Cited by 837Redox biology and oxidative stressAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

Unraveling the biological roles of reactive oxygen species

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Murphy, Michael P., Holmgren, Arne, Larsson, Nils-Göran, Halliwell, Barry, Chang, Christopher J., Kalyanaraman, Balaraman, Rhee, Sue Goo, Thornalley, Paul J. +6 more·2011·Cell Metabolism

Abstract

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.

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Authors
Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., Nyström, T., Belousov, V., Schumacker, P. T., & Winterbourn, C. C.
Affiliations
  • MRC Mitochondrial Biology Unit (GB)
  • Karolinska Institutet (SE)
  • Max Planck Institute for Biology of Ageing (DE)
  • National University of Singapore (SG)
  • Howard Hughes Medical Institute (US)
  • Medical College of Wisconsin (US)
  • Ewha Womans University (KR)
  • University Hospital Coventry (GB)
  • University College London (GB)
  • University of Gothenburg (SE)
  • Institute of Bioorganic Chemistry (RU)
  • Northwestern University (US)
  • University of Otago (NZ)
Corresponding author
Murphy, Michael P.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2011-04
Volume
13
Issue
4
Pages
361-366
ISSN
1550-4131 (ISSN-L)
OpenAlex
W1967236260
Cited by
836
References
49
Citations by year
2026: 31 · 2025: 44 · 2024: 49 · 2023: 55 · 2022: 61 · 2021: 64 · 2020: 61 · 2019: 47 · 2018: 51 · 2017: 53 · 2016: 66 · 2015: 64 · 2014: 60 · 2013: 59 · 2012: 48
FWCI
24.69
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • National University of Singapore (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Wellcome Trust (081394)
  • Medical Research Council (MC_G0901472)
  • Biotechnology and Biological Sciences Research Council (BB/D020786/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
reactive oxygen species, oxidative damage, redox signaling, biological regulation, oxidative stress, redox biology
MeSH terms
Antioxidants, Signal Transduction, Reactive Oxygen Species, Oxidative Stress

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