mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-dependent Foxk1 Phosphorylation

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Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes

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Genome-wide association study of blood lipids in Indians confirms universality of established variants

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The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

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Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification

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Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

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LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions

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FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis

Li, Y., Chen, J., Wang, B., Xu, Z., Wu, C., Ma, J., Song, Q., Geng, Q., Yu, J., Pei, H., et al. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100926 · Cited by 24 · see citing works

FOXK1 Promotes Proliferation and Metastasis of Gallbladder Cancer by Activating AKT/mTOR Signaling Pathway

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FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation

Fujinuma, S., Nakatsumi, H., Shimizu, H., Sugiyama, S., Harada, A., Goya, T., Tanaka, M., Kohjima, M., Takahashi, M., Izumi, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112530 · Cited by 24 · see citing works

Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes

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Foxk1 promotes bone formation through inducing aerobic glycolysis

Peng, S., Liu, C., Feng, N., Wang, Z., Zheng, K., Xie, Y., Long, H., 李志忠, & Long, H. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01371-w · Cited by 19 · see citing works

SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer

Jin, M., Lee, W. K., You, M., Jang, A., Cheng, S.-Y., Kim, W. G., Jeon, M. J., & Lee, Y. (2021) · Endocrine Connections · doi:10.1530/ec-21-0135 · Cited by 19 · see citing works

Targeting mTOR in the Context of Diet and Whole-body Metabolism

Koundouros, N., & Blenis, J. (2022) · Endocrinology · doi:10.1210/endocr/bqac041 · Cited by 19 · see citing works

TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling

Lin, C., Traets, J. J. H., Vredevoogd, D. W., Visser, N. L., & Peeper, D. S. (2023) · The EMBO Journal · doi:10.15252/embj.2022111614 · Cited by 18 · see citing works

WHSC1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Activating mTORC1 Signaling

Dai, J., Jiang, L., Qiu, L., Shao, Y., Shi, P., & Li, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s248570 · Cited by 19 · see citing works

Immunology of sarcoidosis: old companions, new relationships

Cinetto, F., Scarpa, R., Dell’Edera, A., & Jones, M. G. (2020) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000711 · Cited by 19 · see citing works

The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors

Moore, X. T. R., Gheghiani, L., & Fu, Z. (2023) · Cells · doi:10.3390/cells12091344 · Cited by 18 · see citing works

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive statesPreprint

Leng, K., Rose, I. V. L., Kim, H., Xia, W., Romero‐Fernandez, W., Rooney, B., Koontz, M., Li, E., Ao, Y., Wang, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.23.457400 · Cited by 18 · see citing works

A Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/β-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response

Sharma, U., Murmu, M., Barwal, T. S., Tuli, H. S., Jain, M., Prakash, H., Kaceli, T., Jain, A., & Bishayee, A. (2022) · Current Oncology · doi:10.3390/curroncol29040189 · Cited by 17 · see citing works

LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance

Huang, Y.-H., Zhang, R., Lyu, H., Xiao, S., Guo, D. S., Chen, X., Zhou, C., & Tang, J. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.91832 · Cited by 18 · see citing works

Glutamine promotes the generation of B10 + cells via the mTOR/GSK3 pathway

Mielle, J., Morel, J., ElHmioui, J., Combe, B. G., Macia, L., Dardalhon, V., Taylor, N. N., Audo, R., & Daïen, C. (2021) · European Journal of Immunology · doi:10.1002/eji.202149387 · Cited by 16 · see citing works

Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies

Martelli, A. M., Paganelli, F., Evangelisti, C., Chiarini, F., & McCubrey, J. A. (2022) · Cells · doi:10.3390/cells11111812 · Cited by 16 · see citing works

Branched-chain amino acids in muscle growth: mechanisms, physiological functions, and applications

Xu, S., Zhao, G., Hanigan, M., Cantalapiedra-Hijar, G., & Li, M. (2025) · Journal of Animal Science and Biotechnology · doi:10.1186/s40104-025-01300-y · Cited by 15 · see citing works

The role of insulin signaling with FOXO and FOXK transcription factors

Sakaguchi, M. (2024) · Endocrine Journal · doi:10.1507/endocrj.ej24-0205 · Cited by 14 · see citing works

Glycolysis modulation: New therapeutic strategies to improve pulmonary hypertension (Review)

Chen, M., Li, H., Li, Y., Luo, Y., He, Y. Z., Shui, X., & Lei, W. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5439 · Cited by 14 · see citing works

Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion

Zhao, W., Tobe, B. T. D., Udeshi, N. D., Xuan, L. L., Pernia, C. D., Zolg, D. P., Roberts, A. J., Mani, D. R., Blumenthal, S. R., Kurtser, I., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0753-6 · Cited by 14 · see citing works

Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression.

