Mercola, Mark

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

Sharma, A., Burridge, P. W., McKeithan, W. L., Serrano, R., Shukla, P., Sayed, N., Churko, J. M., Kitani, T., Wu, H., Holmström, A., et al. (2017) · Science Translational Medicine

Chemotherapy-induced cardiotoxicity and mitigationPluripotent Stem Cells Research

Cited by 404

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes

Feyen, D. A. M., McKeithan, W. L., Bruyneel, A. A. N., Spiering, S., Hörmann, L., Ulmer, B., Zhang, H., Briganti, F., Schweizer, M., Hegyi, B., et al. (2020) · Cell Reports

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 400

Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex

Foley, A. C., & Mercola, M. (2005) · Genes & Development

Congenital heart defects researchDevelopmental Biology and Gene Regulation

Cited by 195

Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus

Mercola, M., Wang, X.-F., Olsen, J., & Calame, K. (1983) · Science

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 152

miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway

Diez-Cuñado, M., Wei, K., Bushway, P. J., Maurya, M. R., Perera, R., Subramaniam, S., Ruiz-Lozano, P., & Mercola, M. (2018) · Cell Reports

Congenital heart defects researchHippo pathway signaling and YAP/TAZ

Cited by 102

Repurposing drugs to treat cardiovascular disease in the era of precision medicine

Abdelsayed, M., Kort, E. J., Jovinge, S., & Mercola, M. (2022) · Nature Reviews Cardiology

Computational Drug Discovery MethodsHistorical Medical Research and Treatments

Cited by 93

iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy

Briganti, F., Sun, H., Wei, W., Wu, J., Zhu, C., Liss, M., Karakikes, I., Rego, S., Cipriano, A., Snyder, M., et al. (2020) · Cell Reports

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 68

Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

McKeithan, W. L., Feyen, D. A. M., Bruyneel, A. A. N., Okolotowicz, K. J., Ryan, D. A., Sampson, K. J., Potet, F., Savchenko, A., Gómez-Galeno, J., Vu, M., et al. (2020) · Cell stem cell

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

Cited by 50

Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes

Cashman, J. R., Ryan, D., McKeithan, W. L., Okolotowicz, K., Gomez-Galeno, J., Johnson, M., Sampson, K. J., Kass, R. S., Pezhouman, A., Karagueuzian, H. S., et al. (2021) · Journal of Medicinal Chemistry

Cardiac electrophysiology and arrhythmiasIon channel regulation and function

Cited by 11