Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis
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Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
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HSCs synthesize hyaluronic acid via HAS2, which promotes fibrogenicity in a NOTCH1-dependent manner by stimulating TLR4 and CD44 on HSCs.
“Furthermore, HSCs synthesize hyaluronic acid through the expression of hyaluronic acid synthase 2, which promotes fibrogenicity in a NOTCH1-dependent manner by stimulating TLR4 and CD44 expressed on HSCs themselves (154).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [154]
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Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works
Bataller, R. A., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524282 · Cited by 5,087 · see citing works
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909 · see citing works
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works
Self-citationMederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works
Self-citationRegulation of lung injury and repair by Toll-like receptors and hyaluronan
Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401 · see citing works
Self-citationHyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060 · see citing works
Self-citationNational Vital Statistics Reports NCHS.pdf
Hoyert, D. (2012) · Medical Entomology and Zoology · Cited by 982 · see citing works
Murphy, S. L., Xu, J., & Kochanek, K. D. (2013) · PubMed · Cited by 894 · see citing works
Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.003 · Cited by 678 · see citing works
Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
Walton, K. L., Johnson, K. E., & Harrison, C. A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00461 · Cited by 545 · see citing works
Pietras, A., Katz, A. M., Ekström, E. J., Wee, B., Halliday, J. J., Pitter, K. L., Werbeck, J. L., Amankulor, N., Huse, J. T., & Holland, E. C. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.005 · Cited by 538 · see citing works
CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity
Schmits, R., Filmus, J., Gerwin, N., Senaldi, G., Kiefer, F., Kündig, T. M., Wakeham, A. C., Shahinian, A., Catzavelos, C., Rak, J. W., et al. (1997) · Blood · doi:10.1182/blood.v90.6.2217 · Cited by 390 · see citing works
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44
Li, Y., Jiang, D., Liang, J., Meltzer, E. B., Gray, A., Miura, R., Wogensen, L., Yamaguchi, Y., & Noble, P. W. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102510 · Cited by 382 · see citing works
Self-citationMcDonald, B., McAvoy, E. F., Lam, F., Gill, V., de la Motte, C., Savani, R., & Kubes, P. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071765 · Cited by 345 · see citing works
DDR2 receptor promotes MMP-2–mediated proliferation and invasion by hepatic stellate cells
Olaso, E., Ikeda, K., Eng, F. J., Xu, L.-M., Wang, L., Lin, H. C., & Friedman, S. L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112373 · Cited by 291 · see citing works
Liang, J., Zhang, Y., Xie, T., Liu, N., Chen, H., Geng, Y., Kurkciyan, A., Mena, J. M., Stripp, B. R., Jiang, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4192 · Cited by 287 · see citing works
Self-citationYang, C., Zeisberg, M., Mosterman, B., Sudhakar, A., Yerramalla, U. L., Holthaus, K. A., Xu, L.-M., Eng, F. J., Afdhal, N. H., & Kalluri, R. (2003) · Gastroenterology · doi:10.1053/gast.2003.50012 · Cited by 282 · see citing works
Nagy, N., Kuipers, H. F., Frymoyer, A. R., Ishak, H. D., Bollyky, J., Wight, T. N., & Bollyky, P. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00123 · Cited by 280 · see citing works
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis
Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0344 · Cited by 250 · see citing works
Self-citationEmerging roles of Notch signaling in liver disease
Geisler, F., & Strazzabosco, M. (2014) · Hepatology · doi:10.1002/hep.27268 · Cited by 250 · see citing works
Notch signaling is activated by TLR stimulation and regulates macrophage functions
