Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Open accessAbstract
Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
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Causal common variants associated with continuous endophenotypes have been associated with disease in many cases.
“In many cases, causal common variants associated with a continuous endophenotype have been associated with disease [eg80–82]”
From Rare and common variants: twenty arguments (2012) · cites this paper as [80]
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PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
(2000) · PubMed · Cited by 13,173 · see citing works
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works
Lippa, N. C., & Sanderson, S. C. (2013) · Human Heredity · doi:10.1159/000353712 · Cited by 6,093 · see citing works
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531 · see citing works
Self-citationBiological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487 · see citing works
Self-citationMerlin—rapid analysis of dense genetic maps using sparse gene flow trees
Abecasis, G. R., Cherny, S. S., Cookson, W., & Cardon, L. R. (2001) · Nature Genetics · doi:10.1038/ng786 · Cited by 3,323 · see citing works
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works
Self-citationLocusZoom: regional visualization of genome-wide association scan results
Pruim, R. J., Welch, R. P., Sanna, S., Teslovich, T. M., Chines, P. S., Gliedt, T. P., Boehnke, M., Abecasis, G. R., & Willer, C. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq419 · Cited by 2,707 · see citing works
A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609 · see citing works
Genomewide Association Analysis of Coronary Artery Disease
Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044 · see citing works
Self-citationScuteri, A., Sanna, S., Chen, W.-M., Uda, M., Albai, G., Strait, J., Najjar, S., Nagaraja, R., Orrú, M., Usala, G., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030115 · Cited by 1,724 · see citing works
the GIANT Consortium (2009) · Nature Genetics · doi:10.1038/ng.287 · Cited by 1,720 · see citing works
Self-citationReconstructing Indian population history
Reich, D., Thangaraj, K., Patterson, N., Price, A. L., & Singh, L. (2009) · Nature · doi:10.1038/nature08365 · Cited by 1,674 · see citing works
Genetic and Environmental Factors in Relative Body Weight and Human Adiposity
Maes, H. H. M., Neale, M. C., & Eaves, L. J. (1997) · Behavior Genetics · doi:10.1023/a:1025635913927 · Cited by 1,515 · see citing works
Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375 · see citing works
Common variants near MC4R are associated with fat mass, weight and risk of obesity
The Prostate, L., Loos, R. J. F., KORA, Study, N. H., Initiative, D. G., Study, T. S., The Wellcome Trust Case Control Consortium, FUSION, Lindgren, C. M., Li, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.140 · Cited by 1,325 · see citing works
Self-citationObesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works
Genetics of gene expression and its effect on disease
Emilsson, V., Thorleifsson, G., Zhang, B., Leonardson, A. S., Zink, F., Zhu, J., Carlson, S., Helgason, A., Walters, G. B., Gunnarsdottir, S., et al. (2008) · Nature · doi:10.1038/nature06758 · Cited by 1,296 · see citing works
Self-citationAlternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
Araki, E., Lipes, M. A., Patti, M.-E., Brüning, J. C., Haag III, B., Johnson, R. S., & Kahn, C. R. (1994) · Nature · doi:10.1038/372186a0 · Cited by 1,252 · see citing works
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S., et al. (1994) · Nature · doi:10.1038/372182a0 · Cited by 1,082 · see citing works
MAGIC, Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., et al. (2010) · Nature Genetics · doi:10.1038/ng.685 · Cited by 931 · see citing works
Self-citationLindgren, C. M., Heid, I. M., Randall, J. C., Lamina, C., Steinthórsdóttir, V., Qi, L., Speliotes, E. K., Þorleifsson, G., Willer, C. J., Herrera, B. M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000508 · Cited by 701 · see citing works
Self-citationHunter, D. J., Peltonen, L., Guiducci, C., Crawford, G., Hirschhorn, J. N., Lyon, H. N., & Speliotes, E. K. (2009) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 687 · see citing works
Self-citationMeyre, D., Delplanque, J., Chèvre, J.-C., Lecœur, C., Lobbens, S., Gallina, S., Durand, E., Vatin, V., Degraeve, F., Cavalcanti-Proença, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.301 · Cited by 648 · see citing works
Imputation-Based Analysis of Association Studies: Candidate Regions and Quantitative Traits
Servin, B., & Stephens, M. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030114 · Cited by 520 · see citing works
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
Chambers, J. C., Elliott, P., Zabaneh, D., Zhang, W., Li, Y., Froguel, P., Balding, D. J., Scott, J., & Kooner, J. S. (2008) · Nature Genetics · doi:10.1038/ng.156 · Cited by 497 · see citing works
Self-citationRung, J., Cauchi, S., Albrechtsen, A., Shen, L., Rocheleau, G., Cavalcanti-Proença, C., Bacot, F., Balkau, B., Belisle, A., Borch-Johnsen, K., et al. (2009) · Nature Genetics · doi:10.1038/ng.443 · Cited by 479 · see citing works
A survey of genetic human cortical gene expression
Myers, A. J., Gibbs, J. R., Webster, J. A., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., Leung, D., Bryden, L., Nath, P., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.16 · Cited by 479 · see citing works
