Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteins
Open accessAbstract
Apolipoprotein E4 (apoE4), the leading genetic risk factor for Alzheimer's disease (AD), is less lipidated compared to the most common and AD-benign allele, apoE3. We have recently shown that i.p. injections of the ATP-binding cassette A1 (ABCA1) agonist peptide CS-6253 to apoE mice reverse the hypolipidation of apoE4 and the associated brain pathology and behavioral deficits. While in the brain apoE is the main cholesterol transporter, in the periphery apoE and apoA-I both serve as the major cholesterol transporters. We presently investigated the extent to which apoE genotype and CS-6253 treatment to apoE3 and apoE4-targeted replacement mice affects the plasma levels and lipid particle distribution of apoE, and those of plasma and brain apoA-I and apoJ. This revealed that plasma levels of apoE4 were lower and eluted faster following FPLC than plasma apoE3. Treatment with CS-6253 increased the levels of plasma apoE4 and rendered the elution profile of apoE4 similar to that of apoE3. Similarly, the levels of plasma apoA-I were lower in the apoE4 mice compared to apoE3 mice, and this effect was partially reversed by CS-6253. Conversely, the levels of apoA-I in the brain which were higher in the apoE4 mice, were unaffected by CS-6253. The plasma levels of apoJ were higher in apoE4 mice than apoE3 mice and this effect was abolished by CS-6253. Similar but less pronounced effects were obtained in the brain. In conclusion, these results suggest that apoE4 affects the levels of apoA-I and apoJ and that the anti-apoE4 beneficial effects of CS-6253 may be related to both central and peripheral mechanisms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Promotion of ApoE4 lipidation suppresses ApoE4-driven pathology.
“the promotion of ApoE4 lipidation suppresses ApoE4-driven pathology (42, 73)”
From Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes (2024) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works
Apolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836 · see citing works
Plasma lipoproteins: apolipoprotein structure and function.
Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34443-6 · Cited by 1,155 · see citing works
Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714 · see citing works
APOLIPOPROTEIN E ALLELES AS RISK FACTORS IN ALZHEIMER'S DISEASE
Roses, M. D. (1996) · Annual Review of Medicine · doi:10.1146/annurev.med.47.1.387 · Cited by 707 · see citing works
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693 · see citing works
Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575 · see citing works
Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism
Mahley, R. W. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.307023 · Cited by 516 · see citing works
Jones, S. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00155-8 · Cited by 488 · see citing works
Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works
ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease
Oram, J. F., & Vaughan, A. M. (2006) · Circulation Research · doi:10.1161/01.res.0000250171.54048.5c · Cited by 411 · see citing works
Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain
Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.
Linton, M. F., Gish, R., Hubl, S. T., Bütler, E., Esquivel, C., Bry, W. I., Boyles, J. K., Wardell, M. R., & Young, S. G. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115288 · Cited by 367 · see citing works
Apolipoprotein J: structure and tissue distribution
De Silva, H. V., Harmony, J. A. K., Stuart, W. D., Gil, C. M., & Robbins, J. (1990) · Biochemistry · doi:10.1021/bi00474a025 · Cited by 353 · see citing works
Abnormal in vivo metabolism of apolipoprotein E4 in humans.