Palaga, T., Buranaruk, C., Rengpipat, S., Fauq, A. H., Golde, T. E., Kaufmann, S. H. E., & Osborne, B. A. (2007) · European Journal of Immunology · doi:10.1002/eji.200636999 · Cited by 233 · see citing works
DNase I-hypersensitive sites enhance α1(I) collagen gene expression in hepatic stellate cells
Yata, Y., Scanga, A. E., Gillan, A., Yang, L., Reif, S. S., Breindl, M., Brenner, D. A., & Rippe, R. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50067 · Cited by 192 · see citing works
ELIMINATION OF HYALURONIC ACID FROM THE BLOOD STREAM IN THE HUMAN
Fraser, J. R. E., Laurent, T. C., Engström‐Laurent, A., & Laurent, U. B. G. (1984) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1984.tb00235.x · Cited by 192 · see citing works
Doherty, G. J., Tempero, M. A., & Corrie, P. G. (2017) · Future Oncology · doi:10.2217/fon-2017-0338 · Cited by 153 · see citing works
Matsumoto, K., Li, Y., Jakuba, C. M., Sugiyama, Y., Sayo, T., Okuno, M., Dealy, C. N., Toole, B. P., Takeda, J., Yamaguchi, Y., et al. (2009) · Development · doi:10.1242/dev.038505 · Cited by 150 · see citing works
Zhang, Q., Wang, C., Liu, Z., Liu, X., Han, C., Cao, X., & Li, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310375 · Cited by 150 · see citing works
Self-citationNotch in fibrosis and as a target of anti-fibrotic therapy
Hu, B., & Phan, S. H. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.04.010 · Cited by 150 · see citing works
Overexpression of Hyaluronan in the Tunica Media Promotes the Development of Atherosclerosis
Chai, S., Chai, Q., Danielsen, C. C., Hjorth, P., Nyengaard, J. R., Ledet, T., Yamaguchi, Y., Rasmussen, L. M., & Wogensen, L. (2005) · Circulation Research · doi:10.1161/01.res.0000158963.37132.8b · Cited by 143 · see citing works
Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD)
Miletti-González, K. E., Murphy, K. A., Kumaran, M. N., Ravindranath, A. K., Wernyj, R. P., Kaur, S., Miles, G. D., Lim, E. T., Chan, R., Chekmareva, M. A., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.318774 · Cited by 136 · see citing works
Bansal, R., van Baarlen, J., Storm, G., & Prakash, J. (2015) · Scientific Reports · doi:10.1038/srep18272 · Cited by 107 · see citing works
Hyaluronic acid as a non-invasive biomarker of liver fibrosis
Neuman, M. G., Cohen, L. B., & Nanau, R. M. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.07.019 · Cited by 107 · see citing works
Altered Notch Ligand Expression in Human Liver Disease
Nijjar, S. S., Wallace, L. M., Crosby, H. A., Hübscher, S. G., & Strain, A. J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61116-9 · Cited by 104 · see citing works
TMEM2: A missing link in hyaluronan catabolism identified?
Yamaguchi, Y., Yamamoto, H., Tobisawa, Y., & Irie, F. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.020 · Cited by 82 · see citing works
Saikia, P., Bellos, D., McMullen, M. R., Pollard, K. A., de la Motte, C., & Nagy, L. E. (2017) · Hepatology · doi:10.1002/hep.29144 · Cited by 81 · see citing works
Zeng, Q., Jin, C., Ao, L., Cleveland, J. C., Song, R., Xu, D., Fullerton, D. A., & Meng, X. (2012) · Circulation · doi:10.1161/circulationaha.111.083675 · Cited by 78 · see citing works
Carcinoma Cell Hyaluronan as a “Portable” Cancerized Prometastatic Microenvironment
Turley, E. A., Wood, D. K., & McCarthy, J. B. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3114 · Cited by 77 · see citing works
Tamaki, S., Ueno, T., Torimura, T., Sata, M., & Tanikawa, K. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70074-4 · Cited by 75 · see citing works
Sontake, V., Kasam, R. K., Sinner, D. I., Korfhagen, T. R., Reddy, G. B., White, E. S., Jegga, A. G., & Madala, S. K. (2018) · JCI Insight · doi:10.1172/jci.insight.121252 · Cited by 60 · see citing works
Ramnath, D., Irvine, K. M., Lukowski, S. W., Horsfall, L. U., Loh, Z., Clouston, A. D., Patel, P. J., Fagan, K. J., Iyer, A., Lampe, G., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120274 · Cited by 47 · see citing works
Self-citationNovel drug targets for idiopathic pulmonary fibrosis
