Sapkota, Gopal P.

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

Alarcón, C., Zaromytidou, A.-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., et al. (2009) · Cell

TGF-β signaling in diseasesHippo pathway signaling and YAP/TAZ

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Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase

Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry

Gout, Hyperuricemia, Uric AcidNitric Oxide and Endothelin Effects

Cited by 411

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

Ramachandran, A., Vizán, P., Das, D., Chakravarty, P., Vogt, J., Rogers, K. W., Müller, P., Hinck, A. P., Sapkota, G. P., & Hill, C. S. (2018) · eLife

TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

Cited by 204

Advances in targeted degradation of endogenous proteins

Röth, S., Fulcher, L. J., & Sapkota, G. P. (2019) · Cellular and Molecular Life Sciences

Protein Degradation and InhibitorsCRISPR and Genetic Engineering

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An affinity-directed protein missile system for targeted proteolysis

Fulcher, L. J., Macartney, T., Bozatzi, P., Hornberger, A., Rojas-Fernandez, A., & Sapkota, G. P. (2016) · Open Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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Targeting endogenous proteins for degradation through the affinity-directed protein missile system

Fulcher, L. J., Hutchinson, L. D., Macartney, T. J., Turnbull, C., & Sapkota, G. P. (2017) · Open Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

Salinas-Rebolledo, C., Blesa, J., Valenzuela-Nieto, G., Schwefel, D., del Rey, N. L. G., Méndez-Ruette, M., Burkhalter, J., Bátiz, L. F., Jara, R., Obeso, J. A., et al. (2024) · eLife

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

Salinas-Rebolledo, C., Blesa, J., Valenzuela-Nieto, G., Schwefel, D., López-González del Rey, N., Méndez-Ruette, M., Burkhalter, J., Carrazana, E., Díaz-Tejeda, F., Arias Catalán, I., et al. (2025) · eLife

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish its interaction with the Ser/Thr kinase CK1α

Utgés, J. S., Xuan, D. L. Z., Le Chatelier, B., Glennie, L., Macartney, T. J., Wood, N. T., Barton, G. J., & Sapkota, G. P. (2025) · Open Biology

Wnt/β-catenin signaling in development and cancerProtein Structure and Dynamics

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