Hazen, Stanley L.

Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols

Hazen, S. L., Hsu, F. F., Duffin, K., & Heinecke, J. W. (1996) · Journal of Biological Chemistry

Neutrophil, Myeloperoxidase and Oxidative MechanismsAtherosclerosis and Cardiovascular Diseases

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Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Mäkinen, V.-P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segrè, A. V., Ghosh, S., Vivar, J., et al. (2014) · PLoS Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

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Identification of α-Chloro Fatty Aldehydes and Unsaturated Lysophosphatidylcholine Molecular Species in Human Atherosclerotic Lesions

Thukkani, A. K., McHowat, J., Hsu, F.-F., Brennan, M.-L., Hazen, S. L., & Ford, D. A. (2003) · Circulation

Atherosclerosis and Cardiovascular DiseasesNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 194

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential

Skye, S. M., Zhu, W., Romano, K. A., Guo, C.-J., Wang, Z., Jia, X., Kirsop, J., Haag, B., Lang, J. M., DiDonato, J. A., et al. (2018) · Circulation Research

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 189

Trimethylamine N ‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease

Senthong, V., Wang, Z., Fan, Y., Wu, Y., Hazen, S. L., & Tang, W. H. W. (2016) · Journal of the American Heart Association

Peripheral Artery Disease ManagementAtherosclerosis and Cardiovascular Diseases

Cited by 175

Treatment strategies in patients with statin intolerance: the Cleveland Clinic experience

Mampuya, W. M., Frid, D., Rocco, M., Huang, J., Brennan, D. M., Hazen, S. L., & Cho, L. (2013) · American Heart Journal

Lipoproteins and Cardiovascular HealthCancer, Lipids, and Metabolism

Cited by 173

Light-induced Oxidation of Photoreceptor Outer Segment Phospholipids Generates Ligands for CD36-mediated Phagocytosis by Retinal Pigment Epithelium

Sun, M., Finnemann, S. C., Febbraio, M., Shan, L., Annangudi, S. P., Podrez, E. A., Hoppe, G., Darrow, R., Organisciak, D. T., Salomon, R. G., et al. (2006) · Journal of Biological Chemistry

Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative Stress

Cited by 165

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N‐oxide‐generating pathway, modulates platelet responsiveness and thrombosis risk

Zhu, W., Buffa, J. A., Wang, Z., Warrier, M., Schugar, R., Shih, D. M., Gupta, N., Gregory, J. C., Org, E., Fu, X., et al. (2018) · Journal of Thrombosis and Haemostasis

Blood Coagulation and Thrombosis MechanismsPlatelet Disorders and Treatments

Cited by 161

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

Tang, W. H. W., & Hazen, S. L. (2017) · Translational Research

Gut microbiota and healthNutritional Studies and Diet

Cited by 160

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

Hartiala, J., Bennett, B. J., Tang, W. H. W., Wang, Z., Stewart, A. F. R., Roberts, R., McPherson, R., Lusis, A. J., Hazen, S. L., & Allayee, H. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology

Genetic Associations and EpidemiologyNutrition, Genetics, and Disease

Cited by 133

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

Hartiala, J. A., Wilson Tang, W. H., Wang, Z., Crow, A. L., Stewart, A. F. R., Roberts, R., McPherson, R., Erdmann, J., Willenborg, C., Hazen, S. L., et al. (2016) · Nature Communications

Genetic Associations and EpidemiologyMetabolism and Genetic Disorders

Cited by 130

Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery

Brown, J. M., & Hazen, S. L. (2017) · Journal of Biological Chemistry

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 108

Serum Trimethylamine N-oxide, Carnitine, Choline, and Betaine in Relation to Colorectal Cancer Risk in the Alpha Tocopherol, Beta Carotene Cancer Prevention Study

Guertin, K. A., Li, X. S., Graubard, B. I., Albanes, D., Weinstein, S. J., Goedert, J. J., Wang, Z., Hazen, S. L., & Sinha, R. (2017) · Cancer Epidemiology, Biomarkers & Prevention

Gut microbiota and healthNutritional Studies and Diet

Cited by 96

Metaorganismal nutrient metabolism as a basis of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2014) · Current Opinion in Lipidology

Gut microbiota and healthNutritional Studies and Diet

Cited by 80

Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases

Choucair, I., Nemet, I., Li, L., Cole, M. A., Skye, S. M., Kirsop, J. D., Fischbach, M. A., Gogonea, V., Brown, J. M., Tang, W. H. W., et al. (2020) · Journal of Lipid Research

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

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Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3 ) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels—Brief Report

Shih, D. M., Zhu, W., Schugar, R. C., Meng, Y., Jia, X., Miikeda, A., Wang, Z., Zieger, M., Lee, R., Graham, M., et al. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology

Pharmacogenetics and Drug MetabolismBlood Coagulation and Thrombosis Mechanisms

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Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer

Zamanian-Daryoush, M., Lindner, D. J., DiDonato, J. A., Wagner, M., Buffa, J., Rayman, P., Parks, J. S., Westerterp, M., Tall, A. R., & Hazen, S. L. (2017) · Oncotarget

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

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