Sgalla, G., Cocconcelli, E., Tonelli, R., & Richeldi, L. (2016) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2016.1152186 · Cited by 42 · see citing works
Oncogenic role of the Notch pathway in primary liver cancer
Lu, J., Xia, Y., Chen, K., Zheng, Y., Wang, J., Lu, W., YIN, Q., WANG, F., Zhou, Y., & Guo, C. (2016) · Oncology Letters · doi:10.3892/ol.2016.4609 · Cited by 40 · see citing works
Satoh, T., Ichida, T., Matsuda, Y., Sugiyama, M., Yonekura, K., Ishikawa, T., & Asakura, H. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02164.x · Cited by 38 · see citing works
Tanaka, A., Leung, P. S. C., Kenny, T. P., Au-Young, J. K., Prindiville, T. P., Coppel, R. L., Ansari, A. A., & Gershwin, M. E. (2001) · Journal of Autoimmunity · doi:10.1006/jaut.2001.0522 · Cited by 32 · see citing works
Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis
Klose, R., Berger, C., Moll, I., Adam, M., Schwarz, F., Möhr, K., Augustin, H. G., & Fischer, A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv151 · Cited by 30 · see citing works
Notch signaling regulates col1α1 and col1α2 expression in airway fibroblasts
Hu, M., Ou‐Yang, H., Wu, C., Qu, S., Xu, X.-T., & Wang, P. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214538919 · Cited by 30 · see citing works
Nonalcoholic Steatohepatitis: The Second Leading Indication for Liver Transplantation in the USA
Chedid, M. F. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4724-6 · Cited by 29 · see citing works
Liu, J., Li, Q., Kuehn, M. R., Litingtung, Y., Vokes, S. A., & Chiang, C. C. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2012.12.018 · Cited by 27 · see citing works
Ruiz‐García, A., López‐López, S., Garcı́a-Ramı́rez, J. J., Baladrón, V., Ruiz‐Hidalgo, M. J., Lopez‐Sanz, L., Ballesteros, Á., Laborda, J., Monsalve, E. M., & Díaz-Guerrá, M. J. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600421 · Cited by 27 · see citing works
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TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
Dewidar, B., Meyer, C., Dooley, S., & Meindl-Beinker, A. N. (2019) · Cells · doi:10.3390/cells8111419 · Cited by 837 · see citing works
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Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.012 · Cited by 416 · see citing works
Self-citationBhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146987 · Cited by 367 · see citing works
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Berumen, J. A., Baglieri, J., Kisseleva, T., & Mekeel, K. L. (2020) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1499 · Cited by 276 · see citing works
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Matsuda, M., & Seki, E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1708876 · Cited by 189 · see citing works
Self-citationExtracellular vesicles in fatty liver promote a metastatic tumor microenvironment
Wang, Z., Kim, S. Y., Tu, W., Kim, J., Xu, A. M., Yang, Y. M., Matsuda, M., Reolizo, L., Tsuchiya, T., Billet, S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.013 · Cited by 181 · see citing works
Self-citationKumar, V., Xin, X., Ma, J., Tan, C., Osna, N. A., & Mahato, R. I. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113888 · Cited by 164 · see citing works
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Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis
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Self-citationLiu, Y., Zhou, J., Li, Q., Li, L., Jia, Y., Geng, F., Zhou, J., & Yin, T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.02.019 · Cited by 103 · see citing works
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Abati, E., Manini, A., Comi, G. P., & Corti, S. P. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04408-w · Cited by 84 · see citing works
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Lee, J. H., Rivera, F. J. S., He, L. Y., Basnet, H., Chen, F., Spina, E., Li, L., Torner, C., Chan, J. E., Yarlagadda, D. V. K., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.014 · Cited by 80 · see citing works
