:10.1038/s41467-024-51797-6 · Cited by 16
“GRSF1 binds to G4 and unfolds it 62 , and several DEAD or DEAH-box helicases such as DHX36, Pif1, and FANCJ resolve G4 structures 63,64 .”
Chaudhary, S., Kumar, M., & Kaushik, M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.248 · Cited by 15
AKT1 is positively regulated by G-quadruplexes in its promoter and 3′-UTR
Zhang, L., Yan, T., Wang, W., Wu, Q., Li, G., Li, D., Stovall, D. B., Wang, Y., Li, Y., & Sui, G. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.05.029 · Cited by 14
Recent Progress and Potential of G4 Ligands in Cancer Immunotherapy
Lin, J., Gong, Z., Lu, Y., Cai, J., Zhang, J., Tan, J., Huang, Z., & Chen, S. (2025) · Molecules · doi:10.3390/molecules30081805 · Cited by 12
“Studies over the past decades have demonstrated that G4 formation can lead to gene silencing [32] and DNA damage at G4 sites [33], a ff ecting oncogenes, telomeres, and mitochondrial DNA (mtDNA).”
Mgs1 protein supports genome stability via recognition of G‐quadruplex DNA structures
Zacheja, T., Toth, A., Harami, G. M., Yang, Q., Schwindt, E., Kovács, M., Paeschke, K., & Burkovics, P. (2020) · The FASEB Journal · doi:10.1096/fj.202000886r · Cited by 11
Zhao, Z.-Z., Li, X.-R., Cui, Z., Tong, T., Zhang, Y., Zhang, Y.-P., Yang, X.-X., Keerthiga, R., Fu, C., & Fu, A. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01982 · Cited by 9
G4-DNA formation and chromatin remodelling are interdependent in human cells
Lawler, N. B., Ou, A., King, J. J., Evans, C. W., Iyer, K. S., & Smith, N. M. (2023) · Chemical Science · doi:10.1039/d3sc02533k · Cited by 10
Three- and four-stranded nucleic acid structures and their ligands
Hashimoto, Y., Shil, S., Tsuruta, M., Kawauchi, K., & Miyoshi, D. (2025) · RSC Chemical Biology · doi:10.1039/d4cb00287c · Cited by 11
Li, T., Tang, L., Kou, H., & Wang, F. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022165 · Cited by 9
“Since previous studies have reported that PRIMPOL could bind G4s in vitro and restart DNA synthesis downstream of G4s in vertebrate cells [23,24], we wondered if PRIMPOL could contribute to resolving G4-induced replication fork stalling.”
BackgroundWhy to target G‐quadruplexes using peptides: Next‐generation G4‐interacting ligands
Sharma, T., Kundu, N., Kaur, S., Shankaraswamy, J., & Saxena, S. (2023) · Journal of Peptide Science · doi:10.1002/psc.3491 · Cited by 10
“Apart from these, all G4 interacting helicases use ATP hydrolytic energy to unwind G-quadruplex topologies except for WRN and BLM (Bloom helicase), which are enclosed by singlestranded DNA [40].”
BackgroundComplexity of Guanine Quadruplex Unfolding Pathways Revealed by Atomistic Pulling Simulations
Stadlbauer, P., Mlýnský, V., Krepl, M., & Šponer, J. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c00171 · Cited by 9
“In this context, stall (arrest) force of polymerases is ~15 pN (79-81) (for a comparison, stall force of the motor protein kinesin is just ~5 pN (82)), which means that GQs may act as roadblocks and common polymerases have to employ other strategies to overcome the GQ obstacle (58).”
Thermodynamics and Kinetics‐Directed Regulation of Nucleic Acid‐Based Molecular Recognition
Liu, Y., Zhao, Z., Zeng, Y., He, M., Lyu, Y., & Yuan, Q. (2024) · Small Methods · doi:10.1002/smtd.202401102 · Cited by 8
How DNA secondary structures drive replication fork instability
Sethi, A., Fernández-Casañas, M., Delpino, B., & Coster, G. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103913 · Cited by 7
Vinyard, W. A., Fleming, A. M., Ma, J., & Burrows, C. J. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00749 · Cited by 8
Werner helicase interacting protein 1 contributes to G-quadruplex processing in human cells
Hegedűs, L., Toth, A., Harami, G. M., Pálinkás, J., Karatayeva, N., Sajben-Nagy, E., Bene, S., Jaktajdinani, S. A., Kovács, M., Juhász, S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-66425-y · Cited by 7
“Thus, persistent G4 structures have been proposed to impact genome stability and gene function by interfering with replication fork progression, transcription elongation, and DNA repair mechanisms 5,52–54 .”
BackgroundPolymerase ζ Is Involved in Mitochondrial DNA Maintenance Processes in Concert with APE1 Activity
Schreier, H. K., Wiehe, R. S., Ricchetti, M., & Wiesmüller, L. (2022) · Genes · doi:10.3390/genes13050879 · Cited by 7
“Given that not only APE1 binds to G4 sequences when oxidatively damaged [92,93], but also POLZ is thought to act on G4 [81], we propose that POLZ promotes APE1 binding to damaged and/or difficult-to-replicate sequences in the Set2 region, accelerating their cleavage.”
BackgroundSpin-selectivity effect of G-quadruplex DNA molecules
Deng, L., Bhat, I. H., & Guo, A. (2023) · The Journal of Chemical Physics · doi:10.1063/5.0156389 · Cited by 7
Zhang, Z., Mlýnský, V., Krepl, M., Šponer, J., & Stadlbauer, P. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c00227 · Cited by 6
The age‐related decline of helicase function—how G‐quadruplex structures promote genome instability
Frobel, J., & Hänsel‐Hertsch, R. (2024) · FEBS Letters · doi:10.1002/1873-3468.14939 · Cited by 6
Davletgildeeva, A. T., & Kuznetsov, N. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146951 · Cited by 5
“In addition to the specialized helicases that are capable of resolving G-quadruplex structures along the replication fork passage, polymerases that carry out trans-lesion synthesis (TLS) are also capable of dealing with such obstacles in the cell [60].”