Validation of the insulin sensitivity index (ISI0,120): comparison with other measures
Gutt, M., Davis, C. L., Spitzer, S. B., Llabre, M. M., Kumar, M., Czarnecki, E. M., Schneiderman, N., Skyler, J. S., & Marks, J. B. (2000) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00116-3 · Cited by 464 · see citing works
Scherag, A., Christian Dina, C., Hinney, A., Vatin, V., Scherag, S., Vogel, C. I. G., Müller, T. D., Grallert, H., Wichmann, H. ‐., Balkau, B., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000916 · Cited by 327 · see citing works
Self-citationInsulin resistance in type 2 diabetes: role of fatty acids
Arner, P. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.254 · Cited by 324 · see citing works
It's Not How Fat You Are, It's What You Do with It That Counts
Virtue, S., & Vidal‐Puig, A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060237 · Cited by 309 · see citing works
Self-citationHeard‐Costa, N. L., Zillikens, M. C., Monda, K. L., Johansson, Å., Harris, T. B., Fu, M., Haritunians, T., Feitosa, M. F., Aspelund, T., Eiríksdóttir, G., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000539 · Cited by 282 · see citing works
Self-citationThe adipocyte as an active participant in energy balance and metabolism
Badman, M. K., & Flier, J. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.058 · Cited by 256 · see citing works
Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies
Zhong, H., Yang, X., Kaplan, L. M., Molony, C. M., & Schadt, E. E. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.02.020 · Cited by 234 · see citing works
Self-citationSprouty proteins, masterminds of receptor tyrosine kinase signaling
Cabrita, M. A., & Christofori, G. (2008) · Angiogenesis · doi:10.1007/s10456-008-9089-1 · Cited by 230 · see citing works
Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation
Miki, H., Yamauchi, T., Suzuki, R., Komeda, K., Tsuchida, A., Kubota, N., Terauchi, Y., Kamon, J., Kaburagi, Y., Matsui, J., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.7.2521-2532.2001 · Cited by 214 · see citing works
Type 2 diabetes and cardiovascular risk in the UK south Asian community
Barnett, A. H., Dixon, A., Bellary, S., Hanif, M. W., O’Hare, J. P., Raymond, N. T., & Kumar, S. (2006) · Diabetologia · doi:10.1007/s00125-006-0325-1 · Cited by 213 · see citing works
Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation
Tseng, Y.-H., Kriauciunas, K. M., Kokkotou, E., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1918-1929.2004 · Cited by 173 · see citing works
Wang, Z. V., Deng, Y., Wang, Q. A., Sun, K., & Scherer, P. E. (2010) · Endocrinology · doi:10.1210/en.2010-0136 · Cited by 156 · see citing works
Lipoatrophic diabetes in Irs1−/−/Irs3−/− double knockout micePreprint
Laustsen, P. G., Michael, M. D., Crute, B. E., Cohen, S. E., Ueki, K., Kulkarni, R. N., Keller, S. R., Lienhard, G. E., & Kahn, C. R. (2002) · Genes & Development · doi:10.1101/gad.1034802 · Cited by 131 · see citing works
Lee, C.-C., Putnam, A. J., Miranti, C. K., Gustafson, M. F., Wang, L.-M., Woude, G. F. V., & Gao, C.-F. (2004) · Oncogene · doi:10.1038/sj.onc.1207646 · Cited by 124 · see citing works
The C Terminus of Sprouty Is Important for Modulation of Cellular Migration and Proliferation
Yigzaw, Y., Cartin, L., Pierre, S. C., Scholich, K., & Patel, T. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100123200 · Cited by 106 · see citing works
Kaburagi, Y., Satoh, S., Tamemoto, H., Yamamoto‐Honda, R., Tobe, K., Veki, K., Yamauchi, T., Kono‐Sugita, E., Sekihara, H., Aizawa, S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25839 · Cited by 101 · see citing works
The 60 kDa Insulin Receptor Substrate Functions Like an IRS Protein (pp60IRS3) in Adipose Cells
Smith-Hall, J., Pons, S., Patti, M., Burks, D. J., Yenush, L., Sun, X., Kahn, C. R., & White, M. F. (1997) · Biochemistry · doi:10.1021/bi9630974 · Cited by 83 · see citing works
Regulation of Vascular Smooth Muscle Cell Proliferation and Migration by Human Sprouty 2
Zhang, C., Chaturvedi, D., Jaggar, L., Magnuson, D. J., Lee, J. M., & Patel, T. B. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000155461.50450.5a · Cited by 62 · see citing works
Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation
Urs, S., Venkatesh, D., Tang, Y., Henderson, T., Yang, X., Friesel, R. E., Rosen, C. J., & Liaw, L. (2010) · The FASEB Journal · doi:10.1096/fj.10-155127 · Cited by 58 · see citing works
Physiologic Characterization of Type 2 Diabetes–Related Loci
Grarup, N., Sparsø, T., & Hansen, T. F. (2010) · Current Diabetes Reports · doi:10.1007/s11892-010-0154-y · Cited by 55 · see citing works
Zhou, L., Chen, H., Lin, C. H., Cong, L.-N., McGibbon, M. A., Sciacchitano, S., Lesniak, M. A., Quon, M. J., & Taylor, S. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29829 · Cited by 53 · see citing works
Multiple sites of insulin resistance: muscle, liver and adipose tissue
Stümvoll, M., & Jacob, S. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212083 · Cited by 52 · see citing works
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Study, T. L. C., Locke, A. E., The ADIPOGen Consortium, The AGEN-BMI Working Group, The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The, G. L. G. C., The, I. C. B. P., The MAGIC Investigators, The MuTHER Consortium, et al. (2015) · Nature · doi:10.1038/nature14177 · Cited by 4,534 · see citing works
