Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

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A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

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Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

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A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

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In vivo sequence requirements of the SV40 early promoter region

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The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

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The role of gene dosage and genetic transpositions in carcinogenesis

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Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

Payne, G. S., Bishop, J. M., & VARMUS, H. E. (1982) · Nature · doi:10.1038/295209a0 · Cited by 625 · see citing works

Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.

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Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas

Stanton, L. W., Watt, R. A., & Marcu, K. B. (1983) · Nature · doi:10.1038/303401a0 · Cited by 455 · see citing works

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P., & Cole, M. D. (1982) · Cell · doi:10.1016/0092-8674(82)90137-4 · Cited by 454 · see citing works

Simian virus 40 tandem repeated sequences as an element of the early promoter.

Gruss, P., Dhar, R., & Khoury, G. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.943 · Cited by 432 · see citing works

Immunoglobulin Genes

Honjo, T. (1983) · Annual Review of Immunology · doi:10.1146/annurev.iy.01.040183.002435 · Cited by 345 · see citing works

Transcriptional activation of the translocated c- myc oncogene in Burkitt lymphoma

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A small segment of polyoma virus DNA enhances the expression of a cloned β-globin gene over a distance of 1400 base pairs

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Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus

Levinson, B., Khoury, G., Woude, G. V., & Gruß, P. (1982) · Nature · doi:10.1038/295568a0 · Cited by 255 · see citing works

Activation of the Transforming Potential of a Normal Cell Sequence: A Molecular Model for Oncogenesis

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Transcriptionally active c- myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia

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Mouse c-myc Oncogene Is Located on Chromosome 15 and Translocated to Chromosome 12 in Plasmacytomas

Crews, S. T., Barth, R., Hood, L., Prehn, J., & Calame, K. L. (1982) · Science · doi:10.1126/science.7146913 · Cited by 194 · see citing works

Differences in human α-, β- and δ-globin gene expression in monkey kidney cells

Humphries, R. K. (1982) · Cell · doi:10.1016/0092-8674(82)90023-x · Cited by 172 · see citing works

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

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Transcription of mouse kappa chain genes: implications for allelic exclusion.

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Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors.

Adams, J. M., Gerondakis, S., Webb, E., Mitchell, J. A., Bernard, O., & Cory, S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.22.6966 · Cited by 119 · see citing works

Transcriptional regulation of immunoglobulin V genes

Mather, E. L., & Perry, R. P. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.24.6855 · Cited by 75 · see citing works

Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas.

Zúñiga, M. C., D’Eustachio, P., & Ruddle, N. H. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.9.3015 · Cited by 60 · see citing works

An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development

Clarke, C. F., Berenson, J. R., Goverman, J. M., Boyer, P. D., Crews, S. T., Siu, G., & Calame, K. L. (1982) · Nucleic Acids Research · doi:10.1093/nar/10.23.7731 · Cited by 51 · see citing works

Isolation of cellular DNA sequences that allow expression of adjacent genes.

Fried, M., Griffiths, M., Davies, B., Bjursell, G., Mantia, G. L., & Lania, L. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.8.2117 · Cited by 48 · see citing works

Transformation by Cloned Harvey Murine Sarcoma Virus DNA: Efficiency Increased by Long Terminal Repeat DNA

Chang, E. H., Ellis, R. W., Scolnick, E. M., & Lowy, D. R. (1980) · Science · doi:10.1126/science.6254153 · Cited by 45 · see citing works

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754 · see citing works

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

Tsujimoto, Y., Finger, L. R., Yunis, J. J., Nowell̀, P. C., & Croce, C. M. (1984) · Science · doi:10.1126/science.6093263 · Cited by 1,769 · see citing works

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

Potter, H., Weir, L., & Leder, P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.22.7161 · Cited by 866 · see citing works

Translocations Among Antibody Genes in Human Cancer

Leder, P., Battey, J., Lenoir, G., Moulding, C. T., Murphy, W., Potter, H., Stewart, T. A., & Taub, R. A. (1983) · Science · doi:10.1126/science.6356357 · Cited by 712 · see citing works