Wang, Y., Engel, T., & Teng, X. (2024) · Biochimica et Biophysica Acta. Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2024.195005 · Cited by 15 · see citing works

Macrophage Biology in Human Granulomatous Skin Inflammation

Klapproth, H., Arana, M. H., & Fabri, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054624 · Cited by 12 · see citing works

Using published pathway figures in enrichment analysis and machine learning

Shin, M., & Pico, A. R. (2023) · BMC Genomics · doi:10.1186/s12864-023-09816-1 · Cited by 12 · see citing works

Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism

Chong, Y. K., Tartey, S., Yoshikawa, Y., Imami, K., Li, S., Yoshinaga, M., Hirabayashi, A., Liu, G., Vandenbon, A., Hia, F., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abm5011 · Cited by 12 · see citing works

The emerging roles of long noncoding RNAs in lymphatic vascular development and disease

Ivanov, K. I., Samuilova, O. V., & Zamyatnin, A. A. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04842-4 · Cited by 11 · see citing works

Deciphering the Clinical Significance and Kinase Functions of GSK3α in Colon Cancer by Proteomics and Phosphoproteomics

Gao, L. P., Lü, Y., Chen, H., Li, Z., Hu, M. X., Zhang, R., Wang, X., Xu, Z., Gong, Y., Wang, R., et al. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100545 · Cited by 11 · see citing works

Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift

Migdał, M., Tralle, E., Nahia, K. A., Bugajski, Ł., Kedzierska, K., Garbicz, F., Piwocka, K., Winata, C. L., & Pawlak, M. (2021) · BMC Genomics · doi:10.1186/s12864-021-08173-1 · Cited by 9 · see citing works

Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier Formation

Wang, J., Eming, S. A., & Ding, X. (2022) · Biology · doi:10.3390/biology11060931 · Cited by 8 · see citing works

Identification of key pathways, genes and immune cell infiltration in hypoxia of high-altitude acclimatization via meta-analysis and integrated bioinformatics analysis

Li, Q., Xu, Z., Fang, F., Shen, Y., Lei, H., & Shen, X. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1055372 · Cited by 8 · see citing works

Identification and validation of new ERK substrates by phosphoproteomic technologies including Phos-tag SDS-PAGE

Yoshikawa, H., Nishino, K., & Kosako, H. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2022.104543 · Cited by 8 · see citing works

Metabolic effects of SGLT2i and metformin on 3-hydroxybutyric acid and lactate in db/db mice

Harada, M., Han, S., Shi, M., Ge, J., Yu, S., Adam, J., Adamski, J., Scheerer, M. F., Neschen, S., de Angelis, M. H., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130962 · Cited by 7 · see citing works

GSK3 inhibition reduces ECM production and prevents age-related macular degeneration–like pathology

DiCesare, S. M., Ortega, A. J., Collier, G. E., Daniel, S., Thompson, K. N., McCoy, M. K., Posner, B. A., & Hulleman, J. D. (2024) · JCI Insight · doi:10.1172/jci.insight.178050 · Cited by 6 · see citing works

FOXK2 transcription factor and its roles in tumorigenesis (Review)

Wang, Z., Liu, X., Wang, Z., & Hu, Z. (2022) · Oncology Letters · doi:10.3892/ol.2022.13581 · Cited by 7 · see citing works

Emerging roles of FOXK2 in cancers and metabolic disorders

Xing, X., Que, X., Zheng, S., Wang, S., Song, Q., Yao, Y., & Zhang, P. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1376496 · Cited by 6 · see citing works

USP28-mediated deubiquitination of FOXK1 activates the Hippo signaling pathway to regulate cell proliferation and radiosensitivity in lung cancer

Meng, Y., Xu, Y., Qiu, A., Lin, M., Yang, L., & Huang, Y. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123483 · Cited by 6 · see citing works

Regulation of CD4 + T cell differentiation and function by glucose metabolism

Liu, Y., Zhou, Y., Zhang, J., Li, J., & Zou, L. (2025) · Genes and Immunity · doi:10.1038/s41435-025-00340-8 · Cited by 6 · see citing works

Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling

van Haften, F. J., van der Sluis, T. C., Hepp, H. S., Mülling, N., Nadafi, R., Sampadi, B. K., van Duikeren, S., Mostert, J. S., van der Sterre, R., van Veelen, P. A., et al. (2026) · Nature Immunology · doi:10.1038/s41590-025-02407-0 · Cited by 8 · see citing works

mTORC1 Deficiency Prevents the Development of MC903-Induced Atopic Dermatitis through the Downregulation of Type 2 Inflammation

Gupta, A., Lee, K., & Oh, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065968 · Cited by 6 · see citing works

mTORC1 promotes metabolic reprogramming by suppression of GSK3-dependent Foxk1 phosphorylation

He, L. (2018) · Data Archiving and Networked Services (DANS) · doi:10.17632/jt5rg8n3zk.1

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

Khatri, S., Yepiskoposyan, H., Gallo, C. A., Tandon, P., & Plas, D. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121871 · Cited by 81 · see citing works

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase

Mori, S., Nada, S., Kimura, H., Tajima, S., Takahashi, Y., Kitamura, A., Oneyama, C., & Okada, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088891 · Cited by 106 · see citing works

FOXK1: a multifaceted regulator in metabolic reprogramming and disease progression

He, T., Ma, G., & Yuan, G. (2026) · Biology Direct · doi:10.1186/s13062-026-00862-9