Modeling psychiatric disorders with patient-derived iPSCs

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992 · see citing works

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620 · see citing works

Organogenesis in a dish: Modeling development and disease using organoid technologies

Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931 · see citing works

Cortical inhibitory neurons and schizophrenia

Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works

Animal models of neuropsychiatric disorders

Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works

Dopamine in schizophrenia: a review and reconceptualization

Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,021 · see citing works

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

Kriks, S., Shim, J., Piao, J., Ganat, Y. M., Wakeman, D. R., Xie, Z., Carrillo‐Reid, L., Auyeung, G., Antonacci, C. L., Buch, A., et al. (2011) · Nature · doi:10.1038/nature10648 · Cited by 1,912 · see citing works

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

Paşca, A. M., Sloan, S. A., Clarke, L. E., Tian, Y., Makinson, C. D., Huber, N., Kim, C. H., Park, J.-Y., O'Rourke, N. A., Nguyen, K. D., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3415 · Cited by 1,609 · see citing works

Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells

Ramsköld, D., Luo, S., Wang, Y.-C., Li, R., Deng, Q., Faridani, O. R., Daniels, G. A., Khrebtukova, I., Loring, J. F., Laurent, L. C., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2282 · Cited by 1,609 · see citing works

CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism

Splawski, I., Timothy, K. W., Sharpe, L. M., Decher, N., Kumar, P., Bloise, R., Napolitano, C., Schwartz, P. J., Joseph, R. M., Condouris, K., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.011 · Cited by 1,586 · see citing works

Modelling schizophrenia using human induced pluripotent stem cells

Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., et al. (2011) · Nature · doi:10.1038/nature09915 · Cited by 1,375 · see citing works

Development and Evolution of the Human Neocortex

Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342 · see citing works

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H., & Muotri, A. R. (2010) · Cell · doi:10.1016/j.cell.2010.10.016 · Cited by 1,329 · see citing works

Interneuron dysfunction in psychiatric disorders

Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190 · see citing works

Genetic architectures of psychiatric disorders: the emerging picture and its implications

Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

Sato, T., & Clevers, H. (2013) · Science · doi:10.1126/science.1234852 · Cited by 1,170 · see citing works

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168 · see citing works

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

Mariani, J., Coppola, G., Zhang, P., Abyzov, A., Provini, L., Tomasini, L., Amenduni, M., Szekely, A., Palejev, D., Wilson, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.06.034 · Cited by 1,149 · see citing works

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315710110 · Cited by 999 · see citing works

Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988 · see citing works

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

Shi, Y., Kirwan, P., & Livesey, F. J. (2012) · Nature Protocols · doi:10.1038/nprot.2012.116 · Cited by 972 · see citing works

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

Lee, G., Papapetrou, E. P., Kim, H., Chambers, S. M., Tomishima, M. J., Fasano, C. A., Ganat, Y. M., Menon, J., Shimizu, F., Viale, A. J., et al. (2009) · Nature · doi:10.1038/nature08320 · Cited by 870 · see citing works

CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics

Malhotra, D., & Sebat, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.039 · Cited by 854 · see citing works

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

Shi, Y., Kirwan, P., Smith, J., Robinson, H. P. C., & Livesey, F. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3041 · Cited by 813 · see citing works

Treatment-resistant depression: therapeutic trends, challenges, and future directions

Al-harbi (2012) · Patient Preference and Adherence · doi:10.2147/ppa.s29716 · Cited by 796 · cited 1× · see citing works

Reward processing dysfunction in major depression, bipolar disorder and schizophrenia

Whitton, A. E., Treadway, M. T., & Pizzagalli, D. A. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000122 · Cited by 740 · see citing works

L1 retrotransposition in neurons is modulated by MeCP2

Muotri, A. R., Marchetto, M. C. N., Coufal, N. G., Oefner, R., Yeo, G., Nakashima, K., & Gage, F. H. (2010) · Nature · doi:10.1038/nature09544 · Cited by 626 · see citing works

A genome-wide linkage and association scan reveals novel loci for autism

The Gene Discovery Project of Johns Hopkins & the Autism Consortium, Weiss, L. A., & Arking, D. E. (2009) · Nature · doi:10.1038/nature08490 · Cited by 619 · see citing works

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

Paşca, S. P., Portmann, T., Voineagu, I., Yazawa, M., Shcheglovitov, A., Paşca, A. M., Cord, B., Palmer, T. D., Chikahisa, S., Nishino, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2576 · Cited by 585 · see citing works