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

Yancopoulos, G. D. (1985) · Cell · doi:10.1016/0092-8674(85)90141-2 · Cited by 696 · see citing works

Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation

Tsujimoto, Y., Yunis, J. J., Onorato-Showe, L., Erikson, J., Nowell̀, P. C., & Croce, C. M. (1984) · Science · doi:10.1126/science.6610211 · Cited by 650 · see citing works

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

Weiss, A., Imboden, J. B., Hardy, K. J., Manger, B., Terhorst, C., & Stobo, J. D. (1986) · Annual Review of Immunology · doi:10.1146/annurev.iy.04.040186.003113 · Cited by 621 · see citing works

Transcriptional Enhancers in Animal Development and Evolution

Levine, M. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.070 · Cited by 449 · see citing works

Towards a comprehensive catalogue of validated and target-linked human enhancers

Gasperini, M., Tome, J. M., & Shendure, J. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0209-0 · Cited by 396 · see citing works

Comparison of Intron-Dependent and Intron-Independent Gene Expression

Buchman, A. R., & Berg, P. R. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.10.4395-4405.1988 · Cited by 370 · see citing works

Transcriptionally active chromatin

Reeves, R. (1984) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(84)90044-7 · Cited by 348 · see citing works

Regulation of disease-associated gene expression in the 3D genome

Krijger, P. H. L., & de Laat, W. L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.138 · Cited by 316 · see citing works

Enhancer biology and enhanceropathies

Smith, E. R., & Shilatifard, A. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2784 · Cited by 310 · see citing works

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

Reth, M. G., & Alt, F. W. (1984) · Nature · doi:10.1038/312418a0 · Cited by 255 · see citing works

Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells

Linney, E. A., Davis, B. R., Overhauser, J., Chao, E., & Fan, H. (1984) · Nature · doi:10.1038/308470a0 · Cited by 241 · see citing works

Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

Mercola, M. A., Goverman, J. M., Mirell, C. J., & Calame, K. L. (1985) · Science · doi:10.1126/science.3917575 · Cited by 240 · see citing works

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

Atchison, M. L., & Perry, R. P. (1987) · Cell · doi:10.1016/0092-8674(87)90362-x · Cited by 232 · see citing works

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

Serwe, M., & Sablitzky, F. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05886.x · Cited by 217 · see citing works

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

Ferrier, P., Krippl, B., Blackwell, T. K., Furley, A. J., Suh, H., Winoto, A., Cook, W. D., Hood, L., Costantini, F. D., & Alt, F. W. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08087.x · Cited by 215 · see citing works

Super-enhancers include classical enhancers and facilitators to fully activate gene expression

Blayney, J. W., Francis, H., Rampasekova, A., Camellato, B., Mitchell, L., Stolper, R., Cornell, L., Babbs, C., Boeke, J. D., Higgs, D. R., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.030 · Cited by 196 · see citing works

Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

Brinster, R. L., Ritchie, K. A., Hammer, R. E., O’Brien, R. L., Arp, B., & Storb, U. (1983) · Nature · doi:10.1038/306332a0 · Cited by 194 · see citing works

Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation

Yang, J. H., & Hansen, A. S. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00710-6 · Cited by 191 · see citing works

Two regulatory elements for immunoglobulin kappa light chain gene expression.

Bergman, Y., Rice, D. A., Grosschedl, R., & Baltimore, D. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.22.7041 · Cited by 189 · see citing works

Correlation between G2m(n) immunoglobulin allotype and human antibody response and susceptibility to polysaccharide encapsulated bacteria.

