Klenerman, David

Accurate whole human genome sequencing using reversible terminator chemistry

Bentley, D. R., Balasubramanian, S., Swerdlow, H. P., Smith, G. P., Milton, J., Brown, C. G., Hall, K. P., Evers, D. J., Barnes, C. L., Bignell, H. R., et al. (2008) · Nature

Genomics and Phylogenetic StudiesGenomics and Rare Diseases

Cited by 3,684

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Ludtmann, M. H. R., Angelova, P. R., Horrocks, M. H., Choi, M. L., Rodrigues, M., Baev, A. Y., Berezhnov, A. V., Yao, Z., Little, D., Banushi, B., et al. (2018) · Nature Communications

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 513

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

De, S., Wirthensohn, D. C., Flagmeier, P., Hughes, C., Aprile, F. A., Ruggeri, F. S., Whiten, D. R., Emin, D., Xia, Z., Varela, J. A., et al. (2019) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 448

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

Hughes, C. D., Choi, M. L., Ryten, M., Hopkins, L., Drews, A., Botía, J. A., Iljina, M., Rodrigues, M., Gagliano, S. A., Gandhi, S., et al. (2019) · Acta Neuropathologica

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 177

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

Meisl, G., Hidari, E., Allinson, K., Rittman, T., DeVos, S. L., Sanchez, J. S., Xu, C. K., Duff, K. E., Johnson, K. A., Rowe, J. B., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 127

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Hughes, C., Choi, M. L., Yi, J.-H., Kim, S.-C., Drews, A., George-Hyslop, P. S., Bryant, C., Gandhi, S., Cho, K., & Klenerman, D. (2020) · Communications Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 107

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

Meng, J. X., Zhang, Y., Saman, D., Haider, A. M., De, S., Sang, J. C., Brown, K., Jiang, K., Humphrey, J., Julian, L., et al. (2022) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 84

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

Esteras, N., Kundel, F., Amodeo, G. F., Pavlov, E. V., Klenerman, D., & Abramov, A. Y. (2021) · The FEBS Journal

Alzheimer's disease research and treatmentsAldose Reductase and Taurine

Cited by 78

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.

Iljina, M., Garcia, G. A., Dear, A. J., Flint, J., Narayan, P., Michaels, T. C. T., Dobson, C. M., Frenkel, D., Knowles, T. P. J., & Klenerman, D. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 68

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Xia, Z., Prescott, E. E., Urbanek, A., Wareing, H. E., King, M. C., Olerinyova, A., Dakin, H., Leah, T., Barnes, K. A., Matuszyk, M. M., et al. (2024) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 67

Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses

Mallucci, G. R., Klenerman, D., & Rubinsztein, D. C. (2020) · Annual Review of Cell and Developmental Biology

Heat shock proteins researchAlzheimer's disease research and treatments

Cited by 62

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

Rajani, R. M., Ellingford, R., Hellmuth, M., Harris, S. S., Taso, O. S., Graykowski, D., Lam, F. K. W., Arber, C., Fertan, E., Danial, J. S. H., et al. (2024) · PLOS Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 62

Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.

Danial, J. S. H., Lam, J. Y. L., Wu, Y., Woolley, M., Dimou, E., Cheetham, M. R., Emin, D., & Klenerman, D. (2022) · Nature Protocols

Advanced Fluorescence Microscopy TechniquesForce Microscopy Techniques and Applications

Cited by 40

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia

Preman, P., Moechars, D., Fertan, E., Wolfs, L., Serneels, L., Shah, D., Lamote, J., Poovathingal, S., Snellinx, A., Mancuso, R., et al. (2024) · EMBO Molecular Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 32

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy

Fertan, E., Böken, D., Murray, A., Danial, J. S. H., Lam, J. Y. L., Wu, Y., Goh, P. A., Alić, I., Cheetham, M. R., Lobanova, E., et al. (2024) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 31

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

Leithner, A., Staufer, O., Mitra, T., Liberta, F., Valvo, S., Kutuzov, M., Dada, H., Spaeth, J., Zhou, W., Schiele, F., et al. (2025) · Proceedings of the National Academy of Sciences

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 22

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

Leithner, A., Staufer, O., Mitra, T., Liberta, F., Valvo, S., Kutuzov, M., Dada, H., Spaeth, J., Zhou, S., Schiele, F., et al. (2022) · Proceedings of the National Academy of Sciences

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 21

A computational suite for the structural and functional characterization of amyloid aggregates

Xia, Z., Wu, Y., Lam, J. Y. L., Zhang, Z., Burke, M., Fertan, E., Ranasinghe, R. T., Hidari, E., Danial, J. S. H., & Klenerman, D. (2023) · Cell Reports Methods

Alzheimer's disease research and treatmentsCell Image Analysis Techniques

Cited by 13