Repurposing drugs to treat cardiovascular disease in the era of precision medicine

Drug repurposing: progress, challenges and recommendations

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Biological, clinical and population relevance of 95 loci for blood lipids

Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487 · see citing works

Applications of machine learning in drug discovery and development

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Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

Cohen, J. C., Boerwinkle, E., Mosley, T. H., & Hobbs, H. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054013 · Cited by 3,181 · see citing works

Efficacy and safety of low-dose colchicine after myocardial infarction

Tardif, J.-C., Kouz, S., Waters, D. D., Bertrand, O. F., Diaz, R., Maggioni, A. P., Pinto, F. J., Ibrahim, R., Gamra, H., Kiwan, G. S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1912388 · Cited by 3,159 · see citing works

Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

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Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Molina, D. M., Jafari, R., Ignatushchenko, M., Seki, T., Larsson, E. A., Dan, C., Sreekumar, L., Cao, Y., & Nordlund, P. (2013) · Science · doi:10.1126/science.1233606 · Cited by 2,261 · see citing works

How were new medicines discovered?

Swinney, D. C., & Anthony, J. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3480 · Cited by 1,812 · see citing works

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

Gfeller, D., Grosdidier, A., Wirth, M., Daina, A., Michielin, O. A., & Zoete, V. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku293 · Cited by 1,811 · see citing works

Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Habashi, J. P., Judge, D. P., Holm, T. M., Cohn, R. D., Loeys, B. L., Cooper, T. K., Myers, L., Klein, E. C., Liu, G., Calvi, C., et al. (2006) · Science · doi:10.1126/science.1124287 · Cited by 1,794 · see citing works

Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease and stroke: systematic review and meta-analysis

Law, M. R., Wald, N. J., & Rudnicka, A. R. (2003) · BMJ · doi:10.1136/bmj.326.7404.1423 · Cited by 1,720 · see citing works

Predicting new molecular targets for known drugs

Keiser, M. J., Setola, V., Irwin, J. J., Laggner, C., Abbas, A. I., Hufeisen, S. J., Jensen, N. H., Kuijer, M. B., Matos, R. C., Tran, T. B., et al. (2009) · Nature · doi:10.1038/nature08506 · Cited by 1,667 · see citing works

Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes&lt;SUBTITLE&gt;The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial&lt;/SUBTITLE&gt;

Vogel, V. G. (2006) · JAMA · doi:10.1001/jama.295.23.joc60074 · Cited by 1,652 · see citing works

SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: A meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

Zannad, F., Ferreira, J. P., Pocock, S. J., Anker, S. D., Butler, J., Filippatos, G., Brueckmann, M., Ofstad, A. P., Pfarr, E., Jamal, W., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31824-9 · Cited by 1,408 · see citing works

Drug target identification using side-effect similarity

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Opportunities and challenges in phenotypic drug discovery: an industry perspective

Moffat, J. G., Vincent, F., Lee, J. A., Eder, J., & Prunotto, M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.111 · Cited by 939 · see citing works

Rethinking drug design in the artificial intelligence era

Schneider, P., Walters, W. P., Plowright, A. T., Sieroka, N., Listgarten, J., Goodnow, R. A., Fisher, J., Jansen, J. M., Duca, J. S., Rush, T. S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0050-3 · Cited by 894 · see citing works

ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

Yarchoan, R., Weinhold, K. J., Lyerly, H. K., Gelmann, E. P., Blum, R., Shearer, G. M., Mitsuya, H., Collins, J., Myers, C., Klecker, R. W., et al. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92808-4 · Cited by 802 · see citing works

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Folkersen, L., Gustafsson, S., Wang, Q., Hansen, D. H., Hedman, Å. K., Schork, A., Page, K., Zhernakova, D. V., Wu, Y., Peters, J., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00287-2 · Cited by 705 · see citing works

Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure

Everett, B. M., Cornel, J. H., Lainscak, M., Anker, S. D., Abbate, A., Thuren, T., Libby, P., Glynn, R. J., & Ridker, P. M. (2019) · Circulation · doi:10.1161/circulationaha.118.038010 · Cited by 658 · see citing works

The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: A multicenter randomized trial

Nassif, M. E., Windsor, S. L., Borlaug, B. A., Kitzman, D. W., Shah, S. J., Tang, F., Khariton, Y., Malik, A. O., Khumri, T., Umpierrez, G., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01536-x · Cited by 618 · see citing works