Gregg, R. E., Zech, L. A., Schaefer, E. J., Stark, D., Wilson, D., & Brewer, H. B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112645 · Cited by 345 · see citing works
Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
Riddell, D. R., Zhou, H., Atchison, K., Warwick, H. K., Atkinson, P. J., Jefferson, J., Xu, L., Aschmies, S., Kirksey, Y., Hu, Y., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1972-08.2008 · Cited by 342 · see citing works
Poirier, J., Baccichet, A., Dea, D., & Gauthier, S. G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90456-p · Cited by 329 · see citing works
Cerebrovascular Effects of Apolipoprotein E: Implications for Alzheimer Disease
Zlokovic, B. V. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2152 · Cited by 263 · see citing works
HDL and cholesterol handling in the brain
Vitali, C., Wellington, C. L., & Calabresi, L. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu148 · Cited by 254 · see citing works
Michikawa, M., Fan, Q., Isobe, I., & Yanagisawa, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741008.x · Cited by 244 · see citing works
Fagan, A. M., Holtzman, D. M., Munson, G., Mathur, T., Schneider, D., Chang, L. K., Getz, G. S., Reardon, C. A., Lukens, J., Shah, J. A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30001 · Cited by 222 · see citing works
Lipoproteins in the Central Nervous System
LaDu, M. J., Reardon, C. A., Eldik, L. J. V., Fagan, A. M., Bu, G., HOLTZMAN, D., & Getz, G. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06365.x · Cited by 206 · see citing works
Apolipoproteins in the brain: implications for neurological and psychiatric disorders
Elliott, D. A., Weickert, C. S., & Garner, B. (2010) · Clinical Lipidology · doi:10.2217/clp.10.37 · Cited by 196 · see citing works
Stress-induced transcription of the clusterin/apoJ gene
Michel, D., Chatelain, G., North, S., & Brun, G. (1997) · Biochemical Journal · doi:10.1042/bj3280045 · Cited by 194 · see citing works
Formation and function of apolipoprotein E-containing lipoproteins in the nervous system.
Vance, J., & Hayashi, H. (2010) · Biochimica et Biophysica Acta · doi:10.1016/j.bbalip.2010.02.007 · Cited by 185 · see citing works
DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., Sullivan, P. M., Fagan, A. M., Han, X., & Holtzman, D. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00049-3 · Cited by 180 · see citing works
Jonas, A., Wald, J. H., Toohill, K. L., Krul, E. S., & Kézdy, K. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45679-7 · Cited by 179 · see citing works
Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice.
Hedrick, C. C., Castellani, L. W., Warden, C. H., Puppione, D. L., & Lusis, A. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80777-7 · Cited by 175 · see citing works
The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy
Yu, J.-T., & Tan, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8237-1 · Cited by 174 · see citing works
Putting cholesterol in its place: apoE and reverse cholesterol transport
Mahley, R. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28632 · Cited by 173 · see citing works
New insights into the determination of HDL structure by apolipoproteins
Phillips, M. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r034025 · Cited by 172 · see citing works
Tai, L. M., Bilousova, T., Jungbauer, L., Roeske, S. K., Youmans, K. L., Yu, C., Poon, W. W., Cornwell, L. B., Miller, C. A., Vinters, H. V., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442103 · Cited by 165 · see citing works
Hu, J., Liu, C.-C., Chen, X.-F., Zhang, Y.-W., Xu, H., & Bu, G. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0001-3 · Cited by 161 · see citing works
Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease
Poirier, J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.003 · Cited by 159 · see citing works
Levi, O., Jongen‐Rêlo, A. L., Feldon, J., Roses, A. D., & Michaelson, D. M. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00045-7 · Cited by 145 · see citing works
Self-citationATP-binding cassette transporter A1: From metabolism to neurodegeneration
Koldamova, R., Fitz, N. F., & Lefterov, I. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.007 · Cited by 144 · see citing works
Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosis.