Self-citationVisscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425 · see citing works
Ageing as a Risk Factor for Disease
Niccoli, T., & Partridge, L. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.024 · Cited by 1,831 · see citing works
The genetics of obesity: From discovery to biology
Loos, R. J. F., & Yeo, G. S. H. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00414-z · Cited by 1,291 · see citing works
Self-citationRare and common variants: twenty arguments
Gibson, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3118 · Cited by 1,278 · see citing works
Li, G., Ruan, X., Auerbach, R. K., Sandhu, K. S., Zheng, M., Wang, P., Poh, H. M., Goh, Y., Lim, J., Zhang, J., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.014 · Cited by 1,232 · see citing works
The bigger picture of FTO—the first GWAS-identified obesity gene
Loos, R. J. F., & Yeo, G. S. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.227 · Cited by 724 · see citing works
Self-citationAdiposity and cancer risk: new mechanistic insights from epidemiology
Renehan, A. G., Zwahlen, M., & Egger, M. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3967 · Cited by 654 · see citing works
Lotta, L. A., Gulati, P., Day, F. R., Payne, F., Ongen, H., van de Bunt, M., Gaulton, K. J., Eicher, J. D., Sharp, S. J., Luan, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3714 · Cited by 587 · see citing works
Self-citationMetabolically Healthy Obesity and Risk of All-Cause and Cardiovascular Disease Mortality
Hamer, M., & Stamatakis, E. A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3475 · Cited by 565 · see citing works
Dastani, Z., Hivert, M., Timpson, N. J., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002607 · Cited by 490 · see citing works
Self-citationVoight, B. F., Kang, H. M., Ding, J., Palmer, C. D., Sidore, C., Chines, P. S., Burtt, N. P., Fuchsberger, C., Li, Y., Erdmann, J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002793 · Cited by 464 · see citing works
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Iacobini, C., Pugliese, G., Blasetti Fantauzzi, C., Federici, M., & Menini, S. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.009 · Cited by 453 · see citing works
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Saltiel, A. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142241 · Cited by 446 · see citing works
Pigeyre, M., Yazdi, F., Kaur, Y., & Meyre, D. (2016) · Clinical Science · doi:10.1042/cs20160136 · Cited by 405 · see citing works
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Rohde, K., Keller, M., la Cour Poulsen, L., Blüher, M., Kovacs, P., & Böttcher, Y. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.007 · Cited by 355 · see citing works
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Self-citationLu, Y., Vitart, V., Burdon, K. P., Khor, C. C., Bykhovskaya, Y., Mirshahi, A., Hewitt, A. W., Koehn, D., Hysi, P. G., Ramdas, W. D., et al. (2013) · Nature Genetics · doi:10.1038/ng.2506 · Cited by 310 · see citing works
Self-citationZhang, M., Wang, B., Liu, Y., Sun, X., Luo, X., Wang, C., Li, L., Zhang, L., Ren, Y., Zhao, Y., et al. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0514-x · Cited by 307 · see citing works
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Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V. A., Cousminer, D. L., Dastani, Z., Drong, A., Esko, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms10495 · Cited by 285 · see citing works
Self-citationStančáková, A., Civelek, M., Saleem, N. K., Soininen, P., Kangas, A. J., Cederberg, H., Paananen, J., Pihlajamäki, J., Bonnycastle, L. L., Morken, M. A., et al. (2012) · Diabetes · doi:10.2337/db11-1378 · Cited by 279 · see citing works
Self-citationFox, C. S., Liu, Y., White, C. C., Feitosa, M. F., Smith, A. V., Heard‐Costa, N. L., Lohman, K., Johnson, A. D., Foster, M. C., Greenawalt, D. M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002695 · Cited by 276 · see citing works
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Maity, A., & Das, B. (2015) · FEBS Journal · doi:10.1111/febs.13614 · Cited by 249 · see citing works
Rask-Andersen, M., Karlsson, T., Ek, W. E., & Johansson, Å. (2019) · Nature Communications · doi:10.1038/s41467-018-08000-4 · Cited by 245 · see citing works
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Albuquerque, D., Stice, E. M., Rodríguez‐López, R., Manco, L., & Nóbrega, C. (2015) · Molecular Genetics and Genomics · doi:10.1007/s00438-015-1015-9 · Cited by 223 · see citing works
Yaghootkar, H., Scott, R. A., White, C. C., Zhang, W., Speliotes, E. K., Munroe, P. B., Ehret, G., Bis, J. C., Fox, C. S., Walker, M., et al. (2014) · Diabetes · doi:10.2337/db14-0318 · Cited by 218 · see citing works
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
Zillikens, M. C., Demissie, S., Hsu, Y., Yerges-Armstrong, L. M., Chou, W., Stolk, L., Livshits, G., Broer, L., Johnson, T., Koller, D. L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00031-7 · Cited by 186 · see citing works
Self-citationRichmond, R. C., Davey Smith, G., Ness, A. R., den Hoed, M., McMahon, G., & Timpson, N. J. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001618 · Cited by 167 · see citing works
Scott, R. A., Fall, T., Pasko, D., Barker, A., Sharp, S. J., Arriola, L., Balkau, B., Barricarte, A., Barroso, I., Boeing, H., et al. (2014) · Diabetes · doi:10.2337/db14-0319 · Cited by 172 · see citing works