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

Dudley, J. T., Sirota, M., Shenoy, M. M., Pai, R. K., Roedder, S., Chiang, A. P.-F., Morgan, A. A., Sarwal, M., Pasricha, P. J., & Butte, A. J. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002648 · Cited by 604 · see citing works

Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction

Lønborg, J., Vejlstrup, N., Kelbæk, H., Bøtker, H. E., Kim, W. Y., Mathiasen, A. B., Jørgensen, E. O., Helqvist, S., Saunamäki, K. I., Clemmensen, P. M., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr309 · Cited by 550 · see citing works

Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen: A Phase IIb Randomized, Placebo-Controlled Trial

Ridker, P. M., Howard, C. P., Walter, V., Everett, B., Libby, P., Hensen, J., & Thuren, T. (2012) · Circulation · doi:10.1161/circulationaha.112.122556 · Cited by 530 · see citing works

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

Mathur, A., Loskill, P., Shao, K., Huebsch, N., Hong, S., Marcus, S. G., Marks, N. C., Mandegar, M. A., Conklin, B. R., Lee, L. P., et al. (2015) · Scientific Reports · doi:10.1038/srep08883 · Cited by 527 · see citing works

Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease

Sawkar, A. R., Cheng, W., Beutler, E., Wong, C., Balch, W. E., & Kelly, J. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192582899 · Cited by 508 · see citing works

Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders

Gandini, S., Puntoni, M., Heckman-Stoddard, B. M., Dunn, B. K., Ford, L., DeCensi, A., & Szabo, E. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0424 · Cited by 457 · see citing works

Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis

Buch, M. H., Smolen, J. S., Betteridge, N., Breedveld, F. C., Burmester, G. R., Dörner, T., Ferraccioli, G., Gottenberg, J., Isaacs, J. D., Kvien, T. K., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.144998 · Cited by 457 · see citing works

Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction

Broch, K., Anstensrud, A. K., Woxholt, S., Sharma, K., Tøllefsen, I. M., Bendz, B., Aakhus, S., Ueland, T., Amundsen, B. H., Damås, J. K., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.02.049 · Cited by 457 · see citing works

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

Baraban, S. C., Dinday, M. T., & Hortopan, G. A. (2013) · Nature Communications · doi:10.1038/ncomms3410 · Cited by 432 · see citing works

Statins: a repurposed drug to fight cancer

Jiang, W., Hu, J.-W., He, X.-R., Jin, W.-L., & He, X.-Y. (2021) · Journal of Experimental &amp; Clinical Cancer Research · doi:10.1186/s13046-021-02041-2 · Cited by 417 · see citing works

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

Sharma, A., Burridge, P. W., McKeithan, W. L., Serrano, R., Shukla, P., Sayed, N., Churko, J. M., Kitani, T., Wu, H., Holmström, A., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2584 · Cited by 404 · see citing works

iPS cells: a game changer for future medicine

Inoue, H., Nagata, N., Kurokawa, H., & Yamanaka, S. (2014) · The EMBO Journal · doi:10.1002/embj.201387098 · Cited by 403 · see citing works

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

Peterson, R., Shaw, S., Peterson, T. A., Milan, D., Zhong, T., Schreiber, S., Macrae, C., & Fishman, M. (2004) · Nature Biotechnology · doi:10.1038/nbt963 · Cited by 395 · see citing works

Use of genome-wide association studies for drug repositioning

Sanséau, P., Agarwal, P., Barnes, M. R., Pastinen, T., Richards, J. B., Cardon, L. R., & Mooser, V. (2012) · Nature Biotechnology · doi:10.1038/nbt.2151 · Cited by 387 · see citing works

Phenotypic drug discovery: recent successes, lessons learned and new directions

Vincent, F., Nueda, A., Lee, J. L. C., Schenone, M., Prunotto, M., & Mercola, M. A. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00472-w · Cited by 372 · see citing works

Estimated costs of pivotal trials for novel therapeutic agents approved by the US Food and Drug Administration, 2015–2016

Moore, T. J., Zhang, H., Anderson, G., & Alexander, G. C. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.3931 · Cited by 356 · see citing works

The first 3500 years of aspirin history from its roots – A concise summary

Montinari, M. R., Minelli, S., & Caterina, R. D. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.10.008 · Cited by 330 · see citing works

