Porter, Nicholas J.

Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

Hai, Y., Shinsky, S. A., Porter, N. J., & Christianson, D. W. (2017) · Nature Communications

Polyamine Metabolism and ApplicationsHistone Deacetylase Inhibitors Research

Cited by 200

Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors

Porter, N. J., Mahendran, A., Breslow, R., & Christianson, D. W. (2017) · Proceedings of the National Academy of Sciences

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 190

Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases

Porter, N. J., & Christianson, D. W. (2019) · Current Opinion in Structural Biology

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 146

Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity

Porter, N. J., Osko, J. D., Diedrich, D., Kurz, T., Hooker, J. M., Hansen, F. K., & Christianson, D. W. (2018) · Journal of Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 111

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

Vögerl, K., Ong, N., Senger, J., Herp, D., Schmidtkunz, K., Marek, M., Müller, M., Bartel, K., Shaik, T. B., Porter, N. J., et al. (2019) · Journal of Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchPhenothiazines and Benzothiazines Synthesis and Activities

Cited by 104

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6

Porter, N. J., Wagner, F. F., & Christianson, D. W. (2018) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 64

A combinatorially complete epistatic fitness landscape in an enzyme active site

Johnston, K. E., Almhjell, P. J., Watkins-Dulaney, E. J., Liu, G., Porter, N. J., Yang, J., & Arnold, F. H. (2024) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsEnzyme Catalysis and Immobilization

Cited by 44

A combinatorially complete epistatic fitness landscape in an enzyme active site

Johnston, K. E., Almhjell, P. J., Watkins-Dulaney, E. J., Liu, G., Porter, N. J., Yang, J., & Arnold, F. H. (2024) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsEnzyme Catalysis and Immobilization

Cited by 44

Structural and Functional Influence of the Glycine-Rich Loop G 302 GGGY on the Catalytic Tyrosine of Histone Deacetylase 8

Porter, N. J., Christianson, N. H., Decroos, C., & Christianson, D. W. (2016) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 33