Drost, Jarno

Organoids in cancer research

Drost, J., & Clevers, H. (2018) · Nature Reviews Cancer

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 1,790

Sequential cancer mutations in cultured human intestinal stem cells

Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., et al. (2015) · Nature

Cancer Cells and MetastasisGenetic factors in colorectal cancer

Cited by 1,067

eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

Melo, C. A., Drost, J., Wijchers, P. J., van de Werken, H., de Wit, E., Vrielink, J. A. F. O., Elkon, R., Melo, S. A., Léveillé, N., Kalluri, R., et al. (2013) · Molecular Cell

Genomics and Chromatin DynamicsCancer-related Molecular Pathways

Cited by 544

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., et al. (2017) · Science

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

Cited by 461

Xenograft and organoid model systems in cancer research

Bleijs, M., van de Wetering, M., Clevers, H., & Drost, J. (2019) · The EMBO Journal

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 400

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo, C. S., Overmeer, R. M., Ponsioen, B., Drost, J., Mertens, S., Verlaan-Klink, I., Gerwen, B. V., van der Ven, M., Wetering, M. V. D., Egan, D. A., et al. (2016) · eLife

Colorectal Cancer Treatments and StudiesProtein Kinase Regulation and GTPase Signaling

Cited by 263

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Fessler, E., Drost, J., van Hooff, S. R., Linnekamp, J. F., Wang, X., Jansen, M., De Sousa E Melo, F., Prasetyanti, P. R., IJspeert, J. E., Franitza, M., et al. (2016) · EMBO Molecular Medicine

TGF-β signaling in diseasesColorectal Cancer Treatments and Studies

Cited by 159

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Miao, Y., Ha, A., de Lau, W., Yuki, K., Santos, A. J. M., You, C., Geurts, M. H., Puschhof, J., Pleguezuelos-Manzano, C., Peng, W. C., et al. (2020) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 151

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

Loayza-Puch, F., Drost, J., Rooijers, K., Lopes, R., Elkon, R., & Agami, R. (2013) · Genome Biology

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 114

Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

Lin, L., DeMartino, J., Wang, D., van Son, G. J. F., van der Linden, R., Begthel, H., Korving, J., Andersson-Rolf, A., van den Brink, S., Lopez-Iglesias, C., et al. (2023) · Science

Developmental Biology and Gene RegulationDigestive system and related health

Cited by 50