Efficacy and safety of topiramate on weight loss: a meta‐analysis of randomized controlled trials

Kramer, C. K., Leitão, C. B., Pinto, L. C. F., Canani, L. H. S., de Azevedo, M. J., & Gross, J. L. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00846.x · Cited by 323 · see citing works

Fingolimod for Multiple Sclerosis

Pelletier, D., & Hafler, D. A. (2012) · New England Journal of Medicine · doi:10.1056/nejmct1101691 · Cited by 317 · see citing works

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation

Cutler, C. S., Multani, P. S., Robbins, D., Kim, H. T., Le, T. M., Hoggatt, J., Pelus, L. M., Desponts, C., Chen, Y., Rezner, B., et al. (2013) · Blood · doi:10.1182/blood-2013-05-503177 · Cited by 302 · see citing works

Overcoming barriers to NLP for clinical text: the role of shared tasks and the need for additional creative solutions

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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Al-Olabi, L., Polubothu, S., Dowsett, K., Andrews, K. A., Stadnik, P., Joseph, A. P., Knox, R. G., Pittman, A. M., Clark, G. R., Baird, W., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98589 · Cited by 293 · see citing works

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

Scannell, J. W., & Bosley, J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0147215 · Cited by 279 · see citing works

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Drawnel, F. M., Boccardo, S., Prummer, M., Delobel, F., Graff, A., Weber, M., Gérard, R., Badi, L., Kam-Thong, T., Bu, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.055 · Cited by 247 · see citing works

Overcoming the legal and regulatory barriers to drug repurposing

Breckenridge, A. M., & Jacob, R. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.92 · Cited by 228 · see citing works

Colchicine Use Is Associated with Decreased Prevalence of Myocardial Infarction in Patients with Gout

Crittenden, D. B., Lehmann, R. A., SCHNECK, L., Keenan, R. T., Shah, B., Greenberg, J. D., Cronstein, B. N., Sedlis, S. P., & Pillinger, M. H. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.111533 · Cited by 223 · see citing works

Artery/Vein Specification Is Governed by Opposing Phosphatidylinositol-3 Kinase and MAP Kinase/ERK Signaling

Hong, C. C., Peterson, Q. P., Hong, J.-Y., & Peterson, R. T. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.046 · Cited by 222 · see citing works

ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor

Li, D., March, M., Gutiérrez-Uzquiza, Á., Kao, C., Seiler, C., Pinto, E. M., Matsuoka, L. S., Battig, M. R., Bhoj, E. J. K., Wenger, T. L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0479-2 · Cited by 218 · see citing works

Patient and Disease–Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics

Paik, D. T., Chandy, M., & Wu, J. C. (2019) · Pharmacological Reviews · doi:10.1124/pr.116.013003 · Cited by 216 · see citing works

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

Xu, H., Aldrich, M. C., Chen, Q., Liu, H., Peterson, N. B., Dai, Q., Levy, M. A., Shah, A., Han, X., Ruan, X., et al. (2014) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2014-002649 · Cited by 211 · see citing works

Cardiovascular Drug Development

Fordyce, C. B., Roe, M. T., Ahmad, T., Libby, P., Borer, J. S., Hiatt, W. R., Bristow, M. R., Packer, M., Wasserman, S. M., Braunstein, N., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.016 · Cited by 202 · see citing works

Phase II clinical trial of metformin as a cancer stem cell–targeting agent in ovarian cancer

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Cardiovascular Safety of Tocilizumab Versus Tumor Necrosis Factor Inhibitors in Patients With Rheumatoid Arthritis: A Multi‐Database Cohort Study

Kim, S. C., Solomon, D. H., Rogers, J. R., Gale, S. L., Klearman, M., Sarsour, K., & Schneeweiß, S. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40084 · Cited by 196 · see citing works

Generating Hypotheses by Discovering Implicit Associations in the Literature: A Case Report of a Search for New Potential Therapeutic Uses for Thalidomide

Weeber, M. (2003) · Journal of the American Medical Informatics Association · doi:10.1197/jamia.m1158 · Cited by 184 · see citing works

Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation

Gibson, C. C., Zhu, W., Davis, C. T., Bowman-Kirigin, J. A., Chan, A. C., Jing, L., Walker, A. E., Goitre, L., Monache, S. D., Retta, S. F., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.010403 · Cited by 175 · see citing works

Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes

Ratner, R. E., Han, J., Nicewarner, D., Yushmanova, I., Hoogwerf, B. J., & Shen, L. Z. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-22 · Cited by 152 · see citing works

2019 FDA drug approvals

Mullard, A. (2020) · Nature Reviews Drug Discovery · doi:10.1038/d41573-020-00001-7 · Cited by 150 · see citing works

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis

Wainger, B. J., Macklin, E. A., Vucic, S., McIlduff, C. E., Paganoni, S., Maragakis, N. J., Bedlack, R., Goyal, N., Rutkove, S. B., Lange, D. J., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.4300 · Cited by 142 · see citing works

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

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Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype

Bliley, J. M., Vermeer, M. C. S. C., Duffy, R. M., Batalov, I., Kramer, D., Tashman, J. W., Shiwarski, D. J., Lee, A. R., Teplenin, A. S., Volkers, L., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd1817 · Cited by 134 · see citing works

The Potential Effect of Metformin on Cancer: An Umbrella Review

Yu, H., Zhong, X. Z., Gao, P., Shi, J., Wu, Z., Guo, Z., Wang, Z., & Song, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00617 · Cited by 133 · see citing works

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development

del Álamo, J. C., Lemons, D., Serrano, R., Savchenko, A., Cerignoli, F., Bodmer, R., & Mercola, M. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.003 · Cited by 131 · see citing works

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Lintner, N. G., McClure, K. F., Petersen, D. N., Londregan, A. T., Piotrowski, D. W., Wei, L., Xiao, J., Bolt, M. W., Loria, P. M., Maguire, B. A., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001882 · Cited by 129 · see citing works

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

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Dapoxetine: a new option in the medical management of premature ejaculation

McMahon, C. G. (2012) · Therapeutic Advances in Urology · doi:10.1177/1756287212453866 · Cited by 109 · see citing works

Impact of Blockade of Histamine H2Receptors on Chronic Heart Failure Revealed by Retrospective and Prospective Randomized Studies

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Online tools to support literature-based discovery in the life sciences

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Aspirin Use and Risk of Colorectal Cancer Among Older Adults

Guo, C., Ma, W., Drew, D. A., Cao, Y., Nguyen, L. H., Joshi, A. D., Ng, K., Ogino, S., Meyerhardt, J. A., Song, M., et al. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2020.7338 · Cited by 104 · see citing works

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

Fiedler, L. R., Chapman, K., Xie, M., Maifoshie, E., Jenkins, M., Golforoush, P. A., Bellahcene, M., Noseda, M., Faust, D., Jarvis, A., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.01.013 · Cited by 103 · see citing works

Revealing the role of the human blood plasma proteome in obesity using genetic drivers

Zaghlool, S. B., Sharma, S., Molnar, M., Matías‐García, P. R., Elhadad, M. A., Waldenberger, M., Peters, A., Rathmann, W., Graumann, J., Gieger, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21542-4 · Cited by 100 · see citing works

Severe Lymphatic Disorder Resolved With MEK Inhibition in a Patient With Noonan Syndrome and SOS1 Mutation

Dori, Y., Smith, C. L., Pinto, E. M., Snyder, K., March, M., Hakonarson, H. H., & Belasco, J. B. (2020) · PEDIATRICS · doi:10.1542/peds.2020-0167 · Cited by 99 · see citing works

Association between treatment for erectile dysfunction and death or cardiovascular outcomes after myocardial infarction

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Large-scale Direct Targeting for Drug Repositioning and Discovery

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Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial

van Andel, M. M., Indrakusuma, R., Jalalzadeh, H., Balm, R., Timmermans, J., Scholte, A. J. H. A., van den Berg, M. P., Zwinderman, A. H., Mulder, B. J. M., de Waard, V., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa377 · Cited by 84 · see citing works

Human iPSC modeling of heart disease for drug development

Hnatiuk, A. P., Briganti, F., Staudt, D., & Mercola, M. A. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.02.016 · Cited by 79 · see citing works

Atomoxetine in patients with ADHD: A clinical and pharmacological review of the onset, trajectory, duration of response and implications for patients

Clemow, D. B., & Bushe, C. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115602489 · Cited by 74 · see citing works

Considering benefits and harms of duloxetine for treatment of stress urinary incontinence: a meta-analysis of clinical study reports

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Why Colchicine Should Be Considered for Secondary Prevention of Atherosclerosis: An Overview

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Shared molecular, cellular, and environmental hallmarks in cardiovascular disease and cancer: Any place for drug repurposing?