Parekh, V. J., Węgrzyn, G., Arluison, V., & Sinden, R. R. (2023) · Genes · doi:10.3390/genes14091720 · Cited by 4
“One might expect these proteins to be potential therapeutic targets [28].”
BackgroundRare genetic diseases associated with G-quadruplex-induced replication stress
Herr, L. M., Mukhopadhyay, S., Anderson, O. M., Couch, T. H., Jones, C. M., Brosh, R. M., & Rossi, M. S. (2026) · Communications Biology · doi:10.1038/s42003-026-09966-4 · Cited by 4
Self-citationSommers, J. A., Estep, K. N., Maul, R. W., & Brosh, R. M. (2021) · Methods · doi:10.1016/j.ymeth.2021.12.005 · Cited by 3
Self-citationCellular Assays to Study the Functional Importance of Human DNA Repair Helicases
Awate, S., Dhar, S., Sommers, J. A., & Brosh, R. M. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9500-4_11 · Cited by 2
Self-citationG-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets
Shitikov, E. A., Bespiatykh, D., Bodoev, I. N., & Zaychikova, M. V. (2022) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750822040084 · Cited by 2
G-quadruplex structures in bacteria: functional properties and prospects for use as biotargets
Shitikov, E. A., Bespiatykh, D. A., Bodoev, I. N., & Zaychikova, M. V. (2022) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20226802093 · Cited by 1
Anomalies in dye-terminator DNA sequencing caused by a natural G-quadruplex
Brush, G. S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0279423 · Cited by 1
“Additional studies have shown that other RecQ-type helicases can unwind G4 DNA, as can a number of other helicases including human FANCJ and S . cerevisiae Pif1 helicase [25–30].”
Primary Sequence-Intrinsic Immune Evasion by Viral Proteins Guides CTL-Based Vaccine Strategies
Wan, L., Shuda, M., Chang, Y., & Moore, P. S. (2025) · Viruses · doi:10.3390/v17081035 · Cited by 1
“For example, in herpes simplex virus-1 (HSV-1), G4s located in the promoters of immediate-early genes ICP0 and ICP4 interfere with transcription factor binding and RNA polymerase access, thereby repressing gene expression [23].”
Okano, T., Takata, M., Fujita, M., & Katsuki, Y. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103911 · Cited by 1
Purification and biochemical characterization of the G4 resolvase and DNA helicase FANCJ
Kulikowicz, T., Sommers, J. A., Fuchs, K. F., Wu, Y., & Brosh, R. M. (2024) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2023.12.006 · Cited by 1
Self-citationMajorana zero modes in a G-quadruplex DNA with an s-wave superconductor
Tang, H.-Z., Wang, Z., & Zhai, L.-X. (2024) · Physics Letters A · doi:10.1016/j.physleta.2024.129903 · Cited by 1
Non-standard and higher-order DNA structures: DNA–DNA recognition
Neidle, S., & Sanderson, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819677-9.00003-2 · Cited by 1
DHX9 resolves G-quadruplex condensation to prevent DNA double-strand breaksPreprint
Xue, Y., Chen, J., Ling, X., Zhao, Y., Li, S., Li, M., Zhao, H., Yang, X., Tsui, W., Cao, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2184718/v1 · Cited by 1
Prosperi, M. (2019) · Current Medicinal Chemistry · doi:10.2174/092986732616190820105842
Tóth, Á. (2021) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.10661
Exploring the Mechanisms of Telomerase Regulation in Saccharomyces cerevisiae
Fekete-Szücs, E. (2023) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.777966042
Badugu, S. B., Dhyani, K. M., Thakur, M., & Muniyappa, K. (2024) · eLife · doi:10.7554/elife.96933.1
Enzymatic bypass of G-quadruplex structures containing oxidative lesions
Podbevšek, P., & Plavec, J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1157
Burkhart, I., Limmer, M. B., Penedo, J. C., Sauer, L.-C., Schwalbe, H., & Paeschke, K. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1055
“The current model suggests that G4s form transiently within cells, and that their folding, unfolding, and stability are regulated by proteins that both enable G4 function and prevent genome instability [ 29–32 ].”
G-quadruplex structures affect the immune response to bacterial infection in mouse macrophages
Schult, P., Kastl, M. A., Szlapa, J., Symeonidis, K., Maasewerd, S., Franklin, B., Radcke, A., Juranek, S., Abdullah, Z., & Paeschke, K. (2026) · Nature Communications · doi:10.1038/s41467-026-78610-w
Metadata
- Authors
- Estep, K. N., Butler, T. J., Ding, J., & Brosh, R. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Brosh, Robert M.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2019-08-26
- Volume
- 26
- Issue
- 16
- Pages
- 2881-2897
- ISSN
- 0929-8673 (ISSN-L)
- PMC
- PMC6663639
- OpenAlex
- W2770563537
- Cited by
- 58
- References
- 138
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 4 · 2019: 2
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (Z01AG000741)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- G-quadruplex, DNA helicase, DNA polymerase, DNA replication, translesion DNA polymerases, PrimPol, telomere maintenance, mitochondrial genome, promoter, transcriptional regulation, anticancer drug targets
- MeSH terms
- Algorithms, DNA, DNA-Directed DNA Polymerase, DNA Replication, DNA Helicases, Humans, Sequence Analysis, DNA, Genomic Instability, G-Quadruplexes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
