Hazen, Stanley L.

A Tale of Two Controversies

Brennan, M.-L., Wu, W., Fu, X., Shen, Z., Song, W., Frost, H., Vadseth, C., Narine, L., Lenkiewicz, E., Borchers, M. T., et al. (2002) · Journal of Biological Chemistry

Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Cited by 486

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

Gregory, J. C., Buffa, J. A., Org, E., Wang, Z., Levison, B. S., Zhu, W., Wagner, M. A., Bennett, B. J., Li, L., DiDonato, J. A., et al. (2015) · Journal of Biological Chemistry

Gut microbiota and healthAtherosclerosis and Cardiovascular Diseases

Cited by 486

Common variants in KCNN3 are associated with lone atrial fibrillation

Ellinor, P. T., Lunetta, K. L., Glazer, N. L., Pfeufer, A., Alonso, A., Chung, M. K., Sinner, M. F., de Bakker, P. I. W., Mueller, M., Lubitz, S. A., et al. (2010) · Nature Genetics

Cardiac electrophysiology and arrhythmiasAtrial Fibrillation Management and Outcomes

Cited by 485

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

Li, X. S., Obeid, S., Klingenberg, R., Gencer, B., Mach, F., Räber, L., Windecker, S., Rodondi, N., Nanchen, D., Muller, O., et al. (2017) · European Heart Journal

Gut microbiota and healthAcute Myocardial Infarction Research

Cited by 479

Association of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy

Shishehbor, M. H., Aviles, R. J., Brennan, M.-L., Fu, X., Goormastic, M., Pearce, G. L., Gokce, N., Keaney, J. F., Penn, M. S., Sprecher, D. L., et al. (2003) · JAMA

Nitric Oxide and Endothelin EffectsLipoproteins and Cardiovascular Health

Cited by 464

Microbial modulation of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology

Gut microbiota and healthNutritional Studies and Diet

Cited by 440

The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases

Brown, J. M., & Hazen, S. L. (2015) · Annual Review of Medicine

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 438

Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation

Zhang, R., Brennan, M.-L., Shen, Z., MacPherson, J. C., Schmitt, D., Molenda, C. E., & Hazen, S. L. (2002) · Journal of Biological Chemistry

Neutrophil, Myeloperoxidase and Oxidative MechanismsAntioxidant Activity and Oxidative Stress

Cited by 432

Oxidized phosphatidylserine–CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells

Greenberg, M. E., Sun, M., Zhang, R., Febbraio, M., Silverstein, R., & Hazen, S. L. (2006) · The Journal of Experimental Medicine

Phagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Cited by 430

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

Warrier, M., Shih, D. M., Burrows, A. C., Ferguson, D., Gromovsky, A. D., Brown, A. L., Marshall, S., McDaniel, A., Schugar, R. C., Wang, Z., et al. (2015) · Cell Reports

Cholesterol and Lipid MetabolismGut microbiota and health

Cited by 414

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure

Organ, C. L., Otsuka, H., Bhushan, S., Wang, Z., Bradley, J., Trivedi, R., Polhemus, D. J., Tang, W. H. W., Wu, Y., Hazen, S. L., et al. (2016) · Circulation: Heart Failure

Cardiac Fibrosis and RemodelingGut microbiota and health

Cited by 382

Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension

Xu, W., Kaneko, F. T., Zheng, S., Comhair, S. A. A., Janocha, A. J., Goggans, T., Thunnissen, F. B. J. M., Farver, C., Hazen, S. L., Jennings, C., et al. (2004) · The FASEB Journal

Pulmonary Hypertension Research and TreatmentsNitric Oxide and Endothelin Effects

Cited by 369

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

Shih, D. M., Wang, Z., Lee, R., Meng, Y., Che, N., Charugundla, S., Qi, H., Wu, J., Pan, C., Brown, J. M., et al. (2015) · Journal of Lipid Research

Pharmacogenetics and Drug MetabolismLipid metabolism and disorders

Cited by 335

Oxidative and nitrosative events in asthma

Andreadis, A. A., Hazen, S. L., Comhair, S. A. A., & Erzurum, S. C. (2003) · Free Radical Biology and Medicine

Asthma and respiratory diseasesRedox biology and oxidative stress

Cited by 327

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

Koeth, R. A., Lam-Galvez, B. R., Kirsop, J., Wang, Z., Levison, B. S., Gu, X., Copeland, M. F., Bartlett, D., Cody, D. B., Dai, H. J., et al. (2018) · Journal of Clinical Investigation

Gut microbiota and healthNutritional Studies and Diet

Cited by 327

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

Tang, W. H. W., Wang, Z., Shrestha, K., Borowski, A. G., Wu, Y., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2015) · Journal of Cardiac Failure

Cardiovascular Function and Risk FactorsHeart Failure Treatment and Management

Cited by 325

Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry

Wang, Z., Levison, B. S., Hazen, J. E., Donahue, L., Li, X.-M., & Hazen, S. L. (2014) · Analytical Biochemistry

Metabolomics and Mass Spectrometry StudiesMetabolism and Genetic Disorders

Cited by 320

Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks

Li, X.-M., Tang, W. H. W., Mosior, M. K., Huang, Y., Wu, Y., Matter, W., Gao, V., Schmitt, D., DiDonato, J. A., Fisher, E. A., et al. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 301

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 291

Gut Microbe-Generated Trimethylamine N -Oxide From Dietary Choline Is Prothrombotic in Subjects

Zhu, W., Wang, Z., Tang, W. H. W., & Hazen, S. L. (2017) · Circulation

Gut microbiota and healthNutritional Studies and Diet

Cited by 274

Intestinal Microbiota‐Generated Metabolite Trimethylamine‐ N‐ Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort

Senthong, V., Wang, Z., Li, X. S., Fan, Y., Wu, Y., Wilson Tang, W. H., & Hazen, S. L. (2016) · Journal of the American Heart Association

Gut microbiota and healthNutritional Studies and Diet

Cited by 270

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., et al. (2013) · Journal of Clinical Investigation

Paraoxonase enzyme and polymorphismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 269

Eosinophil peroxidase nitrates protein tyrosyl residues

Wu, W., Chen, Y., & Hazen, S. L. (1999) · Journal of Biological Chemistry

Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Cited by 265

Plasma Trimethylamine N -Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden

Senthong, V., Li, X. S., Hudec, T., Coughlin, J., Wu, Y., Levison, B., Wang, Z., Hazen, S. L., & Tang, W. H. W. (2016) · Journal of the American College of Cardiology

Gut microbiota and healthAtherosclerosis and Cardiovascular Diseases

Cited by 242