Takahashi, Akiko

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M. T., Obuse, C., et al. (2017) · Nature Communications

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 761

Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S.-I., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H., & Hara, E. (2006) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 528

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

Takasugi, M., Okada, R., Takahashi, A., Virya Chen, D., Watanabe, S., & Hara, E. (2017) · Nature Communications

Extracellular vesicles in diseaseTelomeres, Telomerase, and Senescence

Cited by 410

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Takahashi, A., Loo, T. M., Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G. N., et al. (2018) · Nature Communications

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 350

The p16INK4a-RB pathway : molecular link between cellular senescence and tumor suppression

Ohtani, N., Yamakoshi, K., Takahashi, A., & Hara, E. (2004) · The Journal of Medical Investigation

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 276

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer

Loo, T. M., Miyata, K., Tanaka, Y., & Takahashi, A. (2020) · Cancer Science

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 232

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Wakita, M., Takahashi, A., Sano, O., Loo, T. M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, S., Ohtani, N., et al. (2020) · Nature Communications

Telomeres, Telomerase, and SenescenceProtein Degradation and Inhibitors

Cited by 206

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells

Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., et al. (2012) · Molecular Cell

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 205

Real-time in vivo imaging of p16Ink4a reveals cross talk with p53

Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D. J., Ohmura, M., Hirao, A., Saya, H., et al. (2009) · Journal of Cell Biology

Cancer-related Molecular PathwaysEpigenetics and DNA Methylation

Cited by 172

Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination

Yasuda, T., Koiwa, M., Yonemura, A., Miyake, K., Kariya, R., Kubota, S., Yokomizo-Nakano, T., Yasuda-Yoshihara, N., Uchihara, T., Itoyama, R., et al. (2021) · Cell Reports

Telomeres, Telomerase, and SenescenceTGF-β signaling in diseases

Cited by 165

Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo

Takeuchi, S., Takahashi, A., Motoi, N., Yoshimoto, S., Tajima, T., Yamakoshi, K., Hirao, A., Yanagi, S., Fukami, K., Ishikawa, Y., et al. (2010) · Cancer Research

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 136

Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.

Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N., & Hara, E. (2014) · Cell Reports

FOXO transcription factor regulationTelomeres, Telomerase, and Senescence

Cited by 84

Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer

Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T. M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., et al. (2021) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 74

Visualizing the dynamics of p21 Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals

Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., et al. (2007) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCircadian rhythm and melatonin

Cited by 73

Cellular senescence: a double‐edged sword in the fight against cancer

Ohtani, N., Takahashi, A., Mann, D. J., & Hara, E. (2012) · Experimental Dermatology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 57

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Sugawara, S., Okada, R., Loo, T. M., Tanaka, H., Miyata, K., Chiba, M., Kawasaki, H., Katoh, K., Kaji, S., Maezawa, Y., et al. (2022) · Communications Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 23

Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment

Miyata, K., Zhou, X., Nishio, M., Hanyu, A., Chiba, M., Kawasaki, H., Osako, T., Takeuchi, K., Ohno, S., Ueno, T., et al. (2023) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 14

Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression

Miyata, K., & Takahashi, A. (2022) · Nucleus

Genomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

Cited by 5