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Matsuda, M., & Seki, E. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111556 · Cited by 64 · see citing works
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Self-citationNiu, Z.-S., Wang, W., & Niu, X.-J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i46.6433 · Cited by 47 · see citing works
Luo, J., Zhang, Z., Zeng, Y., Dong, Y., & Ma, L. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117964 · Cited by 47 · see citing works
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Radhakrishnan, S., Ke, J., & Pellizzon, M. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa078 · Cited by 40 · see citing works
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Merens, V., Knetemann, E., Gürbüz, E., Smet, V. D., Messaoudi, N., Reynaert, H., Verhulst, S., & van Grunsven, L. A. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101223 · Cited by 35 · see citing works
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Li, X., Li, Y., Zhang, W., Jiang, F., Lin, L., Wang, Y., Wu, L., Zeng, H., & Zheng, J. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1793 · Cited by 33 · see citing works
Xu, D., Qu, X., Tian, Y., Zhao, J., Xi, Z., Xue, F., Ma, X., Zhu, J., & Xia, Q. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00901-8 · Cited by 32 · see citing works
Andreichenko, I. N., Tsitrina, A. A., Fokin, A. V., Gabdulkhakova, A. I., Maltsev, D. I., Perelman, G., Bulgakova, E. V., Куликов, А. М., Mikaelyan, A. S., & Kotelevtsev, Y. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246301 · Cited by 31 · see citing works
Kim, S. M., Song, G. Y., Shim, A., Lee, J. H., Eom, C. B., Liu, C., Yang, Y. M., & Seki, E. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00781-5 · Cited by 29 · see citing works
Self-citation‘Two-faces’ of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment
Liu, Y., Li, L., Wang, L., Lu, L., Li, Y., Huang, G., & Song, J. (2023) · Discover Oncology · doi:10.1007/s12672-023-00618-1 · Cited by 29 · see citing works
Lam, K.-H., & Ma, S. (2022) · Hepatology · doi:10.1002/hep.32629 · Cited by 28 · see citing works
Rizwan, M., Fokina, A., Kivijärvi, T., Ogawa, M., Kufleitner, M., Laselva, O., Smith, L. J., Bear, C. E., Ogawa, S., Keller, G. M., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202006116 · Cited by 27 · see citing works
Yang, Y. M., Kim, J., Wang, Z., Kim, J., Kim, S. Y., Cho, G. J., Lee, J. H., Kim, S. M., Tsuchiya, T., Matsuda, M., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci180802 · Cited by 26 · see citing works
Self-citationModulation of hyaluronan signaling as a therapeutic target in human disease
Garantziotis, S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107993 · Cited by 26 · see citing works
Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection
Barnes, H. W., Demirdjian, S., Haddock, N. L., Kaber, G., Martinez, H. A., Nagy, N., Karmouty‐Quintana, H., & Bollyky, P. L. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.02.001 · Cited by 26 · see citing works
Li, B., Huang, Y., Bao, J., Xu, Z., Yan, X., & Zou, Q. (2023) · Small · doi:10.1002/smll.202304675 · Cited by 24 · see citing works
Ravichandra, A., Bhattacharjee, S., & Affò, S. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.01.009 · Cited by 22 · see citing works
The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
Zhu, L., Luo, S., Zhu, Y., Tang, S., Li, C., Jin, X., Wu, F.-L., Jiang, H., Wu, L., & Xu, Y. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s385977 · Cited by 21 · see citing works
Zhou, Z., Liu, Y., Gao, S., Zhou, M., Qi, F., Ding, N., Zhang, J., Li, R., Wang, J., Shi, J., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166303 · Cited by 21 · see citing works
Mukherjee, S. K., Chakraborty, M., Ulmasov, B., McCommis, K. S., Zhang, J., Carpenter, D. H., Msengi, E. N., Haubner, J., Guo, C. H., Pike, D. P., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101364 · Cited by 20 · see citing works
4-Methylumbelliferone Targets Revealed by Public Data Analysis and Liver Transcriptome Sequencing
