Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk

Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

Wahlstrom, A. M., Sayin, S. I., Marschall, H., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,903 · see citing works

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714 · see citing works

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924 · see citing works

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885 · see citing works

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487 · see citing works

Targeting bile‐acid signalling for metabolic diseases

Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., & Schoonjans, K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2619 · Cited by 1,422 · see citing works

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Chávez-Talavera, O., Tailleux, A., Lefebvre, P., & Staels, B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.055 · Cited by 970 · see citing works

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

Hofmann, A. F., & Hagey, L. R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7568-6 · Cited by 858 · see citing works

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3760 · Cited by 738 · see citing works

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Pols, T. W. H., Nomura, M., Harach, T., Sasso, G. L., Oosterveer, M. H., Thomas, C., Rizzo, G., Gioiello, A., Adorini, L., Pellicciari, R., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.006 · Cited by 622 · see citing works

Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism

Pathak, P., Xie, C., Nichols, R. G., Ferrell, J. M., Boehme, S., Krausz, K. W., Patterson, A. D., Gonzalez, F. J., & Chiang, J. Y. L. (2018) · Hepatology · doi:10.1002/hep.29857 · Cited by 567 · see citing works

Intestinal Microbiota in Cardiovascular Health and Disease

Tang, W. H. W., Bäckhed, F., Landmesser, U., & Hazen, S. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.024 · Cited by 508 · see citing works

Beyond intestinal soap—bile acids in metabolic control

Kuipers, F., Bloks, V. W., & Groen, A. K. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.60 · Cited by 453 · see citing works

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

Devlin, A. S., & Fischbach, M. A. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1864 · Cited by 448 · see citing works

Role of bile acids in metabolic control

Molinaro, A., Wahlström, A., & Marschall, H.-U. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.11.002 · Cited by 447 · see citing works

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids

Haeusler, R. A., Astiarraga, B., Camastra, S., Accili, D., & Ferrannini, E. (2013) · Diabetes · doi:10.2337/db13-0639 · Cited by 444 · see citing works

Microbial modulation of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440 · see citing works

Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment

Gu, Y., Wang, X., Li, J., Zhang, Y., Zhong, H., Liu, R., Zhang, D., Feng, Q., Xie, X., Hong, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01682-2 · Cited by 396 · see citing works

A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR

Downes, M., Verdecia, M. A., Roecker, A. J., Hughes, R. O., Hogenesch, J. B., Kast-Woelbern, H. R., Bowman, M. E., Ferrer, J.-L., Anisfeld, A. M., Edwards, P. A., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00104-7 · Cited by 392 · see citing works

Hepatic insulin resistance directly promotes formation of cholesterol gallstones

Biddinger, S. B., Haas, J. T., Yu, B. B., Bézy, O., Jing, E., Zhang, W., Unterman, T. G., Carey, M. C., & Kahn, C. R. (2008) · Nature Medicine · doi:10.1038/nm1785 · Cited by 367 · see citing works

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

García‐Cañaveras, J. C., Donato, M. T., Castell, J. V., & Lahoz, A. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d028803 · Cited by 276 · see citing works

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Velazquez-Villegas, L. A., Perino, A., Lemos, V., Zietak, M., Nomura, M., Pols, T. W. H., & Schoonjans, K. (2018) · Nature Communications · doi:10.1038/s41467-017-02068-0 · Cited by 268 · see citing works

Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC–MS/MS

Alnouti, Y., Csanaky, I. L., & Klaassen, C. D. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.08.018 · Cited by 259 · see citing works

Rapid quantification of bile acids and their conjugates in serum by liquid chromatography–tandem mass spectrometry

Scherer, M., Gnewuch, C., Schmitz, G., & Liebisch, G. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.09.038 · Cited by 216 · see citing works

Bile Acid Profiling and Quantification in Biofluids Using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

Sarafian, M. H., Lewis, M. R., Pechlivanis, A., Ralphs, S., McPhail, M. J. W., Patel, V., Dumas, M., Holmes, E. C., & Nicholson, J. K. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01556 · Cited by 215 · see citing works

Glucose and Insulin Induction of Bile Acid Synthesis

Li, T., Ferrell, J. M., Boehme, S., Ochoa, A., Zhang, Y., Klaassen, C. D., Erickson, S. K., & Chiang, J. Y. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.305789 · Cited by 211 · see citing works

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation.

