Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus
Open accessAbstract
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
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Activation of PV+ interneurons promotes new neuron cell survival while suppression of PV+ interneuron activity reduces new neuron cell survival.
“Since activation of PV+ interneurons has been shown to promote new neuron cell survival while suppression of PV+ interneuron activity reduces new neuron cell survival (Song et al., 2013)”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Song et al., 2013
Adult-generated neurons form connections with PV+ inhibitory interneurons.
“Additionally, adult-generated neurons also form connections with PV+ inhibitory interneurons (38; 39).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [38]
Interneurons modulate neuronal circuitry controlling hippocampal neurogenesis and the activity of new neurons in vivo.
“Immature neurons project to interneurons in the DG and reports have documented the role of interneurons in modulating neuronal circuitry controlling hippocampal neurogenesis, as well as the activity of new neurons in vivo (38;39).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [38]
Immature neurons project to interneurons in the dentate gyrus.
“Immature neurons project to interneurons in the DG and reports have documented the role of interneurons in modulating neuronal circuitry controlling hippocampal neurogenesis, as well as the activity of new neurons in vivo (38;39).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [38]
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- Authors
- Song, J., Sun, J., Moss, J., Wen, Z., Sun, G. J., Hsu, D., Zhong, C., Davoudi, H., Christian, K. M., Toni, N., Ming, G.-L., & Song, H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Johns Hopkins University (US)
- University of Lausanne (CH)
- Corresponding author
- Toni, Nicolas
- Ming, Guo-li
- Song, Hongjun
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2013-11-10
- Volume
- 16
- Issue
- 12
- Pages
- 1728-1730
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4096812
- OpenAlex
- W2057386575
- Cited by
- 223
- References
- 30
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 10 · 2023: 17 · 2022: 17 · 2021: 14 · 2020: 19 · 2019: 25 · 2018: 19 · 2017: 19 · 2016: 21 · 2015: 27 · 2014: 16
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- UNC Libraries
- Funders
- National Science Foundation
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- National Alliance for Research on Schizophrenia and Depression (NS047344, NS048271)
- Maryland Stem Cell Research Fund (NS048271)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (119026)
- Fondation Leenaards
- National Institutes of Health (NS048271, NS047344)
- National Institute on Aging (R01AG024984)
- National Institute of Mental Health (R21MH087874, R33MH087874, P20MH084018)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R37NS047344, R56NS047344)
- National Institute of Environmental Health Sciences (R21ES021957, ES021957)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD069184, HD069184)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- parvalbumin interneurons, adult hippocampal neurogenesis, neural progenitor cells, newborn neuron survival, neuronal maturation, neural stem cell quiescence, optogenetic stimulation
- MeSH terms
- Doublecortin Domain Proteins, Animals, Animals, Newborn, Cell Survival, Hippocampus, Interneurons, Luminescent Proteins, Membrane Proteins, Mice, Inbred C57BL, Microtubule-Associated Proteins, Nerve Net, Nerve Tissue Proteins, Neuropeptides, Phenylurea Compounds, Phosphoproteins, Transduction, Genetic, Mice, Adult Stem Cells, Neurogenesis
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