Wen, Zhexing

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., et al. (2016) · Cell

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 2,127

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E. M., et al. (2016) · Cell Stem Cell

Mosquito-borne diseases and controlNeurogenesis and neuroplasticity mechanisms

Cited by 1,292

Synaptic dysregulation in a human iPS cell model of mental disorders

Wen, Z., Nguyen, H. N., Guo, Z., Lalli, M. A., Wang, X., Su, Y., Kim, N.-S., Yoon, K.-J., Shin, J., Zhang, C., et al. (2014) · Nature

Pluripotent Stem Cells ResearchSchizophrenia research and treatment

Cited by 549

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

Qian, X., Su, Y., Adam, C. D., Deutschmann, A. U., Pather, S. R., Goldberg, E. M., Su, K., Li, S., Lu, L., Jacob, F., et al. (2020) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 479

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

Yoon, K.-J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N.-S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., et al. (2014) · Cell Stem Cell

Genomic variations and chromosomal abnormalitiesSchizophrenia research and treatment

Cited by 240

Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus

Song, J., Sun, J., Moss, J., Wen, Z., Sun, G. J., Hsu, D., Zhong, C., Davoudi, H., Christian, K. M., Toni, N., et al. (2013) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 223

Long-range GABAergic inputs regulate neural stem cell quiescence and control adult hippocampal neurogenesis

Bao, H., Asrican, B., Li, W., Gu, B., Wen, Z., Lim, S.-A., Haniff, I., Ramakrishnan, C., Deisseroth, K., Philpot, B., et al. (2017) · Cell stem cell

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 151

Modeling psychiatric disorders with patient-derived iPSCs

Wen, Z., Christian, K. M., Song, H., & Ming, G.-L. (2016) · Current Opinion in Neurobiology

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 84

Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer's disease with real-world clinical validation

Yan, C., Grabowska, M. E., Dickson, A. L., Li, B., Wen, Z., Roden, D. M., Michael Stein, C., Embí, P. J., Peterson, J. F., Feng, Q., et al. (2024) · npj Digital Medicine

Alzheimer's disease research and treatmentsComputational Drug Discovery Methods

Cited by 73

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience

Kumar, A., Karuppagounder, S. S., Chen, Y., Corona, C., Kawaguchi, R., Cheng, Y., Balkaya, M., Sagdullaev, B. T., Wen, Z., Stuart, C., et al. (2023) · Neuron

Endoplasmic Reticulum Stress and DiseaseDietary Effects on Health

Cited by 64

Drug repurposing for Alzheimer’s disease from 2012–2022—a 10-year literature review

Grabowska, M. E., Huang, A., Wen, Z., Li, B., & Wei, W.-Q. (2023) · Frontiers in Pharmacology

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 55

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.

Raj, N., McEachin, Z. T., Harousseau, W., Zhou, Y., Zhang, F., Merritt-Garza, M. E., Taliaferro, J. M., Kalinowska, M., Marro, S. G., Hales, C. M., et al. (2021) · Cell Reports

Genetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 54

APOE expression and secretion are modulated by mitochondrial dysfunction

Wynne, M. E., Ogunbona, O., Lane, A. R., Gokhale, A., Zlatic, S. A., Xu, C., Wen, Z., Duong, D. M., Rayaprolu, S., Ivanova, A., et al. (2023) · eLife

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 35