Cherepanov, Peter

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells

Cherepanov, P., Maertens, G., Proost, P., Devreese, B., Van Beeumen, J., Engelborghs, Y., De Clercq, E., & Debyser, Z. (2003) · Journal of Biological Chemistry

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 704

Retroviral intasome assembly and inhibition of DNA strand transfer

Hare, S., Gupta, S. S., Valkov, E., Engelman, A., & Cherepanov, P. (2010) · Nature

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 678

LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., De Clercq, E., Debyser, Z., & Engelborghs, Y. (2003) · Journal of Biological Chemistry

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 493

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

Shun, M.-C., Raghavendra, N. K., Vandegraaff, N., Daigle, J. E., Hughes, S., Kellam, P., Cherepanov, P., & Engelman, A. (2007) · Genes & Development

HIV Research and TreatmentVirus-based gene therapy research

Cited by 467

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75

Cherepanov, P., Ambrosio, A. L. B., Rahman, S., Ellenberger, T., & Engelman, A. (2005) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 408

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

Hare, S., Vos, A. M., Clayton, R. F., Thuring, J. W., Cummings, M. D., & Cherepanov, P. (2010) · Proceedings of the National Academy of Sciences

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 305

The mechanism of retroviral integration from X-ray structures of its key intermediates

Maertens, G. N., Hare, S., & Cherepanov, P. (2010) · Nature

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 296

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 Integrase

Cherepanov, P., Devroe, E., Silver, P. A., & Engelman, A. (2004) · Journal of Biological Chemistry

HIV Research and TreatmentGenomics and Chromatin Dynamics

Cited by 287

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

Hare, S., Smith, S. J., Métifiot, M., Jaxa-Chamiec, A., Pommier, Y., Hughes, S. H., & Cherepanov, P. (2011) · Molecular Pharmacology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 264

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Cherepanov, P., Sun, Z.-Y. J., Rahman, S., Maertens, G., Wagner, G., & Engelman, A. (2005) · Nature Structural & Molecular Biology

HIV Research and TreatmentProtein Structure and Dynamics

Cited by 235

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

Engelman, A., & Cherepanov, P. (2008) · PLoS Pathogens

HIV Research and TreatmentVirus-based gene therapy research

Cited by 231

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

Cherepanov, P. (2007) · Nucleic Acids Research

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 173

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

Hare, S., Shun, M.-C., Gupta, S. S., Valkov, E., Engelman, A., & Cherepanov, P. (2009) · PLoS Pathogens

Virus-based gene therapy researchHIV Research and Treatment

Cited by 166

3′‐Processing and strand transfer catalysed by retroviral integrase in crystallo

Hare, S., Maertens, G. N., & Cherepanov, P. (2012) · The EMBO Journal

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 153

Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration

Gupta, S. S., Maetzig, T., Maertens, G. N., Sharif, A., Rothe, M., Weidner-Glunde, M., Galla, M., Schambach, A., Cherepanov, P., & Schulz, T. F. (2013) · Journal of Virology

Virus-based gene therapy researchHIV Research and Treatment

Cited by 139

Structural basis for retroviral integration into nucleosomes

Maskell, D. P., Renault, L., Serrao, E., Lesbats, P., Matadeen, R., Hare, S., Lindemann, D., Engelman, A. N., Costa, A., & Cherepanov, P. (2015) · Nature

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 138

Functional and structural characterization of the integrase from the prototype foamy virus

Valkov, E., Gupta, S. S., Hare, S., Helander, A., Roversi, P., McClure, M., & Cherepanov, P. (2009) · Nucleic Acids Research

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 130

Structure and function of retroviral integrase

Maertens, G. N., Engelman, A. N., & Cherepanov, P. (2022) · Nature Reviews Microbiology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 124

Structural Basis for Functional Tetramerization of Lentiviral Integrase

Hare, S., Di Nunzio, F., Labeja, A., Wang, J., Engelman, A., & Cherepanov, P. (2009) · PLoS Pathogens

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 122

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Cook, N. J., Li, W., Berta, D., Badaoui, M., Ballandras-Colas, A., Nans, A., Kotecha, A., Rosta, E., Engelman, A. N., & Cherepanov, P. (2020) · Science

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 108

A supramolecular assembly mediates lentiviral DNA integration

Ballandras-Colas, A., Maskell, D. P., Serrao, E., Locke, J., Swuec, P., Jónsson, S. R., Kotecha, A., Cook, N. J., Pye, V. E., Taylor, I. A., et al. (2017) · Science

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 107

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

Ballandras-Colas, A., Brown, M., Cook, N. J., Dewdney, T. G., Demeler, B., Cherepanov, P., Lyumkis, D., & Engelman, A. N. (2016) · Nature

Virus-based gene therapy researchHIV Research and Treatment

Cited by 98

Key determinants of target DNA recognition by retroviral intasomes

Serrao, E., Ballandras-Colas, A., Cherepanov, P., Maertens, G. N., & Engelman, A. N. (2015) · Retrovirology

Virus-based gene therapy researchHIV Research and Treatment

Cited by 62

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Serrao, E., Krishnan, L., Shun, M.-C., Li, X., Cherepanov, P., Engelman, A., & Maertens, G. N. (2014) · Nucleic Acids Research

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 59