Mizushima, Noboru

The autophagy gene ATG5 plays an essential role in B lymphocyte development

Miller, B. C., Zhao, Z., Stephenson, L. M., Cadwell, K., Pua, H. H., Lee, H. K., Mizushima, N., Iwasaki, A., He, Y.-W., Swat, W., et al. (2008) · Autophagy

Autophagy in Disease and TherapyT-cell and B-cell Immunology

Cited by 352

Autophagy-monitoring and autophagy-deficient mice

Kuma, A., Komatsu, M., & Mizushima, N. (2017) · Autophagy

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 336

Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)

Koike, M., Shibata, M., Waguri, S., Yoshimura, K., Tanida, I., Kominami, E., Gotow, T., Peters, C., von Figura, K., Mizushima, N., et al. (2005) · The American Journal of Pathology

Lysosomal Storage Disorders ResearchAutophagy in Disease and Therapy

Cited by 330

Induction of Autophagy in Axonal Dystrophy and Degeneration

Wang, Q. J., Ding, Y., Kohtz, S., Mizushima, N., Cristea, I. M., Rout, M. P., Chait, B. T., Zhong, Y., Heintz, N., & Yue, Z. (2006) · The Journal of Neuroscience

Autophagy in Disease and TherapyNeuroinflammation and Neurodegeneration Mechanisms

Cited by 308

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

Maeda, S., Yamamoto, H., Kinch, L. N., Garza, C. M., Takahashi, S., Otomo, C., Grishin, N. V., Forli, S., Mizushima, N., & Otomo, T. (2020) · Nature Structural & Molecular Biology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 305

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

Itakura, E., Kishi-Itakura, C., Koyama-Honda, I., & Mizushima, N. (2012) · Journal of Cell Science

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 286

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

Liu, S., Hartleben, B., Kretz, O., Wiech, T., Igarashi, P., Mizushima, N., Walz, G., & Huber, T. B. (2012) · Autophagy

Autophagy in Disease and TherapyAcute Kidney Injury Research

Cited by 271

Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells

Asano, T., Komatsu, M., Yamaguchi-Iwai, Y., Ishikawa, F., Mizushima, N., & Iwai, K. (2011) · Molecular and Cellular Biology

Iron Metabolism and DisordersAutophagy in Disease and Therapy

Cited by 265

Intracellular Inclusions Containing Mutant α1-Antitrypsin Z Are Propagated in the Absence of Autophagic Activity

Kamimoto, T., Shoji, S., Hidvegi, T., Mizushima, N., Umebayashi, K., Perlmutter, D. H., & Yoshimori, T. (2006) · Journal of Biological Chemistry

Autophagy in Disease and TherapyLiver physiology and pathology

Cited by 259

Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism.

Kuma, A., & Mizushima, N. (2010) · Seminars in Cell & Developmental Biology

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 237

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H.-C., Ikeda, K., Kanegae, Y., et al. (2019) · Nature Communications

Autophagy in Disease and TherapyPeroxisome Proliferator-Activated Receptors

Cited by 193

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

DeVorkin, L., Pavey, N., Carleton, G., Comber, A., Ho, C., Lim, J., McNamara, E., Huang, H., Kim, P., Zacharias, L. G., et al. (2019) · Cell Reports

Autophagy in Disease and TherapyT-cell and B-cell Immunology

Cited by 185

Aberrant Membranes and Double-Membrane Structures Accumulate in the Axons of Atg5-Null Purkinje Cells before Neuronal Death

Nishiyama, J., Miura, E., Mizushima, N., Watanabe, M., & Yuzaki, M. (2007) · Autophagy

Autophagy in Disease and TherapyGenetic Neurodegenerative Diseases

Cited by 159

The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis

Zhao, Y. G., Sun, L., Miao, G., Ji, C., Zhao, H., Sun, H., Miao, L., Yoshii, S. R., Mizushima, N., Wang, X., et al. (2015) · Autophagy

Autophagy in Disease and TherapyNeurological diseases and metabolism

Cited by 148

SKD1 AAA ATPase-Dependent Endosomal Transport is Involved in Autolysosome Formation.

Nara, A., Mizushima, N., Yamamoto, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2002) · Cell Structure and Function

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 144

Deletion of Autophagy-related 5 (Atg5) and Pik3c3 Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation

Morishita, H., Eguchi, S., Kimura, H., Sasaki, J., Sakamaki, Y., Robinson, M. L., Sasaki, T., & Mizushima, N. (2013) · Journal of Biological Chemistry

Autophagy in Disease and TherapyConnexins and lens biology

Cited by 141

Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons

Yoshii, S. R., Kuma, A., Akashi, T., Hara, T., Yamamoto, A., Kurikawa, Y., Itakura, E., Tsukamoto, S., Shitara, H., Eishi, Y., et al. (2016) · Developmental Cell

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 127

Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

King, M. A., Hands, S., Hafiz, F., Mizushima, N., Tolkovsky, A. M., & Wyttenbach, A. (2008) · Molecular Pharmacology

Genetic Neurodegenerative DiseasesAutophagy in Disease and Therapy

Cited by 120

Organelle degradation in the lens by PLAAT phospholipases

Morishita, H., Eguchi, T., Tsukamoto, S., Sakamaki, Y., Takahashi, S., Saito, C., Koyama-Honda, I., & Mizushima, N. (2021) · Nature

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 111

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

Wang, C., Chen, S., Yeo, S., Karsli-Uzunbas, G., White, E., Mizushima, N., Virgin, H. W., & Guan, J.-L. (2016) · Journal of Cell Biology

Autophagy in Disease and TherapyNeurogenesis and neuroplasticity mechanisms

Cited by 69

Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates

Yang, Z., Yoshii, S. R., Sakai, Y., Zhang, J., Chino, H., Knorr, R. L., & Mizushima, N. (2024) · The EMBO Journal

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 47

The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

Hama, Y., Fujioka, Y., Yamamoto, H., Mizushima, N., & Noda, N. N. (2025) · eLife

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 10

The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

Hama, Y., Fujioka, Y., Yamamoto, H., Mizushima, N., & Noda, N. N. (2025) · eLife

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 5