Michaelson, Daniel M.

ApoE4: an emerging therapeutic target for Alzheimer’s disease

Safieh, M., Korczyn, A. D., & Michaelson, D. M. (2019) · BMC Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 449

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

Michaelson, D. M. (2014) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 331

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury

Chen, Y., Lomnitski, L., Michaelson, D. M., & Shohami, E. (1997) · Neuroscience

Traumatic Brain Injury and Neurovascular DisturbancesAlzheimer's disease research and treatments

Cited by 214

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

Rawat, V., Wang, S., Sima, J., Bar, R., Liraz, O., Gundimeda, U., Parekh, T., Chan, J., Johansson, J. O., Tang, C., et al. (2019) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 165

Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene

Boehm-Cagan, A., & Michaelson, D. M. (2014) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 134

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

Schmukler, E., Solomon, S., Simonovitch, S., Goldshmit, Y., Wolfson, E., Michaelson, D. M., & Pinkas-Kramarski, R. (2020) · Cell Death & Disease

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 125

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

Liraz, O., Boehm-Cagan, A., & Michaelson, D. M. (2013) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 118

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

Boehm-Cagan, A., Bar, R., Liraz, O., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 116

Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: The allele E3 is neuroprotective whereas E4 increases fatalities

Sabo, T., Lomnitski, L., Nyska, A., Beni, S., Maronpot, R. R., Shohami, E., Roses, A. D., & Michaelson, D. M. (2000) · Neuroscience

Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Cited by 104

A nontransgenic mouse model shows inducible amyloid-β (Aβ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade

Dolev, I., & Michaelson, D. M. (2004) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 102

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

Belinson, H., Lev, D., Masliah, E., & Michaelson, D. M. (2008) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 101

The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo

Simonovitch, S., Schmukler, E., Masliah, E., Pinkas-Kramarski, R., & Michaelson, D. M. (2019) · Journal of Alzheimer's Disease

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 59

Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice

Salomon-Zimri, S., Boehm-Cagan, A., Liraz, O., & Michaelson, D. M. (2013) · Neurodegenerative Diseases

Alzheimer's disease research and treatmentsMemory and Neural Mechanisms

Cited by 34

Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteins

Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · PLOS ONE

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 29

ApoE4‐Driven Accumulation of Intraneuronal Oligomerized A β 42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E., & Michaelson, D. M. (2011) · International Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 23

APOE4 impairs autophagy and Aβ clearance by microglial cells

Bassal, R., Rivkin-Natan, M., Rabinovich, A., Michaelson, D. M., Frenkel, D., & Pinkas-Kramarski, R. (2025) · Inflammation Research

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 23