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), Lee, S. H., The International Schizophrenia Consortium (ISC), The Molecular Genetics of Schizophrenia Collaboration (MGS), DeCandia, T. R., Ripke, S., Yang, J., Sullivan, P. F., Goddard, M. E., Keller, M. C., et al. (2012) · Nature Genetics · doi:10.1038/ng.1108 · Cited by 579 · see citing works

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

Espuny-Camacho, I., Michelsen, K. A., Gall, D., Linaro, D., Hasche, A., Bonnefont, J., Bali, C., Orduz, D., Bilheu, A., Herpoel, A., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.011 · Cited by 568 · see citing works

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Study, T. P. O. B. D., Mertens, J., Wang, Q.-W., Kim, Y., Yu, D. X., Pham, S., Yang, B., Zheng, Y., Diffenderfer, K. E., Zhang, J., et al. (2015) · Nature · doi:10.1038/nature15526 · Cited by 562 · see citing works

Synaptic dysregulation in a human iPS cell model of mental disorders

Wen, Z., Nguyen, H. N., Guo, Z., Lalli, M. A., Wang, X., Su, Y., Kim, N.-S., Yoon, K.-J., Shin, J., Zhang, C., et al. (2014) · Nature · doi:10.1038/nature13716 · Cited by 549 · see citing works

Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development

Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D. L., Arnold, C. M., Chen, Y.-J. J., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.005 · Cited by 513 · see citing works

Advances in Autism

Geschwind, D. H. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.053107.121225 · Cited by 512 · see citing works

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

Gonzalez-Burgos, G., Cho, R. Y., & Lewis, D. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.010 · Cited by 497 · see citing works

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

Karayiorgou, M., Simon, T. J., & Gogos, J. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2841 · Cited by 474 · see citing works

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

Shcheglovitov, A., Shcheglovitova, O., Yazawa, M., Portmann, T., Shu, R., Sebastiano, V., Krawisz, A., Froehlich, W., Bernstein, J. A., Hallmayer, J. F., et al. (2013) · Nature · doi:10.1038/nature12618 · Cited by 470 · see citing works

GABA system dysfunction in autism and related disorders: From synapse to symptoms

Coghlan, S., Horder, J., Inkster, B., Méndez, M. A., Murphy, D., & Nutt, D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.005 · Cited by 437 · see citing works

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

Marchetto, M. C. N., Muotri, A. R., Mu, Y., Smith, A. M., Cezar, G. G., & Gage, F. H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.10.001 · Cited by 424 · see citing works

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

Brennand, K., Savas, J. N., Kim, Y., Tran, N., Simone, A. D., Hashimoto‐Torii, K., Beaumont, K. G., Kim, H., Topol, A., Ladran, I., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.22 · Cited by 406 · see citing works

Next-generation regenerative medicine: organogenesis from stem cells in 3D culture.

Sasai, Y. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.009 · Cited by 388 · see citing works

Large-scale genomics unveils the genetic architecture of psychiatric disorders

Gratten, J., Wray, N. R., Keller, M. C., & Visscher, P. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3708 · Cited by 363 · see citing works

Alterations of GABAergic Signaling in Autism Spectrum Disorders

Pizzarelli, R., & Cherubini, E. (2011) · Neural Plasticity · doi:10.1155/2011/297153 · Cited by 323 · see citing works

Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

Swistowski, A., Peng, J., Liu, Q., Mali, P., Rao, M. S., Cheng, L., & Zeng, X. (2010) · Stem Cells · doi:10.1002/stem.499 · Cited by 317 · see citing works

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

Li, X.-J., Zhang, X., Johnson, M. A., Wang, Z.-B., LaVaute, T. M., & Zhang, S. (2009) · Development · doi:10.1242/dev.036624 · Cited by 312 · see citing works

Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia

Bundo, M., Toyoshima, M., Okada, Y., Akamatsu, W., Ueda, J., Nemoto-Miyauchi, T., Sunaga, F., Toritsuka, M., Ikawa, D., Kakita, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.053 · Cited by 301 · see citing works

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

Liu, Y., Liu, H., Sauvey, C., Yao, L., Żarnowska, E. D., & Zhang, S. (2013) · Nature Protocols · doi:10.1038/nprot.2013.106 · Cited by 300 · see citing works

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

Krencik, R., & Zhang, S. (2011) · Nature Protocols · doi:10.1038/nprot.2011.405 · Cited by 300 · see citing works

Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits

Liu, Y., Weick, J. P., Liu, H., Krencik, R., Zhang, X., Ma, L., Zhou, G., Ayala, M., & Zhang, S. (2013) · Nature Biotechnology · doi:10.1038/nbt.2565 · Cited by 276 · see citing works

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

Cheung, A. Y. L., Horvath, L. M., Grafodatskaya, D., Pasceri, P., Weksberg, R., Hotta, A., Carrel, L., & Ellis, J. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr093 · Cited by 271 · see citing works

