Soranzo, Nicole

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 442

Genetic architecture: the shape of the genetic contribution to human traits and disease

Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J., & Richards, J. B. (2018) · Nature Reviews Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 434

Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach

Menni, C., Fauman, E., Erte, I., Perry, J. R. B., Kastenmüller, G., Shin, S.-Y., Petersen, A.-K., Hyde, C., Psatha, M., Ward, K. J., et al. (2013) · Diabetes

Metabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 416

Impact of common genetic determinants of hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Wheeler, E., Leong, A., Liu, C.-T., Hivert, M.-F., Strawbridge, R. J., Podmore, C., Li, M., Yao, J., Sim, X., Hong, J., et al. (2017) · PLOS Medicine

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 408

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Gräf, S., Haimel, M., Bleda, M., Hadinnapola, C., Southgate, L., Li, W., Hodgson, J., Liu, B., Salmon, R. M., Southwood, M., et al. (2018) · Nature Communications

Pulmonary Hypertension Research and TreatmentsVascular Anomalies and Treatments

Cited by 380

Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements

Grundberg, E., Meduri, E., Sandling, J. K., Hedman, Å. K., Keildson, S., Buil, A., Busche, S., Yuan, W., Nisbet, J., Sekowska, M., et al. (2013) · The American Journal of Human Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 370

Common variants near TERC are associated with mean telomere length

Wellcome Trust Case Control Consortium, Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., et al. (2010) · Nature Genetics

Telomeres, Telomerase, and SenescenceGenetic Associations and Epidemiology

Cited by 344

Human serum metabolic profiles are age dependent

Yu, Z., Zhai, G., Singmann, P., He, Y., Xu, T., Prehn, C., Römisch‐Margl, W., Lattka, E., Gieger, C., Soranzo, N., et al. (2012) · Aging Cell

Metabolomics and Mass Spectrometry StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 340

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpeläinen, T. O., Zillikens, M. C., Stančákova, A., Finucane, F. M., Ried, J. S., Langenberg, C., Zhang, W., Beckmann, J. S., Luan, J., Vandenput, L., et al. (2011) · Nature Genetics

Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Cited by 335

Genetic evidence of assortative mating in humans

Robinson, M. R., Kleinman, A., Graff, M., Vinkhuyzen, A. A. E., Couper, D., Miller, M. B., Peyrot, W. J., Abdellaoui, A., Zietsch, B. P., Nolte, I. M., et al. (2017) · Nature Human Behaviour

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 326

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

CHARGE-Heart Failure Consortium, Surendran, P., EchoGen Consortium, METASTROKE Consortium, GIANT Consortium, EPIC-InterAct Consortium, Study, L. C., Wellcome Trust Case Control Consortium, Understanding Society Scientific Group, EPIC-CVD Consortium, et al. (2016) · Nature Genetics

Genetic Associations and EpidemiologyBlood Pressure and Hypertension Studies

Cited by 312

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., McArdle, P. F., Smith, A. V., Aspelund, T., Bandinelli, S., Boerwinkle, E., et al. (2009) · Nature Genetics

Hypothalamic control of reproductive hormonesGenetic Associations and Epidemiology

Cited by 294

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Teumer, A., Chaker, L., Groeneweg, S., Li, Y., Di Munno, C., Barbieri, C., Schultheiss, U. T., Traglia, M., Ahluwalia, T. S., Akiyama, M., et al. (2018) · Nature Communications

Thyroid Disorders and TreatmentsGenetic Associations and Epidemiology

Cited by 280

Building pangenome graphs

Garrison, E., Guarracino, A., Heumos, S., Villani, F., Bao, Z., Tattini, L., Hagmann, J., Vorbrugg, S., Marco-Sola, S., Kubica, C., et al. (2024) · Nature Methods

Genomics and Phylogenetic StudiesGenome Rearrangement Algorithms

Cited by 277

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene ( AUTS2 ) in the regulation of alcohol consumption

Schumann, G., Coin, L. J., Lourdusamy, A., Charoen, P., Berger, K. H., Stacey, D., Desrivières, S., Aliev, F. A., Khan, A. A., Amin, N., et al. (2011) · Proceedings of the National Academy of Sciences

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 264

Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology

Levy, D., Neuhausen, S. L., Hunt, S. C., Kimura, M., Hwang, S.-J., Chen, W., Bis, J. C., Fitzpatrick, A. L., Smith, E., Johnson, A. D., et al. (2010) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetic Associations and Epidemiology

Cited by 259

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Coviello, A. D., Haring, R., Wellons, M., Vaidya, D., Lehtimäki, T., Keildson, S., Lunetta, K. L., He, C., Fornage, M., Lagou, V., et al. (2012) · PLoS Genetics

Genetic Associations and EpidemiologyHormonal and reproductive studies

Cited by 250

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins, N., Kang, J., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., et al. (2022) · Biological Psychiatry

Suicide and Self-Harm StudiesGenetic Associations and Epidemiology

Cited by 238

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

Medici, M., Porcu, E., Pistis, G., Teumer, A., Brown, S. J., Jensen, R. A., Rawal, R., Roef, G. L., Plantinga, T. S., Vermeulen, S. H., et al. (2014) · PLoS Genetics

Thyroid Disorders and TreatmentsGenetic Associations and Epidemiology

Cited by 218

A Map of Transcriptional Heterogeneity and Regulatory Variation in Human Microglia

Young, A. M. H., Kumasaka, N., Calvert, F., Hammond, T. R., Knights, A., Panousis, N., Park, J. S., Schwartzentruber, J., Liu, J., Kundu, K., et al. (2021) · Nature Genetics

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 213

Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

Anderson, C. A., Soranzo, N., Zeggini, E., & Barrett, J. C. (2011) · PLoS Biology

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 114

Whole-genome sequence-based analysis of thyroid function

Taylor, P. N., Porcu, E., Chew, S., Campbell, P. J., Traglia, M., Brown, S. J., Mullin, B. H., Shihab, H. A., Min, J., Walter, K., et al. (2015) · Nature Communications

Genetic Associations and EpidemiologyThyroid Disorders and Treatments

Cited by 104

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Southam, L., Soranzo, N., Montgomery, S. B., Frayling, T. M., McCarthy, M. I., Barroso, I., & Zeggini, E. (2009) · Diabetologia

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 103

The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue

Drong, A. W., Nicholson, G., Hedman, Å. K., Meduri, E., Grundberg, E., Small, K. S., Shin, S.-Y., Bell, J. T., Karpe, F., Soranzo, N., et al. (2013) · PLoS ONE

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 79