Self-citationKubota, T., Kubota, N., & Kadowaki, T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.004 · Cited by 169 · see citing works
Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci
Liu, C.-T., Monda, K. L., Taylor, K. C., Lange, L. A., Demerath, E. W., Palmas, W., Wojczynski, M. K., Ellis, J., Vitolins, M. Z., Liu, S., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003681 · Cited by 163 · see citing works
Self-citationSex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Lagou, V., Mägi, R., Hottenga, J., Grallert, H., Perry, J. R. B., Bouatia‐Naji, N., Marullo, L., Rybin, D. V., Jansen, R., Min, J. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-19366-9 · Cited by 154 · see citing works
Self-citationInherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
Agrawal, S., Wang, M., Klarqvist, M. D. R., Smith, K., Shin, J. H., Dashti, H., Diamant, N., Choi, S. H., Jurgens, S. J., Ellinor, P. T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30931-2 · Cited by 151 · see citing works
Sex differences in energy metabolism: natural selection, mechanisms and consequences
Mauvais‐Jarvis, F. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00781-2 · Cited by 159 · see citing works
Yaghootkar, H., Lotta, L. A., Tyrrell, J., Smit, R. A. J., Jones, S. E., Donnelly, L. A., Beaumont, R. N., Campbell, A. I., Tuke, M. A., Hayward, C., et al. (2016) · Diabetes · doi:10.2337/db15-1671 · Cited by 152 · see citing works
Self-citationDevelopments in Obesity Genetics in the Era of Genome-Wide Association Studies
Day, F. R., & Loos, R. J. F. (2011) · Lifestyle Genomics · doi:10.1159/000332158 · Cited by 150 · see citing works
Self-citationGenomic insights into the causes of type 2 diabetes
Langenberg, C., & Lotta, L. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31132-2 · Cited by 142 · see citing works
Self-citationKoceva, A., Herman, R., Janež, A., Rakuša, M., & Jensterle, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137342 · Cited by 167 · see citing works
Pleiotropic genes for metabolic syndrome and inflammation
Kraja, A. T., Chasman, D. I., North, K. E., Reiner, A. P., Yanek, L. R., Kilpeläinen, T. O., Smith, J. A., Dehghan, A., Dupuis, J., Johnson, A. D., et al. (2014) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2014.04.007 · Cited by 147 · see citing works
Self-citationHamer, M., Batty, G. D., & Kivimaki, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.30 · Cited by 132 · see citing works
Loos, R. J. F. (2018) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2018.02.009 · Cited by 127 · see citing works
Self-citationHeymsfield, S. B., Avena, N. M., Baier, L. J., Brantley, P. J., Bray, G. A., Burnett, L. C., Butler, M. G., Driscoll, D. J., Egli, D. M., Elmquist, J. K., et al. (2014) · Obesity · doi:10.1002/oby.20646 · Cited by 129 · see citing works
Self-citationVolkov, P., Olsson, A. H., Gillberg, L., Jørgensen, S. W., Brøns, C., Eriksson, K., Groop, L., Jansson, P., Nilsson, E., Rönn, T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157776 · Cited by 121 · see citing works
Self-citationEringa, E. C., Serné, E. H., Meijer, R. I., Schalkwijk, C. G., Houben, A. J. H. M., Stehouwer, C. D. A., Smulders, Y. M., & van Hinsbergh, V. W. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9239-7 · Cited by 122 · see citing works
Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M., Warren, L. L., Stančáková, A., Buxbaum, S. G., Lyytikäinen, L., Henneman, P., et al. (2013) · Diabetes · doi:10.2337/db13-0128 · Cited by 121 · see citing works
Self-citationLi, S., Chen, W., Srinivasan, S. R., Xu, J., & Berenson, G. S. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws236 · Cited by 122 · see citing works
Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease
Goodarzi, M. O., & Rotter, J. I. (2020) · Circulation Research · doi:10.1161/circresaha.119.316065 · Cited by 117 · see citing works
Sex Differences in Genomic Drivers of Adipose Distribution and Related Cardiometabolic Disorders
Lumish, H. S., O'Reilly, M. E., & Reilly, M. P. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313154 · Cited by 118 · see citing works
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa
Hübel, C., Gaspar, H., Coleman, J., Finucane, H., Purves, K., Hanscombe, K. B., Prokopenko, I., Graff, M., Ngwa, J., Workalemahu, T., et al. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32709 · Cited by 110 · see citing works
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
Huang, L. O., Rauch, A., Mazzaferro, E., Preuss, M. H., Carobbio, S., Bayrak, Ç. S., Chami, N., Wang, Z., Schick, U. M., Yang, N. Y., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00346-2 · Cited by 113 · see citing works
Self-citationObesity genomics: assessing the transferability of susceptibility loci across diverse populations
Lu, Y., & Loos, R. J. F. (2013) · Genome Medicine · doi:10.1186/gm459 · Cited by 109 · see citing works
Self-citationFrayling, T. M., Beaumont, R. N., Jones, S. E., Yaghootkar, H., Tuke, M. A., Ruth, K. S., Casanova, F., West, B., Locke, J., Sharp, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.070 · Cited by 101 · see citing works
Self-citationJi, Y., Yiorkas, A. M., Frau, F., Mook‐Kanamori, D. O., Staiger, H., Thomas, E. L., Atabaki‐Pasdar, N., Campbell, A., Tyrrell, J., Jones, S. E., et al. (2018) · Diabetes · doi:10.2337/db18-0708 · Cited by 101 · see citing works
Self-citationChildren With Metabolically Healthy Obesity: A Review