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

Ricciardi, S., Ungaro, F., Hambrock, M., Rademacher, N., Stefanelli, G., Brambilla, D., Sessa, A., Magagnotti, C., Bachi, A., Giarda, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2566 · Cited by 266 · see citing works

Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells

Yu, D. X., Giorgio, F. P. D., Yao, J., Marchetto, M. C., Brennand, K., Wright, R., Mei, A., McHenry, L. K., Lisuk, D., Grasmick, J. M., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.01.009 · Cited by 264 · see citing works

Differentiation of human oligodendrocytes from pluripotent stem cells

Hu, B., Du, Z., & Zhang, S. (2009) · Nature Protocols · doi:10.1038/nprot.2009.186 · Cited by 260 · see citing works

Glutamatergic theories of schizophrenia.

Javitt, D. C. (2010) · PubMed · Cited by 248 · see citing works

The 15q11.2 BP1–BP2 Microdeletion Syndrome: A Review

Cox, D., & Butler, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16024068 · Cited by 243 · cited 1× · see citing works

Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia.

Javitt, D. (1987) · PubMed · Cited by 240 · see citing works

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

Yoon, K.-J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N.-S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.05.003 · Cited by 240 · see citing works

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

Griesi-Oliveira, K., Acab, A., Gupta, A. R., Sunaga, D. Y., Chailangkarn, T., Nicol, X., Nunez, Y., Walker, M. F., Murdoch, J. D., Sanders, S. J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.141 · Cited by 236 · see citing works

Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients

Robicsek, O., Karry, R., Petit, I., Kesner, N. S., Müller, F.-J., Klein, E., Aberdam, D., & Ben‐Shachar, D. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.67 · Cited by 229 · see citing works

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice

Doherty, J. L., & Owen, M. J. (2014) · Genome Medicine · doi:10.1186/gm546 · Cited by 228 · see citing works

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

Juopperi, T. A., Kim, W. R., Chiang, C.-H., Yu, H., Margolis, R. L., Ross, C. A., Ming, G., & Song, H. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-17 · Cited by 228 · see citing works

A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder

Sachs, N. A., Sawa, A., Holmes, S. E., Ross, C. A., DeLisi, L. E., & Margolis, R. L. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001667 · Cited by 221 · see citing works

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1

Pak, C., Dankó, T., Zhang, Y., Aoto, J. N., Anderson, G. R., Maxeiner, S., Yi, F., Wernig, M., & Südhof, T. C. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.07.017 · Cited by 217 · see citing works

Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model

Ananiev, G. E., Williams, E. C., Li, H.-D., & Chang, Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025255 · Cited by 216 · see citing works

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

Madison, J. M., Zhou, F., Nigam, A., Hussain, A. H., Barker, D., Nehme, R., van der Ven, K., Hsu, J. Y., Wolf, P., Fleishman, M., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.7 · Cited by 174 · see citing works

Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived from a Schizophrenic Patient

Paulsen, B. D. S., Maciel, R. D. M., Galina, A., Silveira, M. S., Souza, C. D. S., Drummond, H., Pozzatto, E. N., Silva, H., Chicaybam, L., Massuda, R., et al. (2011) · Cell Transplantation · doi:10.3727/096368911x600957 · Cited by 162 · see citing works

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder

Bavamian, S., Mellios, N., Lalonde, J., Fass, D. M., Wang, J., Sheridan, S. D., Madison, J. M., Zhou, F., Rueckert, E. H., Barker, D., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.176 · Cited by 162 · see citing works

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

Chen, H. M., DeLong, C. J., Bame, M., Rajapakse, I., Herron, T. J., McInnis, M. G., & O’Shea, K. S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.12 · Cited by 153 · see citing works

Specification of neuronal and glial subtypes from human pluripotent stem cells

Liu, H., & Zhang, S. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0770-y · Cited by 142 · see citing works

DISC1 at 10: connecting psychiatric genetics and neuroscience

Porteous, D. J., Millar, J. K., Brandon, N. J., & Sawa, A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.09.002 · Cited by 137 · see citing works

7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages

Adamo, A., Atashpaz, S., Germain, P.-L., Zanella, M., D'Agostino, G., Albertin, V., Chenoweth, J., Micale, L., Fusco, C., Unger, C., et al. (2015) · Nature Genetics · doi:10.1038/ng.3169 · Cited by 129 · see citing works

Schizophrenia: Overview and Dopamine Dysfunction

Abi-Dargham, A. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13078tx2c · Cited by 128 · see citing works