Tsitrina, A. A., Halimani, N., Andreichenko, I. N., Sabirov, M. S., Nesterchuk, M. V., Dashenkova, N. O., Romanov, R. A., Bulgakova, E. V., Mikaelyan, A. S., & Kotelevtsev, Y. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032129 · Cited by 20 · see citing works
Llewellyn, J., Fede, C., Loneker, A. E., Friday, C. S., Hast, M. W., Theise, N. D., Furth, E. E., Guido, M., Stecco, C., & Wells, R. G. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100760 · Cited by 20 · see citing works
Yang, Z., Zuo, H., Hou, Y., Zhou, S., Zhang, Y., Yang, W., He, J., Shen, X., & Peng, Q. (2024) · Small · doi:10.1002/smll.202406860 · Cited by 19 · see citing works
Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer
Yu, M., Zhang, K., Wang, S., Li, X., Chen, Z., Ning, F., Ning, C., Wang, L., Li, J., Zhang, B., et al. (2021) · BioMed Research International · doi:10.1155/2021/8861766 · Cited by 19 · see citing works
Hao, M., Fu, R., Tai, J., Tian, Z., Yuan, X., Chen, Y., Wang, M., Jiang, H., Ji, M., Lai, F., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.10.006 · Cited by 18 · see citing works
Yang, Q., Tan, T., He, Q., Guo, C., Chen, D., Tan, Y., Feng, J., Song, X., Gong, T., & Li, J. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s407762 · Cited by 17 · see citing works
Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment
Yang, Y., Zhao, Y., Li, W., Wu, Y., Wang, X., Wang, Y., Liu, T.-M., Ye, T., Xie, Y., Cheng, Z., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112311 · Cited by 17 · see citing works
Self-citationMenko, A. S., Romisher, A., & Walker, J. L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.862423 · Cited by 17 · see citing works
Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection
Marshall, P. L., Nagy, N., Kaber, G., Barlow, G. L., Ramesh, A., Xie, B. J., Linde, M. H., Haddock, N. L., Lester, C. A., Tran, Q., et al. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.12.001 · Cited by 15 · see citing works
Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles
Wu, S., Xu, T., Gao, J., Zhang, Q., Huang, Y., Liu, Z., Hao, X., Yao, Z., Hao, X., Wu, P., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06894-5 · Cited by 15 · see citing works
Self-citationWang, J., Teng, F., Chai, H., Zhang, C., Liang, X., & Yang, Y. (2021) · BMC Cancer · doi:10.1186/s12885-021-08202-y · Cited by 15 · see citing works
Self-citationYang, Y. M., Wang, Z., Matsuda, M., & Seki, E. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01309-7 · Cited by 15 · see citing works
Self-citationLoss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2
Hong, D.-G., Song, G. Y., Eom, C. B., Ahn, J.-H., Kim, S. M., Shim, A., Han, Y., Roh, Y., Han, C. Y., Bae, E. J., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.027 · Cited by 15 · see citing works
Self-citationWang, L., Huang, Y., Chen, J., Gao, J., Chen, S., Zhao, M., Lin, J., Zhou, S., Shen, Y., & Cheng, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1635763 · Cited by 14 · see citing works
Hyaluronic Acid in Liver Fibrosis: Role in Inflammation, Tissue Remodeling, and Disease Progression
Rojano-Alfonso, C., López‐Vicario, C., Romero-Grimaldo, B., Contreras, B. J., Clària, J., & Titos, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010139 · Cited by 14 · see citing works
Markovic, J., Li, R., Khanal, R., Peng, Q., Möbus, S., Yuan, Q., Engel, B., Taubert, R., Vondran, F. W. R., Bantel, H., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.08.014 · Cited by 14 · see citing works
Activated cardiac fibroblasts are a primary source of high-molecular-weight hyaluronan production
Little, D. T., Howard, C. M., Pendergraft, E., Brittian, K. R., Audam, T. N., Lukudu, E. W., Smith, J. L., Nguyen, D. C., Nishida, Y., Yamaguchi, Y., et al. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00786.2024 · Cited by 14 · see citing works
Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease
Aasadollahei, N., Rezaei, N., Golroo, R., Agarwal, T., Vosough, M., & Piryaei, A. (2023) · EXCLI journal · doi:10.17179/excli2022-5892 · Cited by 14 · see citing works