Ambrosino, D. M., Schiffman, G., Gotschlich, E. C., Schur, P. H., Rosenberg, G., DeLange, G. G., van Loghem, E., & Siber, G. R. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111909 · Cited by 175 · see citing works

The human β-globin gene contains a downstream developmental specific enhancer

Kollias, G. A., Hurst, J., de Boer, E., & Grosveld, F. G. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.14.5739 · Cited by 158 · see citing works

Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer

Kohwi-shigematsu, T., & Kohwi, Y. (1990) · Biochemistry · doi:10.1021/bi00493a009 · Cited by 134 · see citing works

Promoter Elements of Genes Coding for Proteins and Modulation of Transcription by Estrogens and Progesterone

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Replication of SV40 and Polyoma Virus Chromosomes

DePamphilis, M. L., & Bradley, M. K. (1986) · Springer eBooks · doi:10.1007/978-1-4613-2221-4_3 · Cited by 132 · see citing works

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

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The immunoglobulin heavy‐chain B‐lymphocyte enhancer efficiently stimulates transcription in non‐lymphoid cells.

Wasylyk, C., & Wasylyk, B. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04246.x · Cited by 124 · see citing works

Effects of the Position of the Simian Virus 40 Enhancer on Expression of Multiple Transcription Units in a Single Plasmid

Kadesch, T. R., & Berg, P. R. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.7.2593 · Cited by 121 · see citing works

Transcriptional Regulation by (Super)Enhancers: From Discovery to Mechanisms

Grosveld, F., van Staalduinen, J., & Stadhouders, R. (2021) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-122220-093818 · Cited by 115 · see citing works

Enhanced Identification of Transcriptional Enhancers Provides Mechanistic Insights into Diseases

Murakawa, Y., Yoshihara, M., Kawaji, H., Nishikawa, M., Zayed, H., Suzuki, H., & Hayashizaki, Y. (2016) · Trends in Genetics · doi:10.1016/j.tig.2015.11.004 · Cited by 111 · see citing works

Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin μ locus in a Burkitt lymphoma

Gelmann, E. P., Psallidopoulos, M. C., Papas, T. S., & Favera, R. D. (1983) · Nature · doi:10.1038/306799a0 · Cited by 113 · see citing works

Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoter.

Eaton, S., & Calame, K. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7634 · Cited by 113 · see citing works

Negative Regulation Contributes to Tissue Specificity of the Immunoglobulin Heavy-Chain Enhancer

Imler, J., Lemaire‐Vieille, C., Wasylyk, C., & Wasylyk, B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.7.2558 · Cited by 113 · see citing works

Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region.

Milich, D. R., McNamara, M., McLachlan, A., Thornton, G. B., & Chisari, F. V. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8168 · Cited by 108 · see citing works

An enhancer element is located 340 base pairs upstream from the adenovirus-2 E1A capsite

Hen, R., Borrelli, E., Sassone‐Corsi, P., & Chambon, P. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.24.8747 · Cited by 108 · see citing works

A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer.Preprint

Scheuermann, R. H., & Chen, U. (1989) · Genes & Development · doi:10.1101/gad.3.8.1255 · Cited by 107 · see citing works

Systematic Binding Analysis of the Insulin Gene Transcription Control Region: Insulin and Immunoglobulin Enhancers Utilize Similar Transactivators

Moss, L. G., Moss, J. B., & Rutter, W. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.6.2620-2627.1988 · Cited by 104 · see citing works

A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.

Hagman, J., Rudin, C. M., Haasch, D., Chaplin, D., & Storb, U. (1990) · Genes & Development · doi:10.1101/gad.4.6.978 · Cited by 100 · see citing works

Genomic editing of intronic enhancers unveils their role in fine-tuning tissue-specific gene expression in Arabidopsis thaliana

Meng, F., Zhao, H., Zhu, B., Zhang, T., Yang, M., Li, Y., Han, Y., & Jiang, J. (2021) · The Plant Cell · doi:10.1093/plcell/koab093 · Cited by 91 · see citing works

Coming full circle: On the origin and evolution of the looping model for enhancer–promoter communication

Popay, T. M., & Dixon, J. R. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102117 · Cited by 94 · see citing works

Trans-acting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells.

