Kieffer, Timothy J.

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 1,575

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

Kieffer, T. J., McIntosh, C. H., & Pederson, R. A. (1995) · Endocrinology

Diabetes Treatment and ManagementPeptidase Inhibition and Analysis

Cited by 1,124

Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Rezania, A., Bruin, J. E., Riedel, M. J., Mojibian, M., Asadi, A., Xu, J., Gauvin, R., Narayan, K., Karanu, F., O’Neil, J. J., et al. (2012) · Diabetes

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 582

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism

Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 498

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

Ramzy, A., Thompson, D. M., Ward-Hartstonge, K. A., Ivison, S., Cook, L., Garcia, R. V., Loyal, J., Kim, P. T. W., Warnock, G. L., Levings, M. K., et al. (2021) · Cell Stem Cell

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 342

Leptin Receptors Expressed on Pancreatic β-Cells

Kieffer, T. J., Heller, R. S., & Habener, J. F. (1996) · Biochemical and Biophysical Research Communications

Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 326

Leptin Suppression of Insulin Secretion and Gene Expression in Human Pancreatic Islets: Implications for the Development of Adipogenic Diabetes Mellitus1

Seufert, J., Kieffer, T. J., Leech, C. A., Holz, G. G., Moritz, W., Ricordi, C., & Habener, J. F. (1999) · The Journal of Clinical Endocrinology & Metabolism

Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 278

Functional GIP Receptors Are Present on Adipocytes

Yip, R. G.-C., Boylan, M. O., Kieffer, T. J., & Wolfe, M. M. (1998) · Endocrinology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 237

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Bruin, J. E., Rezania, A., Xu, J., Narayan, K., Fox, J. K., O’Neil, J. J., & Kieffer, T. J. (2013) · Diabetologia

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 216

Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats

Lynn, F. C., Pamir, N., Ng, E. H. C., McIntosh, C. H. S., Kieffer, T. J., & Pederson, R. A. (2001) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 208

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

Seufert, J., Kieffer, T. J., & Habener, J. F. (1999) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 193

Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Adult Hippocampus and Induces Progenitor Cell Proliferation

Nyberg, J., Anderson, M. F., Meister, B., Alborn, A.-M., Ström, A.-K., Brederlau, A., Illerskog, A.-C., Nilsson, O., Kieffer, T. J., Hietala, M. A., et al. (2005) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsRegulation of Appetite and Obesity

Cited by 191

Insulinotropic Glucagon-Like Peptide I Receptor Expression in Glucagon-Producing α-Cells of the Rat Endocrine Pancreas

Heller, R. S., Kieffer, T. J., & Habener, J. F. (1997) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 179

Link between GIP and osteopontin in adipose tissue and insulin resistance

Ahlqvist, E., Osmark, P., Kuulasmaa, T., Pilgaard, K., Omar, B., Brøns, C., Kotova, O., Zetterqvist, A. V., Stančáková, A., Jonsson, A., et al. (2013) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesBone Metabolism and Diseases

Cited by 96

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells

Laubner, K., Kieffer, T. J., Lam, N. T., Niu, X., Jakob, F., & Seufert, J. (2005) · Diabetes

Pancreatic function and diabetesCytokine Signaling Pathways and Interactions

Cited by 85

FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1

Kwon, M. M., O’Dwyer, S. M., Baker, R. K., Covey, S. D., & Kieffer, T. J. (2015) · Cell Reports

Fibroblast Growth Factor ResearchAdipose Tissue and Metabolism

Cited by 77

Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas

Szabat, M., Lynn, F. C., Hoffman, B. G., Kieffer, T. J., Allan, D. W., & Johnson, J. D. (2012) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 68

Advances in Islet Transplantation and the Future of Stem Cell–Derived Islets to Treat Diabetes

Kieffer, T. J., Hoesli, C. A., & Shapiro, A. M. J. (2025) · Cold Spring Harbor Perspectives in Medicine

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 7