Liu, J., Liu, X., Shan, Y., Ting, H. J., Yu, X., Wang, J., & Liu, B. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122506 · Cited by 13 · see citing works
Gao, H., Wang, X., Ma, H., Lin, S., Zhang, D., Wu, W., Liao, Z., Chen, M., Ye, H., Li, Q., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-25738-6 · Cited by 13 · see citing works
Nokkeaw, A., Thamjamrassri, P., Tangkijvanich, P., & Ariyachet, C. (2023) · Cells · doi:10.3390/cells12030378 · Cited by 13 · see citing works
Kim, K., & Kim, K. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072296 · Cited by 13 · see citing works
Shao, C., Xu, H., Sun, X., Pan, Y., Liang, X., Huang, J., He, Y., Guo, W., Ye, L., & Zhang, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117486 · Cited by 12 · see citing works
Interactions between hepatic stellate cells and immune cells: Implications for liver fibrosis
Xie, D., Huang, Y., Yu, Y., Jin, W., Zhang, X., & Yu, F. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.168062 · Cited by 12 · see citing works
Halimani, N., Nesterchuk, M. V., Tsitrina, A. A., Sabirov, M. S., Andreichenko, I. N., Dashenkova, N. O., Petrova, E., Куликов, А. М., Zatsepin, T. S., Romanov, R. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53089-x · Cited by 12 · see citing works
Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma
Affò, S., Sererols-Viñas, L., Garcia‐Vicién, G., Cadamuro, M., Chakraborty, S., & Sirica, A. E. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.009 · Cited by 12 · see citing works
Zhang, X., Zhong, Y., Miao, Z., & Yang, Q. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114035 · Cited by 12 · see citing works
A thioacetamide-induced liver fibrosis model for pre-clinical studies in microminipig
Nishi, K., Yagi, H., Ohtomo, M., Nagata, S., Udagawa, D., Tsuchida, T., Morisaku, T., & Kitagawa, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-42144-8 · Cited by 12 · see citing works
Song, G. Y., Kim, S. M., Back, S. H., Yang, S.-B., & Yang, Y. M. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.083 · Cited by 11 · see citing works
Self-citationLi, B., Bao, J., Huang, Y., Liu, J., Yan, X., & Zou, Q. (2024) · Small · doi:10.1002/smll.202409038 · Cited by 11 · see citing works
Zhang, M., Jing, H., Liu, X., Milichko, V. A., Dou, Y., Ren, Y., Qiu, Z., Li, W., Liu, W., Wang, X., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.008 · Cited by 11 · see citing works
Yu, P., Liu, M., Zhang, B., Yu, Y., Su, E., Xie, S., Zhang, L., Yang, X., Jiang, H., Chen, R., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00340-9 · Cited by 11 · see citing works
Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors
Tsitrina, A. A., Krasylov, I. V., Maltsev, D. I., Andreichenko, I. N., Москвина, В. С., Ivankov, D. N., Bulgakova, E. V., Nesterchuk, M. V., Shashkovskaya, V. S., Dashenkova, N. O., et al. (2021) · Glycobiology · doi:10.1093/glycob/cwab038 · Cited by 11 · see citing works
Kocurková, A., Nešporová, K., Sandanusova, M., Kerberova, M., Lehká, K., Velebný, V., Kubala, L., & Ambrožová, G. (2021) · Biomolecules · doi:10.3390/biom12010045 · Cited by 11 · see citing works
Han, J., Lee, C., Jeong, H., Jeon, S.-H., Lee, M., Lee, H., Choi, Y. H., & Jung, Y. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01042-5 · Cited by 11 · see citing works
Zhang, D., Zhang, J., Zhang, J., Ji, X., Qi, Q., Xu, J., Pan, Y., Liu, X., Sun, F., Zeng, R., et al. (2023) · Respiratory Research · doi:10.1186/s12931-023-02488-1 · Cited by 10 · see citing works
Lv, Q., Wang, J., Yang, H., Chen, X., Zhang, Y., Ji, G.-Y., Hu, L., & Zhang, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155561 · Cited by 9 · see citing works
Zhang, Y., Qu, J., Luo, R., Jia, K., Fan, G., Li, F., Wu, R., Li, J., & Li, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155923 · Cited by 9 · see citing works
Kirkness, K. B., & Scarlata, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010160 · Cited by 9 · see citing works