Perino, A., Pols, T. W., Nomura, M., Stein, S., Pellicciari, R., & Schoonjans, K. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76289 · Cited by 209 · see citing works

Antiatherosclerotic effect of farnesoid X receptor

Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01075.2008 · Cited by 198 · see citing works

Metabolic Profiling of Bile Acids in Human and Mouse Blood by LC–MS/MS in Combination with Phospholipid-Depletion Solid-Phase Extraction

Han, J., Liu, Y., Wang, R., Yang, J., Ling, V. W. T., & Borchers, C. H. (2014) · Analytical Chemistry · doi:10.1021/ac503816u · Cited by 189 · see citing works

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

Li, Y. T. Y., Swales, K. E., Thomas, G. J., Warner, T. D., & Bishop-Bailey, D. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.152694 · Cited by 171 · see citing works

Clinical relevance of the bile acid receptor TGR5 in metabolism

van Nierop, F. S., Scheltema, M. J. V., Eggink, H. M., Pols, T. W. H., Sonne, D. P., Knop, F. K., & Soeters, M. R. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30155-3 · Cited by 158 · see citing works

Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia

Haeusler, R. A., Pratt–Hyatt, M., Welch, C. L., Klaassen, C. D., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.010 · Cited by 154 · see citing works

6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

Araya, Z., & Wikvall, K. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00031-1 · Cited by 154 · see citing works

Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS

Hagio, M., Matsumoto, M., Fukushima, M., Hara, H., & Ishizuka, S. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d800041-jlr200 · Cited by 153 · see citing works

Liver–Microbiome Axis in Health and Disease

Adolph, T. E., Grander, C., Moschen, A. R., & Tilg, H. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.05.002 · Cited by 152 · see citing works

Fasting Serum Taurine-Conjugated Bile Acids Are Elevated in Type 2 Diabetes and Do Not Change With Intensification of Insulin

Wewalka, M., Patti, M., Barbato, C., Houten, S. M., & Goldfine, A. B. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3367 · Cited by 130 · see citing works

Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria

Wegner, K., Just, S., Gau, L., Henrike, M., Gérard, P., Lepage, P., Clavel, T., & Rohn, S. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-0048-1 · Cited by 119 · see citing works

Farnesoid X receptor modulators 2014-present: a patent review

Sepe, V., Distrutti, E., Fiorucci, S., & Zampella, A. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1459569 · Cited by 91 · see citing works

Glucuronidation of 6 alpha-hydroxy bile acids by human liver microsomes.

Radominska-p, A., Zimniak, P., Irshaid, Y. M., Lester, R., Tephly, T. R., & Pyrek, J. S. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113053 · Cited by 90 · see citing works

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids

John, C., Werner, P., Worthmann, A., Wegner, K., Tödter, K., Scheja, L., Rohn, S., Heeren, J., & Fischer, M. J. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.064 · Cited by 84 · see citing works

Impacts of the Human Gut Microbiome on Therapeutics

Vázquez‐Baeza, Y., Callewaert, C., Debelius, J. W., Hyde, E. R., Marotz, C. A., Morton, J. T., Swafford, A. D.-E., Vrbanac, A. F., Dorrestein, P. C., & Knight, R. D. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-042017-031849 · Cited by 84 · see citing works

Metabolic pathways of bile acid synthesis

Elliott, W. H., & Hyde, P. M. (1971) · The American Journal of Medicine · doi:10.1016/0002-9343(71)90281-6 · Cited by 74 · see citing works

Cholesterol gallstones in alloxan-diabetic mice.

