Asara, John M.

Age-induced accumulation of methylmalonic acid promotes tumour progression

Gomes, A. P., Ilter, D., Low, V., Endress, J. E., Fernández-García, J., Rosenzweig, A., Schild, T., Broekaert, D., Ahmed, A., Planque, M., et al. (2020) · Nature

Cancer, Lipids, and MetabolismGenetics, Aging, and Longevity in Model Organisms

Cited by 244

Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis

Schweitzer, M. H., Zheng, W., Organ, C. L., Avci, R., Suo, Z., Freimark, L. M., Lebleu, V. S., Duncan, M. B., Vander Heiden, M. G., Neveu, J. M., et al. (2009) · Science

Paleontology and Evolutionary BiologyEvolution and Paleontology Studies

Cited by 238

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

Riedel, C. G., Dowen, R. H., Lourenco, G. F., Kirienko, N. V., Heimbucher, T., West, J. A., Bowman, S. K., Kingston, R. E., Dillin, A., Asara, J. M., et al. (2013) · Nature Cell Biology

FOXO transcription factor regulationGenetics, Aging, and Longevity in Model Organisms

Cited by 207

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

Brown, K. K., Spinelli, J. B., Asara, J. M., & Toker, A. (2017) · Cancer Discovery

Biochemical and Molecular ResearchCancer, Hypoxia, and Metabolism

Cited by 198

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

Perl, A., Hanczko, R., Lai, Z.-W., Oaks, Z., Kelly, R., Borsuk, R., Asara, J. M., & Phillips, P. E. (2015) · Metabolomics

Systemic Lupus Erythematosus ResearchMetabolomics and Mass Spectrometry Studies

Cited by 189

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

Krall, E. B., Wang, B., Munoz, D. M., Ilic, N., Raghavan, S., Niederst, M. J., Yu, K., Ruddy, D. A., Aguirre, A. J., Kim, J. W., et al. (2017) · eLife

Lung Cancer Treatments and MutationsGenomics, phytochemicals, and oxidative stress

Cited by 160

Stromal cues regulate the pancreatic cancer epigenome and metabolome

Sherman, M. H., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., et al. (2017) · Proceedings of the National Academy of Sciences

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 147

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-dependent Foxk1 Phosphorylation

He, L., Gomes, A. P., Wang, X., Yoon, S. O., Lee, G., Nagiec, M. J., Cho, S., Chavez, A., Islam, T., Yu, Y., et al. (2018) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 145

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

Mathur, D., Stratikopoulos, E., Ozturk, S., Steinbach, N., Pegno, S., Schoenfeld, S., Yong, R., Murty, V. V., Asara, J. M., Cantley, L. C., et al. (2017) · Cancer Discovery

Biochemical and Molecular ResearchCancer, Hypoxia, and Metabolism

Cited by 139

Altered propionate metabolism contributes to tumour progression and aggressiveness

Gomes, A. P., Ilter, D., Low, V., Drapela, S., Schild, T., Mullarky, E., Han, J., Elia, I., Broekaert, D., Rosenzweig, A., et al. (2022) · Nature Metabolism

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 104

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., et al. (2017) · Cancer Cell

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 98

SF2312 is a natural phosphonate inhibitor of enolase

Leonard, P. G., Satani, N., Maxwell, D., Lin, Y.-H., Hammoudi, N., Peng, Z., Pisaneschi, F., Link, T. M., Lee, G. R., Sun, D., et al. (2016) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismOrganophosphorus compounds synthesis

Cited by 96

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Juvekar, A., Hu, H., Yadegarynia, S., Lyssiotis, C. A., Ullas, S., Lien, E. C., Bellinger, G., Son, J., Hok, R. C., Seth, P., et al. (2016) · Proceedings of the National Academy of Sciences

PARP inhibition in cancer therapyPI3K/AKT/mTOR signaling in cancer

Cited by 93

Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

Shimizu, K., Gi, M., Suzuki, S., North, B. J., Watahiki, A., Fukumoto, S., Asara, J. M., Tokunaga, F., Wei, W., & Inuzuka, H. (2021) · Cell Reports

Ubiquitin and proteasome pathwaysCell death mechanisms and regulation

Cited by 62

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 10

The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane

Wang, Y., Liao, Y., Sun, Y., Mitra, B., Guo, R., Piedras, B. I., White, S., Tang, H.-Y., Asara, J. M., Tempera, I., et al. (2025) · Nature Communications

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 7

The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane

Wang, Y., Guo, R., Piedras, B. I., Tang, H.-Y., Asara, J. M., Tempera, I., Lieberman, P. M., & Gewurz, B. E. (2024) · Nature Communications

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 7