Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
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TGF-beta and BMP receptor kinases activate Smad transcription factors by C-terminal phosphorylation. We have identified a subsequent agonist-induced phosphorylation that plays a central dual role in Smad transcriptional activation and turnover. As receptor-activated Smads form transcriptional complexes, they are phosphorylated at an interdomain linker region by CDK8 and CDK9, which are components of transcriptional mediator and elongation complexes. These phosphorylations promote Smad transcriptional action, which in the case of Smad1 is mediated by the recruitment of YAP to the phosphorylated linker sites. An effector of the highly conserved Hippo organ size control pathway, YAP supports Smad1-dependent transcription and is required for BMP suppression of neural differentiation of mouse embryonic stem cells. The phosphorylated linker is ultimately recognized by specific ubiquitin ligases, leading to proteasome-mediated turnover of activated Smad proteins. Thus, nuclear CDK8/9 drive a cycle of Smad utilization and disposal that is an integral part of canonical BMP and TGF-beta pathways.
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Several mechanisms have been proposed for how Yap or Taz interact with Smads, including binding to Smad7, promotion of Smad1 transcriptional action, and effects on Smad2/3 localisation.
“Several mechanisms have been proposed that can explain how Yap or Taz can interact with Smads. These include the binding of Yap to the inhibitory Smad7 (7, 49), the promotion of Smad1 transcriptional action by Yap binding (3), and an effect of Yap and Taz on Smad2/3 localisation (137).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [3]
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- Authors
- Alarcón, C., Zaromytidou, A.-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D., & Massagué, J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Johns Hopkins University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Massagué, Joan
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 139
- Issue
- 4
- Pages
- 757-769
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2818353
- OpenAlex
- W2034469841
- Cited by
- 719
- References
- 59
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 36 · 2023: 28 · 2022: 39 · 2021: 31 · 2020: 37 · 2019: 47 · 2018: 46 · 2017: 47 · 2016: 49 · 2015: 60 · 2014: 49 · 2013: 64 · 2012: 71
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1354 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Public Health Service (BFU2008-02795)
- National Eye Institute (EY015708, R01EY015708)
- National Cancer Institute (R37CA034610, CA34610, R01CA034610, P30CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Smad, CDK8, CDK9, TGF-beta signaling, BMP signaling, Smad1, YAP, ubiquitination, proteasomal degradation, transcriptional activation, Hippo signaling pathway, neuronal differentiation, mouse embryonic stem cells
- MeSH terms
- YAP-Signaling Proteins, Animals, Cell Line, Contact Inhibition, Embryo, Mammalian, Humans, Organ Size, Phosphoproteins, Phosphorylation, Signal Transduction, Transcriptional Activation, Transforming Growth Factor beta, Protein Structure, Tertiary, Cell Cycle Proteins, Bone Morphogenetic Proteins, Cyclin-Dependent Kinase 9, Adaptor Proteins, Signal Transducing, Mice, Smad Proteins, Smad1 Protein, Cyclin-Dependent Kinase 8
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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