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Srikanth, P., Han, K., Callahan, D. G., Makovkina, E., Muratore, C., Lalli, M. A., Zhou, H., Boyd, J. D., Kosik, K. S., Selkoe, D. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.061 · Cited by 118 · see citing works

Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders

Hashimoto‐Torii, K., Torii, M., Fujimoto, M., Nakai, A., Fatimy, R. E., Mezger, V., Ju, M. J., Ishii, S., Chao, S.-H., Brennand, K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.002 · Cited by 118 · see citing works

Insights into Cortical Oscillations Arising from Optogenetic Studies

Sohal, V. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.024 · Cited by 113 · see citing works

The Dynamics of Autism Spectrum Disorders: How Neurotoxic Compounds and Neurotransmitters Interact

Quaak, I., Brouns, M. R., & van de Bor, M. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10083384 · Cited by 103 · see citing works

Genome Editing in Human Stem Cells

Byrne, S. M., Mali, P., & Church, G. M. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801185-0.00006-4 · Cited by 96 · see citing works

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

Tian, Y., Voineagu, I., Paşca, S. P., Won, H., Chandran, V., Horvath, S., Dolmetsch, R. E., & Geschwind, D. H. (2014) · Genome Medicine · doi:10.1186/s13073-014-0075-5 · Cited by 93 · see citing works

Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery

Li, H., Zhou, H., Wang, D., Qiu, J., Zhou, Y., Li, X., Rosenfeld, M. G., Ding, S., & Fu, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200305109 · Cited by 85 · see citing works

Analysis of conditional heterozygous STXBP1 mutations in human neurons

Patzke, C., Han, Y., Covy, J. P., Yi, F., Maxeiner, S., Wernig, M., & Südhof, T. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78612 · Cited by 83 · see citing works

A High-Throughput Screen for Wnt/β-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors

Zhao, W., Cheng, C., Theriault, K. M., Sheridan, S. D., Tsai, L., & Haggarty, S. J. (2012) · SLAS DISCOVERY · doi:10.1177/1087057112456876 · Cited by 71 · see citing works

Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes

Gorris, R., Fischer, J., Erwes, K. L., Kesavan, J., Peterson, D. A., Alexander, M., Nöthen, M. M., Peitz, M., Quandel, T., Karus, M., et al. (2015) · Glia · doi:10.1002/glia.22882 · Cited by 64 · see citing works

Modeling neurological diseases using patient-derived induced pluripotent stem cells

Juopperi, T., Song, H.-J., & Ming, G. (2011) · Future Neurology · doi:10.2217/fnl.11.14 · Cited by 41 · see citing works

Directed Differentiation of Dopamine Neurons from Human Pluripotent Stem Cells

Ma, L., Liu, Y., & Zhang, S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-201-4_30 · Cited by 37 · see citing works

Genome engineering of isogenic human ES cells to model autism disorders

Martinez, R. A., Stein, J. L., Krostag, A.-R., Nelson, A. M., Marken, J., Menon, V., May, R., Yao, Z., Kaykas, A., Geschwind, D. H., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv164 · Cited by 18 · see citing works

Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatric disorders

Christian, K. M., Song, H., & Ming, G. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1216-0 · Cited by 6 · see citing works

The use of brain organoids to investigate neural development and disease

Di Lullo, E., & Kriegstein, A. R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.107 · Cited by 788 · see citing works

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

Qian, X., Jacob, F., Song, M. M., Nguyen, H. N., Song, H., & Ming, G. (2018) · Nature Protocols · doi:10.1038/nprot.2017.152 · Cited by 515 · see citing works

Dishing out mini-brains: Current progress and future prospects in brain organoid research

Kelava, I., & Lancaster, M. A. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.06.037 · Cited by 309 · see citing works

The promises and challenges of human brain organoids as models of neuropsychiatric disease

Quadrato, G., Brown, J., & Arlotta, P. (2016) · Nature Medicine · doi:10.1038/nm.4214 · Cited by 304 · see citing works

Using brain organoids to understand Zika virus-induced microcephaly

Qian, X., Nguyen, H. N., Jacob, F., Song, H., & Ming, G. (2017) · Development · doi:10.1242/dev.140707 · Cited by 238 · see citing works

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells

Gunhanlar, N., Shpak, G., van der Kroeg, M., Gouty‐Colomer, L., Munshi, S. T., Lendemeijer, B., Ghazvini, M., Dupont, C., Hoogendijk, W. J. G., Gribnau, J. H., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.56 · Cited by 219 · see citing works

Modeling Neurological Diseases With Human Brain Organoids

Wang, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00015 · Cited by 172 · see citing works

3D Printed Tissue Models: Present and Future

Jang, J., Yi, H., & Cho, D. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00129 · Cited by 163 · see citing works