Heeren, J., Beisiegel, U., & Grewal, T. (2005) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000201282.64751.47 · Cited by 134 · see citing works
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., Landreth, G. E., Castellano, J. M., Jiang, H., Cirrito, J. R., et al. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-13 · Cited by 128 · see citing works
Bielicki, J. K., Zhang, H., Cortez, Y., Zheng, Y. Y., Narayanaswami, V., Patel, A., Johansson, J., & Azhar, S. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003665 · Cited by 126 · see citing works
Self-citationGelissen, I. C., Hochgrebe, T. T., Wilson, M. R., Easterbrook‐Smith, S. B., Jessup, W., Dean, R. T., & Brown, A. J. (1998) · Biochemical Journal · doi:10.1042/bj3310231 · Cited by 123 · see citing works
Liraz, O., Boehm-Cagan, A., & Michaelson, D. M. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-16 · Cited by 118 · see citing works
Self-citationThe cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes
Tang, C., & Oram, J. F. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.03.011 · Cited by 116 · see citing works
ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies
Boehm-Cagan, A., Bar, R., Liraz, O., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160467 · Cited by 116 · see citing works
Self-citationEffect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides
Hanson, A. J., Bayer-Carter, J. L., Green, P. S., Montine, T. J., Wilkinson, C. W., Baker, L. D., Watson, G. S., Bonner, L. M., Callaghan, M., Leverenz, J. B., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.396 · Cited by 102 · see citing works
Belinson, H., Lev, D., Masliah, E., & Michaelson, D. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5633-07.2008 · Cited by 101 · see citing works
Self-citationApolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease
Poirier, J., Miron, J., Picard, C., Gormley, P., Théroux, L., Breitner, J. C. S., & Dea, D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.037 · Cited by 98 · see citing works
High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease
Stukas, S. K., Robert, J., & Wellington, C. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.003 · Cited by 96 · see citing works
Amyloid-β Pathology and APOE Genotype Modulate Retinoid X Receptor Agonist Activity in Vivo
Tai, L. M., Koster, K. P., Luo, J., Lee, S., Wang, Y., Collins, N. C., Aissa, M. B., Thatcher, G. R. J., & LaDu, M. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.600833 · Cited by 93 · see citing works
Stukas, S. K., Robert, J., Lee, M., Kulić, I., Carr, M., Tourigny, K., Fan, J., Namjoshi, D., Lemke, K., DeValle, N., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001156 · Cited by 91 · see citing works
Minagawa, H., Gong, J., Jung, C., Watanabe, A., Lund‐Katz, S., Phillips, M. C., Saito, H., & Michikawa, M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22073 · Cited by 90 · see citing works
Rye, K., Hime, N. J., & Barter, P. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4243 · Cited by 90 · see citing works
Structural Characterization of Clusterin-Chaperone Client Protein Complexes
Wyatt, A. R., Yerbury, J. J., & Wilson, M. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033688 · Cited by 82 · see citing works
Yassine, H. N., Feng, Q., Chiang, J., Petrosspour, L. M., Fonteh, A. N., Chui, H. C., & Harrington, M. G. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002886 · Cited by 80 · see citing works
Robert, J., Stukas, S. K., Button, E. B., Cheng, W. H., Lee, M., Fan, J., Wilkinson, A., Kulić, I., Wright, S. D., & Wellington, C. L. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.005 · Cited by 77 · see citing works
Li, H., Dhanasekaran, P., Alexander, E. T., Rader, D. J., Phillips, M. C., & Lund‐Katz, S. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301193 · Cited by 73 · see citing works
Is apolipoprotein E4 an important risk factor for vascular dementia?
Rohn, T. T. (2014) · PubMed Central · Cited by 68 · see citing works
Huang, Y., von Eckardstein, A., Wu, S., & Assmann, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118336 · Cited by 63 · see citing works
Hafiane, A., Bielicki, J. K., Johansson, J. O., & Genest, J. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131997 · Cited by 61 · see citing works
Self-citationKockx, M., Rye, K.-A., Gaus, K., Quinn, C. M., Wright, J., Sloane, T., Sviridov, D., Fu, Y., Sullivan, D., Burnett, J. R., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401177200 · Cited by 47 · see citing works