Uno, K., Miyajima, K., Toma, M., Suzuki‐Kemuriyama, N., & Nakae, D. (2021) · Journal of Toxicologic Pathology · doi:10.1293/tox.2021-0069 · Cited by 9 · see citing works
Macrophage heterogeneity in liver fibrosis
Wang, W., Li, S., Liu, Y., Ding, X., Yang, Y., Chen, S., Cao, J., Tacke, F., Dong, W., & Lan, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639455 · Cited by 8 · see citing works
Self-citationIncreased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice
Bao, Y., Wu, W., Lin, J., Yang, Y., Lin, S. K., Su, J., Qin, Y., Wang, B., & Duan, S. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01146-0 · Cited by 8 · see citing works
Self-citationMeng, H., Jiang, L., Jia, P., Niu, R., Bu, F., Zhu, Y. Y., Pan, X., Li, J., Liu, J., Zhang, Y., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115451 · Cited by 8 · see citing works
Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc
Wang, J., Ruan, S., Yu, T., Meng, X., Ran, J., Cen, C., Kong, C., Bao, X., Li, Z., Wang, Y., et al. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111218 · Cited by 7 · see citing works
Kim, J. E., Kim, Y., Bae, J., Yoon, E. L., Kim, H. S., Lee, S. R., Yoon, T. H., & Jun, D. W. (2025) · Archives of Pharmacal Research · doi:10.1007/s12272-025-01534-4 · Cited by 7 · see citing works
Cirrhosis Promotes Cardiac Fibrosis Development by Inhibiting Notch1 in Cardiac Fibroblasts
Sun, H., Song, K., Zhou, Z.-Y., Tu, B., Zhou, Y., Lin, L.-C., Liu, Z., Liu, Z., Sha, J.-M., Shi, Y. X., et al. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.11.015 · Cited by 7 · see citing works
Self-citationInflammation-Associated Cytotoxic Agents in Tumorigenesis
Arnhold, J. (2023) · Cancers · doi:10.3390/cancers16010081 · Cited by 7 · see citing works
- Authors
- Yang, Y. M., Noureddin, M., Liu, C., Ohashi, K., Kim, S. Y., Ramnath, D., Powell, E. E., Sweet, M. J., Roh, Y. S., Hsin, I.-F., Deng, N., Liu, Z., Liang, J., Mena, E., Shouhed, D., Schwabe, R. F., Jiang, D., Lu, S. C., Noble, P. W., & Seki, E.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Shanghai University of Traditional Chinese Medicine (CN)
- The University of Queensland (AU)
- California Liver Research Institute (US)
- Columbia University (US)
- Corresponding author
- Noureddin, Mazen
- Liu, Cheng
- Seki, Ekihiro
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-06-12
- Volume
- 11
- Issue
- 496
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6589184
- OpenAlex
- W2952382623
- Cited by
- 166
- References
- 52
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 28 · 2023: 30 · 2022: 19 · 2021: 25 · 2020: 14 · 2019: 5
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA025841, R01 AA027036)
- National Heart, Lung, and Blood Institute (R01HL122068, 1T32HL134637-01, P01HL108793)
- National Institute of Allergy and Infectious Diseases (R01AI052201)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085252, R01DK107288)
- American Liver Foundation (ALF Irwin M. Arias, MD Postdoctoral Research Fellowship, ALF Congressman John Joseph Moakley Postdoctoral Research Fellowship)
- American Association for the Study of Liver Diseases (AASLD The Leonard B. Seeff Award for Outstanding Research by Young Investigator)
- Cedars-Sinai Medical Center (Winnick Research award)
- Kangwon National University
- National Research Foundation of Korea (2014R1A6A3A01054056, 2017R1A5A2015541, 2017R1C1B2004423)
- Colleges and universities in Shanghai (A-U151902)
- National Natural Science Foundation of China (81673788)
- National Health and Medical Research Council of Australia (NHMRC Senior Research Fellowship, ID: 1107914)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- hyaluronic acid, HAS2, liver fibrosis, Notch1, hepatic stellate cells, stellate cell activation, TGF-beta, Wilms tumor 1, CD44, TLR4, 4-methylumbelliferone, extracellular matrix, fibrosis treatment
- MeSH terms
- Hyaluronan Synthases, RNA-Seq, Enzyme-Linked Immunosorbent Assay, Humans, Hyaluronic Acid, Hymecromone, Liver Cirrhosis, Hyaluronan Receptors, Toll-Like Receptor 4, Hepatic Stellate Cells, HEK293 Cells
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