Seki, Ekihiro

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 5,894

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 2,897

TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine

Liver physiology and pathologyImmune Response and Inflammation

Cited by 1,942

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhong, Z., Liang, S., Sanchez-Lopez, E., He, F., Shalapour, S., Lin, X.-J., Wong, J., Ding, S., Seki, E., Schnabl, B., et al. (2018) · Nature

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,208

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhong, Z., Umemura, A., Sanchez-Lopez, E., Liang, S., Shalapour, S., Wong, J., He, F., Boassa, D., Perkins, G., Ali, S. R., et al. (2016) · Cell

Inflammasome and immune disordersNF-κB Signaling Pathways

Cited by 1,197

Hepatic inflammation and fibrosis: Functional links and key pathways

Seki, E., & Schwabe, R. F. (2015) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 972

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 741

Toll‐like receptors and adaptor molecules in liver disease: Update†

Seki, E., & Brenner, D. A. (2008) · Hepatology

Immune Response and InflammationLiver physiology and pathology

Cited by 722

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

Nakagawa, H., Umemura, A., Taniguchi, K., Font-Burgada, J., Dhar, D., Ogata, H., Zhong, Z., Valasek, M. A., Seki, E., Hidalgo, J., et al. (2014) · Cancer Cell

Endoplasmic Reticulum Stress and DiseaseCancer, Lipids, and Metabolism

Cited by 525

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Miura, K., Yang, L., van Rooijen, N., Ohnishi, H., & Seki, E. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 503

CCR1 and CCR5 promote hepatic fibrosis in mice

Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation

Liver physiology and pathologyChemokine receptors and signaling

Cited by 431

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell

Cholangiocarcinoma and Gallbladder Cancer StudiesLiver physiology and pathology

Cited by 416

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

Bhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation

Cancer Cells and MetastasisCellular Mechanics and Interactions

Cited by 367

Transforming Growth Factor Beta Signaling in Hepatocytes Participates in Steatohepatitis Through Regulation of Cell Death and Lipid Metabolism in Mice

Yang, L., Roh, Y. S., Song, J., Zhang, B., Liu, C., Loomba, R., & Seki, E. (2014) · Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 275

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

Machida, K., Tsukamoto, H., Mkrtchyan, H., Duan, L., Dynnyk, A., Liu, H. M., Asahina, K., Govindarajan, S., Ray, R., Ou, J.-H. J., et al. (2009) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyAlcohol Consumption and Health Effects

Cited by 223

CX3CL1-CX3CR1 Interaction Prevents Carbon Tetrachloride-Induced Liver Inflammation and Fibrosis in Mice

Aoyama, T., Inokuchi, S., Brenner, D. A., & Seki, E. (2010) · Hepatology

Liver physiology and pathologyChemokine receptors and signaling

Cited by 211

Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Matsuda, M., & Seki, E. (2020) · Seminars in Liver Disease

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 189

Effect of Weight Loss on Magnetic Resonance Imaging Estimation of Liver Fat and Volume in Patients With Nonalcoholic Steatohepatitis

Patel, N. S., Doycheva, I., Peterson, M. R., Hooker, J., Kisselva, T., Schnabl, B., Seki, E., Sirlin, C. B., & Loomba, R. (2015) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 173

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., et al. (2014) · Journal of Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Yang, Y. M., Noureddin, M., Liu, C., Ohashi, K., Kim, S. Y., Ramnath, D., Powell, E. E., Sweet, M. J., Roh, Y. S., Hsin, I.-F., et al. (2019) · Science Translational Medicine

Liver physiology and pathologyProteoglycans and glycosaminoglycans research

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Modeling alcohol-associated liver disease in a human Liver-Chip

Nawroth, J. C., Petropolis, D. B., Manatakis, D. V., Maulana, T. I., Burchett, G., Schlünder, K., Witt, A., Shukla, A., Kodella, K., Ronxhi, J., et al. (2021) · Cell Reports

Alcohol Consumption and Health Effects3D Printing in Biomedical Research

Cited by 88

TRIF differentially regulates hepatic steatosis and inflammation/fibrosis in mice

Yang, L., Miura, K., Zhang, B., Matsushita, H., Yang, Y. M., Liang, S., Song, J., Roh, Y. S., & Seki, E. (2017) · Cellular and Molecular Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 62

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis

Park, J.-S., Lee, J., Wang, F., Ma, H., Zhou, Z., Lee, Y.-S., Oh, K., Lee, H., Sui, G., Lee, S., et al. (2025) · Experimental & Molecular Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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