Untitled work

Ullrich (2018) · doi:10.1038/mp.2017.188 · Cited by 145 · see citing works

Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models

Buchsbaum, I. Y., & Cappello, S. (2019) · Development · doi:10.1242/dev.163766 · Cited by 128 · see citing works

Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

Zhang, S., Zhang, H., Zhou, Y., Qiao, M., Zhao, S., Kozlova, A., Shi, J., Sanders, A. R., Wang, G., Luo, K., et al. (2020) · Science · doi:10.1126/science.aay3983 · Cited by 127 · see citing works

Phosphoinositides: Regulators of Nervous System Function in Health and Disease

Raghu, P., Joseph, A., Krishnan, H., Singh, P. K., & Saha, S. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00208 · Cited by 121 · see citing works

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Forrest, M. P., Zhang, H., Moy, W., McGowan, H., Leites, C., Dionisio, L. E., Xu, Z., Shi, J., Sanders, A. R., Greenleaf, W. J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.008 · Cited by 118 · see citing works

ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications.

Kumar, A., Pareek, V., Faiq, M. A., Ghosh, S. K., & Kumari, C. (2019) · PubMed Central · Cited by 108 · see citing works

Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence

Yoon, K., Vissers, C. B., Ming, G., & Song, H. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201802117 · Cited by 96 · see citing works

Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems

Silva-Pedrosa, R., Salgado, A. J., & Ferreira, P. E. (2023) · Cells · doi:10.3390/cells12060930 · Cited by 84 · see citing works

New insights on synaptic dysfunction in neuropsychiatric disorders

Caldeira, G. L., Peça, J., & Carvalho, A. L. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.004 · Cited by 76 · see citing works

The Role of Brain Microvascular Endothelial Cell and Blood-Brain Barrier Dysfunction in Schizophrenia

Pong, S., Karmacharya, R., Sofman, M., Bishop, J. R., & Lizano, P. L. (2020) · Complex Psychiatry · doi:10.1159/000511552 · Cited by 71 · see citing works

Toward recovery in schizophrenia: Current concepts, findings, and future research directions

Onitsuka, T., Hirano, Y., Nakazawa, T., Ichihashi, K., Miura, K., Inada, K., Mitoma, R., Yasui‐Furukori, N., & Hashimoto, R. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13342 · Cited by 70 · see citing works

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

Iannielli, A., Ugolini, G. S., Cordiglieri, C., Bido, S., Rubio, A., Colasante, G., Valtorta, M., Cabassi, T., Rasponi, M., & Broccoli, V. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.111 · Cited by 61 · see citing works

Modeling neurological disorders using brain organoids

Zhang, D. Y., Song, H., & Ming, G. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.026 · Cited by 52 · see citing works

Development and Application of Brain Region–Specific Organoids for Investigating Psychiatric Disorders

Zhang, Z., Wang, X., Park, S. S., Song, H., & Ming, G. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.12.015 · Cited by 49 · see citing works

From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care

Tanaka, M. (2025) · Biomedicines · doi:10.3390/biomedicines13010167 · Cited by 49 · see citing works

Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia

Bentea, E., DePasquale, E. A. K., O'Donovan, S. M., Sullivan, C. R., Simmons, M. S., Meador‐Woodruff, J. H., Zhou, Y., Xu, C., Bai, B., Peng, J., et al. (2019) · Molecular Omics · doi:10.1039/c8mo00173a · Cited by 46 · see citing works

Understanding the role of steroids in typical and atypical brain development: Advantages of using a “brain in a dish” approach

Adhya, D., Annuario, E., Lancaster, M. A., Price, J., Baron‐Cohen, S., & Srivastava, D. P. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12547 · Cited by 45 · see citing works

Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders

Wang, X., Ye, F., Wen, Z., Guo, Z., Yu, C., Huang, W., Rojas, F., Su, Y., Zheng, W., Zhou, G., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0485-2 · Cited by 42 · see citing works

Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation

Kim, N.-S., Wen, Z., Liu, J., Zhou, Y., Guo, Z., Xu, C., Lin, Y.-T., Yoon, K., Park, J., Cho, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21713-3 · Cited by 41 · see citing works

NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models

Tumdam, R., Hussein, Y., Garin-Shkolnik, T., & Stern, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212366 · Cited by 39 · see citing works

Modeling genetic epilepsies in a dish

Niu, W., & Parent, J. M. (2019) · Developmental Dynamics · doi:10.1002/dvdy.79 · Cited by 38 · see citing works

Microglia in Alzheimer's Disease: A Role for Ion Channels

Thei, L., Imm, J. L., Kaisis, E., Dallas, M. L., & Kerrigan, T. L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00676 · Cited by 37 · see citing works

Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease

Sun, G. G., Wang, C., Mazzarino, R. C., Perez-Corredor, P. A., Davtyan, H., Blurton-Jones, M., Lopera, F., Arboleda-Velasquez, J. F., & Shi, Y. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114982 · Cited by 36 · see citing works

Building the brain from scratch: Engineering region-specific brain organoids from human stem cells to study neural development and disease

Jacob, F., Schnoll, J. G., Song, H., & Ming, G. (2021) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.12.011 · Cited by 33 · see citing works

Opportunities and limitations for studying neuropsychiatric disorders using patient-derived induced pluripotent stem cells

Hong, Y., Yang, Q., Song, H., & Ming, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01990-8 · Cited by 32 · see citing works

Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice

Lim, C., Kim, M. J., Choi, J. E., Islam, M. A., Lee, Y.-K., Xiong, Y., Shim, K.-W., Yang, J.-E., Lee, R. U., Lee, J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01216-9 · Cited by 32 · see citing works

Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease

Brown, J. R., Quadrato, G., & Arlotta, P. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.03.002 · Cited by 31 · see citing works

Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics

Fantuzzo, J. A., Hart, R. P., Zahn, J. D., & Pang, Z. P. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24665 · Cited by 31 · see citing works

Roles of Microglial Ion Channel in Neurodegenerative Diseases

Cojocaru, A., Burada, E., Bălșeanu, A.-T., Deftu, A., Cătălin, B., Popa‐Wagner, A., & Osiac, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061239 · Cited by 28 · see citing works

Loss of function of OTUD7A in the schizophrenia- associated 15q13.3 deletion impairs synapse development and function in human neurons

Kozlova, A., Zhang, S., Kotlar, A., Jamison, B., Zhang, H., Shi, S. Q. Z., Forrest, M. P., McDaid, J., Cutler, D. J., Epstein, M. P., et al. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2022.07.001 · Cited by 24 · see citing works

Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia

Yamamoto, K., Kuriu, T., Matsumura, K., Nagayasu, K., Tsurusaki, Y., Miyake, N., Yamamori, H., Yasuda, Y., Fujimoto, M., Fujiwara, M., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01676-1 · Cited by 22 · see citing works

Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model

Zhang, S., Moy, W., Zhang, H., Leites, C., McGowan, H., Shi, J., Sanders, A. R., Pang, Z. P., Gejman, P. V., & Duan, J. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.03.014 · Cited by 21 · see citing works

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming

Bellon, A., Wegener, A., Lescallette, A. R., Valente, M., Yang, S., Gardette, R., Matricon, J., Mouaffak, F., Watts, P. J., Vimeux, L., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00323 · Cited by 21 · see citing works

Mechanisms of copy number variants in neuropsychiatric disorders: From genes to therapeutics

Forrest, M. P., & Penzes, P. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102750 · Cited by 18 · see citing works

Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification

Deng, W., Cao, X., Wang, Y., Yu, Q., Zhang, Z., Qu, R., Chen, J., Shao, G., Gao, X., Xu, X., et al. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05661 · Cited by 17 · see citing works

Neuronal Differentiation of Induced Pluripotent Stem Cells from Schizophrenia Patients in Two-Dimensional and in Three-Dimensional Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity

Naujock, M., Speidel, A., Fischer, S. E., Kizner, V., Dorner‐Ciossek, C., & Gillardon, F. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0082 · Cited by 17 · see citing works

Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs

Zhang, H., McCarroll, A., Peyton, L., de León‐Guerrero, S. D., Zhang, S., Gowda, P., Sirkin, D., ElAchwah, M., Duhe, A., Wood, W., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.08.003 · Cited by 15 · see citing works

Modeling neurodevelopmental and psychiatric diseases with human iPSCs

Wen, Z. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24031 · Cited by 15 · see citing works

Making Sense of Patient-Derived iPSCs, Transdifferentiated Neurons, Olfactory Neuronal Cells, and Cerebral Organoids as Models for Psychiatric Disorders

Unterholzner, J., Millischer, V., Wotawa, C., Sawa, A., & Lanzenberger, R. R. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab037 · Cited by 15 · see citing works

Neural Stem Cell Dysfunction in Human Brain Disorders

Liszewska, E., & Jaworski, J. (2018) · Results and problems in cell differentiation · doi:10.1007/978-3-319-93485-3_13 · Cited by 14 · see citing works

Evaluating Translational Methods for Personalized Medicine—A Scoping Review

Fosse, V., Oldoni, E., Gerardi, C., Banzi, R., Fratelli, M., Biétrix, F., Ussi, A. E., Andreu, A. L., McCormack, E., & the PERMIT Group (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071177 · Cited by 13 · see citing works

