Ober, Raimund J.

Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans

Ulrichts, P., Guglietta, A., Dreier, T., van Bragt, T., Hanssens, V., Hofman, E., Vankerckhoven, B., Verheesen, P., Ongenae, N., Lykhopiy, V., et al. (2018) · Journal of Clinical Investigation

Monoclonal and Polyclonal Antibodies ResearchImmunodeficiency and Autoimmune Disorders

Cited by 427

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels

Vaccaro, C., Zhou, J., Ober, R. J., & Ward, E. S. (2005) · Nature Biotechnology

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 407

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of γ-globulin in humans

Firan, M., Bawdon, R., Radu, C., Ober, R. J., Eaken, D., Antohe, F., Ghetie, V., & Ward, E. S. (2001) · International Immunology

Monoclonal and Polyclonal Antibodies ResearchReproductive System and Pregnancy

Cited by 330

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn

Ober, R. J., Martinez, C., Vaccaro, C., Zhou, J., & Ward, E. S. (2004) · The Journal of Immunology

Monoclonal and Polyclonal Antibodies ResearchCellular transport and secretion

Cited by 314

Exocytosis of IgG as mediated by the receptor, FcRn: An analysis at the single-molecule level

Ober, R. J., Martinez, C., Lai, X., Zhou, J., & Ward, E. S. (2004) · Proceedings of the National Academy of Sciences

Cellular transport and secretionMonoclonal and Polyclonal Antibodies Research

Cited by 258

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

Montoyo, H. P., Vaccaro, C., Hafner, M., Ober, R. J., Mueller, W., & Ward, E. S. (2009) · Proceedings of the National Academy of Sciences

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 211

From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling

Ward, E. S., Martinez, C., Vaccaro, C., Zhou, J., Tang, Q., & Ober, R. J. (2005) · Molecular Biology of the Cell

Cellular transport and secretionExtracellular vesicles in disease

Cited by 193

Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy

Prabhat, P., Gan, Z., Chao, J., Ram, S., Vaccaro, C., Gibbons, S., Ober, R. J., & Ward, E. S. (2007) · Proceedings of the National Academy of Sciences

Cellular transport and secretionExtracellular vesicles in disease

Cited by 157

Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery

Gan, Z., Ram, S., Vaccaro, C., Ober, R. J., & Ward, E. S. (2009) · Traffic

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 76

Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway

Gan, Z., Ram, S., Ober, R. J., & Ward, E. S. (2013) · Journal of Cell Science

Cellular transport and secretionAdvanced Fluorescence Microscopy Techniques

Cited by 38

Myelin oligodendrocyte glycoprotein-specific antibodies from multiple sclerosis patients exacerbate disease in a humanized mouse model

Khare, P., Challa, D. K., Devanaboyina, S. C., Velmurugan, R., Hughes, S., Greenberg, B. M., Ober, R. J., & Ward, E. S. (2018) · Journal of Autoimmunity

Multiple Sclerosis Research StudiesMonoclonal and Polyclonal Antibodies Research

Cited by 31

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

Ma, G., Crowley, A. R., Heyndrickx, L., Rogiers, I., Parthoens, E., Van Santbergen, J., Ober, R. J., Bobkov, V., de Haard, H., Ulrichts, P., et al. (2024) · JCI Insight

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 28