Mouchiroud, Laurent

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,210

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine

Genetics, Aging, and Longevity in Model OrganismsPomegranate: compositions and health benefits

Cited by 1,105

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 1,035

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 630

Two conserved histone demethylases regulate mitochondrial stress-induced longevity

Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., Williams, E. G., Mouchiroud, L., Tronnes, S. U., et al. (2016) · Cell

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 363

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

Jovaisaite, V., Mouchiroud, L., & Auwerx, J. (2014) · Journal of Experimental Biology

Mitochondrial Function and PathologyEndoplasmic Reticulum Stress and Disease

Cited by 335

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Mottis, A., Mouchiroud, L., & Auwerx, J. (2013) · Genes & Development

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 297

NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation

Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A. G., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., et al. (2016) · Science Translational Medicine

Sirtuins and Resveratrol in MedicineMuscle Physiology and Disorders

Cited by 256

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

Pirinen, E., Cantó, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., et al. (2014) · Cell Metabolism

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 254

NAD + metabolism: A therapeutic target for age-related metabolic disease

Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013) · Critical Reviews in Biochemistry and Molecular Biology

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 193