Vuković, R., Santos, T. J. D., Ybarra, M., & Atar, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00865 · Cited by 98 · see citing works
The Many Faces of Obesity and Its Influence on Breast Cancer Risk
Agurs‐Collins, T., Ross, S. A., & Dunn, B. K. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00765 · Cited by 97 · see citing works
GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity
Speakman, J. R., Loos, R. J. F., O’Rahilly, S., Hirschhorn, J. N., & Allison, D. B. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0147-5 · Cited by 91 · see citing works
Self-citationEthnic differences in adiposity and diabetes risk – insights from genetic studies
Yaghootkar, H., Whitcher, B. J., Bell, J. D., & Thomas, E. L. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13082 · Cited by 91 · see citing works
Beyond the fourth wave of genome-wide obesity association studies
Sandholt, C. H., Hansen, T. F., & Pedersen, O. B. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.9 · Cited by 87 · see citing works
Genetics of metabolic syndrome
Stančáková, A., & Laakso, M. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9293-9 · Cited by 83 · see citing works
Self-citationRied, J. S., Jeff, J. M., Chu, A. Y., Bragg‐Gresham, J. L., van Dongen, J., Huffman, J. E., Ahluwalia, T. S., Cadby, G., Eklund, N., Eriksson, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13357 · Cited by 84 · see citing works
Self-citation(2007) · doi:10.1139/h06-102 · Cited by 160 · see citing works
Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity
Pei, Y., Zhang, L., Liu, Y., Li, J. M., Shen, H., Liu, Y.-Z., Tian, Q., He, H., Wu, S., Ran, S., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt464 · Cited by 77 · see citing works
Self-citationKrishnan, M., Major, T. J., Topless, R., Dewes, O., Yu, L. H., Thompson, J., McCowan, L. M. E., de Zoysa, J., Stamp, L. K., Dalbeth, N., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4623-1 · Cited by 75 · see citing works
Morton, N. M., Beltram, J., Carter, R. N., Michailidou, Z., Gorjanc, G., McFadden, C., Barrios-Llerena, M. E., Rodríguez‐Cuenca, S., Gibbins, M., Aird, R. E., et al. (2016) · Nature Medicine · doi:10.1038/nm.4115 · Cited by 75 · see citing works
Self-citationLong-term inhibition of miR-21 leads to reduction of obesity in db/db mice
Seeger, T., Fischer, A., Muhly-Reinholz, M., Zeiher, A. M., & Dimmeler, S. (2014) · Obesity · doi:10.1002/oby.20852 · Cited by 71 · see citing works
The genetics of childhood obesity and interaction with dietary macronutrients
Garver, W. S., Newman, S. B., Gonzales‐Pacheco, D., Castillo, J., Jelínek, D., Heidenreich, R. A., & Orlando, R. A. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0339-5 · Cited by 71 · see citing works
Tu, Z., Keller, M. P., Zhang, C., Rabaglia, M. E., Greenawalt, D. M., Yang, X., Wang, I., Dai, H. A., Bruss, M. D., Lum, P. Y., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003107 · Cited by 68 · see citing works
Self-citationAbdominal obesity and circulating metabolites: A twin study approach
Bogl, L. H., Kaye, S. M., Rämö, J. T., Kangas, A. J., Soininen, P., Hakkarainen, A., Lundbom, J., Lundbom, N. M. I., Ortega‐Alonso, A., Rissanen, A., et al. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.027 · Cited by 69 · see citing works
Metabolically healthy obesity and metabolically obese normal weight: a review
Gómez‐Zorita, S., Queralt, M., Vicente, M. Á., González, M. A., & Portillo, M. P. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00781-x · Cited by 75 · see citing works
Challenges in reproducibility of genetic association studies: lessons learned from the obesity field
Li, A., & Meyre, D. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.82 · Cited by 65 · see citing works
Genes that make you fat, but keep you healthy
Loos, R. J. F., & Kilpeläinen, T. O. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12827 · Cited by 60 · see citing works
Self-citationGan, W., Bragg, F., Walters, R. G., Millwood, I. Y., Lin, K., Chen, Y., Guo, Y., Vaucher, J., Bian, Z., Bennett, D., et al. (2019) · Diabetes · doi:10.2337/db19-0224 · Cited by 61 · see citing works
Self-citationGenetics and epigenetics in the obesity phenotyping scenario
Trang, B. K., & Grant, S. F. A. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09804-6 · Cited by 66 · see citing works
The Extending Spectrum of NPC1-Related Human Disorders: From Niemann–Pick C1 Disease to Obesity
Lamri, A., Pigeyre, M., Garver, W. S., & Meyre, D. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00176 · Cited by 62 · see citing works
Recent genetic discoveries in osteoporosis, sarcopenia and obesity [Review]
Urano, T., & Inoue, S. (2015) · Endocrine Journal · doi:10.1507/endocrj.ej15-0154 · Cited by 62 · see citing works
Gene–Lifestyle Interactions in Obesity
van Vliet‐Ostaptchouk, J. V., Snieder, H., & Lagou, V. (2012) · Current Nutrition Reports · doi:10.1007/s13668-012-0022-2 · Cited by 61 · see citing works
Wang, T., Ma, X., Peng, D., Zhang, R., Sun, X., Chen, M., Yan, J. Y., Wang, S., Yan, D., He, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep20691 · Cited by 62 · see citing works
Advances in Exercise, Fitness, and Performance Genomics in 2011
Roth, S. M., Rankinen, T., Hagberg, J. M., Loos, R. J. F., Përusse, L., Sarzynski, M. A., Wolfarth, B., & Bouchard, C. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31824f28b6 · Cited by 67 · see citing works
Self-citationMetabolically healthy obesity: Misleading phrase or healthy phenotype?