Chung, J. H., Sinn, E., Reed, R. R., & Leder, P. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7918 · Cited by 92 · see citing works

Mechanisms that Regulate Immunoglobulin Gene Expression

Calame, K. L. (1985) · Annual Review of Immunology · doi:10.1146/annurev.iy.03.040185.001111 · Cited by 91 · see citing works

Short and long range activation by the SV40 enhancer

Wasylyk, B., Wasylyk, C., & Chambon, P. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.14.5589 · Cited by 87 · see citing works

Translocated c-myc oncogene of Burkitt lymphoma is transcribed in plasma cells and repressed in lymphoblastoid cells.

Croce, C. M., Erikson, J., ar-Rushdi, A., Aden, D. P., & Nishikura, K. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.10.3170 · Cited by 84 · see citing works

Evolution and structure of the fibrinogen genes

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Immunoglobulins or Antibodies: IMGT® Bridging Genes, Structures and Functions

Lefranc, M., & Lefranc, G. (2020) · Biomedicines · doi:10.3390/biomedicines8090319 · Cited by 83 · see citing works

Suppression of leukaemia virus pathogenicity by polyoma virus enhancers

Davis, B. R., Linney, E. A., & Fan, H. (1985) · Nature · doi:10.1038/314550a0 · Cited by 82 · see citing works

The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance

Wang, X., & Calame, K. L. (1985) · Cell · doi:10.1016/0092-8674(85)90238-7 · Cited by 82 · see citing works

Transcriptional enhancers and their communication with gene promoters

Ray-Jones, H., & Spivakov, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03903-w · Cited by 81 · see citing works

Regulation of expression of the human interferon gamma gene.

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Binding In Vitro of Multiple Cellular Proteins to Immunoglobulin Heavy-Chain Enhancer DNA

Peterson, C. L., Orth, K., & Calame, K. L. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.12.4168 · Cited by 80 · see citing works

The NF-kappa B-binding site mediates phorbol ester-inducible transcription in nonlymphoid cells.

Nelsen, B. A., Hellman, L., & Sen, R. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3526 · Cited by 76 · see citing works

Characterization of immunoglobulin enhancer deletions in murine plasmacytomas.

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B-Cell Control Region at the 5′ End of a Major Histocompatibility Complex Class II Gene: Sequences and Factors

Dorn, A., Fehling, H. J., Koch, W., LeMeur, M., GERLINGER, P., Benoist, C. O., & Mathis, D. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.10.3975 · Cited by 70 · see citing works

Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice.

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E2A Expression, Nuclear Localization, and In Vivo Formation of DNA- and Non-DNA-Binding Species during B-Cell Development

Jacobs, Y., Vierra, C., & Nelson, C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7321 · Cited by 65 · see citing works

Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications.

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Contribution of Promoter to Tissue-Specific Expression of the Mouse Immunoglobulin Kappa Gene

Gopal, T. V., Shimada, T., Baur, A. W., & Nienhuis, A. W. (1985) · Science · doi:10.1126/science.2994213 · Cited by 66 · see citing works

Identification of control elements 3' to the human keratin 1 gene that regulate cell type and differentiation-specific expression.

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A highly conserved intronic sequence is involved in transcriptional regulation of the alpha 1(I) collagen gene.

Liska, D. J., Slack, J. L., & BORNSTEIN, P. K. (1990) · Cell Regulation · doi:10.1091/mbc.1.6.487 · Cited by 63 · see citing works

Super-enhancers in transcriptional regulation and genome organization

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Molecular architecture of enhancer–promoter interaction

Hamamoto, K., & Fukaya, T. (2022) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2022.01.003 · Cited by 55 · see citing works

Complex Protein Binding within the Mouse Immunoglobulin Heavy-Chain Enhancer

Peterson, C. L., & Calame, K. L. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.12.4194 · Cited by 58 · see citing works

Sequence and chromatin determinants of transcription factor binding and the establishment of cell type-specific binding patterns

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Expression of a VHCκ chimaeric protein in mouse myeloma cells

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SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation

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