Beachy, Philip A.

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 1,247

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

The Tabula Sapiens Consortium*, Jones, R. C., Karkanias, J., Krasnow, M. A., Pisco, A. O., Quake, S. R., Salzman, J., Yosef, N., Bulthaup, B., Brown, P., et al. (2022) · Science

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 1,056

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

Wang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell

Hedgehog Signaling Pathway StudiesCongenital limb and hand anomalies

Cited by 1,014

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science

Hedgehog Signaling Pathway StudiesPharmacological Effects and Toxicity Studies

Cited by 848

Patched acts catalytically to suppress the activity of Smoothened

Taipale, J., Cooper, M. K., Maiti, T., & Beachy, P. A. (2002) · Nature

Hedgehog Signaling Pathway StudiesWnt/β-catenin signaling in development and cancer

Cited by 794

Ageing hallmarks exhibit organ-specific temporal signatures

Schaum, N., Lehallier, B., Hahn, O., Pálovics, R., Hosseinzadeh, S., Lee, S. E., Sit, R., Lee, D. P., Losada, P. M., Zardeneta, M. E., et al. (2020) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 671

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell

Hedgehog Signaling Pathway StudiesDevelopmental Biology and Gene Regulation

Cited by 581

Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

Porter, J. A., Ekker, S. C., Park, W.-J., von Kessler, D. P., Young, K. E., Chen, C.-H., Ma, Y., Woods, A. S., Cotter, R. J., Koonin, E. V., et al. (1996) · Cell

Hedgehog Signaling Pathway StudiesWnt/β-catenin signaling in development and cancer

Cited by 533

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

Kim, J., Tang, J. Y., Gong, R., Kim, J., Lee, J. J., Clemons, K. V., Chong, C. R., Chang, K. S., Fereshteh, M., Gardner, D., et al. (2010) · Cancer Cell

Hedgehog Signaling Pathway StudiesHippo pathway signaling and YAP/TAZ

Cited by 527

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

Lee, J. J., Perera, R. M., Wang, H., Wu, D.-C., Liu, X. S., Han, S., Fitamant, J., Jones, P. D., Ghanta, K. S., Kawano, S., et al. (2014) · Proceedings of the National Academy of Sciences

Hedgehog Signaling Pathway StudiesPancreatic and Hepatic Oncology Research

Cited by 502

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.

Chiang, C., Litingtung, Y., Harris, M. P., Simandl, B. K., Li, Y., Beachy, P. A., & Fallon, J. F. (2001) · Developmental Biology

Congenital limb and hand anomaliesHedgehog Signaling Pathway Studies

Cited by 427

Segmental distribution of bithorax complex proteins during Drosophila development

Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 413

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., et al. (2007) · Nature Genetics

Genetic and Kidney Cyst DiseasesWnt/β-catenin signaling in development and cancer

Cited by 399

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

Cooper, M. K., Wassif, C. A., Krakowiak, P. A., Taipale, J., Gong, R., Kelley, R. I., Porter, F. D., & Beachy, P. A. (2003) · Nature Genetics

Hedgehog Signaling Pathway StudiesCholesterol and Lipid Metabolism

Cited by 390

Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists

Kim, J., Aftab, B. T., Tang, J. Y., Kim, D., Lee, A. H., Rezaee, M., Kim, J., Chen, B., King, E. M., Borodovsky, A., et al. (2013) · Cancer Cell

Hedgehog Signaling Pathway StudiesGlioma Diagnosis and Treatment

Cited by 346

Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma

Kim, D. J., Kim, J., Spaunhurst, K., Montoya, J., Khodosh, R., Chandra, K., Fu, T., Gilliam, A., Molgo, M., Beachy, P. A., et al. (2014) · Journal of Clinical Oncology

Hedgehog Signaling Pathway StudiesNonmelanoma Skin Cancer Studies

Cited by 289

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice

Rothenberg, M. E., Nusse, Y., Kalisky, T., Lee, J. J., Dalerba, P., Scheeren, F., Lobo, N., Kulkarni, S., Sim, S., Qian, D., et al. (2012) · Gastroenterology

Cancer Cells and MetastasisDigestive system and related health

Cited by 263

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

Zhang, Y., Bulkley, D. P., Xin, Y., Roberts, K. J., Asarnow, D. E., Sharma, A., Myers, B. R., Cho, W., Cheng, Y., & Beachy, P. A. (2018) · Cell

Hedgehog Signaling Pathway StudiesReceptor Mechanisms and Signaling

Cited by 239

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 153

Cell types of origin of the cell-free transcriptome

Vorperian, S. K., Moufarrej, M. N., Tabula Sapiens Consortium, Overall Project Direction and Coordination, Jones, R. C., Karkanias, J., Krasnow, M., Pisco, A. O., Quake, S. R., Salzman, J., et al. (2022) · Nature Biotechnology

Single-cell and spatial transcriptomicsGene expression and cancer classification

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