The research domain criteria framework in drug discovery for neuropsychiatric diseases: focus on negative valence

Nicholson, J. R., & Sommer, B. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818804030 · Cited by 13 · see citing works

Comparing stem cells, transdifferentiation and brain organoids as tools for psychiatric research

Bellon, A. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02780-8 · Cited by 12 · see citing works

Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models

Kaindl, J., & Winner, B. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_111 · Cited by 12 · see citing works

Electrophysiological properties of neurons derived from human stem cells and iNeurons in vitro

Halliwell, R. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.003 · Cited by 11 · see citing works

Does obesity and diabetes mellitus metastasize to the brain? “Metaboptosis” and implications for drug discovery and development

McIntyre, R. S., Rong, C., Mansur, R. B., & Brietzke, E. M. (2019) · CNS Spectrums · doi:10.1017/s1092852918001670 · Cited by 11 · see citing works

Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells

Muhtaseb, A. W., & Duan, J. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.04.003 · Cited by 11 · see citing works

Modeling schizophrenia with iPS cell technology and disease mouse models

Nakazawa, T. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.08.002 · Cited by 8 · see citing works

From Schizophrenia Genetics to Disease Biology: Harnessing New Concepts and Technologies

Duan, J., Sanders, A. R., & Gejman, P. V. (2019) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20190014 · Cited by 8 · see citing works

Optimization of Neurite Tracing and Further Characterization of Human Monocyte-Derived-Neuronal-like Cells

Bellon, A., Hasoğlu, T., Peterson, M. R., Gao, K., Chen, M., Blandin, E., Cortez-Resendiz, A., Clawson, G. A., & Hong, L. E. (2021) · Brain Sciences · doi:10.3390/brainsci11111372 · Cited by 7 · see citing works

Modeling Psychiatric Diseases with Induced Pluripotent Stem Cells

van Hugte, E., & Kasri, N. N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9721-0_15 · Cited by 6 · see citing works

A Comprehensive Review on Preclinical Alzheimer's Disease Models: Evaluating their Clinical Relevance

Kushwaha, V., & Sahu, K. K. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010331845240802073645 · Cited by 5 · see citing works

Stem Cell Technology for (Epi)genetic Brain Disorders

Riemens, R. J. M., Soares, E. S., Esteller, M., & Delgado‐Morales, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_23 · Cited by 5 · see citing works

Psychiatric Drug Discovery and Development

Shahid, M., Neill, J. C., & Hutchison, J. B. (2020) · Cambridge University Press eBooks · doi:10.1017/9781911623465.004 · Cited by 5 · see citing works

Structural Analysis of Cerebral Organoids Using Confocal Microscopy and Transmission/Scanning Electron Microscopy

Noh, S., Park, Y., Kim, B., & Mun, J. Y. (2025) · Microscopy and Microanalysis · doi:10.1093/mam/ozae119 · Cited by 4 · see citing works

Copy Number Variants: Deletion and Duplication Syndromes

Harner, M. K., Bishop, D. V., Pollak, R. M., Purcell, R. H., & Mullé, J. G. (2025) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-121222-120601 · Cited by 4 · see citing works

Dimethyltryptamine (DMT) and ibogaine elicit membrane effects in HEK cells transiently transfected with the human 5-HT2A receptor

Eliasen, J. N., Kristiansen, U., & Kohlmeier, K. A. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149425 · Cited by 2 · see citing works

Functional Analysis of Antipsychotics in Human iPSC-Based Neural Progenitor 2D and 3D Schizophrenia Models

Farkas, K. G., Vincze, K., Tordai, C., Özgen, E. İ., Gürler, D., Deli, V., Lilienberg, J., Erdei, Z., Sarkadi, B., Réthelyi, J., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094444 · Cited by 2 · see citing works

Brain-on-a chip technologies for investigating neuronal diseases: Toward precision medicine applications

Frega, M., Mossink, B., Linda, K., Keller, J., Schubert, D., & Kasri, N. N. (2018) · IEEE International Symposium on Circuits and Systems proceedings · doi:10.1109/iscas.2018.8351848 · Cited by 2 · see citing works

GABAergic neuron dysregulation in a human neurodevelopmental model for major psychiatric disordersPreprint

Guo, Z., Su, Y., Huang, W., Yao, X. S., Hong, Y., Gordin-Kivity, A., Nguyen, H. N., Wen, Z., Rojas, F., Gong, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614564 · Cited by 2 · see citing works

Drug Discovery in Induced Pluripotent Stem Cell Models

Bourque, K., Mnasri, N., Jones-Tabah, J., Martins-Cannavino, K., & Hébert, T. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00049-9 · Cited by 1 · see citing works

