Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Adult Hippocampus and Induces Progenitor Cell Proliferation
Open accessAbstract
The hippocampal dentate gyrus (DG) is an area of active proliferation and neurogenesis within the adult brain. The molecular events controlling adult cell genesis in the hippocampus essentially remain unknown. It has been reported previously that adult male and female rats from the strains Sprague Dawley (SD) and spontaneously hypertensive (SHR) have a marked difference in proliferation rates of cells in the hippocampal DG. To exploit this natural variability and identify potential regulators of cell genesis in the hippocampus, hippocampal gene expression from male SHR as well as male and female SD rats was analyzed using a cDNA array strategy. Hippocampal expression of the gene-encoding glucose-dependent insulinotropic polypeptide (GIP) varied strongly in parallel with cell-proliferation rates in the adult rat DG. Moreover, robust GIP immunoreactivity could be detected in the DG. The GIP receptor is expressed by cultured adult hippocampal progenitors and throughout the granule cell layer of the DG, including progenitor cells. Thus, these cells have the ability to respond to GIP. Indeed, exogenously delivered GIP induced proliferation of adult-derived hippocampal progenitors in vivo as well as in vitro, and adult GIP receptor knock-out mice exhibit a significantly lower number of newborn cells in the hippocampal DG compared with wild-type mice. This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation.
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GIP is thought to potentially decrease food intake through action in the hypothalamus.
“GIP is thought to potentially decrease food intake through action in the hypothalamus (61).”
From New Frontiers in Obesity Treatment: GLP-1 and Nascent Nutrient-Stimulated Hormone-Based Therapeutics (2023) · cites this paper as [61]
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- Authors
- Nyberg, J., Anderson, M. F., Meister, B., Alborn, A.-M., Ström, A.-K., Brederlau, A., Illerskog, A.-C., Nilsson, O., Kieffer, T. J., Hietala, M. A., Ricksten, A., & Eriksson, P. S.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- University of Gothenburg (SE)
- University of British Columbia (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-02-16
- Volume
- 25
- Issue
- 7
- Pages
- 1816-1825
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725940
- OpenAlex
- W2123030262
- Cited by
- 191
- References
- 65
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 10 · 2023: 2 · 2022: 14 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 6
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stiftelsen Handlanden Hjalmar Svenssons
- Sahlgrenska Universitetssjukhuset
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- glucose-dependent insulinotropic polypeptide, GIP receptor, dentate gyrus, adult neurogenesis, progenitor cell proliferation, spontaneously hypertensive rats, Sprague-Dawley rats, gene expression profiling, granular layer
- MeSH terms
- Animals, Cell Division, Female, Gastric Inhibitory Polypeptide, Hypertension, Male, Mice, Inbred C57BL, Neurons, Rats, Inbred SHR, Receptors, Gastrointestinal Hormone, Stem Cells, Rats, Sprague-Dawley, Mice, Knockout, Dentate Gyrus, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice, Rats
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