Tanrıöver, C., Çöpür, S., Gaipov, A., Özlüşen, B., Akcan, R. E., Kuwabara, M., Hornum, M., van Raalte, D. H., & Kanbay, M. (2023) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2023.02.025 · Cited by 62 · see citing works
Babu, D., & Fullwood, M. J. (2015) · Nucleus · doi:10.1080/19491034.2015.1106676 · Cited by 57 · see citing works
Vicente, M., Priehodová, E., Diallo, I., Podgorná, E., Poloni, E. S., Černý, V., & Schlebusch, C. M. (2019) · BMC Genomics · doi:10.1186/s12864-019-6296-7 · Cited by 56 · see citing works
Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat
Fox, C. S., White, C. C., Lohman, K., Heard‐Costa, N. L., Cohen, P., Zhang, Y., Johnson, A. D., Emilsson, V., Liu, C.-T., Chen, Y. I., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002705 · Cited by 58 · see citing works
Self-citationIs Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease?
Laakso, M. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0684-4 · Cited by 58 · see citing works
Self-citationRobiou-du-Pont, S., Bonnefond, A., Yengo, L., Vaillant, E., Lobbens, S., Durand, E., Weill, J., Lantieri, O., Balkau, B., Charpentier, G., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.175 · Cited by 57 · see citing works
Epigenetics and Early Life Origins of Chronic Noncommunicable Diseases
Wang, G., Walker, S. O., Hong, X., Bartell, T. R., & Wang, X. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2012.04.019 · Cited by 58 · see citing works
Karaderi, T., Drong, A., & Lindgren, C. M. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0648-8 · Cited by 57 · see citing works
Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models
Chen, Y., Kim, M., Paye, S. M., & Benayoun, B. A. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105852 · Cited by 56 · see citing works
A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Coral, D., Fernandez-Tajes, J. J., Tsereteli, N., Pomares‐Millan, H., Fitipaldi, H., Mutie, P. M., Atabaki‐Pasdar, N., Kalamajski, S., Poveda, A., Miller‐Fleming, T. W., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-022-00731-5 · Cited by 51 · see citing works
Komolka, K., Albrecht, E., Wimmers, K., Michal, J. J., & Maak, S. (2013) · Journal of Genomics · doi:10.7150/jgen.5260 · Cited by 51 · see citing works
Wang, B., Zhang, M., Wang, S., Wang, C., Wang, J., Li, L., Zhang, L., Ren, Y., Han, C., Zhao, Y., et al. (2017) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2017.10.005 · Cited by 51 · see citing works
Self-citationGenetics and Epigenetics in Obesity: What Do We Know so Far?
Keller, M., Svensson, S. I. A., Rohde‐Zimmermann, K., Kovacs, P. L., & Böttcher, Y. (2023) · Current Obesity Reports · doi:10.1007/s13679-023-00526-z · Cited by 51 · see citing works
Visceral Obesity, Metabolic Syndrome, and Esophageal Adenocarcinoma
Elliott, J. A., & Reynolds, J. V. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.627270 · Cited by 49 · see citing works
Genetics: A Starting Point for the Prevention and the Treatment of Obesity
Novelli, G., Cassadonte, C., Sbraccia, P., & Biancolella, M. (2023) · Nutrients · doi:10.3390/nu15122782 · Cited by 49 · see citing works
- Authors
- Kilpeläinen, T. O., Zillikens, M. C., Stančákova, A., Finucane, F. M., Ried, J. S., Langenberg, C., Zhang, W., Beckmann, J. S., Luan, J., Vandenput, L., Styrkarsdottir, U., Zhou, Y., Smith, A. V., Zhao, J.-H., Amin, N., Vedantam, S., Shin, S.-Y., Haritunians, T., Fu, M., Feitosa, M. F., Kumari, M., Halldorsson, B. V., Tikkanen, E., Mangino, M., Hayward, C., Song, C., Arnold, A. M., Aulchenko, Y. S., Oostra, B. A., Campbell, H., Cupples, L. A., Davis, K. E., Döring, A., Eiriksdottir, G., Estrada, K., Fernández-Real, J. M., Garcia, M., Gieger, C., Glazer, N. L., Guiducci, C., Hofman, A., Humphries, S. E., Isomaa, B., Jacobs, L. C., Jula, A., Karasik, D., Karlsson, M. K., Khaw, K.-T., Kim, L. J., Kivimäki, M., Klopp, N., Kühnel, B., Kuusisto, J., Liu, Y., Ljunggren, Ö., Lorentzon, M., Luben, R. N., McKnight, B., Mellström, D., Mitchell, B. D., Mooser, V., Moreno, J. M., Männistö, S., O'Connell, J. R., Pascoe, L., Peltonen, L., Peral, B., Perola, M., Psaty, B. M., Salomaa, V., Savage, D. B., Semple, R. K., Skaric-Juric, T., Sigurdsson, G., Song, K. S., Spector, T. D., Syvänen, A.-C., Talmud, P. J., Thorleifsson, G., Thorsteinsdottir, U., Uitterlinden, A. G., van Duijn, C. M., Vidal-Puig, A., Wild, S. H., Wright, A. F., Clegg, D. J., Schadt, E., Wilson, J. F., Rudan, I., Ripatti, S., Borecki, I. B., Shuldiner, A. R., Ingelsson, E., Jansson, J.-O., Kaplan, R. C., Gudnason, V., Harris, T. B., Groop, L., Kiel, D. P., Rivadeneira, F., Walker, M., Barroso, I., Vollenweider, P., Waeber, G., Chambers, J. C., Kooner, J. S., Soranzo, N., Hirschhorn, J. N., Stefansson, K., Wichmann, H.-E., Ohlsson, C., O'Rahilly, S., Wareham, N. J., Speliotes, E. K., Fox, C. S., Laakso, M., & Loos, R. J. F.
