Cited by 257Sirtuins and Resveratrol in MedicineMuscle Physiology and DisordersBiochemical and Molecular Research

NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation

Open access
Ryu, Dongryeol, Zhang, Hongbo, Ropelle, Eduardo R., Sorrentino, Vincenzo, Mázala, Davi A. G., Mouchiroud, Laurent, Marshall, Philip L., Campbell, Matthew D. +16 more·2016·Science Translational Medicine

Abstract

NAD + treatment can reverse the functional decline in degenerating muscles.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/scitranslmed.aaf5504

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • NR treatment improved muscle stem cell functions by regulating mitochondrial metabolism in a mouse model of muscular dystrophy.

    “Treatment with NR also improved muscle stem cell functions by regulating mitochondrial metabolism in a mouse model of muscular dystrophy197,198.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Part of this paper’s reference list could not be split into single entries.

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A. G., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., Bellemin, S., Iyer, S. R., Wang, X., Gariani, K., Sauve, A. A., Cantó, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R., Jasmin, B. J., Marcinek, D. J., Menzies, K. J., & Auwerx, J.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • Universidade Estadual de Campinas (UNICAMP) (BR)
  • University of Maryland, College Park (US)
  • University of Ottawa (CA)
  • University of Washington (US)
  • Lyon 1 Université (FR)
  • University of Maryland, Baltimore (US)
  • Weill Cornell Medicine (US)
  • Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
Corresponding author
  • Ryu, Dongryeol
  • Zhang, Hongbo
  • Ropelle, Eduardo R.
  • Menzies, Keir J.
  • Auwerx, Johan
Venue
Science Translational Medicine
Published
2016-10-19
Volume
8
Issue
361
Pages
361ra139-361ra139
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2537034621
Cited by
256
References
61
Citations by year
2026: 8 · 2025: 16 · 2024: 19 · 2023: 32 · 2022: 28 · 2021: 48 · 2020: 26 · 2019: 29 · 2018: 31 · 2017: 15 · 2016: 3
FWCI
15.11
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
  • PubMed Central (acceptedVersion)
  • National University of Singapore (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • Heart and Stroke Foundation of Canada
  • NIH (R01AG043930)
  • Krebsforschung Schweiz/Swiss Cancer League (KFS-3082-02-2013)
  • Systems X (SySX.ch 2013/153)
  • Swiss National Science Foundation (310030B-160318)
  • Horizon 2020 (665667)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords
muscular dystrophy, muscle function, poly(ADP-ribosyl)ation, poly(ADP-ribose), poly(ADP-ribose) polymerase, NAD+ metabolism, neuromuscular degeneration, nicotinamide N-methyltransferase
MeSH terms
Poly ADP Ribosylation, Adenosine Diphosphate, Animals, Cell Line, Fibrosis, Inflammation, Male, Mice, Inbred C57BL, Mice, Transgenic, Muscular Diseases, Muscular Dystrophies, NAD, Nitrosamines, RNA, Messenger, Tyramine, Cytokines, Caenorhabditis elegans, Muscle, Skeletal, Gene Expression Profiling, Mice, Nicotinamide Phosphoribosyltransferase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review