Tchorz, Jan S.

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., et al. (2016) · Nature Cell Biology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 359

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

He, L., Pu, W., Liu, X., Zhang, Z., Han, M., Li, Y., Huang, X., Han, X., Li, Y., Liu, K., et al. (2021) · Science

Liver physiology and pathologyCongenital heart defects research

Cited by 261

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Planas-Paz, L., Sun, T., Pikiolek, M., Cochran, N. R., Bergling, S., Orsini, V., Yang, Z., Sigoillot, F., Jetzer, J., Syed, M., et al. (2019) · Cell Stem Cell

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 216

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

Sun, T., Pikiolek, M., Orsini, V., Bergling, S., Holwerda, S., Morelli, L., Hoppe, P. S., Planas-Paz, L., Yang, Y., Ruffner, H., et al. (2020) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 166

Bipotent transitional liver progenitor cells contribute to liver regeneration

Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., et al. (2023) · Nature Genetics

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 138

Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology

Martini, T., Naef, F., & Tchorz, J. S. (2023) · Annual Review of Pathology: Mechanisms of Disease

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 113

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 84

The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease

Annunziato, S., Sun, T., & Tchorz, J. S. (2022) · Hepatology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 45

Distinct hepatocyte identities in liver homeostasis and regeneration

Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 30

Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease

Saponara, E., Penno, C., Orsini, V., Wang, Z.-Y., Fischer, A., Aebi, A., Matadamas-Guzman, M. L., Brun, V., Fischer, B., Brousseau, M., et al. (2023) · The American Journal of Pathology

Liver Disease Diagnosis and TreatmentWnt/β-catenin signaling in development and cancer

Cited by 22

Single-Cell Transcriptomic Profiling of Cholangiocyte Organoids Derived from Bile Ducts of Primary Sclerosing Cholangitis Patients

Frank, A. K., Chung, B. K., De Novales, M. L. L., Engesæter, L. K., Hoyle, H. W., Øgaard, J., Heslop, J., Karlsen, T. H., Tysoe, O., Brevini, T., et al. (2024) · Digestive Diseases and Sciences

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 14

Prometheus revisited: liver homeostasis and repair

Sun, T., Annunziato, S., & Tchorz, J. S. (2020) · Aging

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 6

The Conundrum of the Pericentral Hepatic Niche: WNT/-Catenin Signaling, Metabolic Zonation, and Many Open Questions

Tchorz, J. S. (2020) · Gene Expression

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 6