Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
Open accessAbstract
Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures of aggregate populations that are closely linked to neurodegenerative conditions, such as Alzheimer’s disease. Here, we find that soluble aggregates formed at different stages of the aggregation process of amyloid beta (Aβ42) induce the disruption of lipid bilayers and an inflammatory response to different extents. Further, by using gradient ultracentrifugation assay, we show that the smaller aggregates are those most potent at inducing membrane permeability and most effectively inhibited by antibodies binding to the C-terminal region of Aβ42. By contrast, we find that the larger soluble aggregates are those most effective at causing an inflammatory response in microglia cells and more effectively inhibited by antibodies targeting the N-terminal region of Aβ42. These findings suggest that different toxic mechanisms driven by different soluble aggregated species of Aβ42 may contribute to the onset and progression of Alzheimer’s disease.
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Misfolded proteins and protein aggregates, including tau, Aβ, α-synuclein, mutant huntingtin, TDP-43, SOD1, and FUS induce microglial activation and neuroinflammation.
“Numerous studies have reported that misfolded proteins and protein aggregates, including tau,136–139 Aβ,138,140 α-synuclein,141–144 mutant huntingtin,145 TDP-43,132,146 superoxide dismutase 1 (SOD1),147–149 and fused in sarcoma (FUS)150 induce microglial activation and neuroinflammation.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [140]
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- Authors
- De, S., Wirthensohn, D. C., Flagmeier, P., Hughes, C., Aprile, F. A., Ruggeri, F. S., Whiten, D. R., Emin, D., Xia, Z., Varela, J. A., Sormanni, P., Kundel, F., Knowles, T. P. J., Dobson, C. M., Bryant, C., Vendruscolo, M., & Klenerman, D.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- De, Suman
- Vendruscolo, Michele
- Klenerman, David
- ORCID
- Venue
- Nature Communications
- Published
- 2019-04-04
- Volume
- 10
- Issue
- 1
- Pages
- 1541-1541
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6449370
- OpenAlex
- W2927667967
- Cited by
- 448
- References
- 53
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 32 · 2023: 30 · 2022: 34 · 2021: 188 · 2020: 114 · 2019: 9 · 2018: 1
- FWCI
- 59.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Apollo
- Funders
- U.S. Department of Veterans Affairs (IIR 16-003)
- Wellcome Trust (669237)
- Alzheimer's Society (317, AS-SF-16-003, AS-SF-16-003)
- Royal Society
- University of Cambridge
- Boehringer Ingelheim Fonds
- Studienstiftung des Deutschen Volkes
- Federal Aviation Administration
- Engineering and Physical Sciences Research Council
- H2020 European Research Council (669237)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta 42, Alzheimer's disease, membrane permeability, lipid bilayer disruption, neuroinflammation, microglia, anti-amyloid antibodies, aggregation kinetics, aggregate size, neurotoxicity
- MeSH terms
- Animals, Cell Membrane Permeability, Lipid Bilayers, Ultracentrifugation, Amyloid beta-Peptides, Microglia, Mice, Protein Aggregation, Pathological
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