Mulder, M., & Terwel, D. (1998) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000022429 · Cited by 40 · see citing works
Jansen, P. J., Lütjohann, D., Thelen, K., von Bergmann, K., Leuven, F. V., Ramaekers, F., & Monique, M. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1150 · Cited by 39 · see citing works
Belinson, H., & Michaelson, D. M. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0218-9 · Cited by 38 · see citing works
Self-citationRegulation of reconstituted high density lipoprotein structure and remodeling by apolipoprotein E
Rye, K., Bright, R., Psaltis, M., & Barter, P. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500525-jlr200 · Cited by 37 · see citing works
Relation between plasma and brain lipids
Wellington, C. L., & Frikke-Schmidt, R. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000291 · Cited by 33 · see citing works
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism
Hopkins, P. C. R., Huang, Y., McGuire, J. G., & Pitas, R. E. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200172-jlr200 · Cited by 31 · see citing works
Okoro, E. U., Zhao, Y., Guo, Z., Zhou, L., Lin, X., & Yang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044430 · Cited by 25 · see citing works
Grosskopf, I., Shaish, A., Afek, A. B., Shemesh, S., Harats, D., & Kamari, Y. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.04.011 · Cited by 21 · see citing works
Self-citationHuman apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass
Robciuc, M. R., Metso, J., Sima, A. V., Ehnholm, C., & Jauhiainen, M. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-59 · Cited by 12 · see citing works
Haas, A., Liraz, O., & Michaelson, D. M. (2012) · Neurodegenerative Diseases · doi:10.1159/000334902 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
ApoE4: an emerging therapeutic target for Alzheimer’s disease
Safieh, M., Korczyn, A. D., & Michaelson, D. M. (2019) · BMC Medicine · doi:10.1186/s12916-019-1299-4 · Cited by 449 · see citing works
Self-citationItoh, N., Itoh, Y., Tassoni, A., Ren, E., Kaito, M., Ohno, A., Ao, Y., Farkhondeh, V., Johnsonbaugh, H., Burda, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716032115 · Cited by 253 · see citing works
ApoE Lipidation as a therapeutic target in Alzheimer’s disease
Lanfranco, M. F., Ng, C. A., & Rebeck, G. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176336 · Cited by 189 · see citing works
Moulton, M. J., Barish, S., Ralhan, I., Chang, J., Goodman, L. D., Harland, J. G., Marcogliese, P. C., Johansson, J. O., Ioannou, M. S., & Bellen, H. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112095118 · Cited by 180 · see citing works
Self-citationTherapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease
Williams, T., Borchelt, D., & Chakrabarty, P. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-0358-9 · Cited by 166 · see citing works
Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
Arenas, F., García‐Ruiz, C., & Fernández-Checa, J. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00382 · Cited by 161 · see citing works
The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease
Kloske, C. M., & Wilcock, D. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00754 · Cited by 152 · see citing works
Flowers, S. A., & Rebeck, G. W. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104724 · Cited by 149 · see citing works
Remembering your A, B, C's: Alzheimer's disease and ABCA1
Lewandowski, C. T., Laham, M. S., & Thatcher, G. R. J. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.011 · Cited by 76 · see citing works
Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease
Torres, S., García‐Ruiz, C., & Fernández-Checa, J. C. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01168 · Cited by 40 · see citing works
The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer’s Disease
Chernick, D., Zhong, R., & Li, L. (2020) · Biomolecules · doi:10.3390/biom10091276 · Cited by 38 · see citing works
Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis
Samant, N. P., & Gupta, G. L. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14949 · Cited by 36 · see citing works
Kloske, C. M., Dugan, A. J., Weekman, E. M., Winder, Z., Patel, E., Nelson, P. T., Fardo, D. W., & Wilcock, D. M. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab085 · Cited by 36 · see citing works
Liu, X., Yang, Q., Li, H., Lan, X., Kan, M., Lin, J., Wang, J., Zhang, Z., Ming, S., Li, Z., et al. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2003061 · Cited by 32 · see citing works
Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys
Noveir, S. D., Kerman, B. E., Xian, H., Meuret, C. J., Smadi, S., Martinez, A. E., Johansson, J., Zetterberg, H., Parks, B. A., Kuklenyik, Z., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01028-1 · Cited by 28 · see citing works
Self-citationAstrocytic transporters in Alzheimer's disease
Ugbode, C., Hu, Y., Whalley, B., Peers, C., Rattray, M., & Dallas, M. L. (2017) · Biochemical Journal · doi:10.1042/bcj20160505 · Cited by 25 · see citing works
Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology
Koren-Iton, A., Salomon‐Zimri, S., Smolar, A., Stein, E. S., Dori, A., Chapman, J., & Michaelson, D. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041289 · Cited by 25 · see citing works
Self-citationRomo, E. Z., Hong, B. V., Patel, R. Y., Agus, J., Harvey, D. J., Maezawa, I., Jin, L., Lebrilla, C. B., & Zivkovic, A. M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1408220 · Cited by 22 · see citing works
Bar, R., Boehm‐Cagan, A., Luz, I., Kleper-Wall, Y., & Michaelson, D. M. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.08.003 · Cited by 19 · see citing works
Self-citationCurrent Drug Targets in Alzheimer’s Associated Memory Impairment: A Comprehensive Review
Chandrashekar, K. S., Mathew, A., Vignesh Balaji, E., Pai, K. S. R., Kishore, A., Pai, V., & Pemmireddy, R. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220401124719 · Cited by 18 · see citing works
APOE-Targeted Therapeutics for Alzheimer's Disease
Yassine, H. N., Hugo, C., O’Donovan, B., Stephens, I. O., Johnson, L. A., Cole, G. M., Julia, T. C. W., Johansson, J. O., Kisler, K., & Chiba‐Falek, O. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1388-25.2025 · Cited by 16 · see citing works
Self-citationThe Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology
Hudák, A., Jósvay, K., Domonkos, I., Letoha, A., Szilák, L., & Letoha, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137070 · Cited by 14 · see citing works
Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes
Komai, M., Noda, Y., Ikeda, A., Kaneshiro, N., Kamikubo, Y., Sakurai, T., Uehara, T., & Takasugi, N. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100510 · Cited by 13 · see citing works
Advances in the Study of APOE and Innate Immunity in Alzheimer’s Disease
Li, Y., Chang, J., Chen, X., Liu, J., & Zhao, L. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230179 · Cited by 6 · see citing works
Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies
Tripathi, S., Sharma, Y., & Kumar, D. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037326839241014054430 · Cited by 4 · see citing works
ABCA1: A Therapeutic Target for Improving Cholesterol Homeostasis in Peripheral Neuropathies
Woo, Y. H., Schmidt, N. E., Johansson, J. O., & Notterpek, L. M. (2026) · Biomolecules · doi:10.3390/biom16020332 · Cited by 2 · see citing works
Self-citationGarrahy, J. P. (2025) · Journal of Alzheimer's Disease · doi:10.1177/13872877251404970 · Cited by 1 · see citing works
The Effect of Statins on the Differentiation and Function of Central Nervous System Cells
Chamani, S., Mobasheri, L., Zerehpoosh, S., Naghizadeh, A., McCloskey, A. P., Rizzo, M., Jamialahmadi, T., & Sahebkar, A. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230308121645 · Cited by 1 · see citing works
Noveir, S. D., Kerman, B. E., Xian, H., Meuret, C. J., Smadi, S., Martinez, A. E., Johansson, J., Zetterberg, H., Parks, B. A., Kuklenyik, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20155656
Self-citation
- Authors
- Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M.
- Affiliations
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Michaelson, Daniel M.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-11-08
- Volume
- 11
- Issue
- 11
- Pages
- e0166195
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5100931
- OpenAlex
- W2552079562
- Semantic Scholar
- 582a1176efde9c4eeda2c8485ba74b7e3fd03ecc
- Cited by
- 29
- References
- 70
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 2 · 2017: 4
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Israel Science Foundation (1575/14)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- APOE ε4, apolipoprotein E3, Alzheimer's disease, apolipoprotein A-I, clusterin, serum lipoproteins, cholesterol transport, APOE genotype
- MeSH terms
- Alzheimer Disease, Animals, Brain, Genotype, Lipoproteins, Male, Mice, Inbred C57BL, Peptide Fragments, Peptides, Amyloid beta-Peptides, Mice, Apolipoprotein E3, Apolipoprotein E4, ATP Binding Cassette Transporter 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