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Navigating the Landscape of Translational Medicine of Calcific Aortic Valve Disease

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Drug repurposing: a promising drug discovery strategy for the treatment of emerging epidemic infectious disease

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Nephroprotective Mechanisms of SGLT2i: Beyond the Glucose-Lowering Effect

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Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation

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Hepatoprotective drug screening identifies daclatasvir, a promising therapeutic candidate for MASLD by targeting PLIN2

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Layered double hydroxides based nanomaterials: recent advances in drug delivery and biomedical applications

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Adsorption behavior of monacolin K onto B12N12 and B12P12 fullerenes as Cardioprotective agent: Spectroscopic and DFT study

Sun, Y., Zhang, M., Ge, B., & Dong, Y. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.123115 · Cited by 7 · see citing works

Global Pipeline of Innovative Medicinal Products: A Narrative Review

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Non-Negative Matrix Tri-Factorization for Representation Learning in Multi-Omics Datasets with Applications to Drug Repurposing and Selection

Messa, L., Testa, C., Carelli, S., Rey, F., Jacchetti, E., Cereda, C., Raimondi, M. T., Ceri, S., & Pinoli, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179576 · Cited by 6 · see citing works

Updates on Intrinsic Medicinal Chemistry of 1,4-dihydropyridines, Perspectives on Synthesis and Pharmacokinetics of Novel 1,4-dihydropyrimidines as Calcium Channel Blockers: Clinical Pharmacology

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Ruxolitinib is a CaMKII inhibitor that can be repurposed to prevent arrhythmias

Huynh, K. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00910-1 · Cited by 6 · see citing works

Tamoxifen may contribute to preserve cardiac function in Duchenne muscular dystrophy

Henzi, B., Lava, S. A. G., Spagnuolo, C., Putananickal, N., Donner, B. C., Pfluger, M. R., Burkhardt, B. E. U., & Fischer, D. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-024-05670-9 · Cited by 6 · see citing works

Advancing target discovery through disease-specific integration of multi-modal target identification models and comprehensive benchmarking system

Leung, H., Duan, C., Gou, W., Chen, J., Xin, Y., Zheng, Z., Naumov, V., Gennert, D. G., Zhang, M., Aliper, A., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-47765-3 · Cited by 5 · see citing works

Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy

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Trends in drug repurposing: Advancing cardiovascular disease management in geriatric populations

Moka, M. K., George, M., Rathakrishnan, D., Jagadeeshwaran, V., & Sriram, D. K. (2025) · Current Research in Translational Medicine · doi:10.1016/j.retram.2025.103496 · Cited by 5 · see citing works

Sodium-Glucose Cotransporter-2 Inhibitors: Elevating Standards in Cardiovascular Secondary Prevention

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Stroke genetics and how it Informs novel drug discovery

Valančienė, J., Melaika, K., Šliachtenko, A., Šiaurytė, K., Ekkert, A., & Jatužis, D. (2024) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2024.2324916 · Cited by 4 · see citing works

Aspirin–Fisetin Combinatorial Treatment Exerts Cytotoxic and Anti-Migratory Activities in A375 Malignant Melanoma Cells

Iftode, C., Minda, D. I., Drăghici, G. A., Geamantan, A., Ursoniu, S., & Enătescu, I. (2024) · Medicina · doi:10.3390/medicina60071125 · Cited by 4 · see citing works

Clinically approved representative small-molecule drugs for cardiopathy therapy

Ma, S., Jiang, M., Wang, X., & Li, B. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117172 · Cited by 4 · see citing works

Conductive Microfibers Improve Stem Cell‐Derived Cardiac Spheroid Maturation

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Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

Aviel, G., Elkahal, J., Umansky, K. B., Bueno-Levy, H., Petrover, Z., Kotlovski, Y., Lendengolts, D., Kain, D., Shalit, T., Zhang, L., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00524-x · Cited by 4 · see citing works

3D digital light processing bioprinting and in situ differentiation of hiPSCs for engineering cardiac tissue

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Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia

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Repurposing of monacolin K decorated BN nanoparticle on inhibition of HMG-CoA reductase: In silico approach

Khori, V., Zahedi, M., Mirzaei, H., Jabbari, A., MojaverAghili, S., & Hosseini, S. G. (2023) · Chemical Physics Impact · doi:10.1016/j.chphi.2023.100384 · Cited by 3 · see citing works

Novel drug design and repurposing: An opportunity to improve translational research in cardiovascular diseases?

