Larsson, Nils-Göran

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 2,734

Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice

Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,594

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., et al. (2022) · Nature Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,514

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 1,087

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 836

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

Ekstrand, M. I., Terzioglu, M., Galter, D., Zhu, S., Hofstetter, C., Lindqvist, E., Thams, S., Bergstrand, A., Hansson, F. S., Trifunovic, A., et al. (2007) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 605

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.-G., & Gustafsson, C. M. (2002) · Nature Genetics

Mitochondrial Function and PathologyGenomics and Chromatin Dynamics

Cited by 598

Mammalian Mitochondria and Aging: An Update

Kauppila, T. E. S., Kauppila, J. H. K., & Larsson, N.-G. (2017) · Cell Metabolism

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 578

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A. T., Dufour, E., Khvorostov, I., Spelbrink, J. N., Wibom, R., Jacobs, H. T., & Larsson, N.-G. (2005) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 555

MOLECULAR GENETIC ASPECTS OF HUMAN MITOCHONDRIAL DISORDERS

Larsson, N.-G., & Clayton, D. A. (1995) · Annual Review of Genetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 493

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.

Wang, J., Wilhelmsson, H., Graff, C., Li, H., Oldfors, A., Rustin, P., Brüning, J. C., Kahn, C. R., Clayton, D. A., Barsh, G. S., et al. (1999) · Nature Genetics

Mitochondrial Function and PathologyCardiac electrophysiology and arrhythmias

Cited by 435

Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

Silva, J. P., Köhler, M., Graff, C., Oldfors, A., Magnuson, M. A., Berggren, P.-O., & Larsson, N.-G. (2000) · Nature Genetics

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 433

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

Kadkhodaei, B., Ito, T., Joodmardi, E., Mattsson, B., Rouillard, C., Carta, M., Muramatsu, S.-I., Sumi-Ichinose, C., Nomura, T., Metzger, D., et al. (2009) · The Journal of Neuroscience

Nuclear Receptors and SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 382

Progressive Increase of the Mutated Mitochondrial DNA Fraction in Kearns-Sayre Syndrome

Larsson, N.-G., Holme, E., Kristiansson, B., Oldfors, A., & Tulinius, M. (1990) · Pediatric Research

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 324

Increased mitochondrial mass in mitochondrial myopathy mice

Wredenberg, A., Wibom, R., Wilhelmsson, H., Graff, C., Wiener, H. H., Burden, S. J., Oldfors, A., Westerblad, H., & Larsson, N.-G. (2002) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 302

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

Ross, J. M., Öberg, J., Brené, S., Coppotelli, G., Terzioglu, M., Pernold, K., Goiny, M., Sitnikov, R., Kehr, J., Trifunovic, A., et al. (2010) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 299

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

Ross, J. M., Stewart, J. B., Hagström, E., Brené, S., Mourier, A., Coppotelli, G., Freyer, C., Lagouge, M., Hoffer, B. J., Olson, L., et al. (2013) · Nature

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 273

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., et al. (2012) · Cell Metabolism

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 245

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression

Wang, J., Silva, J. P., Gustafsson, C. M., Rustin, P., & Larsson, N.-G. (2001) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 245

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

Hansson, A., Hance, N., Dufour, E., Rantanen, A., Hultenby, K., Clayton, D. A., Wibom, R., & Larsson, N.-G. (2004) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 220

Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy

Li, H., Wang, J., Wilhelmsson, H., Hansson, A., Thorén, P., Duffy, J., Rustin, P., & Larsson, N.-G. (2000) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyCardiac electrophysiology and arrhythmias

Cited by 185

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

Milenkovic, D., Matic, S., Kuhl, I., Ruzzenente, B., Freyer, C., Jemt, E., Park, C. B., Falkenberg, M., & Larsson, N.-G. (2013) · Human Molecular Genetics

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 173

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice

Sörensen, L., Ekstrand, M., Silva, J., Lindqvist, E., Xu, B., Rustin, P., Olson, L., & Larsson, N.-G. (2001) · The Journal of Neuroscience

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 167

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

Wredenberg, A., Freyer, C., Sandström, M. E., Katz, A., Wibom, R., Westerblad, H., & Larsson, N.-G. (2006) · Biochemical and Biophysical Research Communications

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 141