Robbins, Paul D.

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Cellular Senescence: Defining a Path Forward

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

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Senolytics improve physical function and increase lifespan in old age

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Regulation of immune responses by extracellular vesicles

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Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

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Fisetin is a senotherapeutic that extends health and lifespan

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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., Zhang, X., LeBrasseur, N. K., Pignolo, R. J., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Nature Communications

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An aged immune system drives senescence and ageing of solid organs

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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017) · Aging

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Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications

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Cellular senescence: a key therapeutic target in aging and diseases

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The Clinical potential of Senolytic Drugs

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NF-κB inhibition delays DNA damage–induced senescence and aging in mice

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SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

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Guidelines for minimal information on cellular senescence experimentation in vivo

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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

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Senolytics reduce coronavirus-related mortality in old mice

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Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

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