Rodríguez‐Zavala, J. S., & Zazueta, C. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400492 · Cited by 2 · see citing works

Drug repurposing using transcriptomics: principles and unmet needs in cardiovascular disease

Leung, S., Miller, C. L., Singh, A., & Wang, Y. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00899.2025 · Cited by 2 · see citing works

Repurposable Drugs for Immunotherapy and Strategies to Find Candidate Drugs

Sakai, N., Kamimura, K., & Terai, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092190 · Cited by 2 · see citing works

In silico approach for fighting human immunodeficiency virus: a drug repurposing strategy

Crisan, L., & Istrate, D. (2024) · Chemical Papers · doi:10.1007/s11696-024-03789-5 · Cited by 2 · see citing works

Gradient coating of extracellular matrix derived from endothelial cells on aligned PCL nanofibers for rapid endothelialization

Zhou, Z., Lin, Y., Liu, N., Zhang, Y., Li, B., & Wang, Y. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1527046 · Cited by 2 · see citing works

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

Perco, P., Ley, M., Kęska, K., Wojenska, D., Bono, E., Walter, S. M., Fillinger, L., & Kratochwill, K. (2025) · PROTEOMICS · doi:10.1002/pmic.202400109 · Cited by 2 · see citing works

In vitro assessment of BBI608 in 2D and 3D culture models for drug repositioning in oral squamous cell carcinoma

Park, D.-G., Kim, H., Lee, S., Jsng, H.-M., Hong, S.-D., Choi, S., & Cho, S.-D. (2025) · Oncology Reports · doi:10.3892/or.2025.8930 · Cited by 2 · see citing works

Evaluation of Pre-Trained CNN Models for 2D Image-Based Drug Discovery

Banegas‐Luna, A. J., & Bonastre-Egea, J. (2024) · Ambient intelligence and smart environments · doi:10.3233/aise240024 · Cited by 2 · see citing works

A dualistic approach to heart repair through FGF10

Koopmans, T., & van Rooij, E. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac123 · Cited by 2 · see citing works

Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes

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Negative findings but positive contributions in cardiovascular research

Chen, K., & Zeng, C. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121494 · Cited by 1 · see citing works

New targets for old drugs

Kumbhar, N., Aparna, M. A., Nimal, S. K., Shewale, P., Barale, S. S., & Gacche, R. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15232-0.00021-7 · Cited by 1 · see citing works

Repurposing of IL 33/ST2 Modulating Drugs as a Cardioprotective Agent: A Promising Approach

Veeraveedu, P. T., Ramamurthy, S., Sainath, P. B., & Radhakrishnan, B. (2024) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-024-09818-w · Cited by 1 · see citing works

Drug repurposing: A multi targetted approach to treat cardiac disease from existing classical drugs to modern drug discovery

Tripathi, S., Rani, K., Raj, V. S., & Ambasta, R. K. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.02.001 · Cited by 1 · see citing works

Recent Advances and Challenges in Targeted Drug Delivery Using Biofunctional Coatings

Bal, T., Anjrini, N., & Zeroual, M. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837675555-00041 · Cited by 1 · see citing works

Repurposed Anti–Multiple Sclerosis Drug Fty720 Targets Carbapenem-Resistant Acinetobacter baumannii via Multiple Pathways

Wu, Y., Pang, Y., Yang, H., Zhu, L., Ma, T., & Chen, X. (2024) · Current Microbiology · doi:10.1007/s00284-024-03986-1 · Cited by 1 · see citing works

Harnessing the power of structure‐based design: A new lease on life for cardiovascular drug development with apelin receptor modulators

Zhang, J., Dong, E., Zhang, Y., & Zhang, Y. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70116 · Cited by 1 · see citing works

Big Data Analysis in Personalized Medicine

Banu, A., Balyan, P., Nisamudheen, N. A., Velayutham, D., Balyan, M. K., & Jithesh, P. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95502-7.00279-7 · Cited by 2 · see citing works

