Appella, Ettore

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,042

DNA damage activates p53 through a phosphorylation–acetylation cascade

Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 1,204

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

Cheng, H.-L., Mostoslavsky, R., Saito, S., Manis, J. P., Gu, Y., Patel, P., Bronson, R., Appella, E., Alt, F. W., & Chua, K. F. (2003) · Proceedings of the National Academy of Sciences

Sirtuins and Resveratrol in MedicineCancer-related Molecular Pathways

Cited by 1,095

DNA damage induces phosphorylation of the amino terminus of p53

Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 818

MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation

Ito, A., Kawaguchi, Y., Lai, C., Kovacs, J. J., Higashimoto, Y., Appella, E., & Yao, T. (2002) · The EMBO Journal

Cancer-related Molecular PathwaysHistone Deacetylase Inhibitors Research

Cited by 570

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes.

Robbins, P. F., El-Gamil, M., Li, Y. F., Kawakami, Y., Loftus, D., Appella, E., & Rosenberg, S. A. (1996) · The Journal of experimental medicine

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 550

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W. H., Marks, M. S., Levi, B. Z., Flanagan, J. R., Appella, E., & Ozato, K. (1990) · Proceedings of the National Academy of Sciences

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 356

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

Hofseth, L. J., Saito, S., Hussain, S. P., Espey, M. G., Miranda, K. M., Araki, Y., Jhappan, C., Higashimoto, Y., He, P., Linke, S. P., et al. (2003) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 355

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

Salvador, J. M., Mittelstadt, P. R., Guszczynski, T., Copeland, T. D., Yamaguchi, H., Appella, E., Fornace, A. J., & Ashwell, J. D. (2005) · Nature Immunology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 306

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

Sakaguchi, K., Saito, S., Higashimoto, Y., Roy, S., Anderson, C. W., & Appella, E. (2000) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 293

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

Lin, D., Shields, M. T., Ullrich, S. J., Appella, E., & Mercer, W. E. (1992) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 267

Proteomic and Bioinformatic Characterization of the Biogenesis and Function of Melanosomes

Chi, A., Valencia, J. C., Hu, Z.-Z., Watabe, H., Yamaguchi, H., Mangini, N. J., Huang, H., Canfield, V. A., Cheng, K. C., Yang, F., et al. (2006) · Journal of Proteome Research

melanin and skin pigmentationAdvanced Proteomics Techniques and Applications

Cited by 199

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

Bovolenta, C., Driggers, P. H., Marks, M. S., Medin, J. A., Politis, A. D., Vogel, S. N., Levy, D. E., Sakaguchi, K., Appella, E., & Coligan, J. E. (1994) · Proceedings of the National Academy of Sciences

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 167

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

Mondal, A. M., Horikawa, I., Pine, S. R., Fujita, K., Morgan, K. M., Vera, E., Mazur, S. J., Appella, E., Vojtesek, B., Blasco, M. A., et al. (2013) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 164

Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.

Weisz, A., Marx, P., Sharf, R., Appella, E., Driggers, P. H., Ozato, K., & Levi, B. Z. (1992) · Journal of Biological Chemistry

interferon and immune responsesGenomics and Chromatin Dynamics

Cited by 152

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 Responses

Chao, C., Hergenhahn, M., Kaeser, M. D., Wu, Z., Saito, S., Iggo, R., Hollstein, M., Appella, E., & Xu, Y. (2003) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 141

Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation

Nelson, N., Kanno, Y., Hong, C., Contursi, C., Fujita, T., Fowlkes, B. J., O’Connell, E., Hu-Li, J., Paul, W. E., Jankovic, D., et al. (1996) · The Journal of Immunology

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 110

Mutation of Mouse p53 Ser23 and the Response to DNA Damage

Wu, Z., Earle, J., Saito, S., Anderson, C. W., Appella, E., & Xu, Y. (2002) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 103

Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element

Kuwata, T., Gongora, C., Kanno, Y., Sakaguchi, K., Tamura, T., Kanno, T., Basrur, V., Martinez, R., Appella, E., Golub, T., et al. (2002) · Molecular and Cellular Biology

interferon and immune responsesGenomics and Chromatin Dynamics

Cited by 69

UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells

Oh, K.-S., Bustin, M., Mazur, S. J., Appella, E., & Kraemer, K. H. (2011) · DNA Repair

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 60

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

Rossi, M., Demidov, O. N., Anderson, C. W., Appella, E., & Mazur, S. J. (2008) · Nucleic Acids Research

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 57

Sialylated Core 1 O-Glycans Influence the Sorting of Pmel17/gp100 and Determine Its Capacity to Form Fibrils

Valencia, J. C., Rouzaud, F., Julien, S., Chen, K. G., Passeron, T., Yamaguchi, Y., Abu-Asab, M., Tsokos, M., Costin, G. E., Yamaguchi, H., et al. (2007) · Journal of Biological Chemistry

Glycosylation and Glycoproteins Researchmelanin and skin pigmentation

Cited by 50

Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation

Manna, A., Zhao, H., Wada, J., Balagopalan, L., Tagad, H. D., Appella, E., Schuck, P., & Samelson, L. E. (2018) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingT-cell and B-cell Immunology

Cited by 24