Akiyoshi, T., Uchida, K., Takase, H., Nomura, Y., & Takeuchi, N. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38774-5 · Cited by 71 · see citing works

Deficiency of Both Farnesoid X Receptor and Takeda G Protein–Coupled Receptor 5 Exacerbated Liver Fibrosis in Mice

Ferrell, J. M., Pathak, P., Boehme, S., Gilliland, T., & Chiang, J. Y. L. (2019) · Hepatology · doi:10.1002/hep.30513 · Cited by 65 · see citing works

Altered Bile Acid Metabolism in Nonobese, Spontaneously Diabetic (NOD) Mice

Uchida, K., Makino, S., & Akiyoshi, T. (1985) · Diabetes · doi:10.2337/diab.34.1.79 · Cited by 59 · see citing works

Alteration of Bile Acid Metabolism by a High-Fat Diet Is Associated with Plasma Transaminase Activities and Glucose Intolerance in Rats

Yoshitsugu, R., Kikuchi, K., Iwaya, H., Fujii, N., Hori, S., Lee, D. G., & Ishizuka, S. (2019) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.65.45 · Cited by 45 · see citing works

Bile Acid Metabolome after an Oral Lipid Tolerance Test by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Schmid, A., Neumann, H., Karrasch, T., Liebisch, G., & Schäffler, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148869 · Cited by 40 · see citing works

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

Zhu, P., Zhang, J., Chen, Y., Yin, S., Su, M., Xie, G., Brouwer, K. L. R., Liu, C., Lan, K., & Jia, W. P. (2018) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-1183-7 · Cited by 35 · see citing works

Deoxycholic acid supplementation impairs glucose homeostasis in mice

Zaborska, K. E., Lee, S. A., Garibay, D., Cha, E., & Cummings, B. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200908 · Cited by 31 · see citing works

Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat

Roda, A., Piazza, F., Baraldini, M., Speroni, E., Guerra, M., Cerré, C., & Forti, G. C. (1998) · Hepatology · doi:10.1002/hep.510270228 · Cited by 25 · see citing works

Bile Acid Analog Intercepts Liver Fibrosis

Filho, C. D. D. M., Downes, M., & Evans, R. M. (2016) · Cell · doi:10.1016/j.cell.2016.08.001 · Cited by 25 · see citing works

Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two‐step hyperglycemic clamp

Wang, S., Deng, Y., Xie, X., Ma, J., Xu, M., Zhao, X., Gu, W., Hong, J., Wang, W., Xu, G., et al. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12771 · Cited by 25 · see citing works

BILE ACID SEQUESTRANTS AND HYPERLIPIDAEMIA

(1988) · The Lancet · doi:10.1016/s0140-6736(88)91070-7 · Cited by 2 · see citing works

Gut microbiota and cardiovascular disease.

Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051 · see citing works

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

Li, C., Stražar, M., Mohamed, A. M., Ávila-Pacheco, J., Walker, R. L., Lebar, T., Zhao, S., Lockart, J., Dame, A., Thurimella, K., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.014 · Cited by 260 · see citing works

The changing metabolic landscape of bile acids – keys to metabolism and immune regulation

Mohanty, I., Allaband, C., Mannochio-Russo, H., Abiead, Y. E., Hagey, L. R., Knight, R. D., & Dorrestein, P. C. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00914-3 · Cited by 227 · see citing works

Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression

Nimer, N. A., Choucair, I., Wang, Z., Nemet, I., Li, L., Gukasyan, J., Weeks, T. L., Alkhouri, N., Zein, N. N., Tang, W. H. W., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154457 · Cited by 149 · see citing works

The role of the gut microbiota in health and cardiovascular diseases

Wang, L., Wang, S., Zhang, Q., He, C., Fu, C., & Wei, Q. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00091-2 · Cited by 124 · see citing works

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Phelps, C. M., Willis, N. B., Duan, T., Lee, A. H., Zhang, Y., Rodriguez J, D. M., Pandey, S. P., Laughlin, C. R., Rosen, A. B. I., McPherson, A. C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.018 · Cited by 91 · see citing works

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism

Pathak, P., Helsley, R. N., Brown, A. L., Buffa, J. A., Choucair, I., Nemet, I., Baleanu‐Gogonea, C., Gogonea, V., Wang, Z., Garcı́a-Garcı́a, J. C., et al. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00584.2019 · Cited by 88 · see citing works

Sulfated bile acid is a host-derived ligand for MAIT cells

Ito, E., Inuki, S., Izumi, Y., Takahashi, M., Dambayashi, Y., Ciacchi, L., Awad, W., Takeyama, A., Shibata, K., Mori, S., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.ade6924 · Cited by 77 · see citing works

