Kadowaki, Takashi

Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels

Nishimura, S., Manabe, I., Nagasaki, M., Hosoya, Y., Yamashita, H., Fujita, H., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2007) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 440

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

Kubota, T., Kubota, N., Kumagai, H., Yamaguchi, S., Kozono, H., Takahashi, T., Inoue, M., Itoh, S., Takamoto, I., Sasako, T., et al. (2011) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 435

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., et al. (1999) · Nature Genetics

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 399

Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial

Kadowaki, T., Isendahl, J., Khalid, U., Lee, S. Y., Nishida, T., Ogawa, W., Tobe, K., Yamauchi, T., & Lim, S. (2022) · The Lancet Diabetes & Endocrinology

Pharmacology and Obesity TreatmentDiabetes Treatment and Management

Cited by 330

Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1

Waki, H., Yamauchi, T., Kamon, J., Kita, S., Ito, Y., Hada, Y., Uchida, S., Tsuchida, A., Takekawa, S., & Kadowaki, T. (2005) · Endocrinology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 319

Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

Ueki, K., Sasako, T., Okazaki, Y., Kato, M., Okahata, S., Katsuyama, H., Haraguchi, M., Morita, A., Ohashi, K., Hara, K., et al. (2017) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 313

Mutations in the Insulin Receptor Gene

TAYLOR, S. I., CAMA, A., ACCILI, D., BARBETTI, F., QUON, M. J., SIERRA, M. D. L. L., SUZUKI, Y., ROLLER, E., LEVY-TOLEDANO, R., WERTHEIMER, E., et al. (1992) · Endocrine Reviews

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 311

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue

Nishimura, S., Manabe, I., Nagasaki, M., Seo, K., Yamashita, H., Hosoya, Y., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2008) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 277

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

Awazawa, M., Ueki, K., Inabe, K., Yamauchi, T., Kubota, N., Kaneko, K., Kobayashi, M., Iwane, A., Sasako, T., Okazaki, Y., et al. (2011) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 277

Acetic Acid Activates Hepatic AMPK and Reduces Hyperglycemia in Diabetic KK-A (y) Mice

Sakakibara, S., Yamauchi, T., Oshima, Y., Tsukamoto, Y., & Kadowaki, T. (2006) · Biochemical and Biophysical Research Communications

Metabolism, Diabetes, and CancerNatural Antidiabetic Agents Studies

Cited by 263

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients

Fruchart, J.-C., Sacks, F. M., Hermans, M. P., Assmann, G., Brown, W. V., Ceska, R., Chapman, M. J., Dodson, P. M., Fioretto, P., Ginsberg, H. N., et al. (2008) · Diabetes and Vascular Disease Research

Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 260

Adipose natural regulatory B cells negatively control adipose tissue inflammation

Nishimura, S., Manabe, I., Takaki, S., Nagasaki, M., Otsu, M., Yamashita, H., Sugita, J., Yoshimura, K., Eto, K., Komuro, I., et al. (2013) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesT-cell and B-cell Immunology

Cited by 251

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

Kubota, N., Terauchi, Y., Tobe, K., Yano, W., Suzuki, R., Ueki, K., Takamoto, I., Satoh, H., Maki, T., Kubota, T., et al. (2004) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 239

Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study

Birkeland, K. I., Bodegard, J., Eriksson, J. W., Norhammar, A., Haller, H., Linssen, G. C. M., Banerjee, A., Thuresson, M., Okami, S., Garal‐Pantaler, E., et al. (2020) · Diabetes, Obesity and Metabolism

Chronic Kidney Disease and DiabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 223

Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease

Freude, S., Hettich, M. M., Schumann, C., Stöhr, O., Koch, L., Köhler, C., Udelhoven, M., Leeser, U., Müller, M., Kubota, N., et al. (2009) · The FASEB Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 218

DialBetics: A Novel Smartphone-based Self-management Support System for Type 2 Diabetes Patients

Waki, K., Fujita, H., Uchimura, Y., Omae, K., Aramaki, E., Kato, S., Lee, H., Kobayashi, H., Kadowaki, T., & Ohe, K. (2014) · Journal of Diabetes Science and Technology

Mobile Health and mHealth ApplicationsDiabetes Management and Education

Cited by 203

Cigarette Smoking as a Risk Factor for Stroke Death in Japan: NIPPON DATA80

Ueshima, H., Reza Choudhury, S., Okayama, A., Hayakawa, T., Kita, Y., Kadowaki, T., Okamura, T., Minowa, M., & Iimura, O. (2004) · Stroke

Acute Ischemic Stroke ManagementSmoking Behavior and Cessation

Cited by 189

Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

Saxena, R., Saleheen, D., Been, L. F., Garavito, M. L., Braun, T., Bjonnes, A., Young, R., Ho, W. K., Rasheed, A., Frossard, P., et al. (2013) · Diabetes

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 185

The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort

Okamura, T., Tanaka, H., Miyamatsu, N., Hayakawa, T., Kadowaki, T., Kita, Y., Nakamura, Y., Okayama, A., & Ueshima, H. (2007) · Atherosclerosis

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 172

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes

Kodama, K., Horikoshi, M., Toda, K., Yamada, S., Hara, K., Irie, J., Sirota, M., Morgan, A. A., Chen, R., Ohtsu, H., et al. (2012) · Proceedings of the National Academy of Sciences

Adipokines, Inflammation, and Metabolic DiseasesGenetic Associations and Epidemiology

Cited by 171

The Extracellular Signal-Regulated Kinase Pathway Phosphorylates AML1, an Acute Myeloid Leukemia Gene Product, and Potentially Regulates Its Transactivation Ability

Tanaka, T., Kurokawa, M., Ueki, K., Tanaka, K., Imai, Y., Mitani, K., Okazaki, K., Sagata, N., Yazaki, Y., Shibata, Y., et al. (1996) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchProtein Tyrosine Phosphatases

Cited by 152

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

Colombo, C., Cutson, J. J., Yamauchi, T., Vinson, C., Kadowaki, T., Gavrilova, O., & Reitman, M. L. (2002) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 147

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

Kubota, N., Kubota, T., Kajiwara, E., Iwamura, T., Kumagai, H., Watanabe, T., Inoue, M., Takamoto, I., Sasako, T., Kumagai, K., et al. (2016) · Nature Communications

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 143

NAD + supplementation rejuvenates aged gut adult stem cells

Igarashi, M., Miura, M., Williams, E., Jaksch, F., Kadowaki, T., Yamauchi, T., & Guarente, L. (2019) · Aging Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 138