Glass, Christopher K.

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell

Immune Response and InflammationEstrogen and related hormone effects

Cited by 647

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 638

Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

Glass, C. K., & Saijo, K. (2010) · Nature Reviews Immunology

Nuclear Receptors and SignalingEstrogen and related hormone effects

Cited by 619

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

Lin, C., Yang, L., Tanasa, B., Hutt, K., Ju, B.-G., Ohgi, K. A., Zhang, J., Rose, D. W., Fu, X.-D., Glass, C. K., et al. (2009) · Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 576

Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ

Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M.-E., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2007) · Molecular Cell

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 561

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Lam, M. T. Y., Cho, H., Lesch, H. P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M. U., Kim, A. S., Kosaka, M., et al. (2013) · Nature

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 548

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

Haney, M. S., Pálovics, R., Munson, C. N., Long, C., Johansson, P. K., Yip, O., Dong, W., Rawat, E., West, E., Schlachetzki, J. C. M., et al. (2024) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 536

Origin of myofibroblasts in the fibrotic liver in mice

Iwaisako, K., Jiang, C., Zhang, M., Cong, M., Moore-Morris, T. J., Park, T. J., Liu, X., Xu, J., Wang, P., Paik, Y.-H., et al. (2014) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 535

Deconstructing repression: evolving models of co-repressor action

Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 532

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

Que, X., Hung, M.-Y., Yeang, C., Gonen, A., Prohaska, T. A., Sun, X., Diehl, C., Määttä, A., Gaddis, D. E., Bowden, K., et al. (2018) · Nature

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 529

Coregulator codes of transcriptional regulation by nuclear receptors

Rosenfeld, M. G., & Glass, C. K. (2001) · Journal of Biological Chemistry

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 509

Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S.-H., Chenoweth, J., Schwartz, P., Pevzner, P. A., Glass, C., Mandel, G., et al. (2002) · Science

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 472

Microbiome–microglia connections via the gut–brain axis

Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsGut microbiota and health

Cited by 471

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

Hevener, A. L., Olefsky, J. M., Reichart, D., Nguyen, M. T. A., Bandyopadyhay, G., Leung, H.-Y., Watt, M. J., Benner, C., Febbraio, M. A., Nguyen, A.-K., et al. (2007) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 459

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 443

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

Liu, W., Tanasa, B., Tyurina, O. V., Zhou, T. Y., Gassmann, R., Liu, W. T., Ohgi, K. A., Benner, C., Garcia-Bassets, I., Aggarwal, A. K., et al. (2010) · Nature

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 441

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

Kurokawa, R., DiRenzo, J., Boehm, M., Sugarman, J., Gloss, B., Rosenfeld, M. G., Heyman, R. A., & Glass, C. K. (1994) · Nature

Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated Receptors

Cited by 429

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., et al. (2019) · Immunity

Liver physiology and pathologyImmune cells in cancer

Cited by 418

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

Hasselmann, J., Coburn, M. A., England, W., Figueroa Velez, D. X., Kiani Shabestari, S., Tu, C. H., McQuade, A., Kolahdouzan, M., Echeverria, K., Claes, C., et al. (2019) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 380

The histone deacetylase-3 complex contains nuclear receptor corepressors

Wen, Y.-D., Perissi, V., Staszewski, L. M., Yang, W.-M., Krones, A., Glass, C. K., Rosenfeld, M. G., & Seto, E. (2000) · Proceedings of the National Academy of Sciences

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 378

Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene

Li, M., Pascual, G., & Glass, C. K. (2000) · Molecular and Cellular Biology

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 377

Signaling by Nuclear Receptors

Sever, R., & Glass, C. K. (2013) · Cold Spring Harbor Perspectives in Biology

Estrogen and related hormone effectsNuclear Receptors and Signaling

Cited by 374

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

Gorden, D. L., Myers, D. S., Ivanova, P. T., Fahy, E., Maurya, M. R., Gupta, S., Min, J., Spann, N. J., McDonald, J. G., Kelly, S. L., et al. (2015) · Journal of Lipid Research

Liver Disease Diagnosis and TreatmentMetabolomics and Mass Spectrometry Studies

Cited by 372

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

Li, A. C., & Glass, C. K. (2004) · Journal of Lipid Research

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Cited by 357