From a single steroid to the steroidome: Trends and analytical challenges

Olesti, E., Boccard, J., Visconti, G., González‐Ruiz, V., & Rudaz, S. L. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105797 · Cited by 74 · see citing works

Role of the microbiota–gut–heart axis between bile acids and cardiovascular disease

Zhang, Z., Lv, T., Wang, X., Wu, M., Zhang, R., Yang, X., Fu, Y., & Liu, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116567 · Cited by 77 · see citing works

Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases

Mutalub, Y. B., Abdulwahab, M., Mohammed, A., Yahkub, A. M., Al-Mhanna, S. B., Yusof, W., Tang, S. P., Rasool, A. H. G., & Mokhtar, S. S. (2022) · Foods · doi:10.3390/foods11172575 · Cited by 60 · see citing works

The Gut Microbial Endocrine Organ in Type 2 Diabetes

Massey, W. J., & Brown, J. M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa235 · Cited by 61 · see citing works

Gut microbiome and its meta-omics perspectives: profound implications for cardiovascular diseases

Xu, J., & Yang, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1936379 · Cited by 56 · see citing works

Bile acid metabolism in type 2 diabetes mellitus

Sandoval, M. C., & Haeusler, R. A. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01067-8 · Cited by 53 · see citing works

Development of an Efficient and Sensitive Chemical Derivatization-Based LC–MS/MS Method for Quantifying Gut Microbiota-Derived Metabolites in Human Plasma and Its Application in Studying Cardiovascular Disease

Liao, H.-Y., Wang, C., Lee, C.-H., Kao, H., Wu, W., & Kuo, C. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00147 · Cited by 43 · see citing works

Phenylacetylglutamine increases the susceptibility of ventricular arrhythmias in heart failure mice by exacerbated activation of the TLR4/AKT/mTOR signaling pathway

Fu, H. Q., Kong, B., Zhu, J., Huang, H., & Shuai, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109795 · Cited by 38 · see citing works

Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome

Jin, Y., Chi, J., LoMonaco, K., Boon, A., & Gu, H. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117155 · Cited by 37 · see citing works

An Integrated Metabolomic Study of Osteoporosis: Discovery and Quantification of Hyocholic Acids as Candidate Markers

Deng, D., Chen, P., Wu, Z., Sun, Y., Liu, C., Xiang, H., Yin, P., & Shang, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.725341 · Cited by 37 · see citing works

Mutual Interplay of Host Immune System and Gut Microbiota in the Immunopathology of Atherosclerosis

Yeh, C., Chen, Y.-H., Liu, S.-F., Kao, H., Wu, M., Yang, K., & Wu, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228729 · Cited by 36 · see citing works

The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives

Papadopoulos, P., Tsigalou, C., Valsamaki, P. N., Konstantinidis, T. G., Voidarou, C. C., & Bezirtzoglou, E. (2022) · Biomedicines · doi:10.3390/biomedicines10050948 · Cited by 38 · see citing works

Circulating bile acid profile characteristics in PCOS patients and the role of bile acids in predicting the pathogenesis of PCOS

Yu, J., Zhang, Y., Zhu, Y., Li, Y., Lin, S., Liu, W., & Tao, T. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1239276 · Cited by 32 · see citing works

Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism

Huang, Y., Xu, W., Dong, W., Chen, G., Sun, Y., & Zeng, X. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.06.027 · Cited by 32 · see citing works

The gut–heart axis: a review of gut microbiota, dysbiosis, and cardiovascular disease development

Abdulrahim, A. O., Doddapaneni, N. S. P., Salman, N., Giridharan, A., Thomas, J., Sharma, K., Abboud, E., Rochill, K., Shreelakshmi, B., Gupta, V., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002789 · Cited by 31 · see citing works

Metabolomics study identified bile acids as potential biomarkers for gastric cancer: A case control study

Chen, P., Deng, D., Wei, T., Wu, Z., Zhang, B., Yuan, Q., Liang, G., Liu, Y., & Yin, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1039786 · Cited by 28 · see citing works

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Ahmad, T. R., Higuchi, S., Bertaggia, E., Hung, A., Shanmugarajah, N., Guilz, N. C., Gamarra, J. R., & Haeusler, R. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012792 · Cited by 24 · see citing works

Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Cao, Y., Aquino-Martínez, R., Hutchison, E. R., Allayee, H., Lusis, A. J., & Rey, F. E. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101557 · Cited by 23 · see citing works

Quantitative Profiling of Bile Acids in Feces of Humans and Rodents by Ultra-High-Performance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry

Zhang, X., Liu, X., Yang, J., Ren, F., & Li, Y. (2022) · Metabolites · doi:10.3390/metabo12070633 · Cited by 21 · see citing works

Advances in gut microbiome in metabonomics perspective: based on bibliometrics methods and visualization analysis

Wang, J., Dong, P., Zheng, S., Mai, Y.-Y., Ding, J., Pan, P., Tang, L., Wan, Y., & Liang, H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1196967 · Cited by 21 · see citing works

Human Gut Microbiota in Cardiovascular Disease

Ronen, D., Rokach, Y., Abedat, S., Qadan, A., Daana, S., Amir, O., & Asleh, R. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230012 · Cited by 28 · see citing works

The role of bile acid metabolism in bone and muscle: from analytics to mechanisms

Herrmann, M., Blanco, G. R., Balasso, M., Sobolewska, K., Semeraro, M. D., Alonso, N., & Herrmann, W. (2024) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2024.2323132 · Cited by 17 · see citing works

Epigenetics and Gut Microbiota Crosstalk: A potential Factor in Pathogenesis of Cardiovascular Disorders

Mehta, V., Nagu, P., Inbaraj, B. S., Sharma, M., Parashar, A., & Sridhar, K. (2022) · Bioengineering · doi:10.3390/bioengineering9120798 · Cited by 17 · see citing works

Insight Into the Metabolomic Characteristics of Post-Transplant Diabetes Mellitus by the Integrated LC-MS and GC-MS Approach- Preliminary Study

Wang, M., Xu, J., Yang, N., Zhang, T., Zhu, H., & Wang, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.807318 · Cited by 16 · see citing works

Prophylactic Inhibition of Colonization by Streptococcus pneumoniae with the Secondary Bile Acid Metabolite Deoxycholic Acid

Vidal, J. E., Wier, M. N., Angulo-Zamudio, U., McDevitt, E., Vidal, A. G. J., Alibayov, B., Scasny, A., Wong, S. M., Akerley, B. J., & McDaniel, L. S. (2021) · Infection and Immunity · doi:10.1128/iai.00463-21 · Cited by 15 · see citing works

The molecular insights of bile acid homeostasis in host diseases

Zhang, J., Lü, A., & Wang, C. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121919 · Cited by 14 · see citing works

Bile acid metabolites enhance expression of cathelicidin antimicrobial peptide in airway epithelium through activation of the TGR5-ERK1/2 pathway

Myszor, I. T., Lapka, K., Hermannsson, K., Rekha, R., Bergman, P., & Gudmundsson, G. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-57251-3 · Cited by 12 · see citing works

Clostridium butyricum Strain CCFM1299 Reduces Obesity via Increasing Energy Expenditure and Modulating Host Bile Acid Metabolism

Liao, J., Liu, Y., Yao, Y., Zhang, J., Wang, H., Zhao, J., Chen, W., & Lu, W. (2023) · Nutrients · doi:10.3390/nu15204339 · Cited by 14 · see citing works

The microbiome’s influence on obesity: mechanisms and therapeutic potential

Tadese, D. A., Mwangi, J., Luo, L., Zhang, H., Huang, X., Michira, B. B., Zhou, S., Kamau, P. M., Lu, Q., & Lai, R. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2759-3 · Cited by 18 · see citing works

Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads

Hill, E. B., Chen, L., Bailey, M. T., Khalsa, A. S., Maltz, R. M., Kelleher, K. J., Spees, C., Zhu, J., & Loman, B. R. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2150502 · Cited by 14 · see citing works

Metabolic Pathways Affected in Patients Undergoing Hemodialysis and Their Relationship with Inflammation

Peris‐Fernández, M., Roca, M., Amengual, J. L., Balaguer-Timor, Á., Viejo-Boyano, I., Soldevila-Orient, A., Devesa-Such, R. J., Pérez, P. S., & Jaras, J. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179364 · Cited by 12 · see citing works

