Prometheus revisited: liver homeostasis and repair
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Conflicting findings challenge the existence of a bona fide liver stem cell.
“In recent years, several putative liver stem cells with increased regenerative potential during homeostasis and regeneration have been proposed, but conflicting findings challenge the existence of a bona fide liver stem cell.13”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [13]
Whether specialised liver stem cells maintain hepatocyte numbers during homeostasis remains controversial.
“Whether specialised liver stem cells maintain hepatocyte numbers during homeostasis remains controversial.13,77”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [13]
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Cites
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486 · see citing works
The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size
Planas-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3337 · Cited by 359 · see citing works
Self-citationDistributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
Lin, S., Nascimento, E. M., Gajera, C. R., Chen, L., Neuhöfer, P., Garbuzov, A., Wang, S., & Artandi, S. E. (2018) · Nature · doi:10.1038/s41586-018-0004-7 · Cited by 241 · see citing works
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration
Chen, F., Jimenez, R. J., Sharma, K., Luu, H. Y., Hsu, B. Y., Ravindranathan, A., Stohr, B. A., & Willenbring, H. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.001 · Cited by 236 · see citing works
Matsumoto, T., Wakefield, L., Tarlow, B. D., & Grompe, M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.014 · Cited by 194 · see citing works
AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration
Sun, T., Pikiolek, M., Orsini, V., Bergling, S., Holwerda, S., Morelli, L., Hoppe, P. S., Planas-Paz, L., Yang, Y., Ruffner, H., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.10.011 · Cited by 166 · see citing works
Self-citationAng, C. H., Hsu, S. H., Guo, F., Tan, C. T., Yu, V. C., Visvader, J. E., Chow, P. K. H., & Fu, N. Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908099116 · Cited by 102 · see citing works
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The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease
Annunziato, S., Sun, T., & Tchorz, J. S. (2022) · Hepatology · doi:10.1002/hep.32328 · Cited by 45 · see citing works
Self-citationDistinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
Self-citationMacrophage pathology in hepatotoxicity
Yamate, J., Izawa, T., & Kuwamura, M. (2022) · Journal of Toxicologic Pathology · doi:10.1293/tox.2022-0112 · Cited by 13 · see citing works
Cellular plasticity at the nexus of development and disease
Spatz, L. B., Jin, R. U., & Mills, J. (2021) · Development · doi:10.1242/dev.197392 · Cited by 9 · see citing works
Epimeteo y Prometeo en los tiempos del COVID-19
Young, P. (2020) · Fronteras en Medicina · doi:10.31954/rfem/202002/0075-0079 · Cited by 7 · see citing works
- Authors
- Sun, T., Annunziato, S., & Tchorz, J. S.
- Affiliations
- Novartis (Switzerland) (CH)
- Corresponding author
- Tchorz, Jan S.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2020-03-23
- Volume
- 12
- Issue
- 6
- Pages
- 4685-4687
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC7138553
- OpenAlex
- W3012945391
- Cited by
- 6
- References
- 8
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- liver homeostasis, liver repair, liver regeneration, hepatocyte senescence, liver fibrosis
- MeSH terms
- Homeostasis, Humans, Liver, Liver Regeneration, Hepatocytes
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