- Affiliations
- MRC Epidemiology Unit (GB)
- Erasmus MC (NL)
- Helmholtz Munich (DE)
- Imperial College London (GB)
- Centre Hospitalier Universitaire Vaudois (CH)
- University of Gothenburg (SE)
- Boston University (US)
- Icelandic Heart Association (IS)
- Broad Institute (US)
- Wellcome Sanger Institute (GB)
- Cedars-Sinai Medical Center (US)
- University of Maryland, Baltimore (US)
- Washington University in St. Louis (US)
- University of Helsinki (FI)
- King's College London (GB)
- Institute of Genetics and Cancer (GB)
- Karolinska Institutet (SE)
- University of Washington (US)
- University of Edinburgh (GB)
- The University of Texas Southwestern Medical Center (US)
- University College London (GB)
- Folkhälsans Forskningscentrum (FI)
- Finnish Institute for Health and Welfare (FI)
- Harvard University (US)
- Lund University (SE)
- University of Cambridge (GB)
- National Institutes of Health (US)
- University of Eastern Finland (FI)
- Wake Forest University Health Sciences (US)
- Uppsala University (SE)
- GlaxoSmithKline (United States) (US)
- Newcastle University (GB)
- Consejo Superior de Investigaciones Científicas (ES)
- Group Health Cooperative (US)
- University of Iceland (IS)
- Sage Bionetworks (US)
- Gen-info (HR)
- Albert Einstein College of Medicine (US)
- Hammersmith Hospital (GB)
- National Heart, Lung, and Blood Institute (US)
- Corresponding author
- Loos, Ruth J F
- ORCID
- Kilpeläinen, Tuomas O
- Zillikens, M Carola
- Finucane, Francis M
- Langenberg, Claudia
- Zhang, Weihua
- Beckmann, Jacques S
- Luan, Jian'an
- Vandenput, Liesbeth
- Zhou, Yanhua
- Smith, Albert Vernon
- Amin, Najaf
- Vedantam, Sailaja
- Shin, So-Youn
- Haritunians, Talin
- Feitosa, Mary F
- Tikkanen, Emmi
- Mangino, Massimo
- Hayward, Caroline
- Song, Ci
- Arnold, Alice M
- Aulchenko, Yurii S
- Campbell, Harry
- Cupples, L Adrienne
- Davis, Kathryn E
- Estrada, Karol
- Gieger, Christian
- Glazer, Nicole L
- Humphries, Steve E
- Jacobs, Leonie C
- Karasik, David
- Karlsson, Magnus K
- Khaw, Kay-Tee
- Kühnel, Brigitte
- Ljunggren, Östen
- Lorentzon, Mattias
- Luben, Robert N
- Mellström, Dan
- Mitchell, Braxton D
- Mooser, Vincent
- Männistö, Satu
- Pascoe, Laura
- Peltonen, Leena
- Peral, Belén
- Perola, Markus
- Psaty, Bruce M
- Salomaa, Veikko
- Savage, David B
- Semple, Robert K
- Syvänen, Ann-Christine
- Talmud, Philippa J
- Uitterlinden, André G
- Wild, Sarah H
- Clegg, Deborah J
- Wilson, James F
- Rudan, Igor
- Ripatti, Samuli
- Borecki, Ingrid B
- Shuldiner, Alan R
- Ingelsson, Erik
- Jansson, John-Olov
- Kaplan, Robert C
- Gudnason, Vilmundur
- Harris, Tamara B
- Groop, Leif
- Kiel, Douglas P
- Rivadeneira, Fernando
- Walker, Mark
- Barroso, Inês
- Waeber, Gérard
- Chambers, John C
- Kooner, Jaspal S
- Soranzo, Nicole
- Hirschhorn, Joel N
- Wichmann, H-Erich
- Ohlsson, Claes
- Wareham, Nicholas J
- Speliotes, Elizabeth K
- Fox, Caroline S
- Laakso, Markku
- Loos, Ruth J F
- Venue
- Nature Genetics
- Published
- 2011-06-26
- Volume
- 43
- Issue
- 8
- Pages
- 753-760
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC3262230
- OpenAlex
- W2145707775
- Cited by
- 335
- References
- 52
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 8 · 2023: 20 · 2022: 14 · 2021: 22 · 2020: 15 · 2019: 19 · 2018: 24 · 2017: 23 · 2016: 20 · 2015: 30 · 2014: 29 · 2013: 35 · 2012: 44
- FWCI
- 22.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- PubMed Central (acceptedVersion)
- IRIS (submittedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- WOS
- Funders
- National Science Foundation (FP7/2007-2013, 33CSCO-122661)
- U.S. Department of Veterans Affairs
- John D. and Catherine T. MacArthur Foundation (HS06516, HL036310)
- American Heart Association (N01-HC-25195)
- AstraZeneca (QLG1-CT-2001-01252)
- GlaxoSmithKline (33CSCO-122661)
- Foundation for Cardiovascular Research
- Finska Läkaresällskapet
- Wellcome Trust (FP7/2007–2013, 095515, 091551, 091746/Z/10/Z, 084723/Z/08/Z, 077016/Z/05/Z, 07/007)
- Cedars-Sinai Medical Center
- Folkhälsanin Tutkimussäätiö (FP7/2007-2013)