Ecological Adaptation and Succession of Human Fecal Microbial Communities in an Automated In Vitro Fermentation System

Gnanasekaran, T., Geraldo, J. A., Ahrenkiel, D. W., Silva, M. C. A., Saenz, C., Khan, A. A., Hanteer, O., Gunalan, V., Trôst, K., Möritz, T., et al. (2021) · mSystems · doi:10.1128/msystems.00232-21 · Cited by 12 · see citing works

The plasma lipidome of the Quaker parrot (Myiopsitta monachus)

Beaufrère, H., Gardhouse, S. M., Wood, R. D., & Stark, K. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240449 · Cited by 12 · see citing works

Further evidence for blood-to-brain influx of unconjugated bile acids by passive diffusion: Determination of their brain-to-serum concentration ratios in rats by LC/MS/MS

Shibuya, T., Sato, A., Nishimoto‐Kusunose, S., Yoshizawa, K., & Higashi, T. (2024) · Steroids · doi:10.1016/j.steroids.2024.109397 · Cited by 11 · see citing works

Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices

Choucair, I., Mallela, D. P., Hilser, J. R., Hartiala, J., Nemet, I., Gogonea, V., Li, L., Lusis, A. J., Fischbach, M. A., Tang, W. H. W., et al. (2024) · Diabetes · doi:10.2337/db23-0676 · Cited by 11 · see citing works

Altered bile acids profile is a risk factor for hyperandrogenism in lean women with PCOS: a case control study

Zhu, Y., Lin, S., Zhang, Y., Yu, J., Fu, J., Li, Y., Shan, C., Cai, J., Liu, W. X., & Tao, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-77645-7 · Cited by 11 · see citing works

Rapid quantification of murine bile acids using liquid chromatography-tandem mass spectrometry

Hermeling, S., Plagge, J., Krautbauer, S., Ecker, J., Burkhardt, R., & Liebisch, G. (2024) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-024-05668-0 · Cited by 11 · see citing works

Altered iso- and oxo-Fecal Bile Acid Concentrations in Dogs with Chronic Enteropathy

Blake, A. B., Toresson, L., Chen, C.-C., Ishii, P. E., Phillips, R. K., Giaretta, P. R., Cavasin, J. P., Lidbury, J. A., & Suchodolski, J. S. (2025) · Pets · doi:10.3390/pets2020018 · Cited by 9 · see citing works

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

Dalton, G. D., Oh, S., Tang, L., Zhang, S. Y., Brown, A. L., Varadharajan, V., Baleanu‐Gogonea, C., Gogonea, V., Pathak, P., Brown, J. M., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103089 · Cited by 9 · see citing works

Effects of Phenylacetylglutamine on the Susceptibility of Atrial Fibrillation in Overpressure-Induced HF Mice

Fu, H. Q., Li, D., Shuai, W., Kong, B., Wang, X., Tang, Y., Huang, H., & Huang, C. (2024) · Molecular and Cellular Biology · doi:10.1080/10985549.2024.2345363 · Cited by 9 · see citing works

Bile Acids and Type 2 Diabetes: Roles in Glucose Homeostasis and Therapeutic Opportunities

Lin, Y., Hu, C., Wang, S., & Lin, H. (2025) · Metabolites · doi:10.3390/metabo15060401 · Cited by 8 · see citing works

Isomers-oriented separation of forty-five plasma bile acids with liquid chromatography-tandem mass spectrometry

Zhang, L., Liu, X., Jin, T., Dong, J., Li, X., Zhang, Y., & Li, X. (2024) · Journal of Chromatography A · doi:10.1016/j.chroma.2024.464827 · Cited by 7 · see citing works

Human Gut Microbiota in Cardiovascular Disease

Ronen, D., Rokach, Y., Abedat, S., Qadan, A., Daana, S., Amir, O., & Asleh, R. (2024) · Comprehensive physiology · doi:10.1002/j.2040-4603.2024.tb00298.x · Cited by 7 · see citing works

Quantitative bile acid profiling in healthy adult dogs and pups from serum, plasma, urine, and feces using LC-MS/MS

