McKay, Paul F.

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

McKay, P. F., Hu, K., Blakney, A. K., Samnuan, K., Brown, J. C., Penn, R., Zhou, J., Bouton, C. R., Rogers, P., Polra, K., et al. (2020) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchRNA Interference and Gene Delivery

Cited by 462

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Blakney, A. K., McKay, P. F., Yus, B. I., Aldon, Y., & Shattock, R. J. (2019) · Gene Therapy

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 206

Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trial

Pollock, K. M., Cheeseman, H. M., Szubert, A. J., Libri, V., Boffito, M., Owen, D., Bern, H., McFarlane, L. R., O'Hara, J., Lemm, N.-M., et al. (2022) · eClinicalMedicine

SARS-CoV-2 and COVID-19 ResearchRNA Interference and Gene Delivery

Cited by 173

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

Blakney, A. K., Zhu, Y., McKay, P. F., Bouton, C. R., Yeow, J., Tang, J., Hu, K., Samnuan, K., Grigsby, C. L., Shattock, R. J., et al. (2020) · ACS Nano

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 155

Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Spencer, A. J., McKay, P. F., Belij-Rammerstorfer, S., Ulaszewska, M., Bissett, C. D., Hu, K., Samnuan, K., Blakney, A. K., Wright, D., Sharpe, H. R., et al. (2021) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 125

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA

Blakney, A. K., McKay, P. F., Bouton, C. R., Hu, K., Samnuan, K., & Shattock, R. J. (2021) · Molecular Therapy

RNA Interference and Gene DeliveryImmunotherapy and Immune Responses

Cited by 105

The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants

Blakney, A. K., McKay, P. F., Ibarzo Yus, B., Hunter, J. E., Dex, E. A., & Shattock, R. J. (2019) · ACS Nano

RNA Interference and Gene DeliveryAdvancements in Transdermal Drug Delivery

Cited by 73

Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway

Zhou, J., Peacock, T. P., Brown, J. C., Goldhill, D. H., Elrefaey, A. M. E., Penrice-Randal, R., Cowton, V. M., De Lorenzo, G., Furnon, W., Harvey, W. T., et al. (2022) · Cell Reports

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 64

Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants

Blakney, A. K., Deletic, P., McKay, P. F., Bouton, C. R., Ashford, M., Shattock, R. J., & Sabirsh, A. (2021) · Journal of Controlled Release

RNA Interference and Gene DeliveryAdvancements in Transdermal Drug Delivery

Cited by 48

Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA

Blakney, A. K., McKay, P. F., Christensen, D., Yus, B. I., Aldon, Y., Follmann, F., & Shattock, R. J. (2019) · Journal of Controlled Release

RNA Interference and Gene DeliveryImmunotherapy and Immune Responses

Cited by 48

Structural components for amplification of positive and negative strand VEEV splitzicons

Blakney, A. K., McKay, P. F., & Shattock, R. J. (2018) · Frontiers in Molecular Biosciences

RNA and protein synthesis mechanismsRNA Interference and Gene Delivery

Cited by 47