Mizushima, Noboru

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 1,361

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004) · Nature Cell Biology

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 1,358

Autophagy-deficient mice develop multiple liver tumors

Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino, O., Tanaka, K., & Mizushima, N. (2011) · Genes & Development

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 1,342

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 1,176

Autophagy in Human Diseases

Mizushima, N., & Levine, B. (2020) · New England Journal of Medicine

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 1,140

Monitoring and Measuring Autophagy

Yoshii, S. R., & Mizushima, N. (2017) · International Journal of Molecular Sciences

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 1,107

The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, N. (2010) · Current Opinion in Cell Biology

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 1,062

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 1,002

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

Itakura, E., & Mizushima, N. (2010) · Autophagy

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 843

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 791

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

Hartleben, B., Gödel, M., Meyer-Schwesinger, C., Liu, S., Ulrich, T., Köbler, S., Wiech, T., Grahammer, F., Arnold, S. J., Lindenmeyer, M. T., et al. (2010) · Journal of Clinical Investigation

Renal Diseases and GlomerulopathiesAutophagy in Disease and Therapy

Cited by 721

A brief history of autophagy from cell biology to physiology and disease

Mizushima, N. (2018) · Nature Cell Biology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 696

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

Katayama, H., Kogure, T., Mizushima, N., Yoshimori, T., & Miyawaki, A. (2011) · Chemistry & Biology

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 650

A critical role for the autophagy gene Atg5 in T cell survival and proliferation

Pua, H. H., Dzhagalov, I., Chuck, M., Mizushima, N., & He, Y.-W. (2007) · The Journal of Experimental Medicine

Autophagy in Disease and TherapyT-cell and B-cell Immunology

Cited by 622

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

Yoshii, S. R., Kishi, C., Ishihara, N., & Mizushima, N. (2011) · Journal of Biological Chemistry

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 612

LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 Localization

Kuma, A., Matsui, M., & Mizushima, N. (2007) · Autophagy

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 555

In vivo requirement for Atg5 in antigen presentation by dendritic cells

Lee, H. K., Mattei, L. M., Steinberg, B. E., Alberts, P., Lee, Y. H., Chervonsky, A., Mizushima, N., Grinstein, S., & Iwasaki, A. (2010) · Immunity

Autophagy in Disease and TherapyImmunotherapy and Immune Responses

Cited by 506

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

Jiang, P., Nishimura, T., Sakamaki, Y., Itakura, E., Hatta, T., Natsume, T., & Mizushima, N. (2014) · Molecular Biology of the Cell

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 501

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

Tsuboyama, K., Koyama-Honda, I., Sakamaki, Y., Koike, M., Morishita, H., & Mizushima, N. (2016) · Science

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 485

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

Saitsu, H., Nishimura, T., Muramatsu, K., Kodera, H., Kumada, S., Sugai, K., Kasai-Yoshida, E., Sawaura, N., Nishida, H., Hoshino, A., et al. (2013) · Nature Genetics

Neurological diseases and metabolismAutophagy in Disease and Therapy

Cited by 474

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., & Yuan, J. (2006) · Journal of Biological Chemistry

Genetic Neurodegenerative DiseasesAutophagy in Disease and Therapy

Cited by 458

Inhibition of autophagy in the heart induces age-related cardiomyopathy

Taneike, M., Yamaguchi, O., Nakai, A., Hikoso, S., Takeda, T., Mizote, I., Oka, T., Tamai, T., Oyabu, J., Murakawa, T., et al. (2010) · Autophagy

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 450

Diverse Cellular Roles of Autophagy

Morishita, H., & Mizushima, N. (2019) · Annual Review of Cell and Developmental Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 376

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.

Raben, N., Hill, V., Shea, L., Takikita, S., Baum, R., Mizushima, N., Ralston, E., & Plotz, P. (2008) · Human Molecular Genetics

Lysosomal Storage Disorders ResearchAutophagy in Disease and Therapy

Cited by 352