Karakuş, E., Proksch, A., Moritz, A., & Geyer, J. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1380920 · Cited by 6 · see citing works

Untargeted metabolomic analysis uncovers metabolic variability of four Bifidobacterial strains for probiotic development

Liu, K., Yao, G., Zhan, Y., Huang, T., Kwok, L., & Zhang, H. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1522036 · Cited by 6 · see citing works

Mass Spectrometric Blood Metabogram: Acquisition, Characterization, and Prospects for Application

Lokhov, P. G., Balashova, E. E., Trifonova, O. P., Maslov, D. L., Grigoriev, A. I., Ponomarenko, E. A., & Archakov, A. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021736 · Cited by 6 · see citing works

Identification of strain-specific cues that regulate biofilm formation in Bacteroides thetaiotaomicron

Glowacki, R. W. P., Engelhart, M. J., Till, J. M., Kadam, A., Nemet, I., Sangwan, N., & Ahern, P. P. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.03419-24 · Cited by 5 · see citing works

The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance

Banerjee, R., Hohe, R. C., Cao, S., Jung, B. M., Horak, A. J., Ramachandiran, I., Massey, W. J., Varadharajan, V., Zajczenko, N., Burrows, A. C., et al. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1371096 · Cited by 5 · see citing works

Modulation of the biological network of lumbar spinal stenosis by Tongdu Huoxue Decoction based on clinical metabolomics

Ji, L., Huang, P. C., Wang, Q., Li, X., & Li, Y. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1074500 · Cited by 5 · see citing works

Bariatric Surgery Is Associated with Lower Concentrations of Fecal Secondary Bile Acids and Their Metabolizing Microbial Enzymes: A Pilot Study

Hussan, H., Ali, M. R., Lyo, V., Webb, A., Pietrzak, M., Zhu, J., Choueiry, F., Li, H., Cummings, B. P., Marco, M. L., et al. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07420-0 · Cited by 4 · see citing works

Gamma-ray Irradiation of Rodent Diets Alters the Urinary Metabolome in Rats with Chemically Induced Mammary Cancer

PRASAIN, J. K., Wilson, L. S., Grubbs, C. J., & Barnes, S. (2022) · Metabolites · doi:10.3390/metabo12100976 · Cited by 4 · see citing works

Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model

Awoniyi, M., Hag, M. I. E., Hernandez, J., Yang, Q., Evans, N., Nemet, I., Ngo, B., Coskuner, D., Zhou, J. Y., Farmer, M., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-336675 · Cited by 3 · see citing works

Towards the clinical use of peripheral bile acids: Recommendations to limit their preanalytical and analytical sources of variability

Joseph, S., de Buyl, S., Leclercq, I. A., Serafimov, K., Féron, O., & Clerbaux, L. (2025) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2025.e00508 · Cited by 3 · see citing works

Bile Derivative T3K Ameliorates Colitis by Regulating the Intestinal Microbiota-Bile Acid Axis

Zhou, Y., Zhang, Y., Li, Y., Chen, Y., Chi, X., 尤忠毓, Zhang, H., Li, Y., & 吴练秋 (2025) · Pharmaceutics · doi:10.3390/pharmaceutics18010020 · Cited by 2 · see citing works

Robust Workflow for Multiclass Host-Gut Microbial Cometabolite Quantitation in Human Stool via 3-Nitrophenylhydrazine Derivatization and LC-MS/MS: A Validated Analytical Platform for Translational Studies

Ng, D. Z. W., Koh, M., Low, A., Liu, L., Jumat, N. H. B., Zhang, Z., Koh, X. Q., Zhu, M., Muthiah, M. D., Dan, Y. Y., et al. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c05360 · Cited by 2 · see citing works

Systemic Metabolomic Remodeling in Pressure Overload-Induced Heart Failure Indicates Modulation of a Gut–Liver–Heart Axis by the Adiponectin Receptor Agonist ALY688

Lei, Y., Li, B., Gosse, T., Cho, S., Sung, H. K., Chen, J., & Sweeney, G. (2026) · Metabolites · doi:10.3390/metabo16010038 · Cited by 1 · see citing works

Multi‐Strain Probiotics BLa80 , LRa05 , and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial

