Robbins, Paul D.

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Lavasani, M., Robinson, A. R., Lu, A., Song, M., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J., et al. (2012) · Nature Communications

Muscle Physiology and DisordersGenetics, Aging, and Longevity in Model Organisms

Cited by 229

Senotherapeutics for healthy ageing

Niedernhofer, L. J., & Robbins, P. D. (2018) · Nature Reviews Drug Discovery

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 190

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., et al. (2018) · Redox Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 155

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Nogueira-Recalde, U., Lorenzo-Gómez, I., Blanco, F. J., Loza, M. I., Grassi, D., Shirinsky, V., Shirinsky, I., Lotz, M., Robbins, P. D., Domínguez, E., et al. (2019) · EBioMedicine

Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and Senescence

Cited by 155

COVID-19 and cellular senescence

Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 153

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

Dorronsoro, A., Santiago, F. E., Grassi, D., Zhang, T., Lai, R. C., McGowan, S. J., Angelini, L., Lavasani, M., Corbo, L., Lu, A., et al. (2021) · Aging Cell

Telomeres, Telomerase, and SenescenceMesenchymal stem cell research

Cited by 153

The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner

Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J., & Wang, Y. (2012) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 142

DNA damage drives accelerated bone aging via an NF- κ B–dependent mechanism

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J., & Ouyang, H. (2013) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 135

Role of Cellular Senescence in Type II Diabetes

Narasimhan, A., Flores, R. R., Robbins, P. D., & Niedernhofer, L. J. (2021) · Endocrinology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 133

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Influence of BMPs on the formation of osteoblastic lesions in metastatic prostate cancer

Feeley, B. T., Gamradt, S. C., Hsu, W. K., Liu, N., Krenek, L., Robbins, P., Huard, J., & Lieberman, J. R. (2005) · Journal of Bone and Mineral Research

TGF-β signaling in diseasesBone health and treatments

Cited by 120

Targeted clearance of p21 ‐ but not p16 ‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Chandra, A., Lagnado, A. B., Farr, J. N., Doolittle, M., Tchkonia, T., Kirkland, J. L., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 120

Recent advances in the discovery of senolytics

Zhang, L., Pitcher, L. E., Prahalad, V., Niedernhofer, L. J., & Robbins, P. D. (2021) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 115

Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: The use of different viral vectors and the effects of injury

Hildebrand, K. A., Deie, M., Allen, C. R., Smith, D. W., Georgescu, H. I., Evans, C. H., Robbins, P. D., & Woo, S. L. (1999) · Journal of Orthopaedic Research

Virus-based gene therapy researchTendon Structure and Treatment

Cited by 94

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., & Robbins, P. D. (2018) · Cell Cycle

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 92

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Tripathi, U., Nchioua, R., Prata, L. G. P. L., Zhu, Y., Gerdes, E. O. W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espindola-Netto, J. M., et al. (2021) · Aging

Telomeres, Telomerase, and SenescenceSARS-CoV-2 and COVID-19 Research

Cited by 88

Development of clinical trials to extend healthy lifespan

Justice, J. N., Niedernhofer, L., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A., & Barzilai, N. (2018) · Cardiovascular Endocrinology & Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 84

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M., & Robbins, P. D. (2020) · GeroScience

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 70

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Han, Y., Zhang, X., Franco, A. C., Kim, S. Y., Wyles, S. P., Prakash, Y. S., et al. (2025) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 45

Advancing biological understanding of cellular senescence with computational multiomics

Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 40

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Samakkarnthai, P., Saul, D., Zhang, L., Aversa, Z., Doolittle, M. L., Sfeir, J. G., Kaur, J., Atkinson, E. J., Edwards, J. R., Russell, G. G., et al. (2023) · Aging

Telomeres, Telomerase, and SenescenceBone health and treatments

Cited by 34

Distinct secretomes in p16- and p21- positive senescent cells across tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Monroe, D. G., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Khosla, S., & Passos, J. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 28