Optimizing the in vitro neuronal microenvironment to mitigate phototoxicity in live-cell imaging

Hoffmann, C. R., Maksour, S., Clarke, J. E., Daniszewski, M., Houghton, F. J., Wang, J., Pébay, A., Gleeson, P. A., Dottori, M., Cho, H., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04591-0 · Cited by 1 · see citing works

Advances in hiPSC ‐Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's Disease

Maciel, E. M. A., Silva, N. C., Santos, L. G. P., & Ribeiro, F. M. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70416 · Cited by 1 · see citing works

Chromatin modification and remodeling in schizophrenia

Duan, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813796-3.00014-6 · Cited by 1 · see citing works

Non-Animal Models in Experimental Subarachnoid Hemorrhage Research: Potentials and the Dilemma of the Translation from Bench to Bedside

Karadağ, C., Gopalakrishnan, J., von Saß, C., Cornelius, J. F., Hänggi, D., van Lieshout, J. H., & Kamp, M. A. (2021) · Translational Stroke Research · doi:10.1007/s12975-021-00950-0 · Cited by 1 · see citing works

Cell adhesion molecules play subclass-specific roles in electrophysiological response and Schizophrenia riskPreprint

Li, X., Hu, H., Johansen, N., & Quon, G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.11.516161 · Cited by 1 · see citing works

Estabelecimento de neurônios serotoninérgicos e organoides cerebrais como modelos in vitro para o estudo do Transtorno Depressivo Maior

Silva, Y. R. D. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2019.tde-10012019-111750

Deciphering the Systems Architecture of the Brain Using Molecular Can Openers

Nathan, N. H., Pernia, C. D., Tobe, B. T. D., Goshima, Y., Haggarty, S. J., Sidman, R. L., & Snyder, E. Y. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-812034-7.00017-0

Genetics of autism spectrum disorders

Gupta, A. R., Fernandez, T. V., & Hoffman, E. J. (2020) · doi:10.1093/med/9780198713005.003.0028

Use of induced pluripotent stem cells and cerebral organoids to profile Zika virus infection: Features and findings

Majolo, F., Marinowic, D. R., Azevedo, P. N., da Silva, G. L., Machado, D. C., & DaCosta, J. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820267-8.00008-x

Faculty Opinions recommendation of Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Kroll, K. L., & Antony, I. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.728639315.793576986

Induced pluripotent stem cells in autism research: a review of current advances and future directions

Ariaei, A., Ketabforoush, A. H. M. E., Bordbar, S., Barati, S., Lotfi, A., Sayahpour, F. A., Faghihi, F., & Abediankenari, S. (2026) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-026-00850-8

Organoid-based models in cerebrovascular disorders: Mechanistic insights and precision medicine

Zhang, J., Zhang, Y., Yu, M., Miao, C., & Sun, H. (2026) · Vascular Pharmacology · doi:10.1016/j.vph.2026.107688

Patient-derived stem cell models of brain endothelial-neuron interactions in early course psychosis

Altunsu, D., Demirlek, C., Nicholson, J., Stiltner, B., Trotti, R. L., Raymond, N., Lee, Y., Rahman, R., Stone, W. S., Karmacharya, R., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1873300

Circuit mechanisms of psychotic symptoms across disorders

Braun, U., Wolf, J., Hirjak, D., Schwarz, E., Tost, H., & Meyer‐Lindenberg, A. (2026) · Neuron · doi:10.1016/j.neuron.2026.09.011

Impacts of different SETD1A mutations and genetic backgrounds on human induced pluripotent stem cell-derived hippocampal neuronsPreprint

Hong, Y., Zhao, T., Yang, Q., Zhang, H., Ma, X., Su, X., Liu, J., Zhang, S., Mendez-Maldonado, K., Zhou, Y., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.07.756381

Synaptic microRNA dysregulation orchestrates aberrant glutamatergic transmission in a human neuronal model of 22q11.2 deletion syndromePreprint

Niu, W., Guo, J., Ran, X., Parker, D., Li, X., Yu, S., Imes, S., Purcell, R. H., Michalski, C., Guo, E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.13.758925

Modeling neuropsychiatric disorders using human induced pluripotent stem cells

Wang, M., Zhang, L., & Gage, F. H. (2019) · Protein & Cell · doi:10.1007/s13238-019-0638-8 · Cited by 75 · see citing works

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Wen, Z. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24031 · Cited by 15 · see citing works

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Ross, P. J., & Ellis, J. (2010) · F1000 Biology Reports · doi:10.3410/b2-84 · Cited by 11 · see citing works