- Cancer Research UK (FP7/2007-2013)
- National Institute for Health and Care Research (FP7/2007–2013)
- British Heart Foundation (HL036310, QLG2-CT-2002-01254, PG/07/133/24260, RG/08/008/25291, SP/07/007/23671, RG 08/008, HS06516, SP/04/002, RG/07/008/23674)
- European Commission (QLG2-CT-2002-01254, 213506, 018947, 201681, LSHG-CT-2006-01947, 2007–2013, FP7 2007-2013, 201550, 201413, 201865, FP7/2007, 266408, 01254, LSHM-CT-2004-512013, FP7-KBBE-2010-4, 01IG07015G, FP7-KBBE, QLG1-CT-2001-01252, LSHG-CT-2006-018947)
- Health and Safety Executive
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (116323, FP7/2007-2013, 112552, 10404, 122661, 33CSCO, 20229, 3100AO-116323/1, 201413, 129494, 124243, 310000)
- Stiftelsen för Strategisk Forskning
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Bundesministerium für Bildung und Forschung (01IG07015G, 01AK803A-H, 01GS0823, 01AK803A)
- Erasmus Medisch Centrum (014-93-015)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (050.060.810, FP7 2007-2013, 911-03-012, 175.010.200)
- Tekes (1510/31/06)
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet (HL036310, FP7/2007-2013, 2006‐3832, HS06516)
- Samfundet Folkhälsan
- Norges Forskningsråd
- Sydäntutkimussäätiö
- Göteborgs Läkaresällskap
- Fondation Leenaards
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois
- Uppsala Universitet
- Svenska Kulturfonden
- Paavo Nurmen Säätiö
- Chinese Society of Clinical Oncology
- Hjartavernd
- Diabetestutkimussäätiö
- Centre for Medical Systems Biology
- National Institutes of Health (5r01ag032098-05, 5r01dk068336-03, n01ag062101-007, n01hc045133-001, n01ag12100-57-0-2, n01hc085079-024, n01hc015103-009, n01cn015103-001, n01ag062103-006, FP7/2007-2013, n01ag062106-007, n01hc085086-022, 5r01hl087700-03, 5r01ag031890-04, n01hc55222-0-0-0, n02hl64278-6-0-0, n01hc025195-11-0-0, n01hc075150-004, n01hc035129-010, AR/AG41398, DK-072488, M01-RR00425, RR00425, N01-HC 25195, DK-063491, HL080295)
- Directorate for Biological Sciences
- Medical Research Council (HL036310, LSHG-CT-2006-018947, HS06516)
- Biotechnology and Biological Sciences Research Council (G20234)
- NIHR Cambridge Biomedical Research Centre
- National Institute on Aging (R01-AG-18728, R01-AG-031890, R01AG032098, N01-AG12100, N01-AG012100, R01AG018728, R01AR/AG 41398, AG 13196, N01 AG062106, R01-AG032098-01A1, R37AG013196, R01-AG031890-01, R01AG013196, N01 AG062103, N01 AG062101)
- National Heart, Lung, and Blood Institute (N01 HC085086, U01HL72515, N01HC15103, N01 HC085079, N01‐HC25195, N01HC‐75150, R01HL087652, U01-HL84756, N01 HC035129, N02 HL064278, U01HL084756, R01-HL087700, N01 HC015103, N01 HC55222, R01 HL08770003, N01‐HC‐45133, N01-HC-025195, U01HL080295, U01HL072515, N01 HC055222, R01HL088119, N01-HC85079-86, N01 HC075150, R01HL117078, R01HL036310, N01 HC045133, N01HC35129)
- National Cancer Institute (N01 CN015103)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, R01DK06833603, R01DK089256, R01-DK068336, R01DK075681, K23DK080145, P30DK072488, R01-DK07568102, R01DK075787, P30DK063491)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR046838, R01AR041398)
- National Center for Research Resources (M01RR016500, M01RR000425, M01RR 16500, M01-RR00425)
- FP7 Food, Agriculture and Fisheries, Biotechnology (266408)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- IRS-1, body fat percentage, adiposity, genetic variants, SPRY2, FTO, type 2 diabetes, coronary artery disease, insulin resistance, dyslipidemia, adiponectin, visceral-to-subcutaneous fat ratio, metabolic profile, lean body mass
- MeSH terms
- Alleles, Body Weight, Female, Humans, Male, Membrane Proteins, Obesity, Genetic Variation, Meta-Analysis as Topic, Body Mass Index, Polymorphism, Single Nucleotide, Intracellular Signaling Peptides and Proteins, Subcutaneous Fat, Adiposity, Body Fat Distribution, Adiponectin, Genome-Wide Association Study, Metabolome, Insulin Receptor Substrate Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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