A regenerable electrochemical sensor for electro-inactive cyclovirobuxine D detection in biological samples

Dong, Y., Zhai, J., Zhang, Z., Peng, C., Zhang, Y., & Zhang, Z. (2023) · The Analyst · doi:10.1039/d2an01859d

Systems immunology approach for targeting inflammation in atherosclerosis

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IN SILICO SCREENING OF SOME OLD DRUGS FOR NEW APPROACHES IN HEART FAILURE

Sava, A. (2023) · The Medical-Surgical Journal · doi:10.22551/msj.2023.03.18

Advancing Sensitivity in Measuring Cardiomyocyte Contraction Force Through Single-Crystal Silicon Strain Sensors

Sun, H., Kim, D., Kim, J., Jeong, Y., & Lee, D. (2023) · Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ... · doi:10.1109/sensors56945.2023.10325188

Leveraging Machine Learning, Transformers, and Large-Scale Chemical Data to Predict TGF-β1 Inhibitors for Cardiac Fibrosis Treatment

Chavda, A. (2024) · IEEE International Conference on Big Data (BigData) · doi:10.1109/bigdata62323.2024.10825095

Computational insights on drug effects on intrinsic stochasticity of mouse pacemaker cell activity

Aspis, N., Weiser-Bitoun, I., & Yaniv, Y. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.07.031

Managing big data for TNBC research

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Bioinformatics and Computational Techniques for Treatment of Atherosclerosis: A Novel Approach by in-silico AnalysisPreprint

Etesam, A., & Jebali, A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5897622

Drug Repurposing for Cardioprotective Therapy

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Comic: explainable drug repurposing via contrastive masking for interpretable connections

Aamer, N., Asim, M. N., & Dengel, A. (2026) · BMC Bioinformatics · doi:10.1186/s12859-025-06337-4

Associated genetic molecular pathway analysis for the current precision medicines of cardiovascular disease

Wang, J. (2026) · International Journal of Clinical and Experimental Medicine · doi:10.62347/xwjf1774

The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities

Chen, F., Wang, L., Liu, H., Khan, Q., Tang, B., & Bao, N. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04551-7

Cellular senescence in atherosclerosis and heart failure: pathophysiology and clinical implications

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GC-MS profiling, network pharmacology, and computational investigations of canola phytochemicals as potential cardioprotective agents

Younas, Z., Ahmad, I., Raja, N. I., Ahmad, A., Fernandes, D. A., & Mashwani, Z. (2026) · In Silico Pharmacology · doi:10.1007/s40203-026-00744-y

An Early Value Assessment of Biomarker-Guided Precision Medicine for Treatment-Resistant Hypertension: A Headroom and Threshold Analysis

Abu-Zahra, T., Grimm, S. E., Scholte, M., Casas, A. I., Saliba‐Gustafsson, P., Parini, P., & Joore, M. A. (2026) · Applied Health Economics and Health Policy · doi:10.1007/s40258-026-01075-x

The kinase inhibitor dabrafenib halts progression of cerebral cavernous malformations in a BRAF-independent manner

Arce, M., Huang, H., Rorsman, C., Erzar, I., Oldenburg, J., Sun, Y., Smith, R., Onyeogaziri, F. C., Barbera, S., Ahlstrand, F. C., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adr0448

Drug repurposing in cardiovascular diseases: Opportunity or hopeless dream?

Gelosa, P., Castiglioni, L., Camera, M., & Sironi, L. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113894 · Cited by 20 · see citing works

Precision Medicine & Drug Repurposing for Cardiovascular Diseases; Challenges and Opportunities

Ahmed, S. (2022) · Precision Medicine Communications · doi:10.55627/pmc.002.01.0092

9 Drug repurposing strategy in the identification of drugs for cardiovascular disorders

Sofi, F. A., & Masoodi, M. H. (2023) · De Gruyter eBooks · doi:10.1515/9783110791150-009

Old Drug, New Opportunity: Drug Repurposing in Cardiovascular Diseases

Ou, X., Liu, S., Sun, P., Yang, Y., Xie, Y., Zhang, B., Li, Y., Li, W., & Sun, T. (2026) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70272 · Cited by 1 · see citing works

Novel drug design and repurposing: An opportunity to improve translational research in cardiovascular diseases?

Rodríguez‐Zavala, J. S., & Zazueta, C. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400492 · Cited by 2 · see citing works