Zhu, S., Qiao, Y., He, W., Xiao, Y., Song, G., Liu, K., & Fang, S. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71735 · Cited by 1 · see citing works

Rapid Diagnosis of Intrahepatic Cholestasis of Pregnancy (ICP): Validation of an Automated Enzymatic Total Bile Acid Assay and Assessment of Ursodeoxycholic Acid Impact on Bile Acid Profiles in an ICP Cohort

Kodger, J. V., Nadim, H., Choucair, I., Sutphin, A., Eid, T., & El-Khoury, J. M. (2026) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfag099 · Cited by 1 · see citing works

Microbial Lipidomics

Ueda, M., Okahashi, N., & Arita, M. (2023) · Wiley eBooks · doi:10.1002/9783527836512.ch27 · Cited by 1 · see citing works

Implications of microbiota in the pathogenesis of diabetes mellitus and cardiovascular disease

Tănase, D. M., Leustean, A. M., & Gosav, E. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00005-8

Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS

Mullapudi, T. R., Ravi, P. R., & Thipparapu, G. (2023) · Journal of Analytical Science & Technology · doi:10.1186/s40543-023-00408-y

Strategies to Overcome Metabolic Syndrome and Related Diseases

(2025) · Frontiers research topics · doi:10.3389/978-2-8325-5556-9

Additional file 1 of Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS

Mullapudi, T. R., Ravi, P. R., & Thipparapu, G. (2023) · Figshare · doi:10.6084/m9.figshare.24320010

The role of gut microbes in production of aromatic carboxaldehydes

Kumar, M., Son, R., Preston, S. M., Glowacki, R. W. P., Carr, K. M., Kim, J., Ma, J. Z., Ahern, P. P., Claesen, J., Sangwan, N., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2632979

Alteration of bile acid metabolism in mice under thermoneutral conditions

Soma, H., Yoshida, R., & Ishizuka, S. (2026) · Steroids · doi:10.1016/j.steroids.2026.109794

HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer

Fotouhi, N., Diaz, R., Alyamani, M., Chung, Y., West, G. A., Mukherjee, P. K., Abdshah, A., Burgess, R. A., Jatana, S., McKay, R. R., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci202725

Development and validation of a UHPLC–HRMS method for bile acids quantification in bronchoalveolar lavage fluid and plasmaPreprint

Bortolato, C., Marco, V. D., Sartori, A., Carnielli, V. P., Cogo, P. E., & Simonato, M. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7629552

MetaTag: A Biochemical Reaction-Guided Design Strategy for New Metabolite Discovery

Li, C., Xu, Q., Zhang, L., Liu, Z., Shi, J., Jia, Z., Cao, Y., Chen, H., Liu, Q., Ke, C., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c09579

A fast and reliable LC-QqQ-MS/MS analytical approach for the quantification of key bile acids in feces, serum, and liver: application to an intergenerational study

Barker‐Tejeda, T. C., Mamani‐Huanca, M., Macías‐Camero, A., Hernández, M. D., Horvat, T., Zubeldia‐Varela, E., Angulo, S. M., Bazire, R., Cabrera‐Freitag, P., Barber, D., et al. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.116957

Targeted analysis of 14 bile acids in serum by LC-MS/MS v1Preprint

Simpson, J. P., Denham, S. G., & Homer, N. Z. M. (2025) · doi:10.17504/protocols.io.81wgbnddogpk/v1

Determination of Human Plasma Bile Acid Metabolic Profiles by Liquid Chromatography-tandem Mass Spectrometry

Chen, Y. (2018) · Tuwhera (Auckland University of Technology)

An Improved Method for the Quantification of the Key Bile Acids in Serum, Liver, and Feces: Application to an Intergenerational Study in Gut MicrobiotaPreprint

Villaseñor, A., Barker‐Tejeda, T. C., Mamani‐Huanca, M., Macías‐Camero, A., Hernández, M. D., Horvat, T., Zubeldia‐Varela, E., Angulo, S., Bazire, R., Barber, D., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5263897

Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria

Wegner, K., Just, S., Gau, L., Henrike, M., Gérard, P., Lepage, P., Clavel, T., & Rohn, S